Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1363, Issue -, Pages 62-70Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2014.07.098
Keywords
Selenoamino acid; Enantiomer; Chiral speciation; Hyphenation technique; Review
Funding
- National Nature Science Foundation of China [21375097, 21205090, 21175102, 20975076]
- Science Fund for Creative Research Groups of NSFC [20621502, 20921062]
- SRFDP [20110141110010]
- China Postdoctoral Science Foundation [20110491197]
Ask authors/readers for more resources
In this paper, the state of the art of chiral speciation of selenoamino acids (SeAAs) in biological samples is critically reviewed. The significance and the features of such studies are highlighted. A special focus lies on chiral speciation of SeAAs by hyphenation techniques in which a chiral separation method (such as gas chromatography (GC), high performance liquid chromatography (HPLC) and capillary electrophoresis (CE)) is on-line coupled with an elemental specific detector, especially inductively coupled plasma mass spectrometry (ICP-MS). The advances in the development and application of hyphenation techniques in chiral speciation of SeAAs in biological samples are summarized and a perspective for future developments including sophisticated and innovative applications is discussed. Overall, HPLC-ICP-MS is more applicable than GC/CE-ICP-MS for chiral speciation of SeAAs. In the future, more novel chiral HPLC methods with high enantio-resolution, low cost and robustness, and their more applications in real biological samples analysis are expected. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available