Article
Cardiac & Cardiovascular Systems
Jari E. Karppinen, Hanna-Kaarina Juppi, Jukka Hintikka, Petri Wiklund, Eero A. Haapala, Matti Hyvaerinen, Tuija H. Tammelin, Pauliina Aukee, Urho M. Kujala, Jari Laukkanen, Eija K. Laakkonen
Summary: This study investigated the relationship between fat oxidation and glucose regulation during cycling in middle-aged women, and found that sex hormone profile did not explain fat oxidation capacity, and higher fat oxidation did not indicate better glucose control.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Margaret C. Weiss, Yu-Hsuan Shih, Molly Scannell Bryan, Brian P. Jackson, David Aguilar, Craig L. Hanis, Maria Argos, Robert M. Sargis
Summary: Hispanics/Latinos have higher rates of type 2 diabetes and may be disproportionately exposed to environmental endocrine-disrupting chemicals (EDCs) including metals. This study found associations between urinary levels of arsenic, molybdenum, copper, and a mixture of 8 metals with measures of glucose homeostasis in a Mexican American population.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jingya Ye, Xuan Ye, Wanzi Jiang, Chenyan Lu, Xiaomei Geng, Chenxi Zhao, Yizhe Ma, Panpan Yang, Sin Man Lam, Guanghou Shui, Tao Yang, John Zhong Li, Yingyun Gong, Zhenzhen Fu, Hongwen Zhou
Summary: The study aimed to investigate the associations between serum sphingolipids and insulin sensitivity as well as insulin secretion. The results showed positive correlations between certain subspecies of serum sphingolipids and insulin sensitivity, while negative correlations were observed with specific SPs. ROC curves indicated that certain serum sphingolipids could serve as good predictors of insulin sensitivity.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Neurosciences
Anais F. Stenson, Vasiliki Michopoulos, Jennifer S. Stevens, Abigail Powers, Tanja Jovanovic
Summary: Recent research found that early trauma exposure may lead to early puberty and increased anxiety risk in Black children, with these associations being sex-specific and having a positive impact on girls.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Peripheral Vascular Disease
Odayme Quesada, Brian Claggett, Fatima Rodriguez, Jianwen Cai, Ashley E. Moncrieft, Karin Garcia, Marina Del Rios Rivera, David B. Hanna, Martha L. Daviglus, Gregory A. Talavera, C. Noel Bairey Merz, Scott D. Solomon, Susan Cheng, Natalie A. Bello
Summary: In a study of Hispanic/Latino adults without diabetes or taking antihypertensive medications, insulin resistance was found to be positively associated with both systolic and diastolic blood pressure. The association between insulin resistance and systolic blood pressure was linear in men but nonlinear in women. Prediabetes status did not significantly affect the association between insulin resistance and blood pressure.
Article
Plant Sciences
Zheng Zhang, Zhi-Peng Shang, Yan Jiang, Zhao-Xia Qu, Ren-Yong Yang, Jing Zhang, Ye-Xi Lin, Feng Zhao
Summary: Protein tyrosine phosphatase 1B (PTP1B) is an important target for treating type 2 diabetes. However, current PTP1B inhibitors lack selectivity and bioavailability. A study on Knoxia valerianoides led to the discovery of a unique anthraquinone-coumarin hybrid with good specificity for PTP1B. Further investigation of this plant led to the isolation of nine new anthraquinone glycosides and two known ones. All compounds showed PTP1B inhibitory activities, with compounds 4 and 8 exhibiting high selectivity for PTP1B over TCPTP.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Endocrinology & Metabolism
Josiane L. Broussard, Leigh Perreault, Emily Macias, Sean A. Newsom, Kathleen Harrison, Hai Hoang Bui, Paul Milligan, Kenneth D. Roth, Travis Nemkov, Angelo D'Alessandro, Joseph T. Brozinick, Bryan C. Bergman
Summary: Sex-specific associations were found between lipid species involved in mitochondrial fatty acid transport, beta-oxidation, and tricarboxylic acid cycle flux, which may provide therapeutic targets to improve insulin sensitivity. Men had lower insulin sensitivity, higher muscle acylcarnitines, serum ceramide, and lysophosphatidylcholine levels compared to women. Localizations of intramuscular lipids did not exhibit sex differences.
Review
Endocrinology & Metabolism
Lijun Yin, Man Luo, Ru Wang, Jianping Ye, Xiaohui Wang
Summary: Androgens play a complex role in regulating insulin sensitivity, with decreased levels posing a risk for insulin resistance in men and excess levels contributing to insulin resistance in women with PCOS. Hormones like androgens and estrogens can induce mitochondrial oxidative phosphorylation, leading to ATP surplus and subsequently insulin resistance in diabetes. The hormone synergy-based view proposes a unified mechanism for the distinct metabolic roles of androgens in controlling insulin action in men with hypogonadism and women with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ala Ud Din, Maria Khan, Muhammad Zahir Shah, Abdur Rauf, Umer Rashid, Anees Ahmed Khalil, Khair Zaman, Yahya S. Al-Awthan, Mohammed A. Al-Duais, Omar Bahattab, Adil A. H. Mujawah, Naveed Muhammad
Summary: The research suggests that ficusonolide from Ficus foveolata has potential antidiabetic activity by enhancing glucose uptake and significantly reducing hyperglycemia in diabetic rats. Additionally, ficusonolide displayed inhibitory activity against key proteins involved in diabetes, indicating a possible mechanism for its antidiabetic effects.
Article
Multidisciplinary Sciences
Sofia Christakoudi, Elio Riboli, Evangelos Evangelou, Konstantinos K. Tsilidis
Summary: This study demonstrates associations between metabolic biomarkers and body shape as measured by waist and hip size, while inflammatory biomarkers were only associated with waist size. This suggests that different mechanistic pathways may contribute to body shape.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Arpita Basu, Andrew Hooyman, Leigh Ann Richardson, Amy C. Alman, Janet K. Snell-Bergeon
Summary: This study found an inverse association between dietary fiber intake and glycemic control in adults with prediabetes, but not in those with type 1 diabetes. This suggests that dietary fiber may have a protective effect on glycemic control in individuals at risk of developing diabetes.
Article
Biochemistry & Molecular Biology
Paul Horn, Sascha Radtke, Uta Barbara Metzing, Ricardo Steidl, Christoph Sponholz, Oliver Sommerfeld, Johannes Roth, Ralf A. Claus, Andreas L. Birkenfeld, Utz Settmacher, Falk Rauchfuss, Christian von Loeffelholz
Summary: This study found that sepsis patients have significant dyslipidemia and the cytokine betatrophin/ANGPTL8 plays an important role in this metabolic disorder. Despite similar mRNA expression levels in adipose tissue, circulating betatrophin/ANGPTL8 is significantly increased in sepsis patients.
Article
Environmental Sciences
Astrid N. Zamora, Erica C. Jansen, Jaclyn M. Goodrich, Martha M. Tellez-Rojo, Peter X. K. Song, John D. Meeker, Dana C. Dolinoy, Libni A. Torres-Olascoaga, Alejandra Cantoral, Karen E. Peterson
Summary: This study examines the relationship between endocrine-disrupting chemicals (EDCs) and metabolic syndrome (MetS) risk in adolescents. The findings from the analysis of data from 344 Mexican youths indicate that exposure to EDCs is associated with an increased risk of MetS and lipid abnormalities in adolescents, especially among males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Georgianna Lin, Rumsha Siddiqui, Zixiong Lin, Joanna M. Blodgett, Shwetak N. Patel, Khai N. Truong, Alex Mariakakis
Summary: Previous studies on blood glucose levels during the menstrual cycle have produced inconsistent results based on limited blood samples. This study used continuous glucose monitors and smartwatches to collect data from 49 individuals over an average duration of 79.3 ± 21.2 days, resulting in 149 cycles and 554 phases in the dataset. The results showed a biphasic pattern of blood glucose levels, with the highest levels during the luteal phase and lowest levels during the late-follicular phase. Factors such as estrogen levels, step count, fatigue, and food cravings were found to be associated with variations in blood glucose levels. The findings suggest that blood glucose could be an important parameter in understanding menstrual health and warrant further investigation into its relationship with the menstrual cycle.
NPJ DIGITAL MEDICINE
(2023)
Article
Genetics & Heredity
Sara Mahdavi, David J. A. Jenkins, Ahmed El-Sohemy
Summary: This study found that the 9p21 risk genotypes have an impact on insulin sensitivity and there is an interaction between dietary patterns and genes. Following a prudent dietary pattern may protect against the effects of 9p21 risk genotypes on insulin sensitivity.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Faisal S. Malik, Angela D. Liese, Beth A. Reboussin, Katherine A. Sauder, Edward A. Frongillo, Jean M. Lawrence, Anna Bellatorre, Catherine Pihoker, Beth Loots, Dana Dabelea, Elizabeth Mayer-Davis, Elizabeth Jensen, Christine Turley, Jason A. Mendoza
Summary: This study assessed the prevalence of household food insecurity (HFI) and Supplemental Nutrition Assistance Program (SNAP) participation among youth and young adults (YYA) with diabetes. The results showed that HFI was more prevalent in type 2 diabetes compared to type 1 diabetes, while SNAP participation was higher in type 2 diabetes compared to type 1 diabetes. YYA receiving Medicaid or Medicare or without insurance, whose parents had lower levels of education, and with lower household income had greater odds of experiencing HFI.
Article
Rheumatology
Jose B. Nergon, Maria A. Lopez-Olivo, Loreto Carmona, Robin Christensen, Francesca Ingegnoli, Natalia Zamora, Jorge I. Gamez-Nava, Laura Gonzalez-Lopez, Vibeke Strand, Niti Goel, Tiffany Westrich-Robertson, Maria E. Suarez-Almazor
Summary: This study aimed to identify patient-centered domains with long-term relevance to people with rheumatoid arthritis (RA). Semi-structured individual cognitive interviews were conducted with RA patients from five different countries. Six main themes were identified, including living with symptoms and functional limitations, lack of participation, partner and family issues, risk of damage to vital organs, coping strategies, and healthcare concerns. These domains are seldom measured in longitudinal registries and should be considered in patient-centered longitudinal studies.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Pharmacology & Pharmacy
Clodoveo Ferri, Vincenzo Raimondo, Laura Gragnani, Dilia Giuggioli, Lorenzo Dagna, Antonio Tavoni, Francesco Ursini, Massimo L'Andolina, Francesco Caso, Piero Ruscitti, Maurizio Caminiti, Rosario Foti, Valeria Riccieri, Serena Guiducci, Roberta Pellegrini, Elisabetta Zanatta, Giuseppe Varcasia, Domenico Olivo, Pietro Gigliotti, Giovanna Cuomo, Giuseppe Murdaca, Riccardo Cecchetti, Rossella De Angelis, Nicoletta Romeo, Francesca Ingegnoli, Franco Cozzi, Veronica Codullo, Ilaria Cavazzana, Michele Colaci, Giuseppina Abignano, Maria De Santis, Ennio Lubrano, Enrico Fusaro, Amelia Spinella, Federica Lumetti, Giacomo De Luca, Silvia Bellando-Randone, Elisa Visalli, Ylenia Dal Bosco, Giorgio Amato, Daiana Giannini, Silvia Bilia, Francesco Masini, Greta Pellegrino, Erika Pigatto, Elena Generali, Giuseppa Pagano Mariano, Giorgio Pettiti, Giovanni Zanframundo, Raffaele Brittelli, Vincenzo Aiello, Rodolfo Caminiti, Daniela Scorpiniti, Tommaso Ferrari, Corrado Campochiaro, Veronica Brusi, Micaela Fredi, Liala Moschetti, Fabio Cacciapaglia, Sabrina Rosaria Paparo, Francesca Ragusa, Valeria Mazzi, Giusy Elia, Silvia Martina Ferrari, Ilenia Di Cola, Marta Vadacca, Sebastiano Lorusso, Monica Monti, Serena Lorini, Maria Letizia Aprile, Marco Tasso, Mario Miccoli, Silvia Bosello, Salvatore D'Angelo, Andrea Doria, Franco Franceschini, Riccardo Meliconi, Marco Matucci-Cerinic, Florenzo Iannone, Roberto Giacomelli, Carlo Salvarani, Anna Linda Zignego, Poupak Fallahi, Alessandro Antonelli
Summary: This Italian study investigated the prevalence, prognostic factors, and outcomes of COVID-19 in autoimmune systemic diseases (ASD) patients. The study found that ASD patients had a higher prevalence of COVID-19 compared to the general population but a comparable death rate. Among ASD patients, systemic sclerosis (SSc) patients had a significantly higher COVID-19-related death rate. Older age, male gender, SSc, pre-existing lung involvement, and long-term steroid treatment were identified as major adverse prognostic factors for developing COVID-19. Patients treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and SSc patients treated with low dose aspirin had a significantly lower prevalence of COVID-19.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Endocrinology & Metabolism
Lauren A. Reid, Siyu Zheng, Jason A. Mendoza, Beth A. Reboussin, Alissa J. Roberts, Katherine A. Sauder, Jean M. Lawrence, Elizabeth Jensen, Leora Henkin, Kate Flory, Lisa M. Knight, Catherine Pihoker, Lawrence M. Dolan, Elaine M. Apperson, Angela D. Liese
Summary: This study aimed to evaluate the relationship between household food insecurity (HFI) and fear of hypoglycemia among young adults and adolescents with type 1 and type 2 diabetes, as well as their parents. The results showed that adults with type 1 and type 2 diabetes experiencing HFI had higher fear of hypoglycemia scores compared to those without HFI. Screening for HFI and fear of hypoglycemia can help healthcare providers customize diabetes education for individuals who have HFI and fear hypoglycemia.
Article
Rheumatology
David Roofeh, Kevin K. Brown, Ella A. Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U. Wells, Ganesh Raghu, Christopher P. Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A. Johannson, Yannick Allanore, Eric L. Matteson, Leticia Kawano-Dourado, John D. Pauling, James R. Seibold, Elizabeth R. Volkmann, Simon L. F. Walsh, Chester Oddis, Eric S. White, Shaney L. Barratt, Elana J. Bernstein, Robyn T. Domsic, Paul F. Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C. Mathai, Vibeke Strand, Tracy J. Doyle, Virginia Steen, Donald F. Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D. Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna
Summary: This study aimed to establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). The results showed that using the proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time.
Article
Rheumatology
Karin Melsens, Maurizio Cutolo, Dieneke Schonenberg-Meinema, Ivan Foeldvari, Maria C. Leone, Yora Mostmans, Valerie Badot, Rolando Cimaz, Joke Dehoorne, Ellen Deschepper, Tracy Frech, Johanna Hernandez-Zapata, Francesca Ingegnoli, Archana Khan, Dorota Krasowska, Hartwig Lehmann, Ashima Makol, Miguel A. Mesa-Navas, Malgorzata Michalska-Jakubus, Ulf Muller-Ladner, Laura Nuno-Nuno, Rebecca Overbury, Carmen Pizzorni, Mislav Radic, Divya Ramadoss, Angelo Ravelli, Silvia Rosina, Clara Udaondo, Merlijn J. van den Berg, Ariane L. Herrick, Alberto Sulli, Vanessa Smith
Summary: This study aimed to standardly assess and describe nailfold videocapillaroscopy (NVC) assessment in children and adolescents with juvenile rheumatic and musculoskeletal diseases (jRMD) vs healthy controls (HCs). The results showed significant differences in NVC assessment between jRMD subgroups and HCs.
Article
Health Care Sciences & Services
Angela Flavia Luppino, Gilberto Cincinelli, Annalisa Orenti, Patrizia Boracchi, Ennio Giulio Favalli, Roberto Caporali, Francesca Ingegnoli
Summary: This study analyzed the impact of different patterns of healthcare delivery on remission of RA patients treated with targeted therapies during the pandemic. The results showed that the different healthcare delivery strategies did not significantly affect the remission rate of RA patients, including difficult-to-treat patients.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Public, Environmental & Occupational Health
Lisa. P. Oakley, Xia Li, Sara Y. Tartof, Madalynne Wilkes-Grundy, Michael J. Fassett, Jean M. Lawrence
Summary: The study aims to examine the rates of severe maternal morbidity (SMM) over a 10-year period and assess racial/ethnic disparities in SMM among insured women in Southern California. The study found an increasing trend in SMM rates from 2008 to 2017. Non-Hispanic Black, Asian/Pacific Islander, and Hispanic women were more likely to experience SMM events compared to non-Hispanic White women. Multilevel approaches are needed to understand the factors associated with racial and ethnic disparities in SMM and develop effective interventions to reduce SMM.
WOMENS HEALTH ISSUES
(2023)
Article
Nutrition & Dietetics
Roberta De Vito, Federica Fiori, Monica Ferraroni, Silvia Cavalli, Roberto Caporali, Francesca Ingegnoli, Maria Parpinel, Valeria Edefonti
Summary: A recent Italian study found that higher consumption of olive oil and nuts may have a positive effect on disease activity in rheumatoid arthritis (RA), especially for patients with more severe or long-standing forms of the disease. Increasing intake of olive oil, olives, and nuts may be beneficial for improving disease activity in RA.
Article
Rheumatology
Rossella De Angelis, Clodoveo Ferri, Dilia Giuggioli, Gianluigi Bajocchi, Lorenzo Dagna, Silvia Bellando-Randone, Giovanni Zanframundo, Rosario Foti, Fabio Cacciapaglia, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Valeria Riccieri, Elisabetta Zanatta, Silvia Laura Bosello, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Giuseppe Murdaca, Giuseppina Abignano, Nicoletta Romeo, Alessandra Della Rossa, Maurizio Caminiti, Anna Maria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Ilenia De Andres, Alessandro Giollo, Marta Saracco, Cecilia Agnes, Edoardo Cipolletta, Federica Lumetti, Amelia Spinella, Luca Magnani, Corrado Campochiaro, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Claudio Di Vico, Antonietta Gigante, Greta Pellagrino, Erika Pigatto, Maria-Grazia Lazzaroni, Franco Franceschini, Elena Generali, Gianna Mennillo, Simone Barsotti, Giuseppa Pagano Mariano, Federica Furini, Licia Vultaggio, Simone Parisi, Clara Lisa Peroni, Davide Rozza, Anna Zanetti, Greta Carrara, Gianpiero Landolfi, Carlo Alberto Scire, Gerolamo Bianchi, Enrico Fusaro, Gian Domenico Sebastiani, Marcello Govoni, Salvatore D'Angelo, Franco Cozzi, Serena Guiducci, Andrea Doria, Carlo Salvarani, Florenzo Iannone, Marco Matucci-Cerinic
Summary: This study aimed to describe the demographic, clinical, and laboratory features of systemic sclerosis sine scleroderma (ssSSc) within a large SSc cohort. The results showed that ssSSc has longer duration of RP, milder disease course, and higher positivity of anticentromere antibodies compared to lcSSc and dcSSc.
Article
Rheumatology
Rossella De Angelis, Valeria Riccieri, Edoardo Cipolletta, Nicoletta Del Papa, Francesca Ingegnoli, Silvia Bosello, Amelia Spinella, Greta Pellegrino, Marco de Pinto, Silvia Papa, Giuseppe Armentaro, Dilia Giuggioli
Summary: Nailfold videocapillaroscopy findings were compared in SSc patients with and without a diagnosis of pulmonary arterial hypertension (PAH). The results showed that patients with SSc-PAH had more severe abnormalities in nailfold videocapillaroscopy. These findings may be helpful in predicting the diagnosis of PAH.
Article
Nutrition & Dietetics
Roberta De Vito, Maria Parpinel, Michela Carola Speciani, Federica Fiori, Rachele Bianco, Roberto Caporali, Francesca Ingegnoli, Isabella Scotti, Tommaso Schioppo, Tania Ubiali, Maurizio Cutolo, Giuseppe Grosso, Monica Ferraroni, Valeria Edefonti
Summary: Through a recent cross-sectional study in Italy, we found that consuming half a pizza more than once a week had beneficial effects on disease activity in rheumatoid arthritis (RA) patients, with significant reductions in disease severity. Mozzarella cheese and olive oil, among the pizza-related food items, showed particularly beneficial effects in patients with more severe RA. Future cohort studies are needed to confirm these findings.
Article
Endocrinology & Metabolism
Sarah S. Casagrande, Jean M. Lawrence
Summary: Disruptions in medical care during the COVID-19 pandemic were associated with a decrease in ABC testing among US adults with diabetes. ABC testing rates in 2021 were lower compared to 2019, and these lower rates were associated with delays or inability to access medical care. After full adjustment, adults who reported delaying or not getting medical care were 50% less likely to receive ABC testing.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Rheumatology
Ilaria Suardi, Cristina Posio, Ester Luconi, Patrizia Boracchi, Roberto Caporali, Francesca Ingegnoli
Summary: This study aimed to determine the main factors influencing the Patient Global Assessment (PGA) score in Rheumatoid Arthritis (RA) patients. Factors related to disease activity, such as the use of low-dose corticosteroids and RAID items for pain and sleep difficulties, were found to be predictive for worse PGA scores. Factors related to disease severity, such as HAQ score and RAID total, were associated with higher PGA scores. There was an increasing trend in PGA scores in patients with longstanding diseases (>15 years).
RHEUMATOLOGY INTERNATIONAL
(2023)
Correction
Rheumatology
Karin Melsens, Maurizio Cutolo, Dieneke Schonenberg-Meinem, Ivan Foeldvari, Maria C. Leone, Yora Mostmans, Valerie Badot, Rolando Cimaz, Joke Dehoorne, Ellen Descheppe, Tracy Frech, Johanna Hernandez-Zapata, Francesca Ingegnoli, Archana Khan, Dorota Krasowska, Hartwig Lehmann, Ashima Makol, Miguel A. Mesa-Navas, Malgorzata Michalska-Jakubus, Ulf Mueller-Ladne, Laura Nuno-Nuno, Rebecca Overbury, Carmen Pizzorni, Mislav Radic, Divya Ramadoss, Angelo Ravelli, Silvia Rosina, Clara Udaondo, Merlijn J. van den Berg, Ariane L. Herrick, Alberto Sulli, Vanessa Smith
