Article
Medicine, Research & Experimental
Khadija Jalloh, Nicole Roeder, John Hamilton, Foteini Delis, Michael Hadjiargyrou, David Komatsu, Panayotis K. Thanos
Summary: This study examined the effects of chronic oral MP treatment on NMDA glutamate receptor binding in rat brain, finding that MP altered NMDA receptor expression throughout the brain and this effect was eliminated following cessation of treatment.
Article
Pediatrics
Youran Xu, Hsingwen Chung, Meng Shu, Yanfang Liu, Yongjing Zhang, Hong Qiu
Summary: This study aims to summarize and visualize the OROS-MPH titration patterns in children and adolescents with ADHD in the United States (US) and Japan. The study found that US patients had higher doses of OROS-MPH compared to Japanese patients, and a minority of patients in both countries underwent dose titration. Different titration patterns were observed between the two countries.
Article
Pharmacology & Pharmacy
Pere Fontova, Helena Colom, Raul Rigo-Bonnin, Oriol Bestard, Anna Vidal-Alabro, Lisanne N. van Merendonk, Gema Cerezo, Carolina Polo, Nuria Montero, Edoardo Melilli, Anna Manonelles, Maria Meneghini, Ana Coloma, Josep M. Cruzado, Joan Torras, Josep M. Grinyo, Nuria Lloberas
Summary: Tacrolimus is considered a key calcineurin inhibitor in transplantation, with the extended-release Meltdose formulation exhibiting superior bioavailability compared to the immediate-release formulation. This study aimed to compare the pharmacodynamic/pharmacokinetic profiles of Tac-IR and Tac-LCP and found that despite higher peak plasma concentrations after Tac-IR, it did not result in stronger inhibition of calcineurin activity compared to Tac-LCP. Tac-LCP demonstrated more sustained inhibition of calcineurin activity between dose intervals, suggesting potential improvement in the pharmacodynamics of Tacrolimus.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Muhammad Talha Saleem, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Kamran Ahmed, Fahad Siddiqui, Zafar Alam Mahmood, Muhammad Sikandar, Muhammad Suleman Imtiaz
Summary: This study focuses on the development of controlled-release tramadol HCl osmotic tablets using the SeDeM expert system and in-silico physiologically based pharmacokinetic (PBPK) modeling. The QbD approach was employed to guide the formulation of the osmotic drug delivery system. The optimized formulation showed satisfactory drug release and stability, and the in-silico PBPK modeling provided a comprehensive pharmacokinetic assessment of the formulation. SeDeM expert tool proved to be effective in evaluating the compression characteristics of excipients for direct compression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Min-Jun Baek, Hyeon-Jong Shin, Ju-Hwan Park, Jaehwan Kim, Il-Mo Kang, Jangik I. Lee, Dae-Duk Kim
Summary: In this study, a doxazosin-bentonite (DXBT) composite formulation for controlled oral delivery was prepared and characterized, and the pharmacokinetics of doxazosin in rats was evaluated. The DXBT composite showed pH-dependent controlled-release profiles, making it a potential oral drug delivery platform.
APPLIED CLAY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jong Hee Kim, Seung Hyun Song, Sang Hoon Joo, Gyu Hwan Park, Kwon-Yeon Weon
Summary: A gastroretentive in situ oral gel containing metformin hydrochloride was prepared using sodium alginate, calcium carbonate, and hydroxyethylcellulose. The optimal formulation was determined based on design of experiments, and the results showed delayed release of metformin hydrochloride without any unexpected interaction.
Article
Polymer Science
Divyambika Catakapatri Venugopal, Reshma Devi Senthilnathan, Saba Maanvizhi, Yasasve Madhavan, Sathasivasubramanian Sankarapandian, Vijayalakshmi Ramshankar, Mangathayaru Kalachaveedu
Summary: Silymarin-based mucoadhesive gel was developed for prolonged release in oral mucosa, and its physicochemical parameters and drug release performance were evaluated. The optimal formulation showed favorable results and demonstrated the ability to permeate through the oral mucosa.
Article
Multidisciplinary Sciences
Soo-Min Kim, Sung Eun Kim, Dong-Yun Lee, DooSeok Choi
Summary: The study evaluated serum estradiol levels in postmenopausal women using different doses and formulations of oral menopausal hormone therapy. It found that serum estradiol levels were not directly proportional to estrogen dose, with estradiol 2 mg showing significantly higher levels compared to estradiol 1 mg and conjugated estrogen 0.45 mg.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Margaret Danielle Weiss, Craig Surman, Atul Khullar, Judith Owens, Ellie He, Marc Cataldo, Graeme Donnelly
Summary: The study analyzed the impact of extended-release methylphenidate on sleep parameters in adolescents with attention-deficit/hyperactivity disorder. Results showed a trend of improvement in sleep quality with PRC-063 that was maintained over 6 months, with no significant differences reported in self-reported sleep outcomes between PRC-063 and placebo on the PSQI scale.
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2021)
Article
Veterinary Sciences
Sihem Bouriche, Angela Alonso-Garcia, Carlos M. Carceles-Rodriguez, Farouk Rezgui, Emilio Fernandez-Varon
Summary: Metformin-loaded PLA microparticles showed promising characteristics in terms of physicochemical properties and potential therapeutic benefits in rabbits, with improved pharmacokinetic profiles observed. However, the impact on bioavailability should be carefully considered for future dose and formulation design, especially before testing in other animal species in veterinary medicine.
BMC VETERINARY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Alireza Ghannad Sabzevari, Hossein Sabahi, Mohsen Nikbakht, Steven J. P. McInnes
Summary: An oral controlled-release formulation of epigallocatechin-3-gallate (EGCG) was developed by intercalating EGCG into mucoadhesive montmorillonite (Mt) nanolayers. The EGCG-loaded Mt showed sustained release of EGCG in a pH-dependent manner, making it a potential nanocarrier for oral administration of EGCG. The study provided valuable insights into the release mechanism and application of EGCG in oral drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jaehyeok Lee, Chul Haeng Lee, Jong-Geon Lee, So Yeon Jeon, Min-Koo Choi, Im-Sook Song
Summary: A pH-modified extended-release formulation of Ursodeoxycholate (UDCA) was developed, which improved the solubility and dissolution profile of UDCA. This formulation increased the oral bioavailability of UDCA in rats by 251%.
Article
Anesthesiology
Terhi J. Lohela, Satu Poikola, Mikko Neuvonen, Mikko Niemi, Janne T. Backman, Klaus T. Olkkola, Tuomas O. Lilius
Summary: Rifampin significantly reduces the concentrations of oral and intravenous hydromorphone by enhancing its first-pass and systemic metabolism, likely involving the induction of glucuronosyltransferase enzymes.
ANESTHESIA AND ANALGESIA
(2021)
Article
Pharmacology & Pharmacy
Asmaa H. Abdelhameed, Wael A. Abdelhafez, Kh I. Saleh, Ahmed Abdulhafez Hamad, Mohamed S. Mohamed
Summary: The aim of this study was to develop and evaluate Fexofenadine HCL nanosuspensions integrated into oral fast-dissolving films (OFDFs) to improve drug bioavailability. The optimized FEX-OFDF showed significantly increased oral bioavailability compared to commercially available tablets.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Clinical Neurology
Itsuki Terao, Asato Yokoi, Hirotaka Fukushima
Summary: This study used a dose-response model-based network meta-analysis to compare the efficacy of immediate-release (QTP-IR) and extended-release (QTP-ER) formulations of quetiapine for the acute treatment of schizophrenia. The results showed that QTP-IR may exhibit comparable peak responses and enhanced antipsychotic effects at lower doses compared to QTP-ER, but may be less effective at higher doses.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Patrick A. Ho, Theodore A. Stern, James K. Rustad
Article
Psychiatry
Julia C. Cromwell, Theodore A. Stern
Article
Psychiatry
Matthew J. Burke, Paulo Lizano, Claire Jacobs, Theodore A. Stern
Article
Psychiatry
Samuel I. Kohrman, James K. Rustad, Timur Suhail-Sindhu, Thomas A. Fortney, Dipak B. Ramkumar, Lance G. Warhold, Devendra Thakur, Christine T. Finn, Theodore A. Stern
Review
Psychiatry
Julia C. Cromwell, Daniel J. Daunis, Theodore A. Stern
Review
Psychiatry
Patrick A. Ho, Christina Girgis, James K. Rustad, Douglas Noordsy, Theodore A. Stern
Article
Psychiatry
Adrienne T. Gerken, David L. Beckmann, Theodore A. Stern
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2021)
Editorial Material
Education & Educational Research
James K. Rustad, Steven C. Schlozman, Justin Chen, Theodore A. Stern
ACADEMIC PSYCHIATRY
(2023)
Article
Psychology, Clinical
Leah B. Rosenberg, Anne K. Fishel, Rebecca Harley, Theodore A. Stern, Linda Emanuel, Jonah N. Cohen
Summary: Palliative medicine is a specialized and comprehensive care for patients facing life-limiting illnesses, which includes significant psychological aspects. This article aims to introduce the psychological aspects of palliative medicine to psychiatrists and psychotherapists through a case presentation and related discussion.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Psychiatry
Shixie Jiang, Richard Czuma, Alexis Cohen-Oram, Kimberly Hartney, Theodore A. Stern
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
(2021)
Article
Psychiatry
Shixie Jiang, Steven Gunther, Kimberly Hartney, Theodore A. Stern
Article
Psychiatry
Heather Burke, Shixie Jiang, Peggy Chatham, Theodore A. Stern
Article
Psychiatry
Debra A. Frost, Colleen K. Snydeman, Martin J. Lantieri, Janet Wozniak, Suzanne Bird, Theodore A. Stern
Article
Education & Educational Research
Hermioni Lokko Amonoo, Esteban A. Barreto, Theodore A. Stern, Karen Donelan
ACADEMIC PSYCHIATRY
(2019)
Article
Psychiatry
Jonathan R. Stevens, Theodore A. Stern
PSYCHIATRIC ANNALS
(2019)