Review
Psychiatry
Ismene Ditrich, Alexandra Philipsen, Swantje Matthies
Summary: Research has shown that both ADHD and BPD patients exhibit impulsivity and emotion regulation issues, with those suffering from both disorders showing the most severe symptoms. Environmental and genetic factors play a role in both disorders, increasing the risk of misdiagnosis during childhood.
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2021)
Article
Clinical Neurology
Estevao Scotti-Muzzi, Thais Chile, Ricardo Moreno, Bruno Fraccini Pastorello, Claudia da Costa Leite, Anke Henning, Maria Concepcion Garcia Otaduy, Homero Vallada, Marcio Gerhardt Soeiro-de-Souza
Summary: This study found that euthymic BD type I patients had a lower Glu/GABA ratio in the dorsal anterior cingulate cortex compared to healthy controls, which was influenced by anticonvulsant and antipsychotic medications, but not lithium. The presence of GAD1 gene single nucleotide polymorphisms may affect the Glu/GABA ratio.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Tuba Aydin, Benjamin A. Parris, Gizem Arabaci, Marina Kilintari, Jacqui Taylor
Summary: An increasing number of studies have found that symptoms of attention deficit hyperactivity disorder (ADHD) are risk factors for technology addictions among young adults, particularly in terms of social media and smartphone addiction. Symptoms of inattention have a smaller impact on internet addiction. This study suggests that individuals with non-clinical, trait-level ADHD, especially those with more symptoms of inattention, are more susceptible to developing certain forms of technology addiction.
CURRENT PSYCHOLOGY
(2023)
Review
Behavioral Sciences
Mandy Meijer, Barbara Franke, Carmen Sandi, Marieke Klein
Summary: DNA methylation is an important epigenetic mechanism that plays a role in the interaction between genes and the environment, and is associated with externalizing behaviors and psychiatric disorders. Previous studies on externalizing behaviors have been limited in sample size, leading to a lack of candidate genes and biomarkers with strong evidence. In this study, we conducted a systematic literature review and identified candidate genes and biological systems for attention-deficit/hyperactivity disorder (ADHD) and aggressive behaviors based on epigenome-wide association studies (EWAS) conducted in peripheral tissue and cord blood. The findings suggest the involvement of neuronal processes and cell marker genes in ADHD, and the relevance of astrocytes and granulocytes to both ADHD and aggression-related behaviors. Only a small proportion of the significant epigenetic findings can be directly explained by genetic factors associated with ADHD. Larger sample sizes and harmonization of assessment instruments are needed to advance the field.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Sofi da Cunha-Bang, Vibe G. Frokjaer, Brenda Mc Mahon, Peter Steen Jensen, Claus Svarer, Gitte Moos Knudsen
Summary: This study investigated the association between brain serotonin transporter (SERT) levels and trait impulsive aggression. The results showed no significant association between SERT binding and trait impulsive aggression. Therefore, this study does not support the involvement of SERT in mediating serotonergic effects on aggression and impulsivity.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Valeska Cid-Jofre, Macarena Moreno, Ramon Sotomayor-Zarate, Gonzalo Cruz, Georgina M. Renard
Summary: This study aimed to evaluate the effects of chronic MOD treatment on neurochemicals, dopamine receptor 2 expression, and behavior in the mesocorticolimbic system of young healthy rats. The results showed that chronic use of MOD during adolescence induces behavioral and neurochemical changes associated with the mesocorticolimbic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Deyana Ivanova, Xiao-Feng Li, Caitlin McIntyre, Kevin T. O'Byrne
Summary: This study reveals that Ucn3 neurons in the MePD inhibit the frequency of the GnRH pulse generator through GABA and glutamate signaling. Additionally, Ucn3 projections from the MePD to the PVN regulate the HPG and HPA axes.
Article
Clinical Neurology
Josua Zimmermann, Niklaus Zolch, Rebecca Coray, Francesco Bavato, Nicole Friedli, Markus R. Baumgartner, Andrea E. Steuer, Antje Opitz, Annett Werner, Georg Oeltzschner, Erich Seifritz, Ann-Kathrin Stock, Christian Beste, David M. Cole, Boris B. Quednow
Summary: This study used proton magnetic resonance spectroscopy (MRS) to measure the glutamate-glutamine complex (GLX) and gamma-aminobutyric acid (GABA) concentrations in the brains of chronic MDMA users and MDMA-naive healthy controls. The results showed that chronic MDMA users had elevated GLX levels in the striatum, which may offer new mechanistic explanations for cognitive deficits observed in MDMA users. Overall, this study suggests that MDMA use affects not only serotonin but also striatal GLX and GABA concentrations.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Dipanwita Pati, Thomas L. Kash
Summary: The study examines the differential effects of TNF-alpha on GABA and dopamine neurons in the vIPAG of female mice, providing new insights into the modulation of pain pathways by TNF-alpha.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Cell Biology
Ryohei Umeda, Hitoshi Teranishi, Kazumasa Hada, Nobuyuki Shimizu, Hiroshi Shiraishi, Hirotaro Urushibata, Shaohong Lai, Masahito Shide, Magdeline E. Carrasco Apolinario, Ryoko Higa, Kenshiro Shikano, Toshitaka Shin, Hiromitsu Mimata, Takatoshi Hikida, Toshikatsu Hanada, Reiko Hanada
Summary: VRK2 is a kinase involved in cell proliferation and survival, and its relationship with neuropsychiatric disorders has not been fully investigated. This study found that vrk2-deficient zebrafish exhibited aggressive behavior and different social preference, with low GABA content in the brain and high density of neuronal dendrites.
Article
Neurosciences
Meng Li, Lena Vera Danyeli, Lejla Colic, Gerd Wagner, Stefan Smesny, Tara Chand, Xin Di, Bharat B. Biswal, Jorn Kaufmann, Juergen R. Reichenbach, Oliver Speck, Martin Walter, Zuemruet Duygu Sen
Summary: Reproducible resting-state functional connectivity patterns and their alterations have significant implications in neuropsychiatric research. This study utilizes multimodal imaging and magnetic resonance spectroscopy to investigate the correlation between regional neurotransmitter levels and rsFC strength, providing insights into the modulation of interaction between brain regions at a macroscopic level.
HUMAN BRAIN MAPPING
(2022)
Article
Substance Abuse
Punitha Subramaniam, Andrew Prescot, Erin McGlade, Perry Renshaw, Deborah Yurgelun-Todd
Summary: This study investigated GABA and Glx levels in adolescent MJ users compared to healthy controls, and their relationship with impulsive behavior. The findings suggest that MJ users have lower GABA levels compared to controls, but no significant differences were found in Glx levels or impulsive behavior between the two groups. Further research is needed to understand the relationship between neurochemical correlates, behavior, and adolescent MJ use.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Neurosciences
Ann-Kathrin Stock, Annett Werner, Paul Kuntke, Miriam-Sophie Petasch, Wiebke Bensmann, Nicolas Zink, Anna Helin Koyun, Boris B. Quednow, Christian Beste
Summary: This study investigates the role of GABA and glutamate in cognitive inhibition during cognitive flexibility. The results suggest that cognitive inhibition and behavioral inhibition are functionally distinct faculties, and they rely on different brain structures and neurotransmitter systems.
Article
Clinical Neurology
Irene O. Lee, David H. Skuse, Paul A. Constable, Fernando Marmolejo-Ramos, Ludvig R. Olsen, Dorothy A. Thompson
Summary: This study compared the electroretinogram (ERG) of individuals with ADHD, ASD, and controls. The results showed significant elevations in the b-wave amplitudes, PhNR responses, and faster timing of the b-wave time-to-peak in individuals with ADHD compared to controls and ASD. These findings suggest imbalances in glutamate and GABA neurotransmission as a common mechanism in both ADHD and ASD.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2022)
Article
Behavioral Sciences
Simon Maier, Ansgard Lena Dueppers, Kimon Runge, Michael Dacko, Thomas Lange, Thomas Fangmeier, Andreas Riedel, Dieter Ebert, Dominique Endres, Katharina Domschke, Evgeniy Perlov, Kathrin Nickel, Ludger Tebartz van Elst
Summary: Adults with autism spectrum disorders have elevated levels of the inhibitory neurotransmitter GABA in the left dorsolateral prefrontal cortex. This finding supports the hypothesis of an imbalance between excitatory and inhibitory equilibrium in patients with autism spectrum disorders.
Article
Clinical Neurology
Julia I. Herzog, Inga Niedtfeld, Sophie Rausch, Janine Thome, Meike Mueller-Engelmann, Regina Steil, Kathlen Priebe, Martin Bohus, Christian Schmahl
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2019)
Article
Health Policy & Services
Lisa Lyssenko, Gerhard Mueller, Nikolaus Kleindienst, Christian Schmahl, Mathias Berger, Georg Eifert, Alexander Koelle, Siegmar Nesch, Jutta Ommer-Hohl, Michael Wenner, Martin Bohus
HEALTH PROMOTION INTERNATIONAL
(2019)
Article
Psychology, Clinical
Annegret Krause-Utz, Julia-Caroline Walther, Stefanie Lis, Christian Schmahl, Martin Bohus
PSYCHOLOGICAL MEDICINE
(2019)
Article
Clinical Neurology
Alexander Sartorius, Traute Demirakca, Andreas Boehringer, Christian Clemm von Hohenberg, Suna Su Aksay, Jan Malte Bumb, Laura Kranaster, Thomas Nickl-Jockschat, Michael Groezinger, Philipp A. Thomann, Robert Christian Wolf, Peter Zwanzger, Udo Dannlowski, Ronny Redlich, Maxim Zavorotnyy, Rebecca Zoellner, Isabel Methfessel, Matthias Besse, David Zilles, Gabriele Ende
Article
Neurosciences
Mark Mikkelsen, Daniel L. Rimbault, Peter B. Barker, Pallab K. Bhattacharyya, Maiken K. Brix, Pieter F. Buur, Kim M. Cecil, Kimberly L. Chan, David Y-T Chen, Alexander R. Craven, Koen Cuypers, Michael Dacko, Niall W. Duncan, Ulrike Dydak, David A. Edmondson, Gabriele Ende, Lars Ersland, Megan A. Forbes, Fei Gao, Ian Greenhouse, Ashley D. Harris, Naying He, Stefanie Heba, Nigel Hoggard, Tun-Wei Hsu, Jacobus F. A. Jansen, Alayar Kangarlu, Thomas Lange, R. Marc Lebel, Yan Li, Chien-Yuan E. Lin, Jy-Kang Liou, Jiing-Feng Lirng, Feng Liu, Joanna R. Long, Ruoyun Ma, Celine Maes, Marta Moreno-Ortega, Scott O. Murray, Sean Noah, Ralph Noeske, Michael D. Noseworthy, Georg Oeltzschner, Eric C. Porges, James J. Prisciandaro, Nicolaas A. J. Puts, Timothy P. L. Roberts, Markus Sack, Napapon Sailasuta, Muhammad G. Saleh, Michael-Paul Schallmo, Nicholas Simard, Diederick Stoffers, Stephan P. Swinnen, Martin Tegenthoff, Peter Truong, Guangbin Wang, Iain D. Wilkinsons, Hans-Joerg Wittsack, Adam J. Woods, Hongmin Xu, Fuhua Yan, Chencheng Zhang, Vadim Zipunnikov, Helge J. Zoellner, Richard A. E. Edden
Article
Clinical Neurology
Liia Kivela, Annegret Krause-Utz, Joanne Mouthaan, Maartje Schoorl, Rianne de Kleine, Bernet Elzinga, Merijn Eikelenboom, Brenda W. J. H. Penninx, Willem van der Does, Niki Antypa
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Letter
Psychiatry
Annegret Krause-Utz, Julia-Caroline Walther, Susanne Schweizer, Stefanie Lis, Adam Hampshire, Christian Schmahl, Martin Bohus
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2020)
Article
Multidisciplinary Sciences
Dina F. Galinsky, Ezgi Erol, Konstantina Atanasova, Martin Bohus, Annegret Krause-Utz, Stefanie Lis
Editorial Material
Psychiatry
Annegret Krause-Utz
Summary: Long-lasting invasive traumatic events, such as childhood abuse and intimate partner violence, can increase the risk of developing mental disorders like PTSD and BPD, along with maladaptive coping behaviors. Research is still needed to understand why some individuals develop psychopathological symptoms after complex trauma while others do not.
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2021)
Article
Psychiatry
Annegret Krause-Utz, Tara Dierick, Tobias Josef, Elianne Chatzaki, Andries Willem, Jan Hoogenboom, Bernet Elzinga
Summary: This study investigated the mediating role of borderline personality disorder features, dissociation, and maladaptive cognitive emotion regulation in the relationship between self-reported child sexual abuse severity and sexual intimate partner violence. The findings indicate that dissociation and maladaptive emotion regulation mediate the association between CSA and sexual IPV, whereas BPD features do not play a mediating role.
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2021)
Article
Psychiatry
Marie-Luise Zeitler, Martin Bohus, Nikolaus Kleindienst, Rebekka Knies, Miriam Ostermann, Christian Schmahl, Lisa Lyssenko
JOURNAL OF PERSONALITY DISORDERS
(2020)
Article
Psychology, Clinical
Lonneke I. M. Lenferink, Marthe R. Egberts, Marie-Louise Kullberg, Maya G. Meentken, Sarah Zimmermann, Yoki L. Mertens, Angela A. T. Schuurmans, Yaara Sadeh, Nancy Kassam-Adams, Annegret Krause-Utz
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2020)
Article
Psychiatry
Annegret Krause-Utz, Ezgi Erol, Athina Brousianou, Sylvia Cackowski, Christian Paret, Gabriele Ende, Bernet Elzinga
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2019)
Article
Neurosciences
Lars Schulze, Andreas Schulze, Babette Renneberg, Christian Schmahl, Inga Niedtfeld
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2019)