Review
Polymer Science
Abderrahman Lamaoui, Abdellatif Ait Lahcen, Aziz Amine
Summary: This review explores the potential of molecularly imprinted polydopamine (MIPda) in cutting-edge sensing applications, including its preparation, sensing applications, and synthesis methods. It also discusses the challenges and prospects for future developments in this research field.
Article
Chemistry, Analytical
Dinh-Hai-Ngan Nguyen, Quang-Hai Le, Tuan-Linh Nguyen, Van-Tuan Dinh, Hoai-Nam Nguyen, Hong -Nam Pham, Tien-Anh Nguyen, Luong-Lam Nguyen, Thi-Mai-Thanh Dinh, Van-Quynh Nguyen
Summary: This work presents the development and application of micropatterned molecular imprinting in a conductive polymer film for the detection of diclofenac molecules. The technique involves combining nanosphere lithography and electrochemical polymerization to generate a nanos-tructured polymer on a glassy carbon electrode. The resulting molecularly imprinted polymer electrode shows good recognition properties for diclofenac molecules in phosphate-buffered saline solution, with increased sensitivity and a lower limit of detection compared to a non-molecular imprinted polymer electrode.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Christine Unger, Peter A. Lieberzeit
Summary: Molecularly imprinted polymers show potential in replacing biological recognition species, such as antibodies, in sensing applications. However, challenges remain in generating surface imprints, increasing binding capacity, and selectivity.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Chemistry, Analytical
Haiping Wang, Hongwei Wang, Qingyan Bai, Yunjia Xu, Chunmiao Bo, Bolin Gong
Summary: In this study, molecularly imprinted polymers with specific recognition of bisphenol A were synthesized using a surface-initiated atom transfer radical polymerization method. The adsorption capacity of bisphenol A was investigated, and the kinetic analysis showed a adsorption equilibrium time of 25 min, consistent with the pseudo-second-order kinetic model. The results of the static adsorption experiments exhibited consistency with the Langmuir adsorption model, demonstrating a maximum adsorption capacity of 387.2 μmol/g. High-performance liquid chromatography analysis of the enriched samples showed excellent selectivity for bisphenol A, with a linear range of 93.4%-99.7% recovery and 1.1%-6.4% relative standard deviation, indicating its high potential for practical bisphenol A detection and enrichment applications.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Biophysics
Patrycja Lach, Alvaro Garcia-Cruz, Francesco Canfarotta, Alistair Groves, Jakub Kalecki, Dominik Korol, Pawel Borowicz, Kostiantyn Nikiforow, Maciej Cieplak, Wlodzimierz Kutner, Sergey A. Piletsky, Piyush Sindhu Sharma
Summary: Redox-active MIP-Gly NPs were developed by incorporating ferrocenylmethyl methacrylate into the synthesis process, enabling them to selectively determine glyphosate without the need for redox probe. MIP-Gly NPs synthesized using allylamine and squaramide-based monomers exhibited the highest selectivity. The MIP-Gly NPs modified Pt-SPEs were characterized using differential pulse voltammetry and electrochemical impedance spectroscopy, with changes in the oxidation peak of the ferrocenyl moieties serving as the analytical signal. The chemosensor showed a low limit of detection and a wide linear dynamic concentration range for glyphosate, allowing successful detection in spiked river water samples.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Multidisciplinary
Irvin Veloz Martinez, Jackeline Iturbe Ek, Ethan C. Ahn, Alan O. Sustaita
Summary: Molecularly imprinted polymers (MIP) have demonstrated their potential as artificial and selective receptors for environmental monitoring. By tailoring these materials through specific binding mechanisms, MIP can mimic the recognition capacity of biological receptors while offering superior stability and versatility in sensing platforms. Controlled/living radical polymerization (CRP) techniques, such as RAFT, have been used to overcome the limitations of traditional polymerization methods, resulting in MIP with enhanced selectivity, sensitivity, and sorption capacity when incorporated as transducing elements in sensors. This study focuses on the design and synthesis strategies of RAFT-MIP to improve binding affinities and their application in environmental contaminant sensing.
Review
Biochemistry & Molecular Biology
Zhigang Wang, Zhuangzhuang Dong, Xiantao Shen, Bin Wu
Summary: Molecularly imprinted polymers (MIPs) have attracted significant attention due to their low cost, mild operating conditions, and excellent selectivity. Yeast, as a biological material, shows great potential as a supporting substrate in the molecular imprinting process. This article focuses on the preparation of different types of MIPs involving yeast, elaborates on its specific roles in each case, discusses the advantages and limitations of yeast in MIPs synthesis, and addresses the challenges and future development trends of yeast in molecular imprinting research.
Article
Chemistry, Analytical
Ece Ozkan, Goksu Ozcelikay, Elif Damla Gok Topak, Emirhan Nemutlu, Sibel A. Ozkan, Omer Dizdar, Sercan Aksoy, Sedef Kir
Summary: In this study, a molecularly imprinted polymer film (P (ANI)@MIP) was fabricated on the electrode surface using aniline as a functional monomer and octreotide as a template molecule. The P (ANI)@MIP film layer was evaluated and optimized to obtain the best electrochemical sensor for octreotide analysis. The developed P (ANI)@MIP/GCE sensor exhibited high sensitivity and selectivity for octreotide and was used to determine its concentration in cancer patient plasma samples.
Article
Chemistry, Analytical
Dominik Korol, Anna Kisiel, Maciej Cieplak, Agata Michalska, Piyush Sindhu Sharma, Krzysztof Maksymiuk
Summary: Electrochemically active molecularly imprinted polypyrrole nanoparticles (PPy NPs) were synthesized using micelles. The NPs with estriol imprinting were prepared by polymerizing pyrrole with the aid of iron(III) p-toluenesulfonate. SEM and TEM confirmed the synthesis of imprinted PPy NPs around 60 nm in size. The NPs prepared with pristine pyrrole showed an imprinting factor of 4.2, while those prepared with derivatized pyrrole showed no imprinting. The electrochemical-based transduction allowed for the determination of estriol in a concentration range of 0.5-5 μM and 10-100 μM, with a limit of detection (LOD) of 0.16 μM. The MIP NP-coated electrode exhibited satisfactory selectivity towards estriol and its structural analogs.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Chemistry, Analytical
Ruoyang Liu, Chi-Chiu Ko
Summary: MIP-based luminescent chemosensors have been widely studied due to their high specificity and sensitivity in molecular recognition and luminescence detection. Different strategies, including incorporation of luminescent functional monomers and surface-imprinting polymerization on luminescent nanomaterials, have been used to construct luminescent MIPs for various analytes. This review discusses the design strategies, sensing approaches, and applications of luminescent MIP-based chemosensors in biosensing, bioimaging, food safety, and clinical diagnosis, as well as the limitations and prospects for future development.
Article
Polymer Science
Guillaume Palaprat, Anne-Francoise Mingotaud, Dominique Langevin, Monique Mauzac, Jean-Daniel Marty
Summary: The study investigated a cholesteric network with two levels of chirality in gas phase towards the sorption properties of two enantiomers of a chiral amine, finding that both levels of chirality improved separation, with the presence of chiral-specific molecular cavities having a greater effect than the chiral environment.
Review
Chemistry, Multidisciplinary
Xinning Dong, Congcong Zhang, Xin Du, Zhenguo Zhang
Summary: Molecularly imprinted polymer (MIP) is a synthetic material that mimics the natural antibody-antigen system and is suitable for use in electrochemical sensors. However, the irregular shape and slow electron transfer rate of MIP limit the sensitivity and conductivity of the sensors. The integration of nanomaterials improves the sensing and recognition capability of MIP sensors.
Review
Chemistry, Analytical
Antonio Martin-Esteban
Summary: The use of molecularly imprinted polymers in sample preparation as selective sorbent materials has gained significant attention in recent years, leading to analytical methods with unprecedented selectivity. However, with the increasing adoption of Green Analytical Chemistry principles, it is important to critically review the greenness of synthesis and further application of molecularly imprinted polymers. This review discusses the preparation steps and strategies, reagents used, as well as their incorporation into microextraction techniques from a green perspective, and offers recent alternatives to enhance the sustainability of molecularly imprinted polymers.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Engineering, Environmental
Azam Nadali, Mostafa Leili, Abbas Afkhami, Abdolrahman Bahrami, Manoochehr Karami
Summary: New magnetic molecularly imprinted polymers (mag-MIP) have been developed for the detection of 1-Aminopyrene (1-Ap) in human urine samples, showing high adsorption capacity and rapid magnetic separation for efficient extraction and detection.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Chemistry, Multidisciplinary
Maylis Garnier, Michele Sabbah, Christine Menager, Nebewia Griffete
Summary: Hybrid molecularly imprinted polymers have the potential to enhance imaging, treatments, or a combination of both in nanomedicine, offering new interesting properties suitable for patient care.
Review
Chemistry, Analytical
Minxuan Wang, Lingyun Li, Limin Zhang, Jinge Zhao, Zhenqi Jiang, Weizhi Wang
Summary: This review summarizes the recent progress of peptide-based biosensors for precise detection, especially in tumor-related analysis, and provides a brief overview of the progress in tumor immune-related detection. The article also discusses the prospective future of peptide-based biosensors.
ANALYTICAL CHEMISTRY
(2022)
Article
Fisheries
Chuanqi Yu, Fan Lin, Guoquan Liu, Jun Yu, Shengkang Li, Xiaobo Wen
Summary: This study found that dietary supplementation of Saccharina japonica (SJ) can reduce serum lipid content and hepatic lipid accumulation (HLA) in black seabream by promoting autophagy and inhibiting the synthesis of fatty acids and bile acids.
Article
Automation & Control Systems
Guoquan Liu, Chaomin Luo, Shumin Zhou, Yuezhong Li, Xianxi Luo
Summary: This research discusses an H-infinity estimation issue for static neural networks (SNNs) and improves the SNN model from two aspects: the inclusion of bounded and unbounded delays and the bounded non-linear activation function within an interval. By constructing a novel Lyapunov-Krasovskii functional (LKF), a state estimator is established, with a gain matrix obtained through linear matrix inequality (LMI). Numerical experiments confirm the validity of the proposed method, highlighting its effectiveness and correctness.
ASIAN JOURNAL OF CONTROL
(2022)
Article
Biophysics
Burkhard Endeward, Yanping Hu, Guangcan Bai, Guoquan Liu, Thomas F. Prisner, Xianyang Fang
Summary: Pulsed electron-electron double resonance (PELDOR or DEER) spectroscopy is a powerful method for studying the structure and dynamics of biological macromolecules, providing distance distribution information from 1.8 to 6 nm when the biomolecules are labeled with paramagnetic tags. This study demonstrates the measurement of long-range distances up to 14 nm on a large RNA molecule using a combination of site-directed spin labeling and RNA perdeuteration. The perdeuteration technique extends the observation time windows of PELDOR and allows for the determination of long distances and conformational flexibility in large RNAs.
BIOPHYSICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Sijin Liu, Biao Wang, Yina Sheng, Suwei Dong, Guoquan Liu
Summary: A rational self-assembly strategy incorporating hydrophobic and hydrophilic groups has been developed to enhance tumor selectivity of MLP-based conjugates, improving their potential as anti-tumor drugs. By targeting mitochondria and integrins, the self-assembly nanoparticles can selectively enter cancer cells and induce apoptosis through disruption of cell membranes.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Robotics
Shubo Liu, Guoquan Liu, Shengbiao Wu
Summary: This study introduces a novel adaptive sliding controller for tracking control of nonlinear uncertain robotic systems in the presence of unknown actuator nonlinearities, ensuring that the tracking error eventually converges to an arbitrarily small neighborhood of zero. Simulation results validate the effectiveness and superiority of the proposed strategy.
Article
Energy & Fuels
Shanxin Xiong, Yukun Zhang, Jiaojiao Zhang, Xiaoqin Wang, Jia Chu, Runlan Zhang, Ming Gong, Bohua Wu, Guoquan Liu, Wen Luo, Jianwei Xu
Summary: In this study, electrochromic films of two-dimension covalent organic frameworks (2D COFs) were prepared by solvothermal synthesis method with different amounts of functionalized carbon nanotubes (FCNT) loading. The findings reveal that the film with 1% FCNT loading exhibits the best electrochromic properties, showing reversible color transformation from orange to dark brown during the redox process. This indicates the potential of FCNT-COF as an electrochromic material with enhanced contrast and stability in various applications such as smart windows and smartphone back cases.
SOLAR ENERGY MATERIALS AND SOLAR CELLS
(2022)
Article
Chemistry, Inorganic & Nuclear
Shuqin Chang, Jipeng Fu, Xuan Sun, Guangcan Bai, Guoquan Liu, Kaina Wang, Ligang Xu, Qi Wei, Thomas Meier, Mingxue Tang
Summary: Ce3+-doped SrS phosphors with Na+ addition were synthesized successfully and showed broad emissions. The white light-emitting diode structure fabricated with SrS:(Ce3+)(0.01), (Na+)(0.015) and Sr2Si5N8:Eu2+ exhibited a high color-rendering index.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
Shang Wu, Limin Zhang, Weizhi Wang
Summary: A new peptide inhibitor was developed to specifically target the critical prion-like domain (PLD) of SARS-CoV-2, effectively blocking the S1 protein and neutralizing the pseudovirus, which holds promise for the prophylactic and therapeutic treatment of COVID-19.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yao Yu, Minxuan Wang, Mengzhen Li, Limin Zhang, Jinge Zhao, Jie Cao, Weizhi Wang
Summary: This study established a novel nanomicellar probe functionalized with a newly developed peptide, demonstrating specific recognition and targeting ability for glioma, and showing satisfactory therapeutic effects in experimental models.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yanping Hu, Yan Wang, Jaideep Singh, Ruirui Sun, Lilei Xu, Xiaolin Niu, Keyun Huang, Guangcan Bai, Guoquan Liu, Xiaobing Zuo, Chunlai Chen, Peter Z. Qin, Xianyang Fang
Summary: Pulsed electron-electron double resonance (PELDOR) spectroscopy, X-ray scattering interferometry (XSI), and single-molecule Forster resonance energy transfer (smFRET) are molecular rulers that provide inter- or intramolecular pair-wise distance distributions in the nanometer range, thus being ideally suitable for structural and dynamic studies of biomolecules including RNAs. However, the current labeling strategies may cause structural perturbation and decrease the accuracy of measurements.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang, Bing Ma, Weizhi Wang
Summary: This article introduces a click chemistry-driven protein sorting strategy that achieves spatial and temporal manipulation of specific proteins along the PD-1 immune checkpoint axis. The strategy shows promising results in tumor-immune therapy both in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Xi Zhao, Xinyu Lian, Jianlan Xie, Guoquan Liu
Summary: Tumor cells can use accumulated cholesterol to inhibit lipid peroxidation (LPO) and ferroptosis, providing a new strategy for tumor treatment.
Article
Materials Science, Biomaterials
Xin Wang, Yao Yu, Limin Zhang, Zijian Zhang, Shixiang Lu, Weizhi Wang
Summary: Glioma is a challenging malignant tumor with difficulties in drug delivery and tumor targeting. Recent research on oncology has revealed the complexity of the immunosuppressive tumor microenvironment, complicating glioma treatment. This study demonstrates the potential of glycopeptide-functionalized micelles for targeted killing of glioma cells and modulating the tumor immune microenvironment.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Limin Zhang, Yuwei Tian, Mengzhen Li, Minxuan Wang, Shang Wu, Zhenqi Jiang, Qiqin Wang, Weizhi Wang
Summary: This study presents a peptide-based nano 'bead-grafting' method for active delivery of quantum-dot nanoparticle drugs (NPDs). This approach combines immune checkpoint blockade (ICB) therapy with sonodynamic therapy (SDT) to effectively inhibit tumor growth and enhance the anti-tumor immune response. This research provides a new strategy for controlling and delivering NPDs with important implications for cancer treatment.
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
