Review
Biochemistry & Molecular Biology
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo
Summary: Potassium ions can enter and exit mitochondria through various channels in the outer and inner membranes, with the ATP-dependent potassium channel being the most studied and playing a crucial role in protecting cells against ischemic and neuronal damage.
Article
Multidisciplinary Sciences
Chen Zhao, Roderick MacKinnon
Summary: K-ATP channels act as metabolic sensors translating ATP/ADP balance to membrane excitability. The structure of human pancreatic K-ATP reveals an open pore, coordinated structural changes within the ATP-binding site and channel gate in Kir, as well as conformational changes in SUR. The pancreatic hK(ATP) exhibits a unique PIP2-independent opening property.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Sha Zhao, MengZhen Wang, ZeGang Ma
Summary: This review highlights the crucial roles of K-ATP channels in the pathogenesis of PD, and provides possible research directions from different perspectives such as vulnerability of dopamine neurons, neurotransmitter releasing, iron metabolism, α-synuclein secretion, and mitochondrial dysfunction, which are critical for investigation of K-ATP channels-targeted precise therapeutic interventions for PD.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Plinio Bezerra Palacio, Geovanna Carvalho de Freitas Soares, Gabriella Moreira Bezerra Lima, Pedro Lourenzo Oliveira Cunha, Anna Lidia Nunes Varela, Heberty Tarso Facundo
Summary: This study investigates the molecular and physiological mechanisms of activators (GTP) and inhibitors (ATP) in the activity of mitoKATP channels. The findings demonstrate that ATP inhibits mitoKATP activity, while GTP reverses this inhibition in a dose-dependent manner. Both nucleotides bind to mitoSUR and competitively affect its function. These results are important for further understanding the role of GTP and ATP in cardioprotection.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Cell Biology
Jirong Lv, Xue Xiao, Mingxia Bi, Tingting Tang, Deao Kong, Meining Diao, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
Summary: ATP-sensitive potassium channels (KATP channels) play a crucial role in linking the electrical activity of the cell membrane with cell metabolism. They have been found to be expressed in various cells and play important roles in neurodegenerative diseases. The KATP channel openers and inhibitors have protective effects on neurons by regulating neuronal excitability and neurotransmitter release, reducing abnormal protein aggregation and Ca2+ overload, and decreasing reactive oxygen species (ROS) production and microglia activation. However, KATP channels also exhibit dual effects in some cases.
AGEING RESEARCH REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Plinio Bezerra Palacio, Aline Maria Brito Lucas, Joana Varlla de Lacerda Alexandre, Pedro Lourenzo Oliveira Cunha, Yuana Ivia Ponte Viana, Amanda Cabral Albuquerque, Anna Lidia Nunes Varela, Heberty Tarso Facundo
Summary: The study reveals competitive binding of glibenclamide and diazoxide at mitoSUR, with the cyclohexylurea portion of glibenclamide being essential for mitoKATP inhibition. IMP-A does not inhibit diazoxide-induced cardioprotection, but glibenclamide effectively inhibits it. This research provides valuable insights into the pharmacological and biochemical aspects of mitoKATP activation and cardioprotection, potentially leading to new therapeutic strategies for ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Neurosciences
Amalie Clement, Sarah Louise Christensen, Inger Jansen-Olesen, Jes Olesen, Song Guo
Summary: Migraine is a leading cause of disability worldwide and has a significant impact on work and social life. Blocking the ATP-sensitive potassium channel may be a promising approach for migraine treatment. However, further research is needed to understand the potential side effects and effectiveness of this approach.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Shiru Bai, Xuechao Wang, Haibo Wu, Tianlei Chen, Xinning Li, Lina Zhang, Xiangming Li, Lu Er, Rongpin Du
Summary: The study demonstrated that anisodamine could protect against myocardial ischemia/reperfusion injury by improving mitochondrial energy metabolism, reducing oxidative stress, and stabilizing mitochondrial membrane potential. The opening of mitoK ATP may play a crucial role in the cardioprotective effects of anisodamine.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Lina T. Al Kury
Summary: Hyperglycemia, a hallmark of diabetes, can lead to various health complications. Medicinal plants offer bioactive compounds with pharmacological effects and fewer side effects. This review focuses on their modulation of the pancreatic K-ATP channel and emphasizes the importance of studying their interaction for diabetes treatment.
Article
Biochemistry & Molecular Biology
Hui Ming Ong, Ahmad Farhan Ahmad Azmi, Sze Wei Leong, Faridah Abas, Enoch Kumar Perimal, Ahmad Akira Omar Farouk, Daud Ahmad Israf, Mohd Roslan Sulaiman
Summary: The study explores the potential involvement of the l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of the novel diarylpentanoid analogue BBHC in a chemical nociceptive model in mice. The results suggest that BBHC's antinociception is mediated through this pathway and can significantly alleviate chemically induced pain, showcasing its potential as an analgesic agent.
Article
Chemistry, Analytical
Qi Liu, Shushu Ding, Rui Gao, Guoyue Shi, Anwei Zhu
Summary: A smart copolymer modified nanochannel was designed to mimic the structure and mechanism of K-ATP channels, achieving ATP responsiveness and demonstrating a possible mechanism for ATP gating.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Physical
Deepshikha Patle, Navneet Khurana, Jeena Gupta, Paranjeet Kaur, Gopal L. Khatik
Summary: Natural products can be structurally modified to achieve desired biological effects, and they are considered safer, cheaper, and more easily accessible compared to synthetic drugs. This research synthesized coixol-based derivatives that may serve as effective antidiabetic agents. In vitro and in vivo experiments demonstrated that compound 14a and 34 have potential for treating Type-II diabetes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Endocrinology & Metabolism
Assmaa ElSheikh, Show-Ling Shyng
Summary: Congenital hyperinsulinism (CHI) is a serious condition characterized by severe recurrent attacks of hypoglycemia in infancy/childhood. Loss of function or expression of ATP-sensitive K+ (K-ATP) channels in pancreatic beta-cells is the main cause of CHI. While progress has been made in understanding the genetics and pathophysiology of K-ATP-HI, treatment remains challenging, especially for patients who do not respond to diazoxide. This review discusses current approaches, limitations, and alternative therapeutic strategies for the diagnosis and treatment of K-ATP-HI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Miao-Miao Chen, Zhao-Li Hu, Jian-Hua Ding, Ren-Hong Du, Gang Hu
Summary: The study suggests that the astrocytic Kir6.1/K-ATP channel plays a role in preventing neurodegeneration in PD by facilitating astrocyte-neuron communication through NF-KB/C3/C3aR signaling. Targeting astroglial Kir6.1/K-ATP channel-NF-kappa B-C3-neuronal C3aR signaling could be a novel therapeutic strategy for PD.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Azin EbrahimAmini, Bojana Stefanovic, Peter L. Carlen
Summary: This study investigates the effect of decreased intracellular ATP concentration on the extracellular potassium ion concentration. It found that reduction in ATP concentration leads to an increase in extracellular potassium ion concentration, possibly due to the impairment of the Na/K ATPase pump and ATP-sensitive potassium channel.
Article
Multidisciplinary Sciences
Yi-Sheng Jiao, Ting-Ting Gong, Yong-Lai Wang, Qi-Jun Wu
SCIENTIFIC REPORTS
(2015)
Article
Cell Biology
Xiaomei Liu, Caixia Liu, Tie Ma, Yisheng Jiao, Jianing Miao, Linlin Gao
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2016)
Article
Obstetrics & Gynecology
Fujie Zhao, Yisheng Jiao, Zhiqiang Guo, Rui Hou, Min Wang
FERTILITY AND STERILITY
(2011)
Article
Oncology
Xiaomei Liu, Aiyuan Wang, Hong Gao, Zhengwei Yuan, Yisheng Jiao
INTERNATIONAL JOURNAL OF ONCOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Yisheng Jiao, Wenbin Ou, Fanguo Meng, Haimeng Zhou, Aiyuan Wang
Article
Multidisciplinary Sciences
Yi Liu, Tiening Zhang, Qijun Wu, Yisheng Jiao, Tingting Gong, Xiaoxin Ma, Da Li
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
Xiaomei Liu, Jun Wang, Linlin Gao, Yisheng Jiao, Caixia Liu
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Cell Biology
Wen Geng, Jiaxu Ren, Huimin Shi, Feng Qin, Xiaohe Xu, Sheng Xiao, Yisheng Jiao, Aiyuan Wang
Summary: The study showed that the RPL41 peptide decreased the viability, migration, and invasion of retinoblastoma cells, promoted apoptosis and cell cycle arrest, and enhanced the antitumor effect of carboplatin. RPL41 sensitized retinoblastoma cells to carboplatin, indicating a potential adjuvant therapy for retinoblastoma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Xiao-Dong Liu, Yi Liu, Ting-Ting Gong, Jing-Yi Guo, Ya-Nan Wang, Ling Wang, Qi-Jun Wu, Yi-Sheng Jiao