Journal
NEURON
Volume 86, Issue 4, Pages 947-954Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.03.061
Keywords
-
Categories
Funding
- Dana Foundation
- NIH/NINDS [R01NS054734, R21NS088536]
- Roman Reed Fund
- NRSA predoctoral fellowship [F31NS074867]
- NRSA postdoctoral fellowship [F32NS056697]
Ask authors/readers for more resources
The complex morphology of axons presents a challenge in understanding axonal responses to injury and disease. By in vivo two-photon imaging of spinal dorsal column sensory axons, we systematically examined the effect of injury location relative to the main bifurcation point on axon degeneration and regeneration following highly localized laser injuries. Retrograde but not anterograde degeneration was strongly blocked at the bifurcation point at both the acute and subacute phases. Eliminating either the ascending or descending branch led to a poor regenerative response, while eliminating both led to a strong regenerative response. Thus, a surviving intact branch suppresses both retrograde degeneration and regeneration of the injured branch, thereby preserving the remaining axon architecture. Regenerating axons exhibited a dynamic pattern with alternating phases of regeneration and pruning over a chronic period. In vivo imaging continues to reveal new insights on axonal responses to injury in the mammalian spinal cord.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available