Journal
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
Volume 52, Issue 2, Pages 133-138Publisher
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
DOI: 10.3164/jcbn.12-118
Keywords
Alzheimer's disease; metabolomics; NMR; oxidative stress; biomarker
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Funding
- National Institute of Biomedical Innovation of Japan [10-45]
- Grants-in-Aid for Scientific Research [22790126, 20390038] Funding Source: KAKEN
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Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia among elderly patients. A biomarker for the disease could make diagnosis easier and more accurate, and accelerate drug discovery. In this study, NMR-based metabolomics analysis in conjunction with multivariate statistics was applied to examine changes in urinary metabolites in transgenic AD mice expressing mutant tau and beta-amyloid precursor protein. These mice showed significant changes in urinary metabolites throughout the progress of the disease. Levels of 3-hydroxykynurenine, homogentisate and allantoin were significantly higher compared to control mice in 4 months (prior to onset of AD symptoms) and reverted to control values by 10 months of age (early/middle stage of AD), which highlights the relevance of oxidative stress to this neurodegenerative disorder even prior the onset of dementia. The level of these changed metabolites at very early period may provide an indication of disease risk at asymptomatic stage.
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