Article
Neurosciences
Amber Nous, Mandy Melissa Jane Wittens, Yannick Vermeiren, Peter Paul De Deyn, Christine Van Broeckhoven, Guy Nagels, Ilse Smolders, Sebastiaan Engelborghs
Summary: This study aimed to evaluate the correlation between serum melatonin levels and spinal CSF melatonin levels in AD. The results showed a positive correlation between daytime serum melatonin levels and spinal CSF melatonin levels in AD patients, but no correlation was found between daytime melatonin levels and changes in cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Julian M. Gaitan, Sanjay Asthana, Cynthia M. Carlsson, Corinne D. Engelman, Sterling C. Johnson, Mark A. Sager, Dan Wang, Dena B. Dubal, Ozioma C. Okonkwo
Summary: This study investigated the variation of Klotho concentrations and its association with Alzheimer's disease risk factors. The results showed that Klotho concentrations were higher in KL-VS carriers and in cerebrospinal fluid compared to serum. Females and younger individuals also had higher Klotho levels. These findings suggest that fluid source, KL-VS genotype, age, and sex should be taken into consideration when analyzing the effects of circulating Klotho on brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Immunology
Kaja Nordengen, Bjorn-Eivind Kirsebom, Grit Richter, Lene Palhaugen, Berglind Gisladottir, Nikias Siafarikas, Arne Nakling, Arvid Rongve, Geir Brathen, Goril Rolfseng Grontvedt, Fernando Gonzalez, Knut Waterloo, Kulbhushan Sharma, Thomas Karikari, Eleonora M. Vromen, Betty M. Tijms, Pieter J. Visser, Per Selnes, Milicia G. Kramberger, Bengt Winblad, Kaj Blennow, Tormod Fladby
Summary: Brain innate immune activation is associated with Alzheimer's disease, with varying degrees of activation at different disease stages. In predementia AD, differences in immune activation levels and biomarker profiles may be related to amyloidosis and tau pathology. Changes in certain biomarkers in cerebrospinal fluid may be linked to cognitive preservation or impairment in predementia AD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Geriatrics & Gerontology
Shimin Hu, Na Pan, Chunyan Liu, Yuping Wang, Tingting Zhang
Summary: The meta-analysis suggested that there is a correlation between CSF sTREM2 levels and AD risk, with age matching being a major influencing factor in the results. However, available high-quality evidence does not fully support this association.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Akinori Futamura, Sotaro Hieda, Yukiko Mori, Kensaku Kasuga, Azusa Sugimoto, Hideyo Kasai, Takeshi Kuroda, Satoshi Yano, Mayumi Tsuji, Takeshi Ikeuchi, Kazuhiro Irie, Kenjiro Ono
Summary: The study compared toxic A beta conformers at different stages of AD, with toxic A beta(42) conformers positively correlated with p-tau in AD, and p-tau negatively correlated with cognitive function, indicating that toxic A beta conformers trigger tau accumulation leading to neuronal impairment in AD pathogenesis.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Anniina Snellman, Juan Lantero-Rodriguez, Andreja Emersic, Agathe Vrillon, Thomas K. Karikari, Nicholas J. Ashton, Milica Gregoric Kramberger, Sasa Cucnik, Claire Paquet, Uros Rot, Henrik Zetterberg, Kaj Blennow
Summary: The study develops new N-terminal-directed CSF total tau assays, which show increased levels ahead of standard t-tau in the Alzheimer's disease continuum, higher levels in patients with CJD or acute neurological diseases, and better potential as Alzheimer's disease blood biomarkers compared to Quanterix total tau.
Article
Clinical Neurology
Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Deniz Yilmazer-Hanke, Sarah Anderl-Straub, Christine von Arnim, Lutz Froelich, Luis Aragao Gomes, Lucrezia Hausner, Andre Huss, Holger Jahn, Jochen Weishaupt, Albert C. Ludolph, Dietmar R. Thal, Markus Otto
Summary: A novel ELISA was established to evaluate beta-synuclein as a potential marker for Alzheimer's disease. The study found increased levels of beta-synuclein in the CSF of some patients, supporting its potential use as a marker of synaptic degeneration. Furthermore, beta-synuclein was localized in glutamatergic synapses, with its expression reduced in AD patients' brain tissue.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Neurosciences
Marcos Pais, Julia Loureiro, Vagner do Vale, Marcia Radanovic, Leda Talib, Florindo Stella, Orestes Forlenza
Summary: Analysis of CSF biomarkers was able to differentiate between AD, MCI, and NC, yet clinical-biological mismatches were observed in a non-negligible proportion of cases.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Obstetrics & Gynecology
Pardes Habib, Joseph Neulen, Shahin Habib, Benjamin Roesing
Summary: Neuroactive steroids such as DHEA, E2, and P4 have different distributional patterns between peripheral and central compartments in pregnant women. While DHEA levels in serum correlate strongly with those in CSF, the relationship between E2 levels in serum and CSF is weaker. Additionally, there is a significant correlation between serum DHEA levels and E2 levels in CSF, suggesting that peripheral DHEA levels may serve as an indicator for central nervous levels of neuroactive steroids DHEA and E2 in pregnant women.
REPRODUCTIVE SCIENCES
(2021)
Article
Clinical Neurology
Nicolas Fissolo, Clara Matute-Blanch, Mohamoud Osman, Carme Costa, Rucsanda Pinteac, Berta Miro, Alex Sanchez, Veronica Brito, Irena Dujmovic, Margarete Voortman, Michael Khalil, Eva Borras, Eduard Sabido, Shohreh Issazadeh-Navikas, Xavier Montalban, Manuel Comabella Lopez
Summary: This study identified two new biomarkers, Serpina3n and S100A4, which were upregulated during the progressive phases of multiple sclerosis and induced during neuronal differentiation. Levels of SERPINA3 and S100A4 were found to be increased in the cerebrospinal fluid of patients with progressive forms of MS compared to noninflammatory neurologic controls. Additionally, CSF SERPINA3 levels were significantly correlated with CSF neurofilament light chain levels in patients with primary progressive MS.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Neurosciences
Fuxia Yang, Lu Yang, Xuhao Fang, Yao Deng, Renling Mao, Aijuan Yan, Wenshi Wei
Summary: The study found that CSF sTREM2 levels were higher in iNPH patients, indicating the involvement of neuroinflammation in the pathogenesis of iNPH. Furthermore, the levels of sTREM2 were positively correlated with YKL-40, suggesting the importance of glial cell interactions in iNPH.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Wei-jiao Zhang, Dan-ning Li, Teng-hong Lian, Peng Guo, Ya-nan Zhang, Jing-hui Li, Hui-ying Guan, Ming-yue He, Wen-jing Zhang, Wei-jia Zhang, Dong-mei Luo, Xiao-min Wang, Wei Zhang
Summary: This study aimed to explore the clinical features and potential mechanisms of Alzheimer's disease (AD) and hearing loss (HL) by analyzing neuropathological biomarkers and blood-brain barrier (BBB). The results showed that AD patients with HL had significantly impaired overall cognitive function, memory, language, attention, execution, and activities of daily living (ADL). The potential mechanisms of AD-HL were elevated levels of AD neuropathological biomarker P-tau (S199) and BBB factor MMP-3, as well as correlations between P-tau (S199) and MMP-2/MMP-3 levels in cerebrospinal fluid (CSF).
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Nicolas Delcourt, Alix-Marie Pouget, Alicia Grivaud, Leonor Nogueira, Frederic Larvor, Philippe Marchand, Eric Schmidt, Bruno Le Bizec
Summary: This study found that PFAS compounds, widely used in various products, are present in human cerebrospinal fluid and are associated with clinical and biological markers of Alzheimer's disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Medicine, General & Internal
D. O. T. Alawode, A. J. Heslegrave, N. J. Ashton, T. K. Karikari, J. Simren, L. Montoliu-Gaya, J. Pannee, A. O'Connor, P. S. J. Weston, J. Lantero-Rodriguez, A. Keshavan, A. Snellman, J. Gobom, R. W. Paterson, J. M. Schott, K. Blennow, N. C. Fox, H. Zetterberg
Summary: Alzheimer's disease is increasingly prevalent worldwide, with a need for earlier and more secure diagnosis techniques. Current biomarker-based guidelines for AD diagnosis heavily rely on neuroimaging and CSF sampling, while blood-based biomarkers show potential for more accessible and cost-effective testing. Plasma neurofilament light chain and phosphorylated tau exhibit promise, but further comparisons are needed for p-tau to differentiate AD from non-AD dementias reliably. Plasma amyloid beta could serve as an early screening tool, but requires precise tests and robust pre-analytical protocols.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Claire Bridel, Charisse Somers, Anne Sieben, Annemieke Rozemuller, Ellis Niemantsverdriet, Hanne Struyfs, Yannick Vermeiren, Christine Van Broeckhoven, Peter P. De Deyn, Maria Bjerke, Guy Nagels, Charlotte E. Teunissen, Sebastiaan Engelborghs
Summary: This study examines the relationship between neuropathology and CSF biomarkers in Alzheimer's disease patients, finding that the associations are stronger and more significant with longer intervals between lumbar puncture and death. This suggests that CSF biomarkers may not be well suited for monitoring neuropathological changes at later disease stages.