Article
Multidisciplinary Sciences
Ozra Tabatabaei-Malazy, Sahar Saeedi Moghaddam, Nazila Rezaei, Ali Sheidaei, Mohammad Javad Hajipour, Negar Mahmoudi, Zohreh Mahmoudi, Arezou Dilmaghani-Marand, Kamyar Rezaee, Mahdi Sabooni, Farideh Razi, Farzad Kompani, Alireza Delavari, Bagher Larijani, Farshad Farzadfar
Summary: The study aimed to estimate the national and sub-national prevalence rates of metabolic syndrome (MetS) in Iran in 2016 through data collected by WHO's STEPwise approach and found a high prevalence rate among Iranian adults, especially females, urban residents, and the elderly. The Joint Interim Statement (JIS) criteria were found to be more appropriate for identifying Iranians at risk of non-communicable diseases (NCDs). Proper management and prevention plans are needed to address this issue.
Article
Clinical Neurology
Torrance L. Nevels, Michael D. Wirth, J. P. Ginsberg, Alexander C. McLain, James B. Burch
Summary: This study examined the individual and combined effects of poor sleep and reduced heart rate variability (HRV) on metabolic syndrome. The results showed that both poor sleep and low HRV were associated with metabolic syndrome, and the combined effect was even stronger.
Article
Cardiac & Cardiovascular Systems
Christina Vassou, Ekavi N. Georgousopoulou, Christina Chrysohoou, Mary Yannakoulia, Christos Pitsavos, Mark Cropley, Demosthenes B. Panagiotakos
Summary: The study highlights the important role of irrational beliefs and anxiety in the development of MetS, emphasizing the need for new holistic approaches focused on the primary prevention of both mental health and MetS.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Genetics & Heredity
Kuan-Hung Yeh, Hsiang-Lin Wan, Ming-Sheng Teng, Hsin-Hua Chou, Lung-An Hsu, Yu-Lin Ko
Summary: This study investigated the genetic determinants of cardiometabolic traits and metabolic syndrome at the APOE locus in a Taiwanese population. The findings revealed several single-nucleotide variations (SNVs) at the APOE locus that were associated with cholesterol levels, metabolic syndrome, and serum albumin levels. Additionally, the study identified CLPTM1 as a new candidate locus for LDL and HDL cholesterol levels, and highlighted the independent associations of APOE and APOC1 variants with metabolic syndrome and serum albumin levels. These results underscore the importance of genetic variants at the APOE locus in predicting cardiometabolic traits and metabolic syndrome.
Review
Gastroenterology & Hepatology
Fredrik Aberg, Christopher D. Byrne, Carlos J. Pirola, Ville Mannisto, Silvia Sookoian
Summary: Alcohol use and metabolic syndrome frequently co-exist and are associated with various health problems including chronic liver disease and hepatocellular carcinoma. The effects of mild-moderate alcohol consumption on the risk of metabolic syndrome and fatty liver disease are unclear, with mixed results from studies. However, prospective studies indicate that mild-moderate alcohol use is associated with an increase in liver-related outcomes. Alcohol and metabolic factors independently and together contribute to liver-related outcomes, and components of metabolic syndrome have additive effects. Central/abdominal obesity measures may predict liver-related outcomes more accurately than BMI, even in individuals who consume harmful amounts of alcohol. The accumulating evidence highlights the multifactorial nature of liver disease and suggests the need for holistic approaches in risk prediction and treatment planning.
JOURNAL OF HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Monica Bignotto, Michele Dei Cas, Rita Paroni, Elena Bianco, Paola Zermiani, Maria G. Gangale, Valentina Zadro, Margherita Maregatti, Alessandra Piagnani, Antonio Russo, Damiano Baldassarre, Franco Folli, Pier Maria Battezzati, Massimo Zuin
Summary: The CA.ME.LI.A study conducted in Italy aimed to estimate the prevalence of cardiovascular risk factors, metabolic syndrome, liver and autoimmune diseases in the adult population, with results showing higher rates of obesity and metabolic syndrome in men compared to women. The study also found that men had higher levels of various physiological indicators, and that elevated CRP levels were associated with obesity. Additionally, metabolic syndrome was more common in men.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Immunology
Carine Teles Sangaleti, Keyla Yukari Katayama, Katia De Angelis, Tercio Lemos de Moraes, Amanda Aparecida Araujo, Heno F. Lopes, Cleber Camacho, Luiz Aparecido Bortolotto, Lisete Compagno Michelini, Maria Claudia Irigoyen, Peder S. Olofsson, Douglas P. Barnaby, Kevin J. Tracey, Valentin A. Pavlov, Fernanda Marciano Consolim Colombo
Summary: The study found that low-dose galantamine treatment has positive effects on oxidative stress, inflammation, and cardiac metabolic parameters in MetS patients, alleviating inflammatory status and insulin resistance, and modulating neural autonomic regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Alexandr Pozharskiy, Valeriya Kostyukova, Gulnaz Nizamdinova, Ruslan Kalendar, Dilyara Gritsenko
Summary: MLO proteins are transmembrane proteins that play crucial roles in plant immunity, host-pathogen interactions, and development processes. This study conducted a phylogenetic analysis of a large set of MLO protein sequences, focusing on tomato and related species. The results identified nine phylogenetic clades, revealed the internal structure of some clades, and provided insights into the presence of monocotyledon species in all MLO clades. The findings and identified protein motifs can be used for further research on mildew resistance in Solanaceae and other plant families.
Review
Nutrition & Dietetics
Francesca Orsini, Floriana D'Ambrosio, Anna Scardigno, Roberto Ricciardi, Giovanna Elisa Calabro
Summary: The prevalence of overweight and obesity in European children and adolescents is a significant public health challenge, with varying rates across countries. Obesity is the main risk factor for the development of MetS and its associated complications.
Review
Environmental Sciences
Hui Gao, Cheng Zhang, Fang-Biao Tao
Summary: The relationship between prenatal phthalate exposure and gestational metabolic syndrome parameters is inconsistently reported, with most studies not observing significant associations regardless of study design. Positive and negative relationships also exist, and overall the current epidemiological data do not support the hypothesis that prenatal exposure to phthalates increases GMS risk.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Ho-Sun Lee, Sanghwan In, Taesung Park
Summary: This study utilized Mendelian Randomization to investigate the causal influence of Homocysteine (Hcy) on Metabolic Syndrome (MetS) and found that increased Hcy levels were significantly associated with increased risk of MetS in the Korean population.
Article
Cardiac & Cardiovascular Systems
Mingyang Wu, Yanling Shu, Lulin Wang, Lulu Song, Shuohua Chen, Yunyun Liu, Jianing Bi, Dankang Li, Yingping Yang, Yonghua Hu, Yu Sun, Youjie Wang, Shouling Wu, Yaohua Tian
Summary: This study found that participants with high variability in metabolic parameters had increased risks of cardiovascular disease and all-cause mortality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Noya Ytzhaik, Dorit Zur, Chen Goldstein, Galit Almoznino
Summary: This study aimed to analyze the associations of obstructive sleep apnea (OSA) with dental parameters while controlling for socio-demographics, health-related habits, and each of the diseases comprising metabolic syndrome (MetS), its consequences, and related conditions. The study found that obesity, male sex, periodontal disease, smoking, and age were positively associated with OSA. These findings emphasize the link between OSA and dental morbidity, particularly periodontitis, and highlight the importance of dental evaluation in the workup of OSA patients.
Article
Clinical Neurology
Ji Hyun Baek, Dong Wook Shin, Maurizio Fava, David Mischoulon, Hyewon Kim, Mi Jin Park, Eun Ji Kim, Kyung-Do Han, Hong Jin Jeon
Summary: The study showed that high variability in metabolic parameters is associated with an increased risk of newly diagnosed depression, even after adjusting for various covariates. This suggests that metabolic parameter variability is an independent risk factor for depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biology
Itzhak Abramovitz, Avraham Zini, Pablo Pribluda, Ron Kedem, Dorit Zur, Noam E. Protter, Galit Almoznino
Summary: The study found that the planned dental unit (SDU-P) rather than the delivered dental unit (SDU-D) is a better predictor of systemic morbidities related to MetS. MetS is associated with a higher dental treatment needs burden, rather than with dental treatments performed de facto. Collaboration between dental and general health authorities is needed to focus on reducing common health-related risk factors among high-risk populations.
Article
Psychology, Developmental
Courtney Dow, Cedric Galera, Marie-Aline Charles, Barbara Heude
Summary: Evidence suggests a link between maternal obesity during pregnancy and offspring attention-deficit hyperactivity disorder. This study aimed to examine the association between maternal pre-pregnancy body mass index (BMI) and child hyperactivity-inattention symptoms (HIS) at different ages. The results showed that maternal pre-pregnancy obesity was associated with increased likelihood of a high HIS trajectory in children from 3 to 8 years old, while pre-pregnancy overweight was not significantly associated.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Letter
Gastroenterology & Hepatology
Coralie Amadou, Oumarou Nabi, Lawrence Serfaty, Karine Lacombe, Jerome Boursier, Philippe Mathurin, Celine Ribet, Victor de Ledinghen, Marie Zins, Marie-Aline Charles
Article
Public, Environmental & Occupational Health
Alexandra Descarpentrie, Jonathan Y. Bernard, Stephanie Vandentorren, Maria Melchior, Cedric Galera, Airu Chia, Mary F-F Chong, Marie-Aline Charles, Barbara Heude, Sandrine Lioret
Summary: This study found that preschoolers' lifestyle patterns were associated with their socio-emotional, behavioural, and BMI outcomes at 8 years old. Boys' healthy lifestyle pattern (nutrient-dense diet and limited screen time) was positively associated with prosocial behaviours and inversely related to hyperactivity-inattention symptoms at 8 years old. Girls' mixed lifestyle pattern (sugar or artificially sweetened beverages, high screen time, physical activity, and low sleep times) was associated with prosocial behaviours.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Rosalie Delvert, Manel Ghozal, Karine Adel-Patient, Manik Kadawathagedara, Barbara Heude, Marie-Aline Charles, Isabella Annesi-Maesano, Muriel Tafflet, Benedicte Leynaert, Raphaelle Varraso, Blandine de Lauzon-Guillain, Annabelle Bedard
Summary: A study investigated the associations between maternal diet quality and allergic and respiratory diseases in children. The results showed that maternal diet quality during pregnancy was not associated with allergic and respiratory diseases, but children from mothers consuming legumes less frequently were at higher risk of having multiple allergies.
Article
Medicine, General & Internal
Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrom, Thorkild I. A. Sorensen, Ahmed Elhakeem, Ana C. Santos, Angela Pinot de Moira, Barbara Heude, Carmen Iniguez, Costanza Pizzi, Elinor Simons, Ellis Voerman, Eva Corpeleijn, Faryal Zariouh, Gilian Santorelli, Hazel M. Inskip, Henrique Barros, Jennie Carson, Jennifer R. Harris, Johanna L. Nader, Justiina Ronkainen, Katrine Strandberg-Larsen, Loreto Santa-Marina, Lucinda Calas, Luise Cederkvist, Maja Popovic, Marie-Aline Charles, Marieke Welten, Martine J. Vrijheid, Meghan Azad, Padmaja Subbarao, Paul Burton, Puishkumar J. Mandhane, Rae-Chi Huang, Rebecca C. Wilson, Sido Haakma, Silvia Fernandez-Barres, Stuart Turvey, Susana Santos, Suzanne C. Tough, Sylvain Sebert, Theo J. Moraes, Theodosia Salika, Vincent W. V. Jaddoe, Deborah A. Lawlor, Anne-Marie Nybo Andersen
Summary: This study found that gestational age is positively associated with body size in infancy, but the association weakens with age. By adolescence, preterm individuals have a similar mean BMI to those born at term.
Article
Nutrition & Dietetics
Maria Somaraki, Blandine de Lauzon-Guillain, Jonathan Y. Bernard, Muriel Tafflet, Marie-Aline Charles, Sophie Nicklaus
Summary: Despite the recommendation of breastfeeding, formula feeding is common in some Western societies, including France. This study investigates the association between the degree of protein hydrolysis in infant formula and child neurodevelopment up to 3.5 years of age in France.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Coralie Amadou, Barbara Heude, Blandine de Lauzon-Guillain, Sandrine Lioret, Alexandra Descarpentrie, Marie Zins, Marie -Aline Charles
Summary: The study examines the association between birth weight and long-term health outcomes in a large adult cohort. The results indicate that low birth weight is associated with various metabolic and mental health conditions, while high birth weight is linked to obesity and fatty liver.
DIABETES & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Lisa Pennells, Stephen Kaptoge, Helena Bleken Ostergaard, Stephanie H. Read, Fabrizio Carinci, Josep Franch-Nadal, Carmen Petitjean, Owen Taylor, Steven H. J. Hageman, Zhe Xu, Fanchao Shi, Sarah Spackman, Stefano Gualdi, Naomi Holman, Rui Bebiano Da Providencia E Costa, Fabrice Bonnet, Hermann Brenner, Richard F. Gillum, Stefan Kiechl, Deborah A. Lawlor, Louis Potier, Ben Schoettker, Reecha Sofat, Henry Voelzke, Johann Willeit, Zane Baltane, Stephen Fava, Sandor Janos, Astrid Lavens, Santa Pildava, Tamara Poljicanin, Ivan Pristas, Peter Rossing, Reiff Sascha, Christa Scheidt-Nave, Iztok Stotl, Gail Tibor, Vilma Urbancic-Rovan, An-Sofie Vanherwegen, Dorte Vistisen, Yong Du, Matthew R. Walker, Peter Willeit, Brian Ference, Dirk De Bacquer, Martin Halle, Radu Huculeci, John William McEvoy, Adam Timmis, Panagiotis Vardas, Jannick A. N. Dorresteijn, Ian Graham, Angela Wood, Bjorn Eliasson, William Herrington, John Danesh, Didac Mauricio, Massimo Massi Benedetti, Naveed Sattar, Frank L. J. Visseren, Sarah Wild, Emanuele Di Angelantonio, Beverley Balkau, Frederic Fumeron, Hannah Stocker, Bernd Holleczek, Sabine Schipf, Carsten Oliver Schmidt, Marcus Doerr, Herbert Tilg, Christoph Leitner, Marlene Notdurfter, Julie Taylor, Caroline Dale, David Prieto-Merino, Richard F. Gillum, Tamara Buble, Pero Ivanko, Bendix Carstensen, Christin Heidemann, Tibor Gall, Janos Sandor, Jana Lepiksone, Caroline J. Magri, Joseph Azzopardi, Jordi Real, Bogdan Vlacho, Manel Mata-Cases
Summary: The study aimed to develop and validate a recalibrated prediction model (SCORE2-Diabetes) for estimating the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. The model showed good discrimination and improvement over previous models, with risk predictions varying based on individuals' diabetes-related factors. SCORE2-Diabetes enhances the identification of individuals at higher risk of CVD in Europe.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Amelie Bonnefond, Ranjit Unnikrishnan, Alessandro Doria, Martine Vaxillaire, Rohit N. Kulkarni, Viswanathan Mohan, Vincenzo Trischitta, Philippe Froguel
Summary: Monogenic diabetes encompasses several clinical conditions characterized by early-onset diabetes, including neonatal diabetes, maturity-onset diabetes of the young (MODY) and diabetes-associated syndromes. It can be misdiagnosed as type 2 diabetes, and different genetic variations can lead to different forms of diabetes. Precision medicine approaches and next-generation sequencing have improved diagnosis and treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Medicine, General & Internal
Melanie Bales, Elodie Pambrun, Charlotte Maguet, Judith van der Waerden, Nine Glangeaud-Freudenthal, Marie-Aline Charles, Corinne Bois, Maria Melchior, Jeannette Milgrom, Bruno Falissard, Helene Verdoux, Anne-Laure Sutter-Dallay
Summary: This study explored the pathways between maternal, infant, and parenthood vulnerabilities or risk/protective factors and postnatal depressive symptoms (PNDS) at 2 months postpartum (PP). The results showed that factors such as prenatal psychological distress, difficult pregnancy experience, family financial difficulties, and consultation with a mental health specialist before pregnancy were directly associated with the severity of maternal PNDS. Lack of perceived postnatal support and infant characteristics like self-regulation difficulties and maternal difficulty in understanding infant crying were also related to PNDS severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Marion Lecorguille, Mireille C. Schipper, Aisling O'Donnell, Adrien M. Aubert, Muriel Tafflet, Malamine Gassama, Alexander Douglass, James R. Hebert, Blandine de Lauzon-Guillain, Cecily Kelleher, Marie-Aline Charles, Catherine M. Phillips, Romy Gaillard, Sandrine Lioret, Barbara Heude
Summary: The study found that parental lifestyle factors during preconception and pregnancy are associated with the future risk of child obesity. Parental smoking, body mass index, gestational weight gain, diet, physical activity, and sedentary behavior all play a role in the risk of overweight and BMI in children. These findings are important for informing early-life family-based and multi-behavioral strategies for child obesity prevention.
FRONTIERS IN NUTRITION
(2023)
Article
Allergy
T. Adam, A. Divaret-Chauveau, C. Roduit, K. Adel-Patient, A. Deschildre, C. Raherison, M. A. Charles, S. Nicklaus, B. de Lauzon-Guillain
Summary: This study examines the correlation between complementary feeding practices in early childhood and allergic diseases. It finds that delayed introduction of complementary feeding beyond 6 months is associated with an increased risk of food allergy. Additionally, a low diversity score in the diet at 8 months is linked to a higher risk of asthma, and the absence of two or more allergenic foods introduced by 10 months is associated with an increased risk of rhinoconjunctivitis and food allergy.
Article
Microbiology
Gael Toubon, Marie-Jose Butel, Jean-Christophe Roze, Ioannis Nicolis, Johanne Delannoy, Cecile Zaros, Pierre-Yves Ancel, Julio Aires, Marie-Aline Charles
Summary: Early life gut microbiota-influencing factors are crucial for long-term health, and this study aimed to investigate the associations between 20 early life factors and gut microbiota composition at 3.5 years old. The results showed that gestational age, mode of delivery, and breastfeeding were significantly associated with gut microbiota differences. Having a sibling and attending daycare center were also linked to specific enterotypes. Maternal factors such as country of birth and preconception body mass index influenced the microbiota characteristics of the children.
Article
Endocrinology & Metabolism
Lise Folon, Morgane Baron, Benedicte Toussaint, Emmanuel Vaillant, Mathilde Boissel, Victoria Scherrer, Helene Loiselle, Audrey Leloire, Alaa Badreddine, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Michel Marre, Soulaimane Aboulouard, Michel Salzet, Mickael Canouil, Mehdi Derhourhi, Philippe Froguel, Amelie Bonnefond
Summary: Rare biallelic pathogenic mutations in PCSK1 cause early-onset obesity and other endocrinopathies. Functional genomic study shows that rare heterozygous variants of PCSK1 can also impact obesity risk.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Frederic Fumeron, Gilberto Velho, Fawaz Alzaid, Ray El Boustany, Claire Vandiedonck, Amelie Bonnefond, Philippe Froguel, Louis Potier, Michel Marre, Beverley Balkau, Ronan Roussel, Nicolas Venteclef
Summary: In this study, we investigated the association between allelic variations in the IRF5 gene and the incidence of chronic kidney disease (CKD) in a general population. Our results showed that several IRF5 SNPs were associated with baseline renal parameters and the incidence of CKD. These findings suggest that IRF5-mediated macrophage polarization may play an important role in the development of CKD.
GENES AND IMMUNITY
(2023)
