Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 51, Issue -, Pages 276-295Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.01.007
Keywords
Magnetic resonance spectroscopy; Glutamate; Glutathione; GABA; Schizophrenia
Categories
Funding
- NIH [T32MH067533, R01MH094520]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH094520, T32MH067533] Funding Source: NIH RePORTER
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In vivo measurement of neurotransmitters and modulators is now feasible with advanced proton magnetic resonance spectroscopy (H-1 MRS) techniques. This review provides a basic tutorial of MRS, describes the methods available to measure brain glutamate, glutamine, gamma-aminobutyric acid, glutathione, N-acetylaspartylglutamate, glycine, and serine at magnetic field strengths of 3 T or higher, and summarizes the neurochemical findings in schizophrenia. Overall, H-1 MRS holds great promise for producing biomarkers that can serve as treatment targets, prediction of disease onset, or illness exacerbation in schizophrenia and other brain diseases. (C) 2015 Elsevier Ltd. All rights reserved.
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