Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 96, Issue 5, Pages 1269-1271Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2010-2922
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Funding
- NIDDK NIH HHS [R21 DK077669, DK82396, DK76486, DK76829, R01 DK078646, DK77669, R01 DK076829, R01 DK082396] Funding Source: Medline
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Novel data show that the bone protein, undercarboxylated osteocalcin, increases islet cell growth and insulin and adiponectin synthesis and enhances glucose metabolism in mice. Human studies, in which undercarboxylated osteocalcin concentrations have been perturbed, show no effect (or a very minor effect) on fasting glucose or insulin concentrations. More extensive and detailed experiments in humans are needed to definitively establish the role of undercarboxylated osteocalcin in human carbohydrate metabolism. (J Clin Endocrinol Metab 96: 1269-1271, 2011)
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