Article
Endocrinology & Metabolism
Sayaka Yamada, Kazuhiko Horiguchi, Masako Akuzawa, Koji Sakamaki, Eijiro Yamada, Atsushi Ozawa, Isao Kobayashi, Yohnosuke Shimomura, Yasuyuki Okamoto, Tetsuro Andou, Yoshitaka Andou, Masanobu Yamada
Summary: This study investigated the age- and sex-based differences in serum thyroid-stimulating hormone (TSH) and thyroid hormone levels in euthyroid individuals. The results showed that using age- and sex-specific reference ranges can avoid over- or underdiagnosis of subclinical thyroid dysfunction.
Article
Endocrinology & Metabolism
Simone Canovi, Silvia Vezzani, Alessandra Polese, Andrea Frasoldati, Clara Schiatti, Cristina Preda, Michele Corradini Zini, Antonio Vitiello, Marco Foracchia, Giuseppina Comitini, Lorenzo Aguzzoli, Tommaso Fasano, Luigi Vecchia
Summary: This study established pregnancy-related reference intervals for serum TSH in singleton pregnant women using real-life clinical data, which may reduce the risk of misclassification in pregnant women undergoing thyroid function testing.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Matthew D. Ettleson, Wesley H. Prieto, Pedro S. T. Russo, Jose de Sa, Wen Wan, Neda Laiteerapong, Rui M. B. Maciel, Antonio C. Bianco
Summary: Despite changes in thyroid-stimulating hormone (TSH) levels, small adjustments in levothyroxine (LT4) dose do not provide clinical benefit. The changes in serum total triiodothyronine (T3) levels may not accurately reflect the changes in TSH levels. Therefore, dose changes in LT4 may minimally affect T3 levels without significant clinical benefit.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Alexander M. Kotlyar, David B. Seifer
Summary: Ethnic/race- and age-related variations in AMH levels have been observed, with black and Hispanic women generally showing lower levels compared to Caucasian women, and Chinese women exhibiting higher levels before age 25. Age is positively correlated with AMH until at least 25 years old, followed by a consistent decline towards menopause. Differences in AMH levels among ethnicities and races highlight the complexity of ovarian reserve testing.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Sylwia Placzkowska, Malgorzata Terpinska, Agnieszka Piwowar
Summary: This study aimed to determine reference intervals (RIs) for TSH and fT4 using the indirect Hoffman method and compare them with commonly used RIs. The results showed varying RIs in different age groups of the examined populations. The established RIs for fT4 were similar to the manufacturer and literature data, while RIs for TSH differed between age groups.
Article
Pediatrics
Gwo-Tsann Chuang, I-Jung Tsai, Yong-Kwei Tsau
Summary: This study assessed age- and sex-specific serum creatinine levels in a pediatric population in Taiwan, generating reference limits for each group. By excluding individuals with potential acute or chronic kidney conditions, the study aids physicians in evaluating renal function in clinical practice.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medical Laboratory Technology
Agata Sobczynska-Malefora, Agata Sobczy, Alexander Katayev, David Steed, Jessica O'Logbon, Martin Crook, Dominic J. Harrington
Summary: This study found that age and ethnicity influence B12 levels, with higher levels in Black adults compared to Asian and White adults. There were no differences between Asian and White adults. Children aged 2-5 had the highest B12 levels. Age- and ethnicity-specific reference intervals were established based on the data.
CLINICAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Gloria Hoi-Yee Li, Ching-Lung Cheung, Elaine Yun-Ning Cheung, Wai-Chi Chan, Kathryn Choon-Beng Tan
Summary: Genetically determined increase in TSH levels within the reference range may lower the risk of Alzheimer's disease, with possible mediation by atrial fibrillation, blood pressure, while no causal association was found between FT4 levels and Alzheimer's disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Hengameh Abdi, Bita Faam, Safoora Gharibzadeh, Ladan Mehran, Maryam Tohidi, Fereidoun Azizi, Atieh Amouzegar
Summary: The study determined age and sex-specific TSH and FT4 reference ranges according to BMI categories. Females had higher TSH levels than males in all BMI categories, while FT4 levels were higher in the normal weight group compared to obese individuals. The upper limits of TSH showed an increasing pattern with increasing BMI, while FT4 levels showed a decreasing pattern.
ENDOCRINE RESEARCH
(2021)
Article
Medicine, General & Internal
Christiane Gaertner, Romy Langhammer, Maria Schmidt, Martin Federbusch, Kerstin Wirkner, Markus Loeffler, Berend Isermann, Ulrich Laufs, Rolf Wachter, Thorsten Kaiser
Summary: Sex-adjusted and age-adjusted upper reference limits for hs-cTnT were identified in a large cohort without cardiac diseases. hs-cTnT values were higher in men of all age groups, and increased with age in both sexes. Renal function showed weak correlation with hs-cTnT, and was not found to have a significant additional effect on hs-cTnT levels. In individuals aged above 60 for men and above 70 for women, the calculated 99th percentiles exceeded commonly applied thresholds.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Joris A. J. Osinga, Arash Derakhshan, Glenn E. Palomaki, Ghalia Ashoor, Tuija Mannisto, Spyridoula Maraka, Liangmiao Chen, Sofie Bliddal, Xuemian Lu, Peter N. Taylor, Tanja G. M. Vrijkotte, Fang-Biao Tao, Suzanne J. Brown, Farkhanda Ghafoor, Kris Poppe, Flora Veltri, Lida Chatzi, Bijay Vaidya, Maarten A. C. Broeren, Beverley M. Shields, Sachiko Itoh, Lorena Mosso, Polina Popova, Anna D. Anopova, Reiko Kishi, Ashraf Aminorroaya, Maryam Kianpour, Abel Lopez-Bermejo, Emily Oken, Amna Pirzada, Marina Vafeiadi, Wichor M. Bramer, Eila Suvanto, Jun Yoshinaga, Kun Huang, Judit Bassols, Laura Boucai, Ulla Feldt-Rasmussen, Elena N. Grineva, Elizabeth N. Pearce, Erik K. Alexander, Victor J. M. Pop, Scott M. Nelson, John P. Walsh, Robin P. Peeters, Layal Chaker, Kypros H. Nicolaides, Mary E. D'Alton, Tim I. M. Korevaar
Summary: This study aims to provide reference intervals for TSH and FT4 during pregnancy and assess the consequences of methodological differences between studies. The study identified significant methodological differences and suggests that future studies can adopt simplified study designs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Critical Care Medicine
Jonathan Witonsky, Jennifer R. Elhawary, Celeste Eng, Jose R. Rodriguez-Santana, Luisa N. Borrell, Esteban G. Burchard
Summary: This study evaluated the influence of genetic ancestry on the fit of race- and ethnicity-based spirometry reference equations in genetically admixed children. The results showed that there were biased estimates of lung function in African American and Puerto Rican children with high variation of African ancestry. Therefore, spirometry could benefit from reference equations that incorporate genetic ancestry.
Article
Pediatrics
Tomohiko Nishino, Shota Endo, Hiroki Miyano, Yoichi Takemasa, Masahito Saito, Chisato Umeda, Yuji Tomii, Yoshitaka Watanabe, Mayu Nakagawa, Daisuke Kakegawa, Shuichiro Fujinaga
Summary: This study established specific reference serum creatinine levels and quintic equations for children with Down syndrome, showing different trajectories for sex, age, and length/height compared to standard levels for healthy children. These findings are useful for assessing renal function in this population.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Yozen Fuse, Yoshiya Ito, Yoshimasa Shishiba, Minoru Irie
Summary: Thyroid diseases in pregnant and lactating women may have negative impacts on both mothers and infants. The study established trimester-specific reference ranges of TSH and FT4 concentrations for Japanese pregnant women, showing higher limits compared to international data. Further research with larger samples is needed.
Article
Endocrinology & Metabolism
Yozen Fuse, Yoshiya Ito, Yoshimasa Shishiba, Minoru Irie
Summary: Thyroid diseases during pregnancy and lactation can have adverse effects on both mothers and infants. Establishing gestational trimester-specific reference ranges for thyroid function is important for Japanese pregnant women, as there have been few studies on this topic. This study compiled data from 481 pregnant women in Japan to determine the reference ranges for serum TSH and FT4 concentrations. The reference ranges for TSH and FT4 in the first trimester were higher in Japan compared to other countries, highlighting the need for further research with larger sample sizes.