Article
Neurosciences
Xiaotong Yin, Yan Liu, Yang Guo, Limei Zhao, Guofei Li, Xiaoping Tan
Summary: The study found significant pharmacokinetic changes in newer antiepileptic drugs in women with epilepsy during pregnancy, highlighting the importance of therapeutic drug monitoring. It is recommended to monitor drug levels at least once per trimester and more frequently for women with poorly controlled seizures before pregnancy. Well-controlled seizures nine months before pregnancy can lower the risk of seizures during pregnancy, emphasizing the importance of pre-pregnancy counseling and seizure management.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Oscar Alcoreza, Sai Jagarlamudi, Andrew Savoia, Susan L. Campbell, Harald Sontheimer
Summary: This study demonstrates the in vivo efficacy of sulfasalazine (SAS) in reducing astrogliosis-mediated seizure burden in a mouse model. It suggests that targeting the astrocytic glutamate antiporter SXC could be a novel approach for treating epilepsy.
Review
Plant Sciences
Licia T. S. Pina, Adriana G. Guimaraes, Wagner B. da R. Santos, Marlange A. Oliveira, Thallita K. Rabelo, Mairim R. Serafini
Summary: This study reviewed 35 monoterpenes with anticonvulsive activity, which have the potential therapeutic effect on epilepsy by reducing seizure activity through targeting key pharmacological targets and reducing neuronal inflammation and oxidative stress caused by seizures. Monoterpenes may represent a promising alternative treatment option, but further research is needed to determine their mechanism of action and safety assessment.
Article
Behavioral Sciences
Avani C. Modi, Anup D. Patel, Constance A. Mara, Matthew Schmidt, Jeffrey R. Tenney, Jack Stevens
Summary: The objective of this study was to examine the feasibility, acceptability, and satisfaction of a social norms adherence intervention in adolescents with epilepsy. The results showed that the intervention had a modest effect on improving adherence, but a larger and adequately powered study is needed to detect significant effects. It is worth noting that the COVID-19 pandemic influenced adherence behaviors during the trial.
EPILEPSY & BEHAVIOR
(2023)
Article
Clinical Neurology
Frank J. E. Vajda, Terence J. O'Brien, Janet E. Graham, Alison A. Hitchcock, Cecilie M. Lander, Mervyn J. Eadie
Summary: During pregnancy, women with previously surgically treated epilepsy had poorer seizure control compared to those with only medically treated epilepsy. This contrasts with a previous study conducted in India on the same question.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Public, Environmental & Occupational Health
Ammar Abdulrahman Jairoun, Sabba Saleh Al-himyari, Moyad Shahwan, Nageeb Hassan, Saleh AL-Tamimi, Maimona Jairoun, Saed H. Zyoud, Abdullah S. Alshehri, Mustfa Faisal Alkhanani, Reem Hasaballah Alhasani, Adnan S. Alharbi, Fahad S. Alshehri, Ahmed M. Ashour, Nasser M. Alorfi
Summary: This study assessed the knowledge of UAE community pharmacists regarding women's issues in epilepsy. The findings revealed a good level of knowledge among community pharmacists, but certain clinical and demographic factors significantly influenced this knowledge. Targeted educational interventions can improve the knowledge and competence of community pharmacists in addressing women's issues in epilepsy.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Amanuel Amare
Summary: This study in Ethiopia focused on assessing the clinical presentation, cause, and treatment outcome of patients with HIV infection presenting with seizures. The majority of patients had late-stage HIV infection with low CD4 counts, recent onset seizures, and high case-fatality rates. The common causes of seizures were central nervous system opportunistic infections, highlighting the importance of early diagnosis and treatment to improve outcomes for HIV-infected patients presenting with seizures.
BMC INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Yadeta Babu Beyene, Fekede Bekele Daba, Kabaye Kumela Goro, Birbirsa Sefera Senbeta
Summary: This study aimed to assess the drug therapy problems and predicting factors among ambulatory epileptic patients at Jimma University Medical Center. The results showed that the majority of patients had drug therapy problems, with non-compliance, adverse drug reactions, and low dosage being the most common problems. Getting drugs by purchasing, poor involvement in therapeutic decision making, uncontrolled seizures, and taking multiple medications were identified as independent predictors of drug therapy problems.
Article
Medicine, General & Internal
Rod W. Hunt, Helen G. Liley, Deepika Wagh, Rachel Schembri, Katherine J. Lee, Andrew D. Shearman, Samantha Francis-Pester, Koert DeWaal, Jeanie Y. L. Cheong, Monika Olischar, Nadia Badawi, Flora Y. Wong, David A. Osborn, Victor Samuel Rajadurai, Peter A. Dargaville, Bevan Headley, Ian Wright, Paul B. Colditz
Summary: This randomized clinical trial aimed to determine whether active management of electrographic and clinical seizures in encephalopathic term or near-term neonates improved survival free of severe disability at 2 years compared with only treating clinically detected seizures. The study found that treating electrographic and clinical seizures with currently used anticonvulsants did not significantly reduce the rate of death or disability at 2 years in a heterogeneous group of neonates with seizures. Additionally, there was evidence that cognitive outcomes were worse in the group where both types of seizures were actively managed.
Article
Behavioral Sciences
Amber Askarieh, Ian Morrison, Kevin Ross, Colin McCowan, Keith Matthews, Brian Kidd, Craig A. Heath
Summary: Mortality rates and emergency healthcare service contact are significantly higher in epilepsy patients receiving opiate replacement therapy, who also show poor adherence to antiepileptic drugs and lack of engagement with outpatient services. Redesigning services to meet the needs of this high-risk population is necessary to reduce mortality and morbidity.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Zanfina Ademi, Clara Marquina, Piero Perucca, Alison Hitchcock, Janet Graham, Mervyn J. J. Eadie, Danny Liew, Terence J. J. O'Brien, Frank J. J. Vajda
Summary: The Raoul Wallenberg Australian Pregnancy Register (APR) has proven to be economically beneficial, with a significant return on investment and cost savings from both societal and health care perspectives. Over a 20-year time horizon, the APR has avoided 9,609 adverse pregnancy outcomes and reduced health care and societal costs by AUD 191 million and AUD 9.0 billion, respectively, making it a cost-effective program.
Article
Behavioral Sciences
Maria Paz Guerrero-Molina, Claudia Rodriguez-Lopez, Luisa Panades-de Oliveira, David Uriarte-Perez de Urabayen, Nicolas Garzo-Caldas, Cecilia E. Garcia-Cena, Rosa A. Saiz-Diaz, Julian Benito-Leon, Jesus Gonzalez de la Aleja
Summary: The study did not find significant differences in eye movement performance between patients with Genetic Generalized Epilepsy and Temporal Lobe Epilepsy, suggesting that the frontal cortical mechanisms responsible for these movements are not explicitly impaired in GGE patients.
EPILEPSY & BEHAVIOR
(2021)
Article
Veterinary Sciences
Abtin Mojarradi, Steven De Decker, Sofie Van Meervenne
Summary: Once-a-day administration of oral PB is safe and effective for controlling seizures in cats with idiopathic epilepsy.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Article
Agriculture, Dairy & Animal Science
Sylvia Garcia-Belenguer, Laura Grasa, Olga Valero, Jorge Palacio, Isabel Luno, Belen Rosado
Summary: The study found differences in gut microbiota composition between epileptic dogs and control dogs, with drug-naive epileptic dogs showing significantly reduced abundance of GABA and SCFAs-producing bacteria, as well as bacteria associated with reduced risk for brain disease. Furthermore, the administration of antiepileptic drugs for a month did not alter the gut microbiota composition. These results may contribute to understanding canine idiopathic epilepsy and offer potential for exploring probiotic intervention as a therapeutic approach.
Review
Pharmacology & Pharmacy
Sonali Kumar, Diksha Attrish, Arpna Srivastava, Jyotirmoy Banerjee, Manjari Tripathi, P. Sarat Chandra, Aparna Banerjee Dixit
Summary: The review explores the role of HDACs in epilepsy, focusing on their action on non-histone substrates and the potential of HDACi as anti-epileptic drugs. It also discusses the importance of identifying novel targets of HDACs for more effective anti-epileptogenic therapy.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
Article
Clinical Neurology
Alexandra D. Beier, Gemi E. Jannotta, E. Dayan Sandler, Harry S. Abram, Raj D. Sheth, Philipp R. Aldana
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2016)
Article
Clinical Neurology
Suprit C. Singh, Raj D. Sheth, James F. Burrows, Paul Rosen
PEDIATRIC NEUROLOGY
(2016)
Article
Clinical Neurology
Eric B. Geller, Tara L. Skarpaas, Robert E. Gross, Robert R. Goodman, Gregory L. Barkley, Carl W. Bazil, Michael J. Berg, Gregory K. Bergey, Sydney S. Cash, Andrew J. Cole, Robert B. Duckrow, Jonathan C. Edwards, Stephan Eisenschenk, James Fessler, Nathan B. Fountain, Alicia M. Goldman, Ryder P. Gwinn, Christianne Heck, Aamar Herekar, Lawrence J. Hirsch, Barbara C. Jobst, David King-Stephens, Douglas R. Labar, James W. Leiphart, W. Richard Marsh, Kimford J. Meador, Eli M. Mizrahi, Anthony M. Murro, Dileep R. Nair, Katherine H. Noe, Yong D. Park, Paul A. Rutecki, Vicenta Salanova, Raj D. Sheth, Donald C. Shields, Christopher Skidmore, Michael C. Smith, David C. Spencer, Shraddha Srinivasan, William Tatum, Paul C. Van Ness, David G. Vossler, Robert E. Wharen, Gregory A. Worrell, Daniel Yoshor, Richard S. Zimmerman, Kathy Cicora, Felice T. Sun, Martha J. Morrell
Article
Clinical Neurology
Barbara C. Jobst, Ritu Kapur, Gregory L. Barkley, Carl W. Bazil, Michel J. Berg, Gregory K. Bergey, Jane G. Boggs, Sydney S. Cash, Andrew J. Cole, Michael S. Duchowny, Robert B. Duckrow, Jonathan C. Edwards, Stephan Eisenschenk, A. James Fessler, Nathan B. Fountain, Eric B. Geller, Alica M. Goldman, Robert R. Goodman, Robert E. Gross, Ryder P. Gwinn, Christianne Heck, Aamr A. Herekar, Lawrence J. Hirsch, David King-Stephens, Douglas R. Labar, W. R. Marsh, Kimford J. Meador, Ian Miller, Eli M. Mizrahi, Anthony M. Murro, Dileep R. Nair, Katherine H. Noe, Piotr W. Olejniczak, Yong D. Park, Paul Rutecki, Vicenta Salanova, Raj D. Sheth, Christopher Skidmore, Michael C. Smith, David C. Spencer, Shraddha Srinivasan, William Tatum, Paul Van Ness, David G. Vossler, Robert E. Wharen, Gregory A. Worrell, Daniel Yoshor, Richard S. Zimmerman, Tara L. Skarpaas, Martha J. Morrell
Review
Clinical Neurology
Trevor Resnick, Raj D. Sheth
JOURNAL OF CHILD NEUROLOGY
(2017)
Article
Clinical Neurology
Emili Leary, Raj D. Sheth, Barry E. Gidal
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2018)
Article
Clinical Neurology
Natalie M. Walker, Daren C. Jackson, Kevin Dabbs, Jana E. Jones, David A. Hsu, Carl E. Stafstrom, Raj D. Sheth, Monica A. Koehn, Michael Seidenberg, Bruce P. Hermann
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2013)
Article
Behavioral Sciences
W. O. Tatum, R. D. Sheth
EPILEPSY & BEHAVIOR
(2012)
Article
Clinical Neurology
D. T. Pulsipher, K. Dabbs, V. Tuchsherer, R. D. Sheth, M. A. Koehn, B. P. Hermann, M. Seidenberg
Article
Clinical Neurology
Firas A. Taha, David N. Hammond, Raj D. Sheth
PEDIATRIC NEUROLOGY
(2013)
Article
Clinical Neurology
Alana Salvucci, Irisa M. Devine, David Hammond, Raj D. Sheth
PEDIATRIC NEUROLOGY
(2014)
Review
Clinical Neurology
Raj D. Sheth
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2019)
Letter
Clinical Neurology
Chethan K. Rao, Raj D. Sheth
PEDIATRIC NEUROLOGY
(2021)
Article
Clinical Neurology
Fernando N. Galan, Alexandra D. Beier, Raj D. Sheth
Summary: Epilepsy surgery is an underused but effective treatment modality for children with epilepsy. When considering surgery versus medication treatment, it is important to weigh the adverse effects of medication against the risks of surgery and nonefficacy. Detailed evaluation and algorithm creation can help in selecting the most appropriate treatment for patients with both generalized and focal epilepsy.
PEDIATRIC NEUROLOGY
(2021)
Article
Clinical Neurology
Amr A. Matoq, Adam S. Rappoport, Yiting Yang, Jessica O'Babatunde, Rubina Bakerywala, Raj D. Sheth
EPILEPSY & BEHAVIOR CASE REPORTS
(2015)
