Article
Neurosciences
Joshua W. Callahan, David L. Wokosin, Mark D. Bevan
Summary: This study used optogenetics and electrophysiology to reveal some characteristics of early Huntington's disease, including abnormal activity of the indirect pathway neurons and changes in inhibitory mechanisms.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yunjie Rong, Zhifeng Xu, Ye Zhu, Xianhai Zhang, Lingfeng Lai, Shuyi Sun, Mingyong Gao, Pi Guo, Guohua Zhang, Yiqun Geng, Xilun Ma, Shuohua Wu, Lin Yang, Zhiwei Shen, Jitian Guan
Summary: This study identified changes in iron deposition and neural microstructure in the substantia nigra as potential indicators of early-stage Parkinson's disease.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Cheng Xiao, Ya-wei Ji, Yi-wen Luan, Tao Jia, Cui Yin, Chun-yi Zhou
Summary: STN-SNr and STN-GPi neurons exhibit differences in synaptic inputs, responses to electrical stimulation, and modifications under parkinsonian conditions. These neurons may play crucial roles in the pathophysiology and therapeutic treatment of Parkinson's disease.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Kathryn L. Todd, Janusz Lipski, Peter S. Freestone
Summary: This study identified a distinct population of dopamine neurons that project to the tail region of the striatum, separate from the classic nigrostriatal pathway. The tail striatum was found to have lower basal and evoked dopamine levels, as well as diverse dopamine release kinetics compared to the dorsolateral striatum. Stimulation of the subthalamic nucleus (STN) exclusively evoked dopamine release in the tail striatum, likely mediated by the SNL. These findings suggest the existence of a novel dopamine pathway to the tail striatum, largely independent of the classic nigrostriatal pathway, and highlight the STN as an important modulator of dopamine release in this pathway.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Nicholas N. Foster, Joshua Barry, Laura Korobkova, Luis Garcia, Lei Gao, Marlene Becerra, Yasmine Sherafat, Bo Peng, Xiangning Li, Jun-Hyeok Choi, Lin Gou, Brian Zingg, Sana Azam, Darrick Lo, Neda Khanjani, Bin Zhang, Jim Stanis, Ian Bowman, Kaelan Cotter, Chunru Cao, Seita Yamashita, Amanda Tugangui, Anan Li, Tao Jiang, Xueyan Jia, Zhao Feng, Sarvia Aquino, Hyun-Seung Mun, Muye Zhu, Anthony Santarelli, Nora L. Benavidez, Monica Song, Gordon Dan, Marina Fayzullina, Sarah Ustrell, Tyler Boesen, David L. Johnson, Hanpeng Xu, Michael S. Bienkowski, X. William Yang, Hui Gong, Michael S. Levine, Ian Wickersham, Qingming Luo, Joel D. Hahn, Byung Kook Lim, Li Zhang, Carlos Cepeda, Houri Hintiryan, Hong-Wei Dong
Summary: The study reveals a complex structure in the brain, with 29 functional domains transmitting information through multiple channels, influencing cognition, sensorimotor behavior, and the development of various neurological and neuropsychiatric disorders.
Article
Neurosciences
Boliang Yu, Ling Li, Xiaojun Guan, Xiaojun Xu, Xueling Liu, Qing Yang, Hongjiang Wei, Chuantao Zuo, Yuyao Zhang
Summary: The study introduces a HybraPD atlas using QSM and T1w images from PD patients, providing templates and manually delineated subcortical nuclei for more accurate segmentation related to PD pathology. This atlas offers a more precise tool for studying brain pathological alterations in subcortical regions for PD research.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Michael De Pretto, Michael Mouthon, Ines Debove, Claudio Pollo, Michael Schuepbach, Lucas Spierer, Ettore A. Accolla
Summary: The study found no behavioral effects of deep brain stimulation of the subthalamic nucleus or internal globus pallidus on proactive inhibition in Parkinson's disease patients, despite an overall improvement in motor performance with subthalamic nucleus stimulation. The results suggest a partly segregated network for proactive inhibition in the subthalamic nucleus group, with a preferential recruitment of the indirect pathway.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Anne Lotz, Beate Pesch, Swaantje Casjens, Martin Lehnert, Wolfgang Zschiesche, Dirk Taeger, Chien-Lin Yeh, Tobias Weiss, Tobias Schmidt-Wilcke, Clara Quetscher, Stefan Gabriel, Maria Angela Samis Zella, Dirk Woitalla, Ulrike Dydak, Christoph van Thriel, Thomas Bruening, Thomas Behrens
Summary: The study found that welders exposed to manganese showed normal fine motor functions, excelling in steadiness tests but slightly slower in motor tests compared to controls. MRI-based biomarkers did not show a correlation between fine motor test results and the levels of manganese deposition in the brain.
Article
Neurosciences
Alipi Bonm, Izaskun Elezgarai, Christina M. Gremel, Katie Viray, Nigel S. Bamford, Richard D. Palmiter, Pedro Grandes, David M. Lovinger, Nephi Stella
Summary: The study shows that CB1R expressed by MSNs play a crucial role in controlling exploration, motor coordination, and amphetamine sensitization. However, the effects on certain behaviors may only be partially or fully rescued.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Maria Paap, Stefanie Perl, Anika Luttig, Franz Plocksties, Christoph Niemann, Dirk Timmermann, Christian Bahls, Ursula van Rienen, Denise Franz, Monique Zwar, Marco Rohde, Rudiger Koehling, Angelika Richter
Summary: This study examined the effects of bilateral electrical stimulation at different frequencies on the severity of dystonia in mutant hamsters. The results showed that 130 Hz DBS was most effective, 40 Hz provided antidystonic effects, while 15 Hz and 130 Hz stimulations did not show significant effects.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Oliver Maith, Javier Baladron, Wolfgang Einhaeuser, Fred H. Hamker
Summary: Humans are capable of adapting quickly to changes in the environment. A new study proposes a 5-choice reversal learning task to investigate exploration behavior after a reversal, comparing it with a neuro-computational model of the basal ganglia. The findings demonstrate that exploration becomes limited to previously rewarded positions, indicating the role of a specific sub-circuit within the basal ganglia pathways in complex behavior.
Article
Clinical Neurology
Kyle T. Mitchell, Stephen L. Schmidt, Jeffrey W. Cooney, Warren M. Grill, Jennifer Peters, Shervin Rahimpour, Hui-Jie Lee, Sin-Ho Jung, Sneha Mantri, Burton Scott, Shivanand P. Lad, Dennis A. Turner
Summary: This study demonstrates that combined stimulation of the subthalamic nucleus (STN) and globus pallidus (GP) through deep brain stimulation (DBS) leads can improve symptom control in patients with Parkinson's disease. It also suggests the potential for biomarker discovery for adaptive DBS therapy.
Article
Behavioral Sciences
Andrea McKavanagh, Adam Ridzuan-Allen, Barbara A. K. Kreilkamp, Yachin Chen, Jose V. Manjon, Pierrick Coupe, Martyn Bracewell, Kumar Das, Peter N. Taylor, Anthony G. Marson, Simon S. Keller
Summary: This study investigated the differences in volume, estimated myelin content, and functional connectivity of midbrain structures in patients with idiopathic generalized epilepsy (IGE). The results revealed increased volume in the right red nucleus and differences in structural volumes of the right subthalamic nucleus between non-refractory and refractory IGE patients. Functional connectivity alterations were also observed, including decreased connectivity between the left substantia nigra and thalamus, and increased connectivity between the right subthalamic nucleus and superior frontal gyrus in IGE patients.
EPILEPSY & BEHAVIOR
(2023)
Article
Clinical Neurology
Ahmad Alhourani, Scott A. Wylie, Jessica E. Summers, Fenna T. Phibbs, Elise B. Bradley, Joseph S. Neimat, Nelleke C. Van Wouwe
Summary: The study aimed to develop predictive models of postoperative VF decline in DBS using a machine learning approach.
Article
Multidisciplinary Sciences
Shinho Cho, Hoon-Ki Min, Myung-Ho In, Hang Joon Jo
SCIENTIFIC REPORTS
(2020)
Article
Engineering, Biomedical
Aaron E. Rusheen, Abhijeet S. Barath, Abhinav Goyal, J. Hudson Barnett, Benjamin T. Gifford, Kevin E. Bennet, Charles D. Blaha, Stephan J. Goerss, Yoonbae Oh, Kendall H. Lee
JOURNAL OF NEURAL ENGINEERING
(2020)
Article
Neurosciences
Julia P. Slopsema, Antonietta Canna, Michelle Uchenik, Lauri J. Lehto, Jordan Krieg, Lucius Wilmerding, Dee M. Koski, Naoharu Kobayashi, Joan Dao, Madeline Blumenfeld, Pavel Filip, Hoon-Ki Min, Silvia Mangia, Matthew D. Johnson, Shalom Michaeli
Summary: This study investigated the effects of direction and orientation of the electric field induced by VL-thalamus DBS on activity in the sensorimotor cortex using a swine animal model. Results showed that directional and orientation-selective stimulation could tune network-level modulation patterns in the sensorimotor cortex.
Article
Clinical Neurology
Qin Chen, Val J. Lowe, Bradley F. Boeve, Scott A. Przybelski, Toji Miyagawa, Matthew L. Senjem, Clifford R. Jack, Timothy G. Lesnick, Walter K. Kremers, Julie A. Fields, Hoon-Ki Min, Christopher G. Schwarz, Jeffrey L. Gunter, Jonathan Graff-Radford, Rodolfo Savica, David S. Knopman, David Jones, Tanis J. Ferman, Neill R. Graff-Radford, Ronald C. Petersen, Kejal Kantarci
Summary: The majority of patients with MCI-LB are characterized by low beta-amyloid deposition and reduced dopaminergic activity, and beta-amyloid PET and 123I-FP-CIT SPECT are complementary in characterizing clinical phenotypes of patients with MCI-LB.
Article
Geriatrics & Gerontology
Toji Miyagawa, Scott A. Przybelski, Daniela Maltais, Hoon-Ki Min, Lennon Jordan, Timothy G. Lesnick, Qin Chen, Jonathan Graff-Radford, David Jones, Rodolfo Savica, David Knopman, Ronald Petersen, Walter K. Kremers, Leah K. Forsberg, Julie A. Fields, Tanis J. Ferman, Laura Allen, Joseph Parisi, R. Ross Reichard, Melissa Murray, Dennis Dickson, Bradley F. Boeve, Kejal Kantarci, Val J. Lowe
Summary: Multimodal imaging with I-123-FP-CIT SPECT helps differentiate DLBs and ADem, providing additional diagnostic value and detecting complex pathology in patients with DLBs and ADem.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
William S. Gibson, Aaron E. Rusheen, Yoonbae Oh, Myung-Ho In, Krzysztof R. Gorny, Joel P. Felmlee, Bryan T. Klassen, Sung Jun Jung, Hoon-Ki Min, Kendall H. Lee, Hang Joon Jo
Summary: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for Parkinson's disease (PD) motor symptoms, but does not always yield optimal outcomes. Combining intraoperative functional MRI (fMRI) with DBS revealed activation patterns predictive of therapeutic and adverse effects, potentially guiding clinical stimulator optimization for patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Pharmacology & Pharmacy
William N. Sanchez, Jose A. Pochapski, Leticia F. Jessen, Marek Ellenberger, Rainer K. Schwarting, Donita L. Robinson, Roberto Andreatini, Claudio Da Cunha
Summary: The study found that diazepam can mitigate the neurochemical and psychostimulant effects of cocaine, such as reducing dopamine signals, inhibiting the increase in 50-kHz calls, and decreasing cocaine-induced locomotion.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jason Yuen, Aaron E. Rusheen, Joshua Blair Price, Abhijeet S. Barath, Hojin Shin, Abbas Z. Kouzani, Michael Berk, Charles D. Blaha, Kendall H. Lee, Yoonbae Oh
Summary: Despite recent advances in depression treatment, many patients still do not respond to serial conventional therapies and are considered treatment resistant. Deep brain stimulation (DBS) has therapeutic potential in this context. This comprehensive review of recent studies of DBS for depression in animal models identifies potential biomarkers for improving therapeutic efficacy and predictability of conventional DBS to aid future development of closed-loop control of DBS system.
Article
Radiology, Nuclear Medicine & Medical Imaging
Burcu Zeydan, Christopher G. Schwarz, Scott A. Przybelski, Timothy G. Lesnick, Walter K. Kremers, Matthew L. Senjem, Orhun H. Kantarci, Paul H. Min, Bradley J. Kemp, Clifford R. Jack, Kejal Kantarci, Val J. Lowe
Summary: This study investigates the use of PET imaging techniques for assessing white matter integrity and demyelination. The results show that both 11C-PiB and 18F-flutemetamol can effectively differentiate between white matter hyperintensities and normal-appearing white matter, and their uptake patterns are associated with age.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Biochemical Research Methods
Jillissa C. Taubel, Nicholas R. Nelson, Aditya Bansal, Geoffrey L. Curran, Lushan Wang, Zengtao Wang, Heather M. Berg, Cynthia J. Vernon, Hoon-Ki Min, Nicholas B. Larson, Timothy R. DeGrado, Karunya K. Kandimalla, Val J. Lowe, Mukesh K. Pandey
Summary: Aberrant insulin signaling has been identified as a risk factor for Alzheimer's disease. A new positron emission tomography (PET) probe has been developed to study the role of insulin in Alzheimer's disease noninvasively. The PET probe showed higher uptake in the brains of Alzheimer's disease mice compared to normal mice. It also demonstrated differential uptake in different brain regions.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeyeon Lee, Brian J. Burkett, Hoon-Ki Min, Emily S. Lundt, Sabrina M. Albertson, Hugo Botha, Matthew L. Senjem, Jeffrey L. Gunter, Christopher G. Schwarz, David T. Jones, David S. Knopman, Clifford R. Jack, Ronald C. Petersen, Val J. Lowe
Summary: In tau PET scans, identifying voxels with stable activity over time can enhance detection of early tau accumulation. The overlap index (OI) method shows improved sensitivity to tau signal elevation in low-SUV regions and is associated with early clinical disease progression and cognitive scores.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Behavioral Sciences
Janaina K. Barbiero, Daniele C. Ramos, Suelen Boschen, Taysa Bassani, Claudio Da Cunha, Maria A. B. F. Vital
Summary: This study confirmed the neuroprotective effects of PPAR-alpha agonist fenofibrate in Parkinson's disease. The administration of fenofibrate reduced behavioral abnormalities, memory impairment, depletion of dopamine levels, dopaminergic neuronal death, and aggregation of alpha-synuclein in parkinsonian rats.
BEHAVIOURAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Melina J. Lim, Suelen L. Boschen, Aishe Kurti, Monica Castanedes Casey, Virginia R. Phillips, John D. Fryer, Dennis Dickson, Karen R. Jansen-West, Leonard Petrucelli, Marion Delenclos, Pamela J. Mclean
Summary: The study aimed to evaluate whether the overexpression of alpha syn and tau in mice resulted in pathological and behavioral phenotypes resembling Lewy body dementia (LBD). The findings showed that the overexpression of alpha syn in hTau and APP/PS1 mice, as well as the overexpression of tau in hThy1-alpha syn mice, did not recapitulate the behavioral and neuropathological phenotypes observed in LBD.
Review
Education & Educational Research
Kasey R. Boehmer, Suelen Lucio Boschen De Souza, Jason D. Doles, Nirusha Lachman, Dennis Mays, Karen E. Hedin, Cheryl A. Dornink, Louis J. Maher, J. Luis Lujan
Summary: The study discusses strategies to increase the representation of underrepresented (UR) students in biomedical research PhD training programs and highlights the importance of interventions that focus on building leadership skills and self-efficacy among UR students. The implementation of novel interventions, such as student-led national research conferences, is seen as crucial in encouraging students to envision themselves as successful faculty members in the future.
FRONTIERS IN EDUCATION
(2021)
Article
Neuroimaging
Kejal Kantarci, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Qin Chen, Julie Fields, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunte, Clifford R. Jack, Paul Min, Manoj Jain, Toji Migayawa, Rodolfo Savica, Jonathan Graff-Radford, Hugo Botha, David T. Jones, David S. Knopman, Neill Graff-Radford, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe
Summary: Patients with mild cognitive impairment (MCI) who progressed to probable dementia with Lewy bodies (DLB) show hypometabolism in the parieto-occipital cortex extending into temporal lobes, substantia nigra, and thalamus. In comparison to those who progressed to Alzheimer's disease (AD) dementia, MCI-DLB patients exhibit preserved medial temporal and posterior cingulate metabolism, along with greater hypometabolism in the substantia nigra. The CIS ratio and medial temporal to substantia nigra ratio are identified as useful in distinguishing prodromal DLB from AD.
NEUROIMAGE-CLINICAL
(2021)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)
