Review
Pharmacology & Pharmacy
Yang Jiang, Qi Zhao, Lin Li, Shumin Huang, Shuai Yi, Zhixi Hu
Summary: Traditional Chinese medicine (TCM) is a healthcare system based on clinical trials that relies on specific theories and practical experiences to treat diseases and improve public health.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Letian Yang, Bo Wang, Liang Ma, Ping Fu
Summary: Hyperuricemia is a common disorder that can lead to kidney disease. Traditional Chinese medicine has been proven effective in reducing uric acid levels and protecting kidney function, making it a widely used treatment for chronic kidney disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shuo Yuan, You Li, Jiao Li, Jia-Chen Xue, Qi Wang, Xiao-Ting Hou, Huan Meng, Ji-Xing Nan, Qing-Gao Zhang
Summary: This paper provides a scientific and theoretical basis for the treatment of IBD by reviewing the mechanism and research status of traditional Chinese medicine and natural products in IBD treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Myong Hak Ri, Yue Xing, Hong Xiang Zuo, Ming Yue Li, Hong Lan Jin, Juan Ma, Xuejun Jin
Summary: This review summarizes the regulatory mechanisms of natural compounds derived from traditional Chinese herbal medicines on the microglial response in animal models of ischemic stroke. The findings suggest that these compounds attenuate the M1 phenotype of microglia, which is involved in detrimental inflammatory response, while enhancing the neuroprotective M2 phenotype. Clinical trials also show significant and safe therapeutic effects, but further well-designed studies are needed.
Review
Integrative & Complementary Medicine
Chenyang Ai, Yi Zou, Hao Liu, Zheqiong Yang, Jinlei Xi
Summary: The prevalence of allergic disorders has increased, leading to a lower quality of life for patients and a higher demand for drugs to treat these diseases. Traditional Chinese medicine offers distinct benefits in treating allergic illnesses, such as long-term treatment maintenance, prevention of disease recurrence, and fewer adverse reactions. Recent developments in Chinese herbal formula, Chinese patent medicine, and active ingredients of traditional Chinese medicine have been analyzed, discussing their components, efficacy, and mechanisms of action. The importance of improving traditional Chinese herbal formulas and developing safe and effective Chinese patent medicines is emphasized in the field of traditional Chinese medicine research.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Liping Qu, Xiuli Li, Yin Xiong, Zhun Wang, Yuehua Zhou, Wenjun Zou, Jianyuan Tang, Mei Wang
Summary: Although TCM herbal remedies are popular in European patients, the access of multi-herbal TCM products to the EU market faces considerable obstacles. This study systematically analyzes the current advances in EU herbal monographs and combination herbal medicinal products (HMPs) granted in member states, and identifies the main features and challenges for multi-herbal TCM products. The results show that the EU is open to combination HMPs, but safety, efficacy, and justification of combinations are key elements for their market access.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Jillian L. Capodice, Barbara M. Chubak
Summary: Traditional Chinese Medicine (TCM) is a comprehensive medical system that has been developed over thousands of years and is utilized in the treatment of COVID-19. This paper highlights the use of TCM in treating COVID-19, discussing concepts and challenges of integrating TCM into medical settings.
Review
Immunology
Li-Ran Zhu, Shan-Shan Li, Wan-Qun Zheng, Wei-Jian Ni, Ming Cai, Hai-Peng Liu
Summary: The gut microbiota plays a crucial role in the occurrence and progression of various liver diseases. Traditional Chinese medicines and natural products have been shown to repair liver injury, improve fatty liver, regulate liver immunity, and even inhibit liver cancer, and these effects are closely related to the gut microbiota. This review comprehensively summarizes and discusses the characteristics, functions, and potential mechanisms of these medicines targeting gut microbiota during liver disease treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Infectious Diseases
Hua Zhong, Lei Han, Ren-Yi Lu, Yan Wang
Summary: Fungal infections pose a growing public health challenge with limited treatment options. To overcome this, the development of new antifungal drugs from natural products and synthetic biology strategies is promising. Traditional Chinese medicine (TCM) holds a vast library of biologically active molecules with antifungal and immunomodulatory properties. Combining antifungal drugs with immunomodulatory agents may yield better results. The review focuses on the latest research progress of TCM components with antifungal and immunomodulatory effects, aiming to inspire the design of novel antifungal compounds and treatment strategies.
Review
Pharmacology & Pharmacy
Liu Liu, Lei Zhang, Ming Li
Summary: Lupus nephritis is a renal disease caused by systemic lupus erythematosus and has serious implications for patients. Traditional Chinese medicine has shown promising effects in alleviating the symptoms and improving the prognosis of LN patients. This review provides supplementary evidence for the development of TCM treatment for LN and serves as a reference for future research and clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Liangshuai Liu, Heping Li, Guosheng Tan, Zhenjiang Ma
Summary: This study reviewed the use of traditional Chinese herbal medicine in treating amenorrhea caused by antipsychotic drugs and conducted a meta-analysis. The results showed that Chinese herbal medicine can effectively treat this condition, although it may take a long time to achieve satisfactory effectiveness.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shan Wu, Chuanchi Wang, Dong Bai, Nanjie Chen, Jingqing Hu, Junhua Zhang
Summary: With the introduction of clinical epidemiology and evidence-based medicine, Traditional Chinese Herbal Medicine (TCHM) in China has improved and internationalization of Traditional Chinese Medicine (TCM) has accelerated. Many Chinese drug products have been approved for marketing in other countries, and several Chinese herbal preparations have been investigated in phase III clinical trials. However, international multi-center clinical trials of TCHM are rare and improvement in evaluation techniques and methods that meet international standards and TCHM characteristics is required.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Integrative & Complementary Medicine
Purumea Jun, Endang Rahmat, Chang-Hyun Han, Changsop Yang, Youngmin Kang
Summary: The decline in birth rates is a serious issue globally, with many countries implementing national programs to increase birth rates using traditional medicines. This review analyzed and compared herbal medicines from traditional Chinese medicine (TCM) and traditional Indonesian medicine (TIM) that pregnant women should avoid for preventing miscarriage and maintaining safety. Despite their differences, TCM and TIM share similarities in concept and treatment, especially regarding herbal medicines, making this review a useful reference for pregnant women to consume herbal medicines safely.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Plant Sciences
Shu-Chun Liu, Meei-Ling Sheu, Yi-Ching Tsai, Yu-Chin Lin, Ching-Wen Chang, De-Wei Lai
Summary: Chi-Bai-San, a traditional Chinese medicine skin whitening agent, has been proven to reduce melanin production and wrinkles. This study extracted and tested the seven compounds in Chi-Bai-San, finding that it can safely reduce melanin production and inhibit key factors involved in melanogenesis.
Review
Pharmacology & Pharmacy
Yi-Qin Chen, Hao-Yin Chen, Qin-Qi Tang, Yi-Fan Li, Xu-Sheng Liu, Fu-Hua Lu, Yue-Yu Gu
Summary: Quercetin, a natural flavonoid, has shown potential in protecting kidneys by alleviating renal toxicity, apoptosis, fibrosis, and inflammation. It could be a promising drug for the treatment of kidney diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)