Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 11, Pages 2192-2194Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2008.03.059
Keywords
Scutellaria baicalensis; Scutellariae Radix; Baicalin; Baicalein; Preparation; Purification
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A simple, rapid and reproducible method was developed to isolate high-purity baicalin from Scutellariae Radix, the dried roots of Scutellaria baicalensis Georgi. The method involves partition/recrystallization steps without repeated column chromatography or special instruments. Isolated baicalin was characterized by comparisons of TLC, HPLC, IR, MS, and NMR data with an authentic sample. Moreover, beta-glucuronidase hydrolysis of baicalin sequentially yielded glucuronic acid and baicalein as confirmed by co-TLC with authentic samples. The purity of baicalin was more than 97% with yield ca. 8.7% (w/w). The method presented here appears Suitable for commercial application. (C) 2008 Elsevier B.V. All rights reserved.
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