Journal
JOURNAL OF CHILD NEUROLOGY
Volume 25, Issue 8, Pages 976-984Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073809356034
Keywords
frontal lobe; traumatic brain injury; diffusion tensor imaging; outcome; Glasgow Coma Scale; Glasgow Outcome Scale
Categories
Funding
- National Institutes of Health [NS021889]
- TIRR Foundation
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This study examined the use of diffusion tensor imaging in detecting white matter changes in the frontal lobes following pediatric traumatic brain injury. A total of 46 children (ages 8-16 years) with moderate to severe traumatic brain injury and 47 children with orthopedic injury underwent 1.5 Tesla magnetic resonance imaging (MRI) at 3 months postinjury. Conventional MRI studies were obtained along with diffusion tensor imaging. Diffusion tensor imaging metrics, including fractional anisotropy, apparent diffusion coefficient, and radial diffusivity, were compared between the groups. Significant group differences were identified, implicating frontal white matter alterations in the injury group that were predictive of later Glasgow Outcome Scale ratings; however, focal lesions were not related to the Glasgow Outcome Scale ratings. Injury severity was also significantly associated with diffusion tensor imaging metrics. Diffusion tensor imaging holds great promise as an index of white matter integrity in traumatic brain injury and as a potential biomarker reflective of outcome.
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