Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1572, Issue -, Pages 37-43Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2018.08.027
Keywords
Enantioseparations; Chiral stationary phases; Segmented chiral-achiral columns; Fast separation of enantiomers
Funding
- RNSF-CNR [04/02 2014-2015, 04/02 2016-2017]
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In this study our preliminary attempt for obtaining fast and highly efficient separations of enantiomers in high-performance liquid chromatography with slightly modified state-of-the-art commercial instrumentation is described. In order to reach this goal after careful selection of chiral analytes, the preparation of chiral stationary phase (CSP), mobile phase composition and column dimensions were optimized. The concept of segmented chiral-achiral column was introduced. As the result of these optimizations baseline separation of enantiomers was achieved with the analysis time between 1-2 s. (C) 2018 Elsevier B.V. All rights reserved.
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