Article
Behavioral Sciences
Kanandra Taisa Bertoncello, Rodrigo Zanandrea, Carla Denise Bonan
Summary: Epilepsy affects patients' quality of life, and our study on zebrafish shows that PTZ exposure can lead to cognitive deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Medicine, General & Internal
Jonathan S. Calvert, Megan L. Gill, Margaux B. Linde, Daniel D. Veith, Andrew R. Thoreson, Cesar Lopez, Kendall H. Lee, Yury P. Gerasimenko, Victor R. Edgerton, Igor A. Lavrov, Kristin D. Zhao, Peter J. Grahn, Dimitry G. Sayenko
Summary: Transcutaneous and epidural spinal stimulation have shown promising results in restoring motor function in individuals with spinal cord injury, with differences observed in how different types of SCI patients respond to stimulation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study found that in individuals with clinically motor complete spinal cord injury, the extent of recovery of lower limb voluntary movements with scES is significantly influenced by the percentage of lumbosacral enlargement coverage by the electrode array and the position of the electrode relative to the lumbosacral enlargement and conus tip.
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study showed that in individuals with chronic spinal cord injury, there was a significant correlation between the coverage rate of lumbosacral enlargement by the electrode array and the position of the electrode, and the number of joints moved during voluntary lower limb movements. However, there was no significant correlation between the cross-section area of the spinal cord at C3 or the length of severe myelomalacia and the ability to move the lower limbs voluntarily.
Article
Engineering, Biomedical
Guangwei Mao, Zhijun Zhou, Hao Su, Yaozhong Chen, Jianjun Zhang, Chiyuan Zhang, Zhigong Wang, Xiaoying Lu
Summary: This paper proposes an ESCS system for animal experimental study, which provides a fully implantable and programmable stimulating system for complete SCI rat model, along with a wireless charging power solution. The system consists of an implantable pulse generator (IPG), a stimulating electrode, an external charging module, and an Android application (APP) via a smartphone. The results of the animal experiment show that the stimulating system can work stably in SCI rats, effectively activating the lower limb muscles and providing an effective tool for studying the ESCS application in motor function recovery.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Antonietta Canna, Lauri J. Lehto, Lin Wu, Sheng Sang, Hanne Laakso, Jun Ma, Pavel Filip, Yuan Zhang, Olli Grohn, Fabrizio Esposito, Clark C. Chen, Igor Lavrov, Shalom Michaeli, Silvia Mangia
Summary: ESCS is widely used for chronic pain treatment and restoring motor function after spinal cord injury, but current protocols have limited specificity and efficiency due to the limited number of leads and lack of flexibility in spatial distribution.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanne Laakso, Lauri J. Lehto, Jaakko Paasonen, Raimo Salo, Antonietta Canna, Igor Lavrov, Shalom Michaeli, Olli Grohn, Silvia Mangia
Summary: This study introduced a multi-band sweep imaging with Fourier transformation technique for spinal cord fMRI in rats during SCS, which showed high tolerance to electrode and motion-induced artifacts. The results demonstrated that MB-SWIFT had higher imaging sensitivity compared to spin echo fMRI, and could detect stimulation frequency-dependent responses to SCS.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
John F. Burke, Nikhita Kunwar, Maria S. Yaroshinsky, Kenneth H. Louie, Prasad Shirvalkar, Paul Su, Melanie Henry, George Pasvankas, Lawrence Poree, Lines Jacques, Doris D. Wang
Summary: This study introduces a novel method for recording electrophysiological activity from the human spinal cord during voluntary movement control. The research demonstrates the safety and feasibility of performing epidural spinal recordings from human subjects during movement tasks.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Sachin Kandhari, Dewaker Sharma, Sachin Samuel, Gaurav Sharma, Pritam Majumdar, V. Reggie Edgerton, Parag Gad
Summary: This study aims to explore the impact of activity-based neurorehabilitation and epidural spinal stimulation on the simultaneous recovery of sensorimotor and autonomic functions in patients with complete motor paralysis due to spinal cord injury. The results demonstrate that within just 2 months of intense neurorehabilitation, multiple organ systems can quantifiably improve, with patients undergoing sub-motor threshold stimulation for self-training. The study also confirms the feasibility of conducting these procedures in a traditional neurorehabilitation clinical setting using off-the-shelf equipment.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Review
Critical Care Medicine
Nadine M. Mansour, Isabela Pena Pino, David Freeman, Kailey Carrabre, Shivani Venkatesh, David Darrow, Uzma Samadani, Ann M. Parr
Summary: Epidural spinal cord stimulation has shown potential as a therapy for chronic spinal cord injury, uncovering residual pathways within the damaged spine. The majority of studies have reported positive outcomes in terms of improving motor function and restoring autonomic function. However, further research is needed to determine which patients benefit the most from this intervention.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Medicine, General & Internal
Ashraf S. Gorgey, Jan J. Gouda
Summary: This study reports the experimental results of the use of percutaneous spinal cord epidural stimulation to restore trunk control and standing ability in individuals with complete paraplegia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Soshi Samejima, Rita Hanna, Brinda K. Cariappa, Rene Arvizu, Surabhi Nimbalkar, Rhea Montgomery-Walsh, Sandra L. Galindo, Richard Henderson, Abed Khorasani, Chet T. Moritz, Sam Kassegne
Summary: There is increasing evidence that electrical stimulation delivered via spinal neural interfaces using carbon-based neural arrays can improve functional recovery after spinal cord injury. In this study, a novel cervical epidural implant with carbon-based surface electrodes was designed, fabricated, and characterized in vivo. The array demonstrated biomechanical compatibility and stable performance for at least four weeks in a rat model of spinal cord injury. These findings highlight the potential of carbon-based electrodes as a spinal neural interface for both mechanistic research and functional restoration in animal models of spinal cord injury.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Ursula S. Hofstoetter, Ivan Perret, Aymeric Bayart, Peter Lackner, Heinrich Binder, Brigitta Freundl, Karen Minassian
Summary: Epidural electrical stimulation is used as an emergent strategy for neurological recovery of lower-extremity motor function. By linking electromyographic data to a population model of the spinal cord, researchers identified a relationship between segmental stimulation sites and activated spinal cord segments. Statistically analyzing the data also revealed the impact of different upper motoneuron disorders on the evoked responses.
Article
Engineering, Biomedical
Thomas Guiho, Stuart N. Baker, Andrew Jackson
Summary: The study found that ventral epidural SCS elicits movements more easily than dorsal sites, which require higher current intensities and are attenuated throughout the training process. Dorsal epidural SCS and transcutaneous SCS were effective at facilitating supraspinal-evoked responses, especially at intermediate stimulation frequencies.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Medicine, Research & Experimental
Aysegul Danis, Yasemin Baranoglu Kilinc, Ibrahim Ethem Torun, Fatma Hanci, Erkan Kilinc, Handan Ankarali
Summary: This study investigated the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and pro-inflammatory biomarkers in two seizure models in rats. The results showed that 10 mg/kg esculetin displayed anticonvulsant effects, improved cognitive impairment, and decreased pro-inflammatory biomarkers levels. Esculetin may be a promising agent for the treatment of epilepsy due to its anticonvulsant and anti-neuroinflammatory effects.
Article
Engineering, Biomedical
Ali Asghar Zarei, Armita Faghani Jadidi, Eugen Romulus Lontis, Winnie Jensen
Summary: TENS has been reported to alleviate pain by cortical inhibition, and high-frequency TENS intervention significantly suppresses cortical activity and reduces the intensity and area size of perceived sensations.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Review
Veterinary Sciences
Suzan Meijs, Martin Schmelz, Sigal Meilin, Winnie Jensen
Summary: The authors reviewed and compared available pig models in pain research, as well as different pain assessment methods used in pigs and humans. Despite the overlap in assessment methodologies, further development is needed for objective pain assessment methods in both species.
Article
Chemistry, Analytical
Felipe Rettore Andreis, Benjamin Metcalfe, Taha Al Muhammadee Janjua, Winnie Jensen, Suzan Meijs, Thomas Gomes Norgaard dos Santos Nielsen
Summary: The VSR technique can improve the classification of neural traffic and enhance the performance of neural prostheses and bioelectronic medicine applications.
Article
Neurosciences
Taha Al Muhammadee Janjua, Thomas Gomes Norgaard dos Santos Nielsen, Felipe Rettore Andreis, Suzan Meijs, Winnie Jensen
Summary: This study successfully utilized Danish Landrace pigs as subjects for the LTP-like pain model, demonstrating the impact of HFS on the cortical response in S1. The results indicate that this pain model can be effectively implemented in pigs.
IBRO NEUROSCIENCE REPORTS
(2021)
Article
Engineering, Biomedical
Ali Asghar Zarei, Winnie Jensen, Armita Faghani Jadidi, Eugen Romulus Lontis, S. Farokh Atashzar
Summary: This study investigated the effect of high-frequency TENS on functional brain network connectivity and corresponding topographical changes. The results showed that the FC between the primary somatosensory cortex and the anterior cingulate cortex, as well as the FC between the somatosensory cortex and the medial prefrontal cortex, significantly increased in the gamma-band after TENS intervention. Significant changes in global and local characteristics of functional brain connectivity in the gamma-band were also observed using graph theory.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Armita Faghani Jadidi, Andrew James Thomas Stevenson, Ali Asghar Zarei, Winnie Jensen, Romulus Lontis
Summary: Transcutaneous electrical nerve stimulation (TENS) has been reported to effectively alleviate chronic pain, including phantom limb pain (PLP). The study focuses on the effects of modulated TENS patterns on corticospinal and motor cortex activity, and finds that these patterns can enhance excitability and increase the volume of the motor cortical map.
Article
Chemistry, Multidisciplinary
Pier Nicola Sergi, Winnie Jensen, Ken Yoshida
Summary: This study investigated the changes in the tip shape of microneedles after insertion into peripheral nerves. The interaction between peripheral nerves and tungsten microneedles was quantified using the Oliver-Pharr formula, and it was found that the interaction force was directly proportional to the power of the normalized indentation depth. Experimental correlations between insertion force and the opening tip angle were described, and the minimum diameter for effective puncture of peripheral nervous tissue was assessed. A computational framework was also presented to describe the local changes affecting the microneedles' tip shape.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Biomedical
Armita Faghani Jadidi, Winnie Jensen, Ali Asghar Zarei, Eugen Romulus Lontis
Summary: Conventional TENS has been used for chronic pain relief, including PLP. However, there is increasing interest in alternative temporal stimulation patterns such as PWM. This study investigated the cortical modulation by PWM TENS for the first time and compared it to conventional TENS. The results suggest that PWM TENS may be a potential therapeutic intervention for PLP reduction.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Anatomy & Morphology
Felipe Rettore Andreis, Benjamin Metcalfe, Taha Al Muhammadee Janjua, Valeria Paula Sassoli Fazan, Winnie Jensen, Suzan Meijs, Thomas Gomes Norgaard dos Santos Nielsen
Summary: This study investigated the morphological characteristics of the Ulnar Nerve (UN) in pigs and found that the proximal segment of the UN had a larger diameter and a higher number of fascicles compared to the distal segment and the dorsal cutaneous branch (DCBUN). Additionally, the mean fascicle diameter was smaller at the DCBUN compared to the other segments.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2023)
Article
Neurosciences
Armita Faghani Jadidi, Winnie Jensen, Ali Asghar Zarei, Eugen Romulus Lontis, S. Farokh Atashzar
Summary: By recording cortical activity using EEG from 12 healthy subjects, this study investigated the effects of PWM TENS on cortical network connectivity. The results showed that PWM TENS had better pain-alleviating effects compared to conventional TENS, supporting its potential as a therapeutic intervention in clinical research.
FRONTIERS IN NEUROSCIENCE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Taha Al Muhammadee Janjua, Thomas Gomes Norgaard dos Santos Nielsen, Felipe Rettore Andreis, Suzan Meijs, Winnie Jensen
Summary: This study investigated changes in the spike activity in the primary somatosensory cortex of Danish landrace pigs in response to LTP-like neuroplasticity induced by high-frequency electrical stimulation. The results showed a significant increase in cortical excitability after intervention, highlighting the potential for developing a translational, large-animal model of LTP-like pain.
2023 11TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, NER
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Suzan Meijs, Carsten Reidies Bjarkam, Felipe Rettore Andreis, Winnie Jensen
Summary: We developed a method to record spinal neuron activity in pigs and found that most activity was recorded at the C7 level. The response of the neurons differed based on the depth of the neural signal, opening new possibilities for studying pain and other spinal mechanisms.
2023 11TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, NER
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Felipe Rettore Andreis, Benjamin Metcalfe, Taha Al Muhammadee Janjua, Valeria Paula Sassoli Fazan, Winnie Jensen, Suzan Meijs, Thomas Gomes Norgaard dos Santos Nielsen
Summary: This study measured the perineurium thickness in the ulnar nerve of pigs and found that the thickness was influenced by the location of the nerve section. Equations were provided to estimate the perineurium thickness based on the fascicle diameter, which can be used to develop more realistic peripheral nerve models and improve the selectivity and reliability of neural interfaces.
2023 11TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, NER
(2023)
Article
Clinical Neurology
Felipe Rettore Andreis, Carsten Dahl Morch, Winnie Jensen, Suzan Meijs
Summary: This study evaluated the reliability of measuring the mechanical nociceptive threshold (MNT) in the forelimb of pigs using a pressure algometer. The results showed that the relative reliability between sessions was 0.71 and within-session was 0.45. The absolute reliability (SEM and CV) was assessed to be 19.1%, with an average SEM of 249.5 kPa. These findings support the use of the pressure algometer as a valuable tool to investigate the nociceptive system in pigs.
FRONTIERS IN PAIN RESEARCH
(2023)
Article
Neurosciences
L. E. D. Lykholt, C. D. Morch, W. Jensen
Summary: This study aimed to investigate the possibility of distinguishing between non-noxious and noxious cortical responses with two different types of anesthesia. The results showed that it was possible to differentiate between different levels of stimulation intensities based on specific features in one type of anesthesia.
