Article
Endocrinology & Metabolism
Lucie Canaff, Vito Guarnieri, Yoojung Kim, Betty Y. L. Wong, Alexis Nolin-Lapalme, David E. C. Cole, Salvatore Minisola, Cristina Eller-Vainicher, Filomena Cetani, Andrea Repaci, Daniela Turchetti, Sabrina Corbetta, Alfredo Scillitani, David Goltzman
Summary: This study investigated the role of variants of the GCM2 gene in familial hypoparathyroidism and familial isolated hyperparathyroidism. The results identified several novel GCM2 variants associated with these disorders, highlighting their potential contribution to the development of parathyroid diseases.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
F. Saponaro, G. Alfi, F. Cetani, A. Matrone, L. Mazoni, M. Apicella, E. Pardi, S. Borsari, M. Laurino, E. Lai, A. Gemignani, C. Marcocci
Summary: This study evaluated cognitive functions in patients with chronic post-surgical hypoparathyroidism and found that low serum calcium levels are associated with a decline in semantic memory abilities and executive function.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Surgery
Matilda Anneback, Jakob Hedberg, Martin Almquist, Peter Stalberg, Olov Norlen
Summary: A Swedish study from 2005 to 2015 investigated the prevalence of permanent hypoparathyroidism after total thyroidectomy for benign disease, finding a rate of 12.5%. Risk factors included parathyroid autotransplantation, higher age, female sex, and surgery at a low volume center, with follow-up data possibly underestimating the rate of permanent hypoparathyroidism.
Article
Endocrinology & Metabolism
Francesco Quaglino, Alex Bruno Bellocchia, Gerdi Tuli, Jessica Munarin, Patrizia Matarazzo, Luca Cestino, Federico Festa, Giulia Carbonaro, Salvatore Oleandri, Claudia Manini, Riccardo Vergano, Luisa De Sanctis
Summary: The study presents the experience of a reference adult endocrine surgery unit in treating pediatric thyroid diseases. Pediatric thyroid nodules have a worse prognosis and higher malignancy rates compared to adult thyroid disease. The malignancy rate is higher in indeterminate TIR 3B lesions. Postoperative hypoparathyroidism is common but transient, and intraoperative nerve monitoring is recommended in patients under 12.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Maria Luiza Garcia Aranha, Mariana Simoes Garcia, Deborah Navit de Carvalho Cavalcante, Ana Priscila Gomes Silva, Mayana Karoline Fontes, Paloma Kachel Gusso-Choueri, Rodrigo Brasil Choueri, Juliana Elaine Perobelli
Summary: This study investigated the hepatic damages caused by exposure to acephate, carbendazim, and mancozeb in juvenile rats. The exposure led to increased DNA damage and activation of the xenobiotic biotransformation system. Interestingly, the ternary mixture did not exacerbate adverse effects, suggesting a possible antagonistic chemical interaction among the three agrochemicals.
Review
Endocrinology & Metabolism
R. Pal, S. K. Bhadada, S. Mukherjee, M. Banerjee, A. Kumar
Summary: In this meta-analysis, it was found that patients with nonsurgical hypoPT have almost a 2-fold increased risk of vertebral fractures. No increased risk of vertebral fractures was observed in patients with postsurgical hypoPT.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Liang Yao, Jing Li, Meixuan Li, Clement Lin, Xu Hui, Divyalakshmi Tamilselvan, Maryam Kandi, Ashwini Sreekanta, Nima Makhdami, Dalal S. Ali, Karel Dandurand, Kehu Yang, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Michael Mannstadt, Lars Rejnmark, Aliya A. Khan, Gordon Guyatt
Summary: The efficacy and safety of PTH therapy for managing long-term hypoparathyroidism is being evaluated, and this systematic review and meta-analysis found that PTH therapy may improve physical health-related quality of life and reduce the dose of active vitamin D and calcium in patients with chronic hypoparathyroidism, but it may increase the risk of hypercalcemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Giuliano Paglia, Lorenzo Antonini, Laura Cervoni, Rino Ragno, Manuela Sabatino, Marco Minacori, Elisabetta Rubini, Fabio Altieri
Summary: The study demonstrates that punicalagin can bind to PDIA1 and PDIA3 with similar affinity, but exhibits higher inhibition efficacy on PDIA3's reductase activity. Furthermore, punicalagin affects the thermal denaturation profile of both proteins differently. Molecular docking and dynamics simulations suggest different effects of punicalagin on the structure of PDIA1 and PDIA3, providing valuable insights for developing punicalagin-based ligands and designing selective inhibitors for PDIA3.
Article
Medical Laboratory Technology
Areti Strati, Martha Zavridou, Galatea Kallergi, Eleni Politaki, Andra Kuske, Tobias M. Gorges, Sabine Riethdorf, Simon A. Joosse, Claudia Koch, Anna-Lena Bohnen, Volkmar Mueller, George Koutsodontis, Emmanouil Kontopodis, Nikiforita Poulakaki, Amanda Psyrri, Dimitris Mavroudis, Vasilis Georgoulias, Klaus Pantel, Evi S. Lianidou
Summary: The study conducted a comprehensive molecular analysis of in vivo isolated CTCs in breast cancer patients, revealing gene expression, DNA mutations, and DNA methylation patterns. The results showed a higher sensitivity in detecting mutations and gene expression changes in CTCs compared to traditional methods like CellSearch or IF staining. This highlights the potential of in vivo-CTC isolation combined with molecular analysis for liquid biopsy-based molecular diagnostics.
CLINICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Oskar Swartling, Marie Evans, Tim Spelman, Wafa Kamal, Olle Kampe, Michael Mannstadt, Ylva Trolle Lagerros, Sigridur Bjornsdottir
Summary: Patients with chronic hypoparathyroidism treated with activated vitamin D and calcium supplementation may have a higher risk of kidney complications. This population-based cohort study found that patients with chronic hypoparathyroidism were at increased risk for developing chronic kidney disease, urolithiasis, and hospitalization compared to controls.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Food Science & Technology
Yue Yu, Fusheng Pei, Zhanming Li
Summary: This study investigated the structure-activity relationships between orientin and vitexin, two flavonoids with similar structures. Molecular docking analysis suggested that both orientin and vitexin suppressed inflammatory responses through modulation of the MAPK signaling pathway. Experimental results using RAW264.7 cells confirmed the anti-inflammatory activities of orientin and vitexin, which were achieved by inhibiting NF-KB translocation via the MAPK/NF-KB signaling pathway.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Yao Xiao, Lujie Ren, Yanan Wang, Huanhuan Wen, Yongqiang Ji, Chenshou Li, Yangqing Yi, Caiying Jiang, Qing Sheng, Zuoming Nie, Qixiang Lu, Zhengying You
Summary: The structure and expression characteristics of the silkworm GRP78 protein were investigated in this study. BmGRP78 was found to be widely expressed in different tissues and developmental stages of the silkworm, and its expression level was upregulated under heat induction and Pb/Hg exposure, but not affected by BmNPV infection. Furthermore, BmGRP78 was observed to translocate into the nucleus after exposure to heat, Pb, Hg, and BmNPV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Otorhinolaryngology
Sam P. J. van Dijk, M. H. Elise van Driel, Caroline M. J. van Kinschot, Maarten F. M. Engel, Gaston J. H. Franssen, Charlotte van Noord, W. Edward Visser, Cornelis Verhoef, Robin P. Peeters, Tessa M. van Ginhoven
Summary: This Meta-analysis evaluated the impact of different treatment strategies for early postoperative hypoparathyroidism on hypocalcemia-related complications and long-term hypoparathyroidism. The results showed that all treatment strategies prevented major complications of hypocalcemia, and the early postoperative treatment protocol did not seem to influence recovery of parathyroid function in the long term.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Surgery
Duntao Su, Fada Xia, Wanze Huang, Zhejia Zhang, Ning Bai, Di Wang, Xin Liao, Xinying Li
Summary: Serum magnesium, phosphorus, and PTH concentrations are important influencing factors and effective predictors of short-term postoperative parathyroid function recovery. Serum ion is an effective auxiliary diagnostic method for hypoparathyroidism after thyroidectomy, with a combined sensitivity of 82.76% for serum magnesium concentration and phosphorus concentration to predict normal parathyroid function recovery on the seventh postoperative day.
Article
Biodiversity Conservation
Xueru Wang, Yang Liu, Jun Sun
Summary: Coccolithophores play important roles in oceanic carbon and nitrogen cycles and have an impact on global climate change. In this study, culturable phycosphere bacteria associated with Chrysotila dentata were isolated and identified. The results showed that the isolated bacteria mainly belonged to α-proteobacteria and γ-proteobacteria, with a small part of CFB group bacteria and firmicutes. The bacteria exhibited different characteristics in terms of their colony characteristics, Gram nature, and physiological and biochemical properties. The findings provided basic experimental data for further understanding the relationship between coccolithophores and culturable phycosphere bacteria.
Article
Genetics & Heredity
Carlos R. Ferreira, Mary E. Hackbarth, Shira G. Ziegler, Kristen S. Pan, Mary S. Roberts, Douglas R. Rosing, Margaret S. Whelpley, Joy C. Bryant, Ellen F. Macnamara, Sisi Wang, Kerstin Mueller, Iris R. Hartley, Emily Y. Chew, Timothy E. Corden, Christina M. Jacobsen, Ingrid A. Holm, Frank Rutsch, Esra Dikoglu, Marcus Y. Chen, M. Zulf Mughal, Michael A. Levine, Rachel I. Gafni, William A. Gahl
Summary: Generalized arterial calcification of infancy (GACI) is usually caused by deficiency of ENPP1, and the natural history of GACI survivors has not been established. Out of 20 subjects, 16 presented with arterial calcifications, but only 5 had residual involvement at the time of evaluation.
GENETICS IN MEDICINE
(2021)
Review
Hematology
Kamyar Kalantar-Zadeh, Tomas Ganz, Henry Trumbo, Melvin H. Seid, Lawrence T. Goodnough, Michael A. Levine
Summary: Phosphorus plays a crucial role in cellular and extracellular metabolism, and maintaining phosphorus homeostasis is vital. Intravenous iron formulations can lead to renal phosphate excretion and hypophosphatemia by increasing serum concentrations of intact fibroblast growth factor 23. Case studies provide insights into acute symptomatic and chronic hypophosphatemia, considering pre-existing conditions, medications, and intravenous iron's role. This review focuses on phosphorus homeostasis and hypophosphatemia, emphasizing the effects of iron deficiency and intravenous iron replacement.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Obstetrics & Gynecology
Sara L. Kornfield, Valerie M. Riis, Clare McCarthy, Michal A. Elovitz, Heather H. Burris
Summary: The study found a significant association between high perceived stress and preterm birth, suggesting that stress during pregnancy could increase the risk of preterm birth, especially among non-Hispanic Black women.
JOURNAL OF PERINATOLOGY
(2022)
Article
Endocrinology & Metabolism
Shira London, Michael A. Levine, Dong Li, Ronen Spiegel, Asaf Lebel, Rephael Halevy, Yardena Tenenbaum-Rakover
Summary: This study describes a child who presented with hypocalcemic seizure at the age of 2.3 years. Whole exome sequencing identified a known homozygous missense mutation in the KCNJ1 gene associated with type 2 BS. The findings expand the clinical spectrum of KCNJ1 mutations and highlight the role of WES in cases of hypocalcemia with suspected genetic causes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Colin P. Hawkes, Jamal M. Al Jubeh, Dong Li, Susan E. Tucker, Tara Rajiyah, Michael A. Levine
Summary: Parathyroid hormone (PTH) gene mutations are rare causes of hypoparathyroidism, which can lead to decreased or elevated levels of PTH. This study describes two novel mutations of the PTH gene, expanding our understanding of the molecular basis for familial isolated hypoparathyroidism (FIH).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Ashley J. Stoffers, David R. Weber, Michael A. Levine
Summary: This review provides the most up-to-date understanding of the pathogenesis, prevention, and treatment of vitamin D deficient rickets in children. Risk factors for developing this disorder include inadequate sunlight exposure, exclusive breast feeding without vitamin D supplementation, and inadequate intake of vitamin D, calcium, or phosphorus. It is critical to have a thorough understanding of the individual's vitamin D levels, which are influenced by both environmental and genetic factors, for the evaluation and treatment of children with rickets. Further research is needed to determine the ideal vitamin D status across diverse populations and the impact of vitamin D status on overall health.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2022)
Article
Genetics & Heredity
Douglas Ralph, Michael A. Levine, Gabriele Richard, Michelle M. Morrow, Elizabeth K. Flynn, Jouni Uitto, Qiaoli Li
Summary: This article provides a comprehensive review of all the pathogenic variants, likely pathogenic variants, and variants of unknown significance in the ENPP1 gene associated with various genetic disorders. Missense variants are the most common. While there is no apparent genotype-phenotype correlation, specific variants are associated with Cole disease.
Article
Genetics & Heredity
Douglas Ralph, Yvonne Nitschke, Michael A. Levine, Matthew Caffet, Tamara Wurst, Amir Hossein Saeidian, Leila Youssefian, Hassan Vahidnezhad, Sharon F. Terry, Frank Rutsch, Jouni Uitto, Qiaoli Li
Summary: This study reveals that variants in the ENPP1 gene can cause both GACI and classic PXE, increasing the clinical and genetic diversity of hereditary ectopic calcification disorders. Additionally, the correlation between plasma PPi levels and the severity of vascular calcification is found to be limited in this study.
Review
Endocrinology & Metabolism
Janice L. Pasieka, Kelly Wentworth, Caitlin T. Yeo, Serge Cremers, David Dempster, Seiji Fukumoto, Ravinder Goswami, Pascal Houillier, Michael A. Levine, Jesse D. Pasternak, Nancy D. Perrier, Antonio Sitges-Serra, Dolores M. Shoback
Summary: This article utilized a systematic review to investigate the etiologies and pathogenesis of hypoparathyroidism, with a particular focus on new knowledge about parathyroid gland viability and intraoperative parathyroid hormone monitoring. Non-surgical factors, especially genetic factors, play a significant role in hypoparathyroidism. Due to the widespread impact of PTH deficiency on multiple organ systems, the article provides a detailed review of skeletal, renal, neuromuscular, and ocular complications. The burden of illness on patients and their caregivers leads to reduced quality of life and increased social costs for this chronic endocrinopathy.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Editorial Material
Obstetrics & Gynecology
Marie T. Tan, Niesha Darden, Karen Peterson, Kimberly K. Trout, Lori Christ, Sara C. Handley, Sara L. Kornfield, Maggie E. Power, Diana Montoya-Williams, Jennifer Lewey, Emily F. Gregory, Scott A. Lorch, Sara B. DeMauro, Lisa D. Levine, Heather H. Burris
JOURNAL OF PERINATOLOGY
(2023)
Review
Endocrinology & Metabolism
Allen W. Root, Michael A. Levine
Summary: The past 50 years of research in pediatric bone and mineral metabolism have led to significant progress in understanding and characterizing disorders that affect the developing skeleton. Key findings include the identification of important proteins and receptors involved in calcium and phosphate metabolism, as well as the genetic causes for various bone and mineral disorders. These discoveries will likely lead to the development of innovative treatments in the next decade that will improve the lives of children with these disorders.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychiatry
Lauren. K. K. White, Sara. L. L. Kornfield, Megan. M. M. Himes, Markolline Forkpa, Rebecca Waller, Wanjiku F. M. Njoroge, Ran Barzilay, Barbara. H. H. Chaiyachati, Heather. H. H. Burris, Andrea. F. F. Duncan, Jakob Seidlitz, Julia Parish-Morris, Michal. A. A. Elovitz, Raquel. E. E. Gur
Summary: Social support is essential for postpartum recovery, adjustment, and bonding, but the COVID-19 pandemic and social distancing measures disrupted it. This study examines changes in social support during the pandemic and their impact on postpartum mental health and maternal-infant bonding.
ARCHIVES OF WOMENS MENTAL HEALTH
(2023)
Article
Endocrinology & Metabolism
Amnon Zung, Galia Barash, Ehud Banne, Michael A. Levine
Summary: We report a novel heterozygous mutation in the CASR gene that causes autosomal dominant hypocalcemia type 1. The mutation increases the sensitivity of the CASR to extracellular calcium. Clinical features included seizures, reduced renal calcium reabsorption, and early lens opacity. Based on the comprehensive clinical data, we propose age-specific upper limit of serum calcium levels to balance the risk of seizures and hypercalciuria.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Nelson B. Watts, John P. Bilezikian, Henry G. Bone, Bart L. Clarke, Douglas Denham, Michael A. Levine, Michael Mannstadt, Munro Peacock, Jeffrey G. Rothman, Tamara J. Vokes, Mark L. Warren, Shaoming Yin, Nicole Sherry, Dolores M. Shoback
Summary: This study evaluated the long-term safety and efficacy of recombinant human parathyroid hormone (1-84) (rhPTH(1-84)) treatment for chronic hypoparathyroidism. The results showed sustained improvements in biochemical parameters, a reduction in the percentage of patients with hypercalciuria, stable renal function, and decreased supplement requirements over 6 years of treatment with rhPTH(1-84). rhPTH(1-84) was well tolerated, and no new safety signals were identified.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Oelisoa M. Andriankaja, Reuben Adatorwovor, Alpdogan Kantarci, Hatice Hasturk, Luciana Shaddox, Michael A. Levine
Summary: This study assessed the association between serum or gingival crevicular fluid endothelial and inflammatory mediators and chronic periodontal disease among Hispanic adults with type 2 diabetes. The findings showed that oral and systemic endothelial and inflammatory mediators are related to periodontal clinical parameters.