Article
Medicine, General & Internal
Shi-Yu Sun, Run-Ze Huang, Huang Huang, Ming-Qi Zhang, Hui-Lin Sun
Summary: This study did not find an association between TCF7L2 gene SNPs and T2DM in the Liannan Yao population, indicating that genetic polymorphisms in this gene are not significantly correlated with T2DM in this population.
Article
Health Care Sciences & Services
Sarah Elhourch, Housna Arrouchi, Nour Mekkaoui, Younes Allou, Fatima Ghrifi, Loubna Allam, Naima Elhafidi, Lahcen Belyamani, Azeddine Ibrahimi, Naoual Elomri, Rachid Eljaoudi
Summary: The study revealed a significant association of TCF7L2 gene polymorphisms (rs7903146 (C/T) and rs12255372 (G/T)) with a higher risk of developing type 2 diabetes mellitus in the Moroccan population, with the T allele being associated with an increased risk of diabetes. There were no significant differences in anthropometric and metabolic parameters between different genotypes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Mohamed Jahromi, Torki Al-Otaibi, Osama Ashry Gheith, Nashwa Farouk Othman, Tarek Mahmoud, Parasad Nair, Medhat A-Halim, Parul Aggarwal, Grace Messenger, Philip Chu, Sacha A. De Serres, Jamil R. Azzi
Summary: New Onset Diabetes After Transplantation (NODAT) is a serious metabolic complication post kidney transplant, and studies have found an association between gene polymorphisms like interferon gamma and NODAT.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Pei Zhang, Mengyao Deng, Wei Li, Qiong Dai, Hua He, Wenpei Zheng, Lu She, Bing Xiang, Jing Zeng, Feng Zhou, Yan Guo, Mei Yang
Summary: The study found that rs4506565, rs7895340, rs7901695, and rs11196205 were the genetic susceptibility SNPs of GDM in the central Chinese population. Further research is needed to validate the findings and elucidate the underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
YuanLiang Xue, Ya Guo, Ning Liu, XiangQi Meng
Summary: It has been found that miR-22-3p is involved in the regulation of osteosarcoma (OS) growth by targeting TCF7L2 and inhibiting the Wnt/beta-catenin pathway. This study suggests that miR-22-3p/TCF7L2 axis could be a potential molecular target for future OS treatment.
Article
Endocrinology & Metabolism
Rujikorn Rattanatham, Nongnuch Settasatian, Nantarat Komanasin, Upa Kukongviriyapan, Kittisak Sawanyawisuth, Phongsak Intharaphet, Vichai Senthong, Chatri Settasatian
Summary: This study revealed a significant association between specific combined genetic variants in TCF7L2 and KCNQ1 with diabetic vascular complications, particularly nephropathy and CAD. The specific pattern of gene variant combination may play a role in the progression of T2DM and life-threatening vascular complications.
DIABETES & METABOLISM JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Junyi Li, Li Zhou, Xinping Ouyang, Pingping He
Summary: TCF7L2, a crucial member of the TCF/LEF family, exerts various anti-atherosclerotic effects through specific molecular mechanisms, with rs7903146 serving as a genetic high-risk factor for type 2 diabetes and linking metabolic disorders to cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Taha Hameed, Zahid Khan, Muhammad Imran, Saif Ali, Abdullah Abdo Albegali, Muhammad Ikram Ullah, Hasan Ejaz
Summary: The study showed significant association between TCF7L2 gene SNPs and susceptibility to T2DM in the population of Khyber Pakhtunkhwa, Pakistan, as well as significant correlations with biochemical parameters such as blood glucose, lipid levels, and creatinine.
AFRICAN HEALTH SCIENCES
(2021)
Article
Endocrinology & Metabolism
J. Li, Y. Yang, Y. Xia, S. Luo, J. Lin, Y. Xiao, X. Li, G. Huang, L. Yang, Z. Xie, Z. Zhou
Summary: This study found that the rs10997866 variant of the SIRT1 gene is associated with susceptibility to T1D in Han Chinese individuals, with the minor allele G conferring a higher risk of T1D. Additionally, the rs10997866 and rs3818292 variants of the SIRT1 gene correlate with the titer of IA-2A in Han Chinese individuals with T1D.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medical Laboratory Technology
Yuqi Wang, Ling Li, Ping Li
Summary: The association between gestational diabetes mellitus (GDM) and single nucleotide polymorphisms (SNPs) has been widely studied. SNPs can provide insights into the pathogenesis of GDM, help predict the risk of GDM, and guide the management of GDM patients. This review focuses on recent studies investigating the association between SNPs and GDM, identifying several SNPs that have been associated with GDM. However, further research is needed to explore the role of SNPs in the prediction, diagnosis, treatment, and prognosis of GDM in diverse ethnic populations.
CLINICA CHIMICA ACTA
(2023)
Article
Genetics & Heredity
Anca Florentina Mitroi, Nicoleta Leopa, Eugen Dumitru, Costel Brinzan, Cristina Tocia, Andrei Dumitru, Razvan Catalin Popescu
Summary: This study found an association between the TCF7L2 rs7903146, CASC8 rs6983267, and GREM1 rs16969681 polymorphisms and the occurrence of both T2DM and CRC.
Article
Virology
Dania Lavysh, Vladimir Mekler, Evgeny Klimuk, Konstantin Severinov
Summary: This study investigated the temporal pattern of gene expression during Salmonella enterica serovar Newport bacteriophage 7-11 infection and compared it to the previously determined transcription strategy of Escherichia coli phage phiEco32. The results revealed the presence of eight promoters in 7-11 phage and the absence of middle promoters and shut-off of sigma(70)-dependent transcription.
Article
Genetics & Heredity
G. Vigneshwaran, Qurratulain Annie Hasan, Rahul Kumar, Avinash Eranki
Summary: This study constructed a framework to identify genes associated with triple-negative breast cancer (TNBC) and screen the single nucleotide polymorphisms (SNPs) reported in these genes. The study found the association of genes such as BRCA1, BRCA2, EGFR, PIK3CA, PTEN, and TP53 with TNBC. The framework was demonstrated to have high accuracy in identifying pathogenic alterations in breast cancer samples.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Delan Ameen Younus, Suhad Asaad Mustafa, Lade Yasin Abdullah, Muzheir Salem Mustafa
Summary: This study is the first to investigate the association between TCF7L2 rs12255372 variant and T2D in the Iraqi Kurdish population, revealing that the TT genotype is significantly associated with increased risk of T2D.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2021)
Article
Gastroenterology & Hepatology
Mona Mahmoud Hassouna, Mohammed Sayed Moustafa, Mona Hamdy, Eman Abdelsameea, Mohamed Abbasy, Mary Naguib
Summary: The TCF7L2 (rs290487) gene polymorphism may be associated with an increased risk of diabetes in cirrhotic patients.
EGYPTIAN LIVER JOURNAL
(2023)