Review
Cell Biology
Ke-Qiong Deng, Xuewei Huang, Fang Lei, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Jingjing Cai, Yan-Xiao Ji, Hongliang Li
Summary: Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide due to the global pandemic of metabolic diseases. This article highlights the links between hepatic lipid species and their mechanisms in mediating the pathogenesis of NAFLD, with a focus on saturated fatty acids, cholesterol, oxidized phospholipids, and their intermediates.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Notarnicola, Alberto Ruben Osella, Maria Gabriella Caruso, Pasqua Letizia Pesole, Antonio Lippolis, Valeria Tutino, Caterina Bonfiglio, Valentina De Nunzio, Maria Principia Scavo, Antonella Mirizzi, Isabella Franco, Tamara Lippolis, Rosalba D'Alessandro, Maria Grazia Refolo, Caterina Messa
Summary: NAFLD is considered as a hepatic manifestation of metabolic syndrome, characterized by excessive lipid accumulation and oxidative stress leading to liver injury. The identification of genetic and epigenetic modifications contributing to NAFLD pathogenesis is crucial, while lifestyle modifications remain the main prevention and treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Yuanye Jiang, Xiaoyu Zhuang, Jiaqi Zhang, Meng Li, Shengnan Du, Jiyun Tian, Yifu Yuan, Guang Ji, Cheng Hu
Summary: This study investigated the clinical and proteomic characteristics of lean individuals with NAFLD, and found that they exhibit distinct clinical profiles compared to overweight individuals with NAFLD. Plasma proteomic profiling revealed potential biomarkers with diagnostic value for lean NAFLD. These proteins are primarily involved in lipid metabolism, immune and complement systems, and platelet degranulation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Jinwang Li, Siyu Xie, Wendi Teng
Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).
Review
Environmental Sciences
Shuilin Zheng, Yue Yang, Cong Wen, Wenya Liu, Linghui Cao, Xiangling Feng, Jihua Chen, Hui Wang, Yan Tang, Li Tian, Xiaoyan Wang, Fei Yang
Summary: The global prevalence of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing, with environmental chemical contaminants being considered as tangible environmental risk factors for NAFLD.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Kun Du, Shibo Li, Chengpan Li, Ping Li, Chunguang Miao, Tianzhi Luo, Bensheng Qiu, Weiping Ding
Summary: This study develops a biomimetic liver lobule chip and establishes a more accurate on-chip NAFLD model, demonstrating for the first time the changes in lipid zonation in a liver lobule with the progression of NAFLD on a microfluidic chip. The application of the induced NAFLD model has shown promise in the prevention and reversibility of drug treatments, providing a platform for understanding NAFLD progression and identifying potential drug therapies.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Jie Liu, Bingyi Yao, Liangcai Gao, Yuanjin Zhang, Shengbo Huang, Xin Wang
Summary: This review provides an overview of the role and potential value of carboxylesterases (CESs) in the progression and treatment of nonalcoholic fatty liver disease (NAFLD). The relationship between CESs and hepatic lipid metabolism and inflammation is analyzed, and the regulation of CESs by nuclear receptors is reviewed. Additionally, the advantages and disadvantages of existing NAFLD animal models are evaluated, and the application of CES-related animal models in NAFLD research is summarized.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Aldo Grefhorst, Ivo P. van de Peppel, Lars E. Larsen, Johan W. Jonker, Adriaan G. Holleboom
Summary: NAFLD is one of the most common liver disorders worldwide, with a complex etiology involving genetic susceptibility and unhealthy lifestyle factors. Disruption of hepatic lipid homeostasis, including the emerging role of lipophagy, is a key feature in the development and progression of NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hu Li, Nan-Nan Liu, Jian-Rui Li, Biao Dong, Mei-Xi Wang, Jia-Li Tan, Xue-Kai Wang, Jing Jiang, Lei Lei, Hong-Ying Li, Han Sun, Jian-Dong Jiang, Zong-Gen Peng
Summary: The combined therapy of bicyclol and berberine has shown significant therapeutic effects on nonalcoholic fatty liver disease (NAFLD) by reducing hepatic inflammation, fibrogenesis, and lipid accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuting Ma, Guangdong Zhang, Zenggguang Kuang, Qian Xu, Tongtong Ye, Xue Li, Na Qu, Fang Han, Chengxia Kan, Xiaodong Sun
Summary: Empagliflozin (EMPA) therapy has been shown to improve non-alcoholic fatty liver disease (NAFLD) patients. This study investigated the functional implications of EMPA on the pathogenesis of NAFLD and identified the underlying molecular mechanisms. The results showed that EMPA treatment reversed liver damage by upregulating Sestrin2 and activating the AMPK-mTOR pathway, leading to the inhibition of lipogenesis and inflammation. These findings suggest that EMPA therapy could target Sestrin2 to alleviate lipogenesis and inflammation in obesity-related NAFLD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Lihui Zhu, Xiao Wu, Rongrong Liao
Summary: Mitochondrial dysfunction is central to the pathobiology of NAFLD, making maintenance of mitochondrial homeostasis crucial for treatment. Mitophagy, a process of selectively clearing damaged mitochondria through autophagy, promotes mitochondrial homeostasis. Strategies regulating mitophagy have shown promise in preclinical experiments. Traditional Chinese medicine, a natural product with active ingredients, has great potential in liver disease prevention and treatment. This review summarizes mitophagy-related pathways and the latest findings on mitophagy regulation in NAFLD, highlighting the potential of Traditional Chinese medicine.
Article
Immunology
Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang, Feng Zhou
Summary: Puerarin improves high-fat and high-fructose diet-induced nonalcoholic fatty liver disease (NAFLD) by modulating liver lipid accumulation, liver function, oxidative stress, and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Hui Han, Yi Jiang, Mengyu Wang, Mebratu Melaku, Lei Liu, Yong Zhao, Nadia Everaert, Bao Yi, Hongfu Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder that is closely related to gut dysfunction. The bidirectional communication between the gut and liver, mediated by metabolites, plays a role in the pathogenesis of NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Cell Biology
Triana Amen, Daniel Kaganovich
Summary: Metabolic regulation is essential for stress response pathways, and the interconnection between stress granule formation and lipid droplet accumulation has been uncovered, revealing a novel relationship between stress adaptation mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Xiaolei Ma, Xiaoyou Yu, Rui Li, Jinjin Cui, Haoyang Yu, Ling Ren, Jiandong Jiang, Wenxuan Zhang, Lulu Wang
Summary: This study compared the efficacy of a salt formulation (BSS) and physical mixture (BSP) of berberine (BBR) and silybin (SIY) in treating nonalcoholic fatty liver disease (NAFLD). The results showed that the BSS formulation had synchronized dissolution, superior permeability, and increased bioavailability compared to BSP. BSS also demonstrated a more potent inhibitory effect on lipid production and improved disease outcomes in NAFLD mouse models.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Cell Biology
Shuxi Qiao, Siang-Boon Koh, Varunika Vivekanandan, Devika Salunke, Krushna Chandra Patra, Elma Zaganjor, Kenneth Ross, Yusuke Mizukami, Sarah Jeanfavre, Athena Chen, Mari Mino-Kenudson, Sridhar Ramaswamy, Clary Clish, Marcia Haigis, Nabeel Bardeesy, Leif W. Ellisen
GENES & DEVELOPMENT
(2020)
Article
Pathology
Yuko Omori, Yusuke Ono, Toshikazu Kobayashi, Fuyuhiko Motoi, Hidenori Karasaki, Yusuke Mizukami, Naohiko Makino, Yoshiyuki Ueno, Michiaki Unno, Toru Furukawa
Article
Oncology
Shion Tachibana, Yusuke Mizukami, Yusuke Ono, Yuya Sugiyama, Tetsuhiro Okada, Arisa Kitazaki, Junpei Sasajima, Motoya Tominaga, Jun Sakamoto, Keisuke Kimura, Yuko Omori, Toru Furukawa, Taichi Kimura, Shinya Tanaka, Kazuo Nagashima, Hidenori Karasaki, Tomoyuki Ohta, Toshikatsu Okumura
FRONTIERS IN ONCOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Seongjae Jang, Younghyun Lee, Seo Songwon, Young Woo Jin, Won-Jin Lee
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2020)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Seongjae Jang, Young Woo Jin, Won-Jin Lee
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Article
Hematology
Masahiro Ieko, Taeko Hotta, Kumiko Watanabe, Tomoko Adachi, Sawako Takeuchi, Sumiyoshi Naito, Mika Yoshida, Kazumasa Ohmura, Nobuhiko Takahashi, Eriko Morishita, Hiroko Tsuda, Dongchon Kang
Summary: The study aimed to assess the harmonization of three different reagents used in Japan for measuring PS activity, finding good correlation between them and the potential for harmonization.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Article
Hematology
Osamu Kumano, Masahiro Ieko, Yutaka Komiyama, Sumiyoshi Naito, Mika Yoshida, Nobuhiko Takahashi, Kazumasa Ohmura, Mineji Hayakawa
Summary: The study compared LIASAUTO P-FDP with three other FDP reagents and found that LIASAUTO P-FDP had higher reactivity to D-dimer and elevated values in samples with enhanced fibrinolysis. This suggests that LIASAUTO P-FDP could be useful for diagnosing DIC as it reacts differently to various fibrin/fibrinogen degradation products based on the fibrinolytic status in different types and stages of DIC.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Seongjae Jang, Sanghyeok Woo, Yang Hee Lee, Susan Yang, Young Woo Jin
Summary: The study evaluated the effects of irradiated transfusion blood components on cytogenetic dose assessment, finding significant changes in mitotic activity and chromosomal aberrations in irradiated blood samples. However, partial transfusion of blood components did not compromise the estimation of exposure dose using cytogenetic dosimetry.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Younghyun Lee, Won Jin Lee, Young Woo Jin, Seongjae Jang
Summary: The study found that interventional radiologists had greater chromosomal damages compared to other occupational groups. Approximately 4.67% of their body was irradiated at an average dose of 4.64 Gy, and their partial-body exposure levels might be high enough to cause local damage.
EUROPEAN RADIOLOGY
(2021)
Article
Biology
Eric Gregoire, Joan Francesc Barquinero, Gaetan Gruel, Mohamedamine Benadjaoud, Juan S. Martinez, Christina Beinke, Adayabalam Balajee, Philip Beukes, William F. Blakely, Inmaculada Dominguez, Pham Ngoc Duy, Octavia Monteiro Gil, Inci Guclu, Kamile Guogyte, Savina Petrova Hadjidekova, Valeria Hadjidekova, Prakash Hande, Seongjae Jang, Katalin Lumniczky, Roberta Meschini, Mirta Milic, Alegria Montoro, Jayne Moquet, Mercedes Moreno, Farrah N. Norton, Ursula Oestreicher, Jelena Pajic, Laure Sabatier, Sylwester Sommer, Antonella Testa, Georgia Terzoudi, Marco Valente, Perumal Venkatachalam, Anne Vral, Ruth C. Wilkins, Andrzej Wojcik, Demetre Zafiropoulos, Ulrike Kulka
Summary: In the event of a mass-casualty radiological incident, networking and inter-laboratory comparisons are crucial for ensuring consistent results in biological dosimetry laboratories. While significant harmonization efforts have been made at the European level, challenges remain with the statistical tools and diversity in dose-effect curves highlighted by this study.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Nuclear Science & Technology
Jae Seok Kim, Byeong Ryong Park, Jaeryong Yoo, Wi-Ho Ha, Seongjae Jang, Won Il Jang, Gyu Seok Cho, Hyun Kim, Insu Chang, Yong Kyun Kim
Summary: The Korea Institute of Radiological and Medical Sciences developed physical human phantoms to evaluate radiation protection quantities. The phantoms utilized a radiophotoluminescent glass dosimeter with a Tin filter for accurate measurements. The study analyzed the measurement uncertainty of the dosimeter and calculated the uncertainties for different dose ranges. The results demonstrated satisfactory readout doses during a blind test.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kenzui Taniue, Tanzina Tanu, Yuki Shimoura, Shuhei Mitsutomi, Han Han, Rika Kakisaka, Yusuke Ono, Nobue Tamamura, Kenji Takahashi, Youichiro Wada, Yusuke Mizukami, Nobuyoshi Akimitsu
Summary: This study provides evidence for the amplification of the EXOSC4 gene in multiple cancer types and its association with poor prognosis in pancreatic cancer patients. The study also demonstrates the essential role of EXOSC4 in the survival of pancreatic cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Younghyun Lee, Jin-Kyu Kang, Yang Hee Lee, Hyo Jin Yoon, Su San Yang, Seung Hyun Kim, Seongjae Jang, Sunhoo Park, Da Hye Heo, Won Il Jang, Hyung Jun Yoo, Eun Kyung Paik, Hyo Rak Lee, Ki Moon Seong
Summary: This study evaluated time-dependent changes in chromosomal aberrations before, during, and after radiotherapy in breast cancer patients, and found that chromosome aberrations can be used to estimate biological absorbed radiation doses.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Public, Environmental & Occupational Health
Younghyun Lee, Seung Hyun Kim, Yang Hee Lee, Su San Yang, Hyo Jin Yoon, Ruth C. Wilkins, Seongjae Jang
Summary: This study assessed the performance of a semi-automated scoring method for dicentric chromosome assay (DCA) and found that it provided accurate dose estimation rapidly. The semi-automated scoring method can be useful as an alternative to manual DCA for biodosimetry in large-scale accidents or cases to monitor radiation exposure of radiation workers.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Kangsan Kim, Kwang Seok Kim, Won Il Jang, Seongjae Jang, Gil Tae Hwang, Sang-Keun Woo
Summary: In this study, a neural network was applied to automate the dicentric chromosome assay (DCA), reducing the time and technical expertise required. The results confirmed that the model effectively detected dicentric chromosomes in images, indicating the potential for automatic DCA based on deep learning for object detection.