Article
Medicine, General & Internal
Rakesh Kumar, Allison M. LeMahieu, Marius N. Stan, Ashok Seshadri, Aysegul Ozerdem, Vanessa K. Pazdernik, Tara L. Haynes, David H. Daugherty III, Vishnu Sundaresh, Marin Veldic, Paul E. Croarkin, Mark A. Frye, Balwinder Singh
Summary: This population-based study investigated the association between thyroid-stimulating hormone (TSH) and clinically relevant depression (CRD), finding that low TSH was associated with higher odds of depression.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Endocrinology & Metabolism
Yi Dou, Yingji Chen, Daixing Hu, Xinliang Su
Summary: This study found that around 74.21% of low-risk PTC patients do not require hormone replacement therapy after lobectomy, while 40.53% develop temporary or permanent hypothyroidism. Multivariate analysis showed that higher preoperative TSH levels, presence of Hashimoto's thyroiditis, and right lobectomy were associated with hypothyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ranran Shi, Ming Zhang, Yao Chen, Meiying Han, Ping Xu, Min Li, Yanjie Ding, Xiaohui Zhang, Yan Kou, Haiyan Xu, Fangru Zong, Xinjian Liu, Hui Wang, Haiying He, Qiang Liu, Weikang Kong, Shiping Niu, Xia Li, Lei Huang, Qinghua Lu, Xiaofang Wang, Liping Deng, Zhenying Yang, Xiao Zhang, Rongrong Sun, Riming Zhao, Jing Shi, Fudong Peng, Xueming Sun, Guoying Zhao, Xinfeng Zhao, Yonghong Ge, Nan Zhang, Renxia Zhu, Jing Li, Haiyan Li, Huijuan Hao, Yonghui Yu
Summary: The study aimed to investigate the relationship between thyroid indicators and postmenstrual age in very preterm infants. The results showed that the percentile charts of TSH values gradually increased initially and then decreased with increasing PMA, while the FT4 values reached their lowest point at PMA26-27 weeks and gradually increased to the level of full-term infants at PMA38-40 weeks.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Camilla Janett-Pellegri, Lea Wildisen, Martin Feller, Cinzia Del Giovane, Elisavet Moutzouri, Oliver Grolimund, Patrick Walter, Gerard Waeber, Pedro Marques-Vidal, Peter Vollenweider, Nicolas Rodondi
Summary: This study assessed the prevalence of chronic levothyroxine use, ranking it second among chronic drugs. Factors associated with chronic levothyroxine use included increasing age, female sex, BMI, number of concomitant drugs, and family history of thyroid pathologies. More than one in four chronic users were found to be outside the usual TSH therapeutic range.
Article
Medical Laboratory Technology
Miao Wang, Jing Li, Youyuan Huang, Tao Chen, Sheng Dong, Ruyi Zhang, Shen Wang, Jian Tan, Qiang Jia, Zhaowei Meng
Summary: This study evaluated the analytical characteristics of a new high-sensitivity hTSH assay and found that it has superior detection sensitivity for profoundly low TSH levels. Comparisons with other ultrasensitive assays showed reasonable agreement.
CLINICAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Hye Jeong Kim, Sang Joon Park, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo
Summary: In euthyroid subjects, thyroid autoimmunity is significantly associated with metabolic syndrome. Subjects with positive TPOAb have a higher risk of developing MetS, suggesting a potential role of thyroid autoimmunity in metabolic disorders. Future longitudinal studies are needed to establish causality.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Justyna Milczarek-Banach, Piotr Miskiewicz
Summary: For reproductive women without autoimmune thyroid disease, thyroid volume is negatively correlated with TSH levels, and a thyroid volume cutoff point of 9 mL is a predictive factor for TSH levels above 2.5 mu IU/mL.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Zhiyuan Wu, Yue Jiang, Di Zhou, Shuo Chen, Yu Zhao, Haiping Zhang, Yue Liu, Xia Li, Wei Wang, Jingbo Zhang, Xiaoping Kang, Lixin Tao, Bo Gao, Xiuhua Guo
Summary: Subclinical hypothyroidism is associated with incident metabolic syndrome in young men, but not in individuals aged 50 years or older.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Carole Ann Spencer
Summary: This review highlights the development of laboratory thyroid tests over the past seven decades, from manual isotopically labeled iodine procedures to automated nonisotopic tests. The introduction of radioimmunoassay techniques and monoclonal antibody technology has played a crucial role in the evolution of thyroid testing. Despite improvements, current tests still face limitations in terms of numerical differences and interferences from reagents and autoantibodies.
Article
Medicine, General & Internal
Juan Jesus Fernandez Alba, Maria Castillo Lara, Jose Manuel Jimenez Heras, Rocio Moreno Cortes, Carmen Gonzalez Macias, Angel Vilar Sanchez, Florentino Carral San Laureano, Luis Javier Moreno Corral
Summary: There is an association between subclinical hypothyroidism and gestational diabetes mellitus (GDM), with higher risk in pregnant women with subclinical hypothyroidism compared to those with normal thyroid function. Elevated thyroid stimulating hormone (TSH) levels within the normal range also increase the risk of GDM in pregnant women. Moreover, pregnant women with positive thyroid antibodies have a significantly higher risk of developing GDM.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Rebecca McCowan, Edith Wild, Angela K. Lucas-Herald, Jane McNeilly, Avril Mason, Sze Choong Wong, S. Faisal Ahmed, M. Guftar Shaikh
Summary: Further research is needed to examine the relationship between COVID-19 and thyroid function in children and young people. Although the overall rates of presentation with thyroid dysfunction have not changed, there has been an increase in presentations with transient thyroid dysfunction that do not require ongoing treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Mariacarla Moleti, Angela Alibrandi, Maria Di Mauro, Giuseppe Paola, Laura Giovanna Perdichizzi, Roberta Granese, Annamaria Giacobbe, Angela Scilipoti, Marta Ragonese, Alfredo Ercoli, Salvatore Benvenga, Francesco Vermiglio
Summary: This study aimed to evaluate the prevalence of first-trimester thyroid insufficiency in women with Hashimoto thyroiditis (HT) who had preconception thyrotropin (T-0-TSH) values consistently less than or equal to 2.5 mIU/L, with or without levothyroxine (LT4) treatment. The optimal T-0-TSH cutoffs were found to be 1.24 mIU/L/1.74 mIU/L in HT women on LT4 treatment, and 1.73 mIU/L/2.07 mIU/L in HT women without LT4 treatment. Exceeding these cutoffs significantly increased the risk of first-trimester thyroid insufficiency.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Alessandro Cattoni, Silvia Molinari, Giulia Capitoli, Nicoletta Masera, Maria Laura Nicolosi, Silvia Barzaghi, Giulia Marziali, Alessandra Lazzerotti, Alessandra Gazzarri, Chiara Vimercati, Debora Sala, Andrea Biondi, Stefania Galimberti, Chiara Fossati
Summary: This study longitudinally assessed TFT in 548 pediatric patients with DS and established syndrome-specific reference ranges for TSH, FT3, and FT4. Median TSH levels were significantly higher than non-syndromic patients at any age, while FT3 and FT4 levels were only significantly lower in specific age groups. TSH levels showed significant fluctuations over time with poor agreement between sequential assessments of TSH centile classes. The 75th centile was identified as the optimal threshold for predicting the future onset of overt hypothyroidism using TSH values.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Connie M. Rhee, Amy S. You, Yoko Narasaki, Gregory A. Brent, John J. Sim, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh, Danh Nguyen
Summary: A prediction tool was developed to identify CKD patients at risk for incident hypothyroidism. Characteristics associated with hypothyroidism were identified, and the model showed good discrimination and fit in CKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Tamer Mohamed Elsherbiny
Summary: Fasting during Ramadan affects thyroid function in both healthy individuals and patients with hypothyroidism. This study found that maintaining euthyroidism in hypothyroid patients during Ramadan is possible, with 80% of patients remaining euthyroid after fasting. However, approximately 20% of patients may experience abnormal thyroid function post-Ramadan. Additionally, adherence during fasting and pre-Ramadan thyroid stimulating hormone levels are related to post-Ramadan thyroid function.
Article
Endocrinology & Metabolism
Kun Zhu, John P. Walsh, Kevin Murray, Michael Hunter, Jennie Hui, Joseph Hung
Summary: The study investigates whether DXA adiposity measures are more effective than standard anthropometric measures in predicting cardiometabolic risk factors in middle-aged individuals. The results suggest that DXA-VAT is superior to other measures in predicting metabolic syndrome and its components.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Article
Nutrition & Dietetics
Amrei M. Bennett, Kevin Murray, Gina L. Ambrosini, Wendy H. Oddy, John P. Walsh, Kun Zhu
Summary: The study found that consistent consumption of sugar-sweetened beverages during adolescence and early adulthood is associated with increased fat mass but not bone mass at 20 years of age.
JOURNAL OF NUTRITION
(2022)
Article
Environmental Sciences
Janis D. Harse, Kun Zhu, Romola S. Bucks, Michael Hunter, Ee Mun Lim, Brian R. Cooke, John P. Walsh, Kevin Murray
Summary: Low vitamin D status has been linked to adverse cognitive outcomes in older adults. However, the relationships at higher levels are uncertain. This study aimed to clarify the association between vitamin D status and cognitive performance. The results showed that increasing levels of vitamin D were associated with better global cognition and attention accuracy in women, while in men, increasing levels of vitamin D were associated with better attention accuracy but poorer semantic verbal fluency and global cognition. Further longitudinal analyses are needed to understand the nature and strength of these relationships.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychiatry
Lamprini Syrogiannouli, Lea Wildisen, Christiaan Meuwese, Douglas C. Bauer, Anne R. Cappola, Jacobijn Gussekloo, Wendy P. J. den Elzen, Stella Trompet, Rudi G. J. Westendorp, J. Wouter Jukema, Luigi Ferrucci, Graziano Ceresini, Bjorn O. Asvold, Layal Chaker, Robin P. Peeters, Misa Imaizumi, Waka Ohishi, Bert Vaes, Henry Voelzke, Jose A. Sgarbi, John P. Walsh, Robin P. F. Dullaart, Stephan J. L. Bakker, Massimo Iacoviello, Nicolas Rodondi, Cinzia Del Giovane
Summary: In non-randomized studies, imbalance of baseline values may introduce bias to the study and meta-analysis estimates. This study compared different methods to account for baseline values of outcome variables in IPD-MA of NRSs. The results showed that ANCOVA provided the most precise estimates, and ANCOVA and change score methods were similar when groups were well-balanced at baseline.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Kun Zhu, Michael Hunter, Bronwyn G. A. Stuckey, John P. Walsh
Summary: This study aimed to establish total hip T-score thresholds for measuring contralateral hip BMD to avoid missed diagnosis of osteoporosis. The research found high correlation between left and right total hip BMD, but in a certain percentage of participants, the left-right difference exceeded the LSC, hence requiring specific T-score thresholds to assist in accurate diagnosis by healthcare professionals.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Article
Clinical Neurology
Sana Tasnim, Scott G. Wilson, John P. Walsh, Dale R. Nyholt
Summary: Genome-wide association study reveals genetic correlation between migraine and thyroid dysfunction, suggesting complex causal relationships between the two traits.
Review
Endocrinology & Metabolism
Nicole Lafontaine, Scott G. Wilson, John P. Walsh
Summary: This review summarizes the current understanding of DNA methylation (DNAm) in autoimmune thyroid disease (AITD), highlighting differential DNAm in several genes implicated in AITD. However, further replication and functional studies are needed to support the causal roles of these differential DNAm in AITD pathogenesis. Additionally, the influence of thyroid hormones on DNAm and the confounding effects of reverse causation need to be considered. Recent studies suggest a potential mechanism for the association between iodine and AITD through differential DNAm patterns in candidate genes. The research focus is shifting towards epigenome-wide studies to elucidate the role of DNAm in AITD and identify diagnostic, prognostic, and therapeutic targets.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Antoine Weihs, Layal Chaker, Tiphaine C. Martin, Kim V. E. Braun, Purdey J. Campbell, Simon R. Cox, Myriam Fornage, Christian Gieger, Hans J. Grabe, Harald Grallert, Sarah E. Harris, Brigitte Kuehnel, Riccardo E. Marioni, Nicholas G. Martin, Daniel L. McCartney, Allan F. McRae, Christa Meisinger, Joyce B. J. van Meurs, Jana Nano, Matthias Nauck, Annette Peters, Holger Prokisch, Michael Roden, Elizabeth Selvin, Marian Beekman, Diana van Heemst, Eline P. Slagboom, Brenton R. Swenson, Adrienne Tin, Pei-Chien Tsai, Andre Uitterlinden, W. Edward Visser, Henry Voelzke, Melanie Waldenberger, John P. Walsh, Anna Koettgen, Scott G. Wilson, Robin P. Peeters, Jordana T. Bell, Marco Medici, Alexander Teumer
Summary: Novel associations between thyroid hormones and DNA methylation were discovered, advancing our understanding of thyroid hormone action particularly related to KLF9. This study demonstrates the utility of integrating EWAS with other -omics data for unraveling thyroid hormone signaling in humans.
Article
Endocrinology & Metabolism
K. Zhu, M. Hunter, A. James, E. M. Lim, J. P. Walsh
Summary: Limited longitudinal data on the relationship between changes in body composition and bone mineral density (BMD) were found in this study. The findings suggest that changes in lean mass have a stronger impact on BMD than changes in fat mass. Maintaining or increasing lean mass can slow down age-related bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Genetics & Heredity
Sarah Rashid, Scott G. Wilson, Kun Zhu, John P. Walsh, Jiake Xu, Benjamin H. Mullin
Summary: This study analyzed the transcriptome of human peripheral blood mononuclear cells and their differentiated osteoclast-like cells in culture, identifying differentially expressed genes and associated biological pathways in the progression of osteoporosis. Several well-established osteoclast genes were significantly upregulated in osteoporosis, and the upregulated genes were involved in cell division, migration, adhesion, as well as oxidative phosphorylation, glycolysis, lysosome, and focal adhesion pathways.
Article
Endocrinology & Metabolism
Tessa A. Mulder, Purdey J. Campbell, Peter N. Taylor, Robin P. Peeters, Scott G. Wilson, Marco Medici, Colin Dayan, Vincent V. W. Jaddoe, John P. Walsh, Nicholas G. Martin, Henning Tiemeier, Tim I. M. Korevaar
Summary: This study found that the effects of many known thyroid function-related genes are already apparent in childhood, and some genes have a greater impact on children compared to adults. These findings provide new insights into the genetic regulation of thyroid function in early life.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Joris A. J. Osinga, Arash Derakhshan, Ulla Feldt-Rasmussen, Kun Huang, Tanja G. M. Vrijkotte, Tuija Mannisto, Judit Bassols, Abel Lopez-Bermejo, Ashraf Aminorroaya, Marina Vafeiadi, Maarten A. C. Broeren, Glenn E. Palomaki, Ghalia Ashoor, Liangmiao Chen, Xuemian Lu, Peter N. Taylor, Fang-Biao Tao, Suzanne J. Brown, Georgiana Sitoris, Lida Chatzi, Bijay Vaidya, Polina Popova, Elena A. Vasukova, Maryam Kianpour, Eila Suvanto, Elena N. Grineva, Andrew Hattersley, Victor J. M. Pop, Scott M. Nelson, John P. Walsh, Kypros H. Nicolaides, Mary E. D'Alton, Kris G. Poppe, Layal Chaker, Sofie Bliddal, Tim I. M. Korevaar
Summary: The study found that using alternative methods to define reference intervals for thyroid hormones in pregnant women can result in overdiagnosis and underdiagnosis compared to population- and trimester-specific reference intervals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Yanning Xu, Arash Derakhshan, Ola Hysaj, Lea Wildisen, Till Ittermann, Alessandro Pingitore, Nazanin Abolhassani, Marco Medici, Lambertus A. L. M. Kiemeney, Niels P. Riksen, Robin P. F. Dullaart, Stella Trompet, Marcus Doerr, Suzanne J. Brown, Boerge Schmidt, Dagmar Fuehrer-Sakel, Mark P. J. Vanderpump, Axel Muendlein, Heinz Drexel, Howard A. Fink, M. Kamran Ikram, Maryam Kavousi, Connie M. Rhee, Isabela M. Bensenor, Fereidoun Azizi, Graeme J. Hankey, Massimo Iacoviello, Misa Imaizumi, Graziano Ceresini, Luigi Ferrucci, Jose A. Sgarbi, Douglas C. Bauer, Nick Wareham, Kristien Boelaert, Stephan J. L. Bakker, J. Wouter Jukema, Bert Vaes, Giorgio Iervasi, Bu B. Yeap, Rudi G. J. Westendorp, Tim I. M. Korevaar, Henry Voelzke, Salman Razvi, Jacobijn Gussekloo, John P. Walsh, Anne R. Cappola, Nicolas Rodondi, Robin P. Peeters, Layal Chaker
Summary: This study aimed to define the optimal healthy ranges of TSH and FT4 based on the risk of cardiovascular disease and mortality. The study found that the 20-40th percentiles of FT4 and the 60-80th percentiles of TSH could represent the optimal healthy ranges of thyroid function.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Biology
Carolina Medina-Gomez, Benjamin H. Mullin, Alessandra Chesi, Vid Prijatelj, John P. Kemp, Chen Shochat-Carvalho, Katerina Trajanoska, Carol Wang, Raimo Joro, Tavia E. Evans, Katharina E. Schraut, Ruifang Li-Gao, Tarunveer S. Ahluwalia, M. Carola Zillikens, Kun Zhu, Dennis O. Mook-Kanamori, Daniel S. Evans, Maria Nethander, Maria J. Knol, Gudmar Thorleifsson, Ivana Prokic, Babette Zemel, Linda Broer, Fiona E. McGuigan, Natasja M. van Schoor, Sjur Reppe, Mikolaj A. Pawlak, Stuart H. Ralston, Nathalie van der Velde, Mattias Lorentzon, Kari Stefansson, Hieab H. H. Adams, Scott G. Wilson, M. Arfan Ikram, John P. Walsh, Timo A. Lakka, Kaare M. Gautvik, James F. Wilson, Eric S. Orwoll, Cornelia M. van Duijn, Klaus Bonnelykke, Andre G. Uitterlinden, Unnur Styrkarsdottir, Kristina E. Akesson, Timothy D. Spector, Jonathan H. Tobias, Claes Ohlsson, Janine F. Felix, Hans Bisgaard, Struan F. A. Grant, J. Brent Richards, David M. Evans, Bram van der Eerden, Jeroen van de Peppel, Cheryl Ackert-Bicknell, David Karasik, Erika Kague, Fernando Rivadeneira
Summary: Skull bone mineral density (SK-BMD) is a suitable trait for studying bone biology, particularly related to intramembranous ossification. A genome-wide association meta-analysis identified 59 loci associated with SK-BMD, which collectively explained 12.5% of the variance in the trait. These loci are involved in skeletal development and osteoporosis, and four of them are related to intramembranous ossification and craniofacial abnormalities.
COMMUNICATIONS BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Benjamin H. Mullin, Nathan J. Pavlos, Suzanne J. Brown, John P. Walsh, Ross A. McKellar, Scott G. Wilson, Bryan K. Ward
Summary: Three novel CASR transmembrane domain missense variants (Thr699Asn, Arg701Gly, and Thr808Pro) were identified in patients provisionally diagnosed with FHH, and their pathogenicity was assessed using bioinformatics and functional analysis. The results showed that these variants resulted in receptor inactivation, likely due to impaired expression and surface localization of the mature receptor, or conformational changes affecting receptor signaling. This study highlights the importance of functional studies in assessing genetic variants in hypercalcemic patients.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)