Article
Nutrition & Dietetics
Caroline Kroll, Dayana Rodrigues Farias, Gilberto Kac, Paulo Henrique Condeixa de Franca, Marco Fabio Mastroeni
Summary: This study found that the TG or GG genotypes of the ADIPOQ-rs2241766 gene are associated with an increased risk of excess body weight in children in the first 6 years of life, especially in girls. In contrast, the LEP-rs7799039 genetic variant showed no association with body weight trajectory.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Xingxing Zhang, Xin Wu, Gengsheng Xiao, Gongliang Liu, Hao Dong, Rui Liu, Qun Lu
Summary: This study found that phenolamide extract (PAE) from apricot bee pollen has a significant weight loss effect on obese mice fed a high-fat diet. PAE can reduce weight gain and lipid accumulation, improve glucose tolerance, reduce insulin resistance, and improve lipid metabolism. In addition, PAE can regulate the gut microbiota and metabolites. This study suggests that PAE can be used as a functional dietary supplement to alleviate HFD-induced obesity.
Article
Medicine, General & Internal
Aleksandra Korac, Biljana Srdic-Galic, Andjelika Kalezic, Ana Stancic, Vesna Otasevic, Bato Korac, Aleksandra Jankovic
Summary: The study found that obese women had increased leptin gene and protein expression in VAT, but decreased leptin expression and low adiponectin levels in SAT. Significant differences in resistin levels were only observed in obese women, with higher gene expression but inconsistent protein expression.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
Alexandra Dietz de Loos, Geranne Jiskoot, Annemerle Beerthuizen, Jan Busschbach, Joop Laven
Summary: The three-component lifestyle intervention was more effective in improving metabolic health compared to usual care. We recommend this intervention for women with polycystic ovary syndrome and excess weight, with a focus on clinically significant weight loss.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Min-zhe Zhang, Jun-xia Shi, Hui Li, Rui Chen, Miao-bing Zheng, Li-jing Yan, Neng-jian Wu, Qi-qiang He
Summary: This study aimed to examine the effects of an educational lifestyle intervention on body weight and psychological health among Chinese community-dwelling overweight/obese patients with severe mental disorders (SMD). The results showed that after 12 months, the intervention group had significant reductions in body weight, body mass index, and waist circumference compared to the control group. Additionally, the intervention group reported higher life satisfaction and a decrease in depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Yu-Min Huang, Yen-Kuang Lin, Wei-Jei Lee, Kyoung Yul Hur, Kazunori Kasama, Anton Kui Sing Cheng, Ming-Hsien Lee, Simon Kin-Hung Wong, Tien-Chou Soong, Kuo-Ting Lee, Davide Lomanto, Muffazal Lakdawala, Yen-Hao Su, Weu Wang
Summary: Metabolic surgery significantly improved body weight, T2D, and other metabolic disorders in Asian patients, with different surgical procedures showing varied outcomes.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Shuai Zheng, Min Shen, Yu Qian, Shushu Li, Yang Chen, Hemin Jiang, Hui Lv, Doudou Chen, Ruiling Zhao, Xuqin Zheng, Min Sun, Tao Yang, Yun Shi, Qi Fu
Summary: This study aimed to evaluate the roles of GDF-15, adiponectin, and GDF-15/adiponectin ratio as biomarkers for detecting metabolic syndrome. The results suggest that the G/A ratio and adiponectin are potential biomarkers for detecting metabolic syndrome in women and men, respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Ju-Hee Nho, Soo-Wan Chae
Summary: This study aimed to examine the effect of a lifestyle intervention on overweight or obese female university students, finding significant improvements in health-promoting behavior, psychological distress, reproductive health, and body composition through the intervention.
Article
Endocrinology & Metabolism
Yanyan Dai, Yujuan Li, Shu Yang, Weiwei Xu, Hong Jia, Chao Yang
Summary: Weight change is associated with the risk of metabolic abnormalities. Long-term excessive weight gain is positively associated with an increased risk of metabolic abnormalities in non-overweight/obese individuals, while long-term weight loss is a protective factor for metabolic health in overweight/obese individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Jinyuan Wang, Biyun Liao, Changsheng Wang, Ou Zhong, Xiaocan Lei, Yuli Yang
Summary: This systematic review and meta-analysis explores the heterogeneity in the beneficial effects of antioxidant supplementation in obese adults. The results indicate that antioxidant supplementation can improve obesity-related indicators, lipid metabolism, antioxidant capacity, inflammation, and liver function in obese patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Endocrinology & Metabolism
Weiling Leng, Danlan Pu, Juan Jiang, Xiaotian Lei, Qinan Wu, Bing Chen
Summary: The combination of metformin and lifestyle changes was found to be a safe and effective strategy for improving metabolic markers and increasing adiponectin, thereby decreasing breast density and the risk of breast cancer. The BIRADS grade showed significant correlations with positive pathological biopsy rate and adiponectin levels, while the positive pathological biopsy rate was strongly associated with the BIRADS grade.
DIABETES METABOLIC SYNDROME AND OBESITY
(2021)
Article
Biochemistry & Molecular Biology
Hyun Suk Yang, Gun-Hyuk Lee, Donghwan Kim, Kyeong Ryong Lee, Mina Hur
Summary: Adiponectin could be a potential biomarker for multi-MetSC in general health checkup subjects with extremely high HDL-C levels, and there are sex differences in the manifestation of metabolic risk factors.
Review
Nutrition & Dietetics
Omar Ramos-Lopez
Summary: This article reviews the evidence on the use of epigenetic signatures as potential biomarkers for predicting metabolic outcomes and discusses their potential application in the field of precision nutrition.
Article
Nutrition & Dietetics
Sandra M. B. P. Moreira, Andre L. L. Bachi, Elias I. Jirjos, Carlos A. A. Malheiros, Sergio Vencio, Vera L. S. Alves, Alan R. T. Sousa, Lucenda A. Felipe, Eduardo A. Perez, Maria E. M. Lino, Shayra K. A. Souza, Juliana M. B. Santos, Miria C. Oliveira, Adriano L. Fonseca, Carlos H. M. Silva, Rodolfo P. Vieira, Giuseppe Insalaco, Wilson R. R. Freitas Junior, Luis V. F. Oliveira
Summary: Obesity is a significant public health problem that increases the risk of various health complications. Bariatric surgery, such as Roux-en-Y gastric bypass (RYGB), is an effective treatment for severe obesity and associated comorbidities. This study investigated the effects of RYGB on women with severe obesity with and without metabolic syndrome (MetS) by analyzing biochemical, glucose, and inflammatory parameters. The results showed significant improvements in weight, body mass index, glucose, cholesterol, and leptin levels, as well as an increase in adiponectin/leptin ratio after RYGB. These findings highlight the beneficial effects of weight loss induced by RYGB on metabolic and inflammatory parameters in women with severe obesity.
Article
Endocrinology & Metabolism
Kyoung Eun Joung, Camilia R. Martin, Sara Cherkerzian, Mark Kellogg, Mandy Brown Belfort
Summary: Leptin intake in milk was positively associated with weight gain and weight z-scores in preterm infants, while adiponectin intake was associated with length z-scores and negatively with head circumference z-scores after adjusting for protein and calorie intake. Insulin intake did not show significant associations with growth outcomes. Further research regarding the long-term effects of milk hormones is warranted.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Ilaria Barchetta, Carla Lubrano, Flavia Agata Cimini, Sara Dule, Giulia Passarella, Arianna Dellanno, Alberto Di Biasio, Frida Leonetti, Gianfranco Silecchia, Andrea Lenzi, Maria Gisella Cavallo
Summary: This study found a close relationship between NAFLD-related liver fibrosis, lower bone mineral density, and degraded microarchitecture in obese individuals. This suggests potential common pathways underlying liver and bone involvement in obesity and insulin resistance-associated disorders.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
D. Bruttomesso, C. Irace, P. Pozzilli
Summary: This study reported on glycemic control in Italian participants with type 1 diabetes and found that younger patients had better glycemic control compared to older patients. Factors such as body mass index and adherence to diet were associated with glycemic control.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Andrology
Daniele Tienforti, Chiara Castellini, Francesca Di Giulio, Maria Totaro, Gilda Dalmazio, Luca Spagnolo, Mario Muselli, Giovanni Corona, Marco Giorgio Baroni, Arcangelo Barbonetti
Summary: This study aimed to determine the effectiveness and safety of selective estrogen receptor modulators in men with obesity-related functional androgen deficiency. The results of the clinical trial with 292 men showed a significant increase in testosterone levels with clomiphene and enclomiphene citrate treatment, with no unexpected safety findings.
Article
Endocrinology & Metabolism
M. L. Morieri, I. Raz, A. Consoli, M. Rigato, A. Lapolla, F. Broglio, E. Bonora, A. Avogaro, G. P. Fadini
Summary: This study compared the effectiveness of dapagliflozin to DPP-4 inhibitors in achieving individualized HbA1c targets and extra-glycaemic endpoints in elderly patients with type 2 diabetes. The results showed that patients initiating dapagliflozin had a lower likelihood of reaching individualized HbA1c targets compared to those initiating DPP-4 inhibitors. However, they experienced greater improvements in body weight and blood pressure.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Ernesto Maddaloni, Lucia Coraggio, Rocco G. Amendolara, Marco G. Baroni, Maria Cavallo, Massimiliano Copetti, Efisio Cossu, Paola D'Angelo, Luca D'Onofrio, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Kyoungmin R. Park, Rury Holman, Vincenzo Trischitta, Raffaella Buzzetti, UMMER Study Diabet Grp
Summary: This study evaluated the possible associations of osteocalcin, osteoprotegerin, and osteopontin with cardiovascular disease (CVD) and diabetic retinopathy (DR) in type 2 diabetes patients. The findings showed that osteocalcin was associated with CVD, while osteoprotegerin and osteopontin were associated with DR.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Federica Sentinelli, Ilaria Barchetta, Flavia Agata Cimini, Sara Dule, Diego Bailetti, Efisio Cossu, Arcangelo Barbonetti, Maria Totaro, Olle Melander, Maria Gisella Cavallo, Marco Giorgio Baroni
Summary: Neurotensin (NT) is a small protein that regulates energy balance and functions as both a neurotransmitter in the brain and a gastrointestinal peptide. This study aimed to investigate the genetic regulation of plasma pro-NT levels. Seven sequence variations in the NT gene (NTS) were identified, including a polymorphism (rs2234762) that was more frequent in individuals with lower pro-NT levels. Carriers of the rs2234762 variant had lower pro-NT levels and reduced insulin resistance, independent of metabolic confounders. This suggests that the NTS rs2234762 gene variant may contribute to a more favorable metabolic profile in overweight and obese children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Flavia Agata Cimini, Antonella Tramutola, Ilaria Barchetta, Valentina Ceccarelli, Elena Gangitano, Simona Lanzillotta, Chiara Lanzillotta, Maria Gisella Cavallo, Eugenio Barone
Summary: BVRA protein levels can change dynamically in response to insulin and are greater in individuals with lower insulin sensitivity, indicating a correlation with insulin resistance and secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alessandra Dei Cas, Raffaella Aldigeri, Alessandro Mantovani, Maria Masulli, Luisa Palmisano, Franco Cavalot, Katia Bonomo, Marco Giorgio Baroni, Efisio Cossu, Gisella Cavallo, Flavia Agata Cimini, Raffaella Buzzetti, Carmen Mignogna, Frida Leonetti, Simonetta Bacci, Roberto Trevisan, Mario Luca Morieri, Riccardo Maria Pollis, Giovanni Targher, Saula Vigili de Kreutzenberg
Summary: This observational study aimed to evaluate sex-related differences in cardiovascular disease (CVD) prevalence and risk in adults with type 1 diabetes. The study found that men had a higher prevalence of CVD than women aged 55 years and above, but the prevalence was comparable between the two sexes in those below 55 years of age. In patients without pre-existing CVD, men had a higher 10-year estimated CVD risk than women until the age of 55, but this difference disappeared after that age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
F. Di Giulio, C. Castellini, D. Tienforti, G. Felzani, M. G. Baroni, A. Barbonetti
Summary: This study aimed to assess the independent association between low 25-hydroxy vitamin D (25(OH)D) levels and non-alcoholic fatty liver disease (NAFLD). The results showed that patients with lower 25(OH)D levels were more likely to have NAFLD and had other related factors. This study's findings suggest a relationship between vitamin D and NAFLD.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Massimiliano Copetti, Marco Giorgio Baroni, Raffaella Buzzetti, Maria Gisella Cavallo, Efiso Cossu, Paola D'Angelo, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Antonio Fernando Savino, Vincenzo Trischitta
Summary: This study aimed to validate the association of a 14-metabolite score with all-cause mortality in type 2 diabetes and explore whether it could improve existing mortality prediction models. The results showed a significant association between the 14-metabolite score and mortality in type 2 diabetes, although the effect size was lower compared to the general population. However, a simplified version of the score without two specific metabolites improved patient analysis and classification of mortality risk.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Valentina Maria Cambuli, Marco Giorgio Baroni
Summary: This article provides a synthetic overview of research in the treatment of type 1 diabetes, focusing on the development of intelligent insulins and the use of artificial intelligence in automated insulin therapy. It outlines the latest developments in the search for intelligent insulins and the promising advances in the use of artificial intelligence for glucose control. The future of insulin treatment in type 1 diabetes appears promising with the potential for a closed-loop artificial pancreas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Dule, Ilaria Barchetta, Flavia Agata Cimini, Giulia Passarella, Arianna Dellanno, Tiziana Filardi, Vittorio Venditti, Enrico Bleve, Diego Bailetti, Elisabetta Romagnoli, Susanna Morano, Marco Giorgio Baroni, Maria Gisella Cavallo
Summary: Type 2 diabetes mellitus is associated with increased fracture risk. This study aimed to explore differences in bone alterations between women with type 2 diabetes and controls, and to identify clinical predictors of bone impairment in type 2 diabetes. The results showed that type 2 diabetes patients had a lower normal bone category and their bone status was correlated with high-density lipoprotein cholesterol and vitamin D levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)