Article
Chemistry, Multidisciplinary
Meiling Zhang, Lvqi Luo, Xiangyi Dai, Yifan He, Jianshe Ma
Summary: This study investigated the pharmacokinetic differences of oleandrin and adynerin in rats and found variations in their bioavailability.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Qingqing Li, Ya-nan Liu, Jing Wang, Yingying Hu, Jinyu Hu, Ren-ai Xu, Liu Shao, Lianguo Chen
Summary: The study effectively quantified the pharmacokinetic profile of voxtalisib in rat plasma using UPLC-MS/MS technology, demonstrating good linear relationship and precision. The method could provide reference for optimizing clinical drug management in the later period.
FRONTIERS IN PHARMACOLOGY
(2022)
Correction
Chemistry, Analytical
Meiyu Lin, Hongmei Gao, Jinping Liu, Liu Han, Qinghe Zhang, Pingya Li
Summary: This study provides a correction for a previous article on the determination of 26-OH-panaxadiol in rat plasma using UPLC-MS/MS and its pharmacokinetic study. The corrected article presents more accurate data and experimental results, which are of significant importance for research in this field.
ANALYTICAL METHODS
(2022)
Article
Biochemistry & Molecular Biology
Zhize Ye, Jinyu Hu, Jing Wang, Ya-nan Liu, Guo-xin Hu, Ren-ai Xu
Summary: The purpose of this study was to investigate the effect of CYP3A4 variants on tofacitinib metabolism and the interaction of tofacitinib with resveratrol. It was found that the clearance rate of CYP3A4.18 variant was significantly decreased compared with CYP3A4.1, and the CYP3A4.28 variant was changed, but not statistically significant. Resveratrol was found to have an IC50 value of 15.67 mu M with a non-competitive mechanism in rat liver microsomes and 8.88 mu M in human liver microsomes. In vivo study showed that the AUC(0-infinity) and Cmax of tofacitinib increased significantly in the presence of resveratrol. In conclusion, resveratrol has a significant impact on the metabolism of tofacitinib.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Gaotong Lin, Zhize Ye, Nanyong Gao, Xiaoqin Hu, Qihui Kong, Xiaodan Zhang, Junwei Li
Summary: This study revealed that anlotinib inhibited the metabolism of oxycodone, suggesting that the dose of oxycodone should be reconsidered when used in combination with anlotinib in clinical practice.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Yanjun Cui, Ying Li, Xiao Li, Liju Fan, Xueru He, Yuhao Fu, Zhanjun Dong
Summary: A method for simultaneous determination of lenvatinib and telmisartan was developed in this study, showing that lenvatinib decreased the systemic exposure of telmisartan. Potential drug interactions were observed between lenvatinib and telmisartan.
Article
Plant Sciences
Ya-nan Liu, Jie Chen, Xinhao Xu, Yingying Hu, Jin-yu Hu, Ren-ai Xu, Guanyang Lin
Summary: This study establishes a method for determining the concentration of derazantinib in rat plasma and investigates the drug-drug interaction between derazantinib and naringin. The results suggest that the metabolism of derazantinib is not significantly affected by naringin, allowing for their safe concomitant administration.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Suili Yang, Xiaoshan Zhang, Yuzhen Wang, Congcong Wen, Chenxiang Wang, Ziye Zhou, Guanyang Lin
Summary: A bioanalytical method was developed to study the potential interaction between dasatinib and posaconazole, demonstrating that dasatinib alters the pharmacokinetics of posaconazole. When co-administered, attention should be paid to the unexpected risk of adverse clinical outcomes.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Veterinary Sciences
Jingyuan Kong, Yuxin Yang, Yu Liu, Jicheng Qiu, Yuying Cao, Xingyuan Cao, Pan Sun
Summary: This study aimed to evaluate the absolute bioavailability of cyclosporine in cats by comparing the pharmacokinetic profiles of oral and intravenous administration. The results showed that the medium dose of cyclosporine had great potential to be absorbed in the body. Monitoring the concentration of cyclosporine is necessary to prevent side effects in clinical use. Taking a blood sample 4 hours after oral administration is recommended for better estimation of absorption extent and prevention of side effects. Rating: 7/10.
VETERINARY SCIENCES
(2023)
Article
Plant Sciences
Huanhuan Wang, Liying Tang, Shaowei Hu, Xixian Kong, Yi Ouyang, Dong Zhang, Yi Zhang, Shihuan Tang, Hongwei Wu, Hongjun Yang
Summary: This study revealed the ingredients, tissue distribution, and pharmacokinetic characteristics of Shengmai injection (SMI). The study found that ginsenosides were the main active compounds in SMI and had high exposure in different tissues. The pharmacokinetic evaluation showed different elimination rates for different types of ginsenosides.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Medicinal
Xiao-nan Gao, Xu-yang Nie, Jing-lin Gao, Tian-fang Heng, Yu-qi Zhang, Li Hua, Ya-qi Sun, Zhang-ying Feng, Ming-xia Wang, Li Jia
Summary: The pharmacokinetics of nalbuphine were characterized in patients with varying degrees of liver dysfunction. The results showed that in patients with moderate/severe liver dysfunction, the elimination half-life and volume of distribution of nalbuphine were significantly increased. Multivariate analysis also revealed associations between weight, platelet count, total bilirubin, and the clearance and half-life of nalbuphine.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemical Research Methods
Jieying Qiu, Xixi Yan, Yingyi Liao, Deguan Yu, Congcong Wen, Zheng Xiang
Summary: This study developed a sensitive and rapid method for determining and studying the pharmacokinetics of D-pinitol in rat plasma, showing that D-pinitol has a slow elimination phase and a potential high affinity binding to blood protein in vivo.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Analytical
Xiaoting Gu, Cuiting Wu, Mengmeng Zhang, Xin Wang, Youping Liu, Xin Di
Summary: A study was conducted to investigate the pharmacokinetic compatibility of two components in the traditional Chinese medicine prescription Jinlingzi San. Results showed a decrease in elimination of one limonoid and alkaloids in the Jinlingzi San group compared to the single herb group, with an increase in exposure of the alkaloids to some extent. The study demonstrated a synergistic effect of combining Fructus Toosendan with Rhizoma Corydalis on the pharmacokinetics of seven bioactive components, providing new insights into the compatibility mechanism of Jinlingzi San.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Hui Chai, Yanhong Ai, Zhigang Cao
Summary: In this study, a quantification method for the simultaneous determination of pyrotinib and its metabolite pyrotinib-lactam in rat plasma using UPLC-MS/MS was established and validated. The method was successfully applied to a pharmacokinetic study of pyrotinib and its metabolite for the first time, showing rapid conversion of pyrotinib into pyrotinib-lactam with lower in vivo exposure.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Plant Sciences
Guanghou Wang, Hongjin Wang, Ziwei Lin, Lijuan Hou, Jia Yue Wang, Lixin Sun
Summary: This study aimed to investigate the phytochemical profile of alkaloids in N. officinalis total alkaloids and determine their pharmacokinetic behaviors. The results showed that 55 alkaloids were identified in N. officinalis total alkaloids, with 25 alkaloids absorbed by rats after oral administration. The established LC-ESI-MS/MS method was successfully applied for the simultaneous determination of major active alkaloids in rat plasma, providing valuable insights for pre-clinical and clinical investigations.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
A. J. Kuszak, D. C. Hopp, J. S. Williamson, J. M. Betz, B. C. Sorkin
DRUG TESTING AND ANALYSIS
(2016)
Article
Nutrition & Dietetics
Barbara C. Sorkin, Adam J. Kuszak, John S. Williamson, D. Craig Hopp, Joseph M. Betz
ADVANCES IN NUTRITION
(2016)
Article
Chemistry, Medicinal
Yulian Zhan, Yunshan Wu, Fangfang Xu, Yunpeng Bai, Yezhi Guan, John S. Williamson, Bo Liu
Review
Chemistry, Medicinal
Andre Lacerda Braga Teles, Roseane R. Silva, Michelle Ko, Glaucio Monteiro Ferreira, Samuel da Rocha Pita, Gustavo Henrique Goulart Trossini, Paulo Carvalho, Marcelo Santos Castilho
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Yike Zou, Xiaojuan Wang, James Sims, Bin Wang, Pankaj Pandey, Colin L. Welsh, Robert P. Stone, Mitchell A. Avery, Robert J. Doerksen, Daneel Ferreira, Clemens Anklin, Frederick A. Valeriote, Michelle Kelly, Mark T. Hamann
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Medicinal
Mohamed A. Helal, Amar G. Chittiboyina, Mitchell A. Avery
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Plant Sciences
Anna J. Kochanowska-Karamyan, Hugo C. Araujo, Xiong Zhang, Abir El-Alfy, Paulo Carvalho, Mitchell A. Avery, Stephen D. Holmbo, Jakob Magolan, Mark T. Hamann
JOURNAL OF NATURAL PRODUCTS
(2020)
Letter
Ophthalmology
Jeff C. Rabin, Paulo Carvalho, Cynthia E. Franklin
JAMA OPHTHALMOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Mohamed Jahan, Francisco Leon, Frank R. Fronczek, Khaled M. Elokely, John Rimoldi, Shabana I. Khan, Mitchell A. Avery
Summary: An efficient synthesis of a tricyclic analog of artemisinin was achieved, with one enantiomer exhibiting antimalarial activity. Unexpectedly, the C-5 hydroxyl group was unreactive, and this unusual reactivity was attributed to a close intramolecular hydrogen bond revealed by X-ray crystallography. Several newly synthesized compounds showed moderate antimalarial activity in vitro.
Article
Chemistry, Medicinal
Tiago Alves de Oliveira, Lucas Rolim Medaglia, Eduardo Habib Bechelane Maia, Leticia Cristina Assis, Paulo Batista de Carvalho, Alisson Marques da Silva, Alex Gutterres Taranto
Summary: This study evaluated different docking methodologies to analyze the interactions between nucleic acids and DNA intercalating agents. A machine learning model was used to estimate the experimental Delta T-m value. The results showed that MolAr is an effective docking method and can be used to estimate the experimental values of DNA intercalating agents.
Article
Biochemistry & Molecular Biology
Mayra Ramos do Bomfim, Deyse Brito Barbosa, Paulo Batista de Carvalho, Alisson Marques da Silva, Tiago Alves de Oliveira, Alex Gutterres Taranto, Franco Henrique Andrade Leite
Summary: Alzheimer's disease is a neurodegenerative pathology with limited treatment options. This study used virtual screening and molecular docking to identify a potential candidate for drug development. The selected molecule showed promise in biological tests.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Meeting Abstract
Chemistry, Multidisciplinary
Yike Zou, Xiaojuan Wang, James Sims, Bin Wang, Pankaj Pandey, Colin Welsh, Robert Stone, Mitchell Avery, Robert Doerksen, Daneel Ferreira, Clemens Anklin, Fred Valeriote, Michelle Kelly, Mark Hamann
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Biochemistry & Molecular Biology
Valeriy A. Bacherikov, Amar G. Chittiboyina, Mitchell A. Avery
CHEMISTRY & BIODIVERSITY
(2017)
Article
Chemistry, Medicinal
Fatemeh Abbasitabar, Vahid Zare-Shahabadi
