Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1250, Issue -, Pages 264-273Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2012.06.029
Keywords
Supercritical fluid chromatography; Preparative chromatography; Flash chromatography; Medicinal chemistry purifications
Ask authors/readers for more resources
Flash chromatography is the preferred approach for small molecule purification in pharmaceutical discovery. This paper will discuss the potential for flash supercritical fluid chromatography (SFC) as an alternative technology for these purifications. It was shown that the high sample loadings seen with flash LC could also be achieved using flash SFC. The dry load injection technique greatly increases the amount of sample that can be applied to a flash SFC column while still achieving separation. Flash SFC has much lower solvent usage and higher purification productivities relative to flash LC. Product concentrations post purification were higher for flash SFC vs. flash LC, reducing the time required to isolate dry product. There still exist a number of technical details to be worked our with flash SFC, mainly around the equipment and column/cartridge technology. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available