Article
Biology
Hossein Poorhemati, Svetlana Komarova
Summary: This study developed a mathematical model describing pH regulation in the interstitial fluid, with findings indicating that the carbonate buffer dominates the electrochemical buffering system in bone interstitial fluid. Additionally, phosphate added during hydroxyapatite dissolution significantly improved buffering capacity, while hydroxyapatite precipitation had limited impact on pH regulation in the interstitial fluid.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Materials Science, Ceramics
Toshiki Miyazaki, Shunki Muroyama
Summary: This study investigated the synthesis of fluorapatite under different conditions and examined the resulting differences in crystalline structure and chemical durability. The effectiveness of F- incorporation was found to be higher with 1-ethyl-3-methylimidazolium tetrafluoroborate compared to 1-ethyl-3-methylimidazolium hexafluorophosphate. Additionally, it was observed that the solubility of the product tended to decrease in acidic conditions with higher amounts of fluorine substituted in the crystal lattice.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Ceramics
Pingan Song, Weiying Wang, Jingguo Li, Shaokui Cao, Jun Shi
Summary: Ti3C2@AuNRs/HAP/PDA nanocomposites with synergistically enhanced NIR responsiveness and excellent drug loading capacity were successfully prepared. These nanocomposites demonstrated pH-/NIR- dual responsive drug release behavior, holding great promise in remote controlled drug delivery and photothermal therapy.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Rongyu Zhang, Jingxin Ding, Xiaoyu Lu, Aihua Yao, Deping Wang
Summary: In this study, a pH-responsive drug carrier consisting of a borate glass core and a mesoporous hydroxyapatite HA shell coated with glutaraldehyde-crosslinked chitosan (CS) was developed. The drug release was accelerated in an acidic environment due to the swelling of CS. The vancomycin-loaded BG-HA@CS showed effective antibacterial activity against S. aureus and E. coli.
CERAMICS INTERNATIONAL
(2023)
Article
Polymer Science
Julien Es Sayed, Cleïment Caito, Abinaya Arunachalam, Armin Amirsadeghi, Larissa van Westerveld, Denise Maret, Roshan Akdar Mohamed Yunus, Eleonora Calicchia, Olivia Dittberner, Giuseppe Portale, Daniele Parisi, Marleen Kamperman
Summary: Complex coacervates are versatile materials formed by electrostatic associations between polyelectrolytes. The viscoelastic properties of these materials can be easily altered by the ionic strength of the medium, resulting in a range of materials from liquids to gels. This study reveals the importance of intermolecular hydrogen bonds on the phase behavior and viscoelasticity of HA-CHI complex coacervates. The density of hydrogen bonds between CHI units increases with pH, leading to elastic gel-like behavior. This pH-dependent behavior is relevant for the design of polyelectrolyte materials.
Article
Environmental Sciences
Precious Cooper, Jing Nie, Steven L. Larson, John H. Ballard, Heather M. Knotek-Smith, Ahmet Celik, Shaloam Dasari, Xianchun Zhu, Fengxiang X. Han
Summary: Uranium, a naturally occurring element, can contaminate groundwater and soil due to industrial activities and nuclear energy accidents. Hydroxyapatite exhibits high uranium affinity, but the presence of carbonates may hinder uranium removal, with temperature having a lesser effect.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Chemistry, Analytical
Ya-Xi Ye, Jing Guan, Xin-Yue Chen, Ya-Wen Yu, Zhu-Min Xu, Shang-Ming-Zhu Zeng, Zhong-Chang Wang, Bao-Zhong Wang, Qing-Cai Jiao, Hai-Liang Zhu
Summary: A new fluorescently labeled bisphosphonate for bone metastasis detection of breast cancer was reported in the study, showing promising potential for clinical application.
Article
Geochemistry & Geophysics
Daniel Sanchez-Campos, Maria Isabel Reyes Valderrama, Susana Lopez-Ortiz, Daniela Salado-Leza, Maria Eufemia Fernandez-Garcia, Demetrio Mendoza-Anaya, Eleazar Salinas-Rodriguez, Ventura Rodriguez-Lugo
Summary: The study successfully synthesized nanosized rod-like monoclinic hydroxyapatite using an optimized microwave assisted hydrothermal method, which has not been previously reported.
Article
Biophysics
Wei Jiang, Qiang Wang, Di Cui, Lixia Han, Ligang Chen, Jiating Xu, Na Niu
Summary: Engineered nanoparticles that respond to tumor microenvironment parameters such as pH have been developed as drug carriers and contrast agents for magnetic resonance imaging (MRI). These nanoparticles have good biocompatibility and specific inhibition of tumor cells. The pH-sensitive nanoparticles can release drugs in acidic environments, making them highly effective for tumor diagnosis and therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Chengyu Li, Ziyou Ding, Yingchao Han
Summary: This study successfully prepared manganese-doped nano-hydroxyapatite nanoparticles for MRI-guided photothermal therapy. The nanoparticles exhibited pH-responsive MRI capacity and efficient photothermal lethality, making them a promising nanotheranostic agent for cancer diagnosis and therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Amirmasoud Samadi, Mehrab Pourmadadi, Fatemeh Yazdian, Hamid Rashedi, Mona Navaei-Nigjeh, Tatiane Eufrasio-da-silva
Summary: This study developed a novel approach to improve loading efficiency and attain sustained-release of quercetin in cancer therapy by incorporating hydrogel nanocomposites. The nanocomposite showed pH-responsive release of quercetin with prolonged-release over 96 hours, and exhibited significant cytotoxicity on MCF-7 cells, making it a potential candidate for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Ceramics
S. V. Rempel, D. A. Eselevich, H. Schroettner, A. A. Valeeva, A. A. Rempel
Summary: The study investigated the structural and thermal behavior of TiOy/HAp nanocomposite materials used in tissue engineering through various analysis methods. It was found that the TiOy additives have a stabilizing effect on HAp composites, with different stoichiometries impacting the interactions between the matrix and nanoparticles.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Environmental
Ying Wang, Haoyu Chen, Chao Chen, Zikun Zhang, Yin Xu, Guangjiao Chen, Yanlong Zhang
Summary: The composition and properties of aHAP, a byproduct of the anammox-HAP process, were analyzed. The aHAP showed good adsorption capacity for Cd(II) removal and pH buffering capacity. This research contributes to achieving high-efficiency nitrogen and phosphorus removal and meeting the requirements of green chemistry.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Chemistry, Physical
Yuchi Guo, Zongxue Yu, Haidong Chen, Bokai Peng, Junlei Tang
Summary: This study aimed to design a composite epoxy coating HZB/EP with pH-responsive behavior by grafting different material functions. ZIF-8 particles were self-assembled on the surface of hydroxyapatite (HAp) through in situ growth, followed by encapsulation of the corrosion inhibitor BTA. The coating demonstrated improved dispersion of HZB in the resin, resulting in reduced coating defects and enhanced corrosion resistance.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
Vahid Mohammadzadeh, Amin Norouzi, Marjan Ghorbani
Summary: Developing pH-sensitive multifunctional nanocomposites for drug targeted delivery and controlled release is a promising approach for cancer treatment. In this study, a nanocomposite of doxorubicin/Lactose@layered double hydroxide-hydroxyapatite was designed and thoroughly analyzed. The nanocomposite showed high encapsulation efficiency, controlled drug release behavior, and strong cytotoxicity against liver cancer cells. These results suggest that the designed nanocomposite could be used for targeted and controlled delivery of anti-cancer drugs and other biomedical applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)