Article
Pharmacology & Pharmacy
Beata A. Raczkowska, Patrycja Mojsak, David Rojo, Beata Telejko, Magdalena Paczkowska-Abdulsalam, Justyna Hryniewicka, Anna Zielinska-Maciulewska, Malgorzata Szelachowska, Maria Gorska, Coral Barbas, Adam Kretowski, Michal Ciborowski
Summary: The study identified specific serum metabolites associated with gestational diabetes mellitus (GDM), with a combination of alpha-HB, beta-HB, and myristic acid showing high specificity and sensitivity for the diagnosis of GDM, as well as predicting the risk of GDM in early pregnancy. These findings suggest potential new markers for the early diagnosis of GDM.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Shiyuan Zhao, Haitao Zhong, Chunmei Geng, Hongjia Xue, Changshui Wang, Wenxue Sun, Ruili Dang, Wenxiu Han, Pei Jiang
Summary: In this study, gas chromatography-mass spectrometry was used to investigate the toxic mechanisms of ACR in the main target tissues of rats, revealing 14 metabolic pathways related to amino acid, fatty acid, purine, and energy metabolism. The study suggests that the toxic mechanism of ACR may involve oxidative stress, inflammation, amino acid metabolism, and energy disorders.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, Legal
Maika Nariai, Hiroko Abe, Yumi Hoshioka, Yohsuke Makino, Hirotaro Iwase
Summary: This study used metabolomics analysis to identify a set of potential metabolites that could be used for forensic diagnosis of diabetes mellitus in postmortem blood samples. The findings suggest that further metabolomics research using postmortem samples is necessary to identify markers for forensic diagnosis.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Jieyi Qin, Qingqing Cheng, Ziyu Cai, Lin Zhang, Tong Xing, Xinglian Xu, Feng Gao
Summary: The aim of this study was to identify biomarkers for the diagnosis of wooden breast (WB) myopathy in male broilers by characterizing the serum metabolic profiles using metabolomics analysis. A clear separation was observed between normal (CON) and WB groups based on the analysis of 73 significantly different metabolites. Nine significantly altered metabolites were identified as excellent discriminant biomarkers for WB myopathy. This study provides new insights into the pathogenesis of WB and offers potential biomarkers for diagnostic purposes.
Article
Chemistry, Analytical
Eliska Ivanovova, Barbora Pisklakova, Jaroslava Friedecka, Ondrej Krystynik, David Friedecky, David Karasek
Summary: This study suggests that changes in the gut microbiome of GDM patients are associated with insulin resistance and obesity. By measuring SCFA and their derivatives, the metabolic status of GDM patients can be understood. The variation in SCFA concentration is important for monitoring GDM patients.
Article
Endocrinology & Metabolism
Si-Ri-Gu-Leng Sana, Guang-Min Chen, Yang Lv, Lei Guo, En-You Li
Summary: This study found differential metabolites in the serum and urine of pregnant women with GDM, and suggests that 2-propanol may be a potential volatile marker to evaluate cognitive impairment in these women.
WORLD JOURNAL OF DIABETES
(2022)
Article
Obstetrics & Gynecology
Mei Lin Peng, Zheng Zhang, Minqi Zhou, Chao He, Lin Xiao, Heng Yin, Kai Zhao
Summary: This study identified differential metabolites between pregnant women with gestational diabetes mellitus (GDM) in the third trimester and those without GDM. Several potential biomarkers for GDM were discovered, which may contribute to the understanding of the pathological mechanism of GDM and the development of efficient and sensitive detection methods for GDM.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Environmental Sciences
Shiyuan Zhao, Jinxiu Guo, Hongjia Xue, Junjun Meng, Dadi Xie, Xi Liu, Qingqing Yu, Haitao Zhong, Pei Jiang
Summary: This study used gas chromatography-mass spectrometry to investigate the effects of fluoride exposure on metabolites in different organs. Potential biomarkers and affected metabolic pathways related to the mechanism of fluorosis were identified.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Youngmin Han, Yeunsoo Yang, Minjoo Kim, Sun Ha Jee, Hye Jin Yoo, Jong Ho Lee
Summary: The study investigated the reliability of retinal and retinoic acid as biomarkers in predicting the development of type 2 diabetes mellitus (T2DM) in subjects with impaired fasting glucose (IFG). The results showed significant decreases in these biomarkers in the IFG-DM group. When added to conventional risk factors for T2DM, these metabolites enhanced the predictive ability for T2DM.
Article
Chemistry, Medicinal
Yahao Gao, Di Jiang, Changshui Wang, Gang An, Li Zhu, Changmeng Cui
Summary: This study comprehensively evaluated the toxicity of sodium valproate (VPA) using metabolomics, and found that VPA-induced toxicity is closely related to 12 key pathways including oxidative stress, inflammation, amino acid metabolism, lipid metabolism, and energy disorder.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Environmental Sciences
Cuiyun Wei, Zhen Zhou, Ling Wang, Zichun Huang, Yong Liang, Jie Zhang
Summary: This study revealed that exposure to PFOS led to disturbances in fatty acid metabolism in C. elegans, characterized by decreased levels of C18:0, increased levels of C18:3n6, decreased C18:3n6: C18:2n6 ratio, and down-regulation of the FA desaturation gene fat-3. Additionally, exposure disrupted mitochondrial function, leading to reduced ATP synthesis.
Article
Multidisciplinary Sciences
Changmeng Cui, Li Zhu, Qian Wang, Ruijuan Liu, Dadi Xie, Yujin Guo, Dingyi Yu, Changshui Wang, Dan Chen, Pei Jiang
Summary: The study investigated the metabolic changes after vancomycin administration in mice, revealing that vancomycin affects the metabolism in various organs, providing new insights for identification of vancomycin-induced toxicity.
Article
Food Science & Technology
Xufang Wu, Fengen Wang, Meiqing Chen, Jiaqi Wang, Yangdong Zhang
Summary: The aim of this research was to establish a method for quantifying 10 short-chain fatty acids (FSCFAs) in raw cow milk. Acidified raw cow milk samples were processed using gas chromatography-mass spectrometry after pretreatment with hydrochloric acid ethanol (0.5%) solution. Except for iso C5:0 and anteiso C5:0 co-elution, the remaining eight FSCFAs were effectively separated by chromatography. The methodological validation showed satisfactory linear relationships, low limits of quantification, good recoveries, and precision. Our study provides a valuable method for future quality and safety control of raw milk and nutritional studies.
Article
Agriculture, Dairy & Animal Science
Fengen Wang, Meiqing Chen, Runbo Luo, Guoxin Huang, Xufang Wu, Nan Zheng, Yangdong Zhang, Jiaqi Wang
Summary: A high-throughput gas chromatography-mass spectrometry method was developed to determine milk fatty acid compositions. The fatty acid profiles of different types of milk were analyzed, and the results showed significant differences among different milk samples. Goat milk and camel milk were considered as potential functional foods.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemical Research Methods
Zhuoru He, Zhongqiu Liu, Lingzhi Gong
Summary: The all-in-one sample preparation method MeOH-MTBE-H2O (1:5:1.5, v/v/v) was identified as the optimal extraction method for plasma metabolomics. In the study of osteoarthritis (OA), a panel of biomarkers including cholesterol, lactic acid, stearic acid, alpha-tocopherol, and oxalic acid showed potential as diagnostic biomarkers for distinguishing OA patients from healthy controls.
ANALYTICAL BIOCHEMISTRY
(2021)
