Journal
NEUROSCIENCE LETTERS
Volume 599, Issue -, Pages 12-19Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.05.024
Keywords
Experimental Parkinson's disease; Lycopene; Oxidative stress; Apoptosis; Behavior
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Funding
- Indian Council of Medical Research, New Delhi, India
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Parkinson's disease (PD) is the second most common neurodegenerative disorder that mainly affects the movement of the aged populations. Lycopene is a carotenoid with unique pharmacological properties and its efficacy on experimental Hunginton's disease and brain ischemia has shown intense neuroprotective effects. The present study was aimed to explore the neuroprotective effect of lycopene against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced PD mice. Administration of lycopene (5, 10 and 20 mg/kg/day orally) protected MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose dependent manner. It also attenuated MPTP-induced oxidative stress and motor abnormalities seen in PD mice. Our western blot studies showed that treatment with lycopene reversed MPTP induced apoptosis may be due to its antioxidant and antiapoptotic properties. As to conclude, lycopene reverses neurochemical deficts, oxidative stress, apoptosis and physiological abnormalities in PD mice and offer promise strategy in the treatment of this neurodegenerative disease. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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