Article
Chemistry, Medicinal
Suili Yang, Xiaoshan Zhang, Yuzhen Wang, Congcong Wen, Chenxiang Wang, Ziye Zhou, Guanyang Lin
Summary: A bioanalytical method was developed to study the potential interaction between dasatinib and posaconazole, demonstrating that dasatinib alters the pharmacokinetics of posaconazole. When co-administered, attention should be paid to the unexpected risk of adverse clinical outcomes.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Anand Gupta, Antonio P. Costa, Xiaoming Xu, Diane J. Burgess
Summary: A continuous polymeric micelle processing platform was developed to eliminate batch-to-batch variation in critical quality attributes. By controlling polymer molecular weight and concentration, precise particle size and low polydispersity were achieved. The optimized conditions produced paclitaxel polymeric micelles equivalent to commercial Genexol PM, with similar quality attributes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Congrong Tang, Xiaohui Niu, Lu Shi, Huidan Zhu, Guanyang Lin, Ren-ai Xu
Summary: In this study, a sensitive UPLC-MS/MS method was developed to detect fedratinib concentrations in rat plasma and investigate the impact of antifungal drugs on fedratinib metabolism. Fluconazole was found to have the strongest inhibitory effect on fedratinib metabolism in rats.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Essam Ezzeldin, Muzaffar Iqbal, Yousif A. Asiri, Ahmed Y. A. Sayed, Rashad Alsalahi
Summary: The highly sensitive and reliable method developed for quantification of tamatinib in rat plasma met the standard requirements and was successfully applied in the pharmacokinetic study in rats.
Article
Plant Sciences
Fan Zhang, Yu Yan, Kang Ding, Wen-Wen Lian, Li Li, Wen-Ping Wang, Cong-Yuan Xia, Hua Yang, Jun He, Wei-Ku Zhang, Jie-Kun Xu
Summary: This study aimed to investigate the pharmacokinetic characteristics and tissue distribution of loganin after oral administration in rats. The results showed that loganin was quickly absorbed and eliminated in rats, with low bioavailability. Loganin was highly distributed in the cortex compared to the hippocampus.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Engineering, Biomedical
Yixin Jiang, Junghan Lee, Jin-Myung Seo, Enkhzaya Davaa, Kyung-Ju Shin, Su-Geun Yang
Summary: This study investigated the potential effect of superparamagnetic iron oxide nanoparticles (SPIO) on the physical and biological properties of theranostic polymeric micelles. The results showed that SPIO formed hydrophobic geometric cavity in the micelle core, significantly affecting the integrity of the micelles and the drug loading capacity. In addition, SPIO enhanced drug absorption and prolonged the drug's half-life.
BIOMATERIALS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zhize Ye, Jinyu Hu, Jing Wang, Ya-nan Liu, Guo-xin Hu, Ren-ai Xu
Summary: The purpose of this study was to investigate the effect of CYP3A4 variants on tofacitinib metabolism and the interaction of tofacitinib with resveratrol. It was found that the clearance rate of CYP3A4.18 variant was significantly decreased compared with CYP3A4.1, and the CYP3A4.28 variant was changed, but not statistically significant. Resveratrol was found to have an IC50 value of 15.67 mu M with a non-competitive mechanism in rat liver microsomes and 8.88 mu M in human liver microsomes. In vivo study showed that the AUC(0-infinity) and Cmax of tofacitinib increased significantly in the presence of resveratrol. In conclusion, resveratrol has a significant impact on the metabolism of tofacitinib.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Gaotong Lin, Zhize Ye, Nanyong Gao, Xiaoqin Hu, Qihui Kong, Xiaodan Zhang, Junwei Li
Summary: This study revealed that anlotinib inhibited the metabolism of oxycodone, suggesting that the dose of oxycodone should be reconsidered when used in combination with anlotinib in clinical practice.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Analytical
Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Tamara King, Raluca Popa, Abhisheak Sharma, Francisco Leon, Bonnie A. Avery, Lance R. McMahon, Christopher R. McCurdy
Summary: Speciociliatine, a minor alkaloid found in kratom, was quantified in rat plasma using a developed method. Pharmacokinetic parameters of speciociliatine in male Sprague-Dawley rats were determined, showing higher systemic exposure compared to other kratom alkaloids. These parameters will aid in understanding the overall effects of kratom product use.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Xueru He, Ying Li, Yinling Ma, Yuhao Fu, Xuejiao Xun, Yanjun Cui, Zhanjun Dong
Summary: This study aimed to investigate the pharmacokinetic interactions between sorafenib (SOR) and dapagliflozin (DAPA) through the development of a UPLC-MS/MS method. The results showed that the co-administration of SOR and DAPA led to significant changes in their pharmacokinetic properties, with UGT1A9 potentially mediating the interactions.
Article
Biochemical Research Methods
Xinhua Hu, Yichao Xu, Jinliang Chen, Yuting Shen, Dandan Yang, Yin Hu, Bo Jiang, Honggang Lou, Zourong Ruan
Summary: A UPLC-MS/MS method was developed and validated for the determination of CX3002 in human plasma, showing good linearity, precision, and accuracy. The method was successfully applied to the pharmacokinetic study of CX3002.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Chaemin Lim, Jacob D. Ramsey, Duhyeong Hwang, Susana C. M. Teixeira, Chi-Duen Poon, Joshua D. Strauss, Elias P. Rosen, Marina Sokolsky-Papkov, Alexander Kabanov
Summary: The study found that the morphology of polymeric micelles significantly affects pharmacological efficacy, with spherical micelles accumulating rapidly in tumor tissue while retaining large amounts of drug, and worm-like micelles accumulating more slowly and only upon releasing significant amounts of drug.
Review
Polymer Science
Suguna Perumal, Raji Atchudan, Wonmok Lee
Summary: This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.
Article
Chemistry, Medicinal
Yuxiang Xu, Xiaonan Gao, Yunfang Zhu, Qi Zhang, Hongxin Qie, Haopeng Zhao, Jinglin Gao, Mingxia Wang
Summary: In this study, a UPLC-MS/MS method was developed for the quantitative analysis of pentoxifylline in beagle dog plasma and applied to a pharmacokinetic study. It was found that the administration of pentoxifylline sustained-release tablets with food significantly increased the AUC(0-t) and C-max values.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Plant Sciences
Ya-nan Liu, Jie Chen, Xinhao Xu, Yingying Hu, Jin-yu Hu, Ren-ai Xu, Guanyang Lin
Summary: This study establishes a method for determining the concentration of derazantinib in rat plasma and investigates the drug-drug interaction between derazantinib and naringin. The results suggest that the metabolism of derazantinib is not significantly affected by naringin, allowing for their safe concomitant administration.
PHARMACEUTICAL BIOLOGY
(2023)