Review
Cardiac & Cardiovascular Systems
Tingyu Huang, Fiona M. Howse, Nina S. Stachenfeld, Charlotte W. Usselman
Summary: Even in the 21st century, female participants are underrepresented in human physiology research due to the perception that including them is more time consuming, less convenient, and more expensive. However, considering the importance of gonadal hormone fluctuations in governing vascular function and the potential misinterpretation of cardiovascular biomarkers, it is necessary for cardiovascular researchers to include females and accurately track their hormone changes. Saliva-derived measures of gonadal hormones provide a simple and noninvasive method for monitoring, which may facilitate the inclusion of females in cardiovascular research studies.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Behavioral Sciences
Malihe Eskandari Torbaghan, Ali Moghimi, Hamid Reza Kobravi, Masoud Fereidoni, Imanollah Bigdeli
Summary: This study aimed to investigate the effect of estradiol on stress and effect of stress on spatial working memory during the menstrual cycle. The results showed that estradiol levels decreased in the late follicular, luteal, and early follicular phases, while galvanic skin response decreased after stress induction in all three phases. Spatial working memory diminished after stress induction in all three phases, but increased in the late follicular phase. Average power spectrum density in all frequency bands increased after stress induction in the frontal and prefrontal channels. Therefore, stress led to spatial working memory dysfunction, while estradiol improved spatial working memory performance in the late follicular phase.
BRAIN AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Tran Dinh, Melissa Emery Thompson, Steven W. Gangestad
Summary: A substantial body of literature has examined the variations in women's psychology and behavior as a result of conception risk across the ovarian cycle. The effects are believed to be influenced by hormonal regulation, particularly estrogens and progesterone. Researchers have found that log-transformed hormone levels and ratios better predict conception risk and its related psychological outcomes.
HORMONES AND BEHAVIOR
(2022)
Review
Behavioral Sciences
Chia-Ming K. Hsu, Luke J. Ney, Cynthia Honan, Kim L. Felmingham
Summary: Research has shown that progesterone level is positively associated with negative recall and negative intrusive memories, while estradiol level is positively associated with extinction recall.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Endocrinology & Metabolism
Darwin A. Guevarra, Courtney C. Louis, Lilianne M. Gloe, Stefanie Russman Block, Deborah A. Kashy, Kelly L. Klump, Jason S. Moser
Summary: The study found increased anhedonic depression in the mid-luteal phase of the menstrual cycle for women, but no significant changes in anxious apprehension and anxious arousal. Additionally, there was a positive association between stress and anxious apprehension as well as anhedonic depression, but not anxious arousal. These associations were not stronger in the mid-luteal phase, providing weak evidence for a window of vulnerability for affective symptoms during this phase.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Biology
Yuki Uchida, Masahiko Izumizaki
Summary: Thermoregulation is essential for human survival in different ambient temperatures. Female hormones, particularly estradiol (E2) and progesterone (P4), have been found to influence physiological functions through TRP channels, such as temperature sensitivity, calcium absorption, and vasoconstriction. However, the effects of female hormones on TREK channels and physiological functions are still being investigated.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Oncology
Peter Lundberg, Mikael F. Forsgren, Jens Tellman, Johan Kihlberg, Anna Rzepecka, Charlotta Dabrosin
Summary: High mammographic density is associated with increased lean tissue fraction and apparent diffusion coefficient in the breast, as well as delayed perfusion dynamics. A total of 270 proteins were identified, with 124 related to inflammation, angiogenesis, and cellular growth significantly upregulated in dense breasts. These proteins correlated significantly with breast density, apparent diffusion coefficient, and perfusion data.
BRITISH JOURNAL OF CANCER
(2022)
Review
Endocrinology & Metabolism
Kathleen V. Casto, Timothy Jordan, Nicole Petersen
Summary: Oral contraceptives (OCs) are widely used and their potential effects on brain structure and function are being studied. Current research suggests that OCs may induce a hyperprogestogenic state in the brain.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Respiratory System
Grayson L. Baird, Thomas Walsh, Jason Aliotta, Melissa Allahua, Ruth Andrew, Ghada Bourjeily, Alexander S. Brodsky, Nina Denver, Mark Dooner, Elizabeth O. Harrington, James R. Klinger, Margaret R. MacLean, Christopher J. Mullin, Mandy Pereira, Athena Poppas, Mary Whittenhall, Corey E. Ventetuolo
Summary: In this study, fluctuations in cardiopulmonary function during menstruation in women with PAH were found to be driven by E2 and DHEA-S. These sex hormones influence transcription of extracellular vesicle miRNAs implicated in the pathobiology of pulmonary vascular disease and cancer, and are associated with clinical markers such as 6-minute walk distance and NT-proBNP levels.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Endocrinology & Metabolism
Hongyi Wang, Jianhua Li, Lan Chen, Lisheng He
Summary: This study investigated the relationship between hormone levels and prosocial behavior in women, and found little evidence supporting this association.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lilianne M. Gloe, Deborah A. Kashy, Emily G. Jacobs, Kelly L. Klump, Jason S. Moser
Summary: The study found that higher levels of worry were associated with lower working memory accuracy when average levels of estradiol were high. Similarly, the same association between higher worry and lower working memory accuracy emerged when average levels of progesterone were high. This highlights the importance of considering ovarian hormones in future studies and current theories of anxiety and cognition.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Oncology
Mayu Nakagawa, Shyoma Higuchi, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Ako Yokoi, Yu Ishibashi, Takashi Ito, Makoto Saegusa
Summary: The study suggests that the interaction between S100A1 and MDM2 may modulate proliferation, susceptibility to apoptosis, and migration through alterations in p53 signaling in normal endometrial cells. However, such correlations were absent in malignant endometrial cells.
Article
Psychiatry
Samantha G. Farris, Jacqueline E. Smith, Dana R. Steinberg, Brianna R. Altman, Geralyn M. Lambert-Messerlian, Shira I. Dunsiger, David M. Williams, Michael E. Saladin, Ana M. Abrantes
Summary: This study presents an observational, prospective study protocol that aims to explore the relationship between estradiol and progesterone, nicotine reinforcement, and anxiety psychopathology. By collecting daily-level naturalistic data, the protocol addresses methodological limitations in existing literature and provides insights into these relationships.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Biological
Marie Lefebvre, Michael P. Hengartner, Enrico Tronci, Toni Mancini, Fabian Ille, Susanna Roblitz, Tillmann Krueger, Brigitte Leeners
Summary: This study aimed to investigate the relationship between ovarian hormones and women's eating behavior. The results showed no significant correlation between women's serum hormone levels and the rating of visually presented food stimuli during different stages of the menstrual cycle and fertility treatments. Additionally, some food rating changes observed in the first menstrual cycle were not replicated in the second cycle.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Dermatology
C. Gu, Y. Wu, Y. Luo, S. Wang, H. Yin, Y. Gao, C. Wang, X. Yao, W. Li
Summary: This study investigated the efficacy and safety of dupilumab for atopic dermatitis in Chinese patients. The results showed that dupilumab demonstrated favourable efficacy and was well-tolerated in this population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Behavioral Sciences
McLeod Frampton Gwynette, Danielle W. Lowe, Erin A. Henneberry, Gregory L. Sahlem, Melanie Gail Wiley, Hussam Alsarraf, Sarah Brice Russo, Jane E. Joseph, Philipp M. Summers, Laura Lohnes, Mark S. George
Article
Neurosciences
Brian J. Sherman, Nathaniel L. Baker, Kathleen T. Brady, Jane E. Joseph, Lisa M. Nunn, Aimee McRae-Clark
PSYCHOPHARMACOLOGY
(2020)
Article
Psychology, Biological
Joshua A. Lile, Joseph L. Alcorn, Lon R. Hays, Thomas H. Kelly, William W. Stoops, Michael J. Wesley, Philip M. Westgate
Summary: While early clinical trials showed potential effects of VDCC ligand gabapentin on reducing cannabis use in treatment seekers, further studies on non-treatment-seeking cannabis users with pregabalin did not support its efficacy as a standalone pharmacotherapy for cannabis use disorder.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Biological
Aaron P. Smith, Thomas H. Kelly, Joshua A. Lile, Catherine A. Martin, Miranda P. Ramirez, Michael J. Wesley
Summary: Recent advances in diagnostic research have shown that individuals with higher impulsivity and sensation-seeking scores tend to have more positive subjective responses to stimulant drugs. This study explored the relationship between personality traits and responses to stimulants, finding that differences in mesocorticolimbic circuitry may play a role in mediating this relationship. The study used fMRI scans to assess brain activity and found that amphetamine administration disrupted connectivity among brain regions, with associations between impulsivity and brain regions changing from negative to positive during placebo and amphetamine conditions. These results suggest that differences in mesocorticolimbic circuitry may be a potential target for diagnostic and treatment strategies for stimulant use disorders.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Hamed Ekhtiari, Mehran Zare-Bidoky, Arshiya Sangchooli, Amy C. Janes, Marc J. Kaufman, Jason A. Oliver, James J. Prisciandaro, Torsten Wustenberg, Raymond F. Anton, Patrick Bach, Alex Baldacchino, Anne Beck, James M. Bjork, Judson Brewer, Anna Rose Childress, Eric D. Claus, Kelly E. Courtney, Mohsen Ebrahimi, Francesca M. Filbey, Dara G. Ghahremani, Peyman Ghobadi Azbari, Rita Z. Goldstein, Anna E. Goudriaan, Erica N. Grodin, J. Paul Hamilton, Colleen A. Hanlon, Peyman Hassani-Abharian, Andreas Heinz, Jane E. Joseph, Falk Kiefer, Arash Khojasteh Zonoozi, Hedy Kober, Rayus Kuplicki, Qiang Li, Edythe D. London, Joseph McClernon, Hamid R. Noori, Max M. Owens, Martin Paulus, Irene Perini, Marc Potenza, Stephane Potvin, Lara Ray, Joseph P. Schacht, Dongju Seo, Rajita Sinha, Michael N. Smolka, Rainer Spanagel, Vaughn R. Steele, Elliot A. Stein, Sabine Steins-Loeber, Susan F. Tapert, Antonio Verdejo-Garcia, Sabine Vollstaedt-Klein, Reagan R. Wetherill, Stephen J. Wilson, Katie Witkiewitz, Kai Yuan, Xiaochu Zhang, Anna Zilverstand
Summary: This study established parameters and reporting standards for cue reactivity research in functional magnetic resonance imaging, and conducted a review on relevant published studies, revealing gaps in the reporting of important items.
Article
Clinical Neurology
Kathleen Crum, Julianne C. Flanagan, Brandon Vaughan, Joseph Aloi, Megan M. Moran-Santa Maria, Sudie E. Back, Kathleen T. Brady, Jane E. Joseph
Summary: Childhood maltreatment is associated with PTSD in adulthood, with oxytocin potentially helping to ameliorate attentional neurocircuitry dysfunction in individuals with PTSD and maltreatment histories. The study also found reduced connectivity between attention networks in individuals with PTSD and a history of sexual abuse.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2021)
Article
Clinical Neurology
Lauren M. Sippel, Julianne C. Flanagan, Paul E. Holtzheimer, Megan M. Moran-Santa-Maria, Kathleen T. Brady, Jane E. Joseph
Summary: The study found that intranasal oxytocin modulates threat salience among childhood trauma-exposed individuals, and these effects vary as a function of gender and hemisphere.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2021)
Article
Endocrinology & Metabolism
Adriene M. Beltz, Michael I. Demidenko, Natasha Chaku, Kelly L. Klump, Jane E. Joseph
Summary: Intrauterine devices (IUDs), the most-used reversible contraceptive method, have potential effects on brain function, cognition, and behavior that are currently not well understood. This paper explores the importance of studying IUD use through neuroimaging, network analyses, and person-specific approaches to advance our knowledge of the interplay between exogenous and endogenous sex hormones. The findings illustrate the feasibility and utility of studying IUD users as a natural experiment to enhance our understanding of basic neuroendocrinology and women's health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Sudie E. Back, Julianne C. Flanagan, Therese Killeen, Tanya C. Saraiya, Delisa G. Brown, Amber M. Jarnecke, Alex O. Rothbaum, Jane Joseph, Elizabeth Santa Ana, Abigail de Arellano, Hannah L. Shoemaker, Reagan Ashley Dixon, Paul J. Nietert, Kathleen T. Brady
Summary: This study aims to investigate the synergistic effects of a novel pharmacotherapy and psychotherapy for individuals with co-occurring alcohol use disorder and posttraumatic stress disorder. The study will examine the effects of treatment on corticolimbic connectivity using functional magnetic resonance imaging, and may lead to improved treatment outcomes for individuals with this comorbidity.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Developmental Biology
Christopher T. Sege, Lisa M. McTeague, Molly Kegley, Curtisha Shacklewood, Colleen A. Halliday, Casey D. Calhoun, Jane E. Joseph, Zachary W. Adams, Greg Hajcak, Carla Kmett Danielson
Summary: This article examines potential changes in the processing of predictable events during the childhood-to-adolescence transition. The study finds that children show enhanced processing of predicted scary content, but unlike adults, they show reduced anticipatory processing of scary images in predictable contexts.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Developmental Biology
Christopher T. Sege, Lisa M. McTeague, Molly Kegley, Curtisha Shacklewood, Colleen A. Halliday, Casey D. Calhoun, Jane E. Joseph, Zachary W. Adams, Greg Hajcak, Carla Kmett Danielson
Summary: This article examines the regulation of emotional response and attention modulation during the processing of predictable unpleasant events in children and adolescents. The study found that blink reflexes and brain event-related potentials (ERPs) were increased during aversive anticipation, but decreased after the predictable aversive event occurred. These findings suggest that individuals have the ability to downregulate defensive priming and maintain attentional modulation once the awaited aversive event happens, even in pre-adolescents.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Psychology, Clinical
Sudie E. Back, Julianne C. Flanagan, Jim Mintz, Kathleen T. Brady, Jennifer Jones, Amber M. Jarnecke, Jane E. Joseph, David W. Shirley, Robert J. Malcolm, Mark Hamner, Brett T. Litz, Barbara L. Niles, Stacey Young-McCaughan, Terence M. Keane, Alan L. Peterson, Consortium Alleviate PTSD
Summary: The aim of this study was to determine the efficacy of doxazosin for the treatment of co-occurring PTSD and AUD. The results showed that doxazosin was safe and tolerable but not more effective than placebo in reducing the severity of PTSD or AUD.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Article
Neurosciences
Ashley A. Huggins, Lisa M. McTeague, Megan M. Davis, Nicholas Bustos, Kathleen I. Crum, Rachel Polcyn, Zachary W. Adams, Laura A. Carpenter, Greg Hajcak, Colleen A. Halliday, Jane E. Joseph, Carla Kmett Danielson
Summary: Childhood socioeconomic disadvantage may affect how the brain perceives and responds to potential threats. Future longitudinal studies are crucial for understanding how these effects persist throughout the lifespan and how health outcomes can be improved through community interventions and policies.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2022)
Article
Medicine, Research & Experimental
Sheri L. Robb, Thomas H. Kelly, Victoria L. King, Jason T. Blackard, Patricia C. McGuire
Summary: The CTSI Career Development Award (KL2) programs aim to provide protected time and multidisciplinary, mentored research training for junior faculty in clinical and translational science research. The KL2 Visiting Scholars Program was designed to promote collaborative training, leverage academic strengths, and support career development. Post-visit and outcomes surveys showed that most scholars found the program valuable for career and research development.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Health Care Sciences & Services
Daniel R. Baer, Andrew B. Lawson, Jane E. Joseph
Summary: To better identify the risk of Alzheimer's disease, this study developed Bayesian hierarchical models through space-time modeling of Alzheimer's disease incidence data. By borrowing risk information from antecedent conditions, such as mild cognitive impairment, the models showed improved goodness of fit and highlighted the importance of diagnosing label-switching problems and model specification for accurately capturing the contribution of time in modeling Alzheimer's disease risk.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)