Article
Clinical Neurology
Mette Scheller Nissen, Maren Synnove Orvik, Anna Christine Nilsson, Matias Ryding, Magnus Lydolph, Morten Blaabjerg
Summary: The incidence of NMDARE in Denmark is 0.17/100,000 persons per year and has been increasing since 2009. Older patients with underlying malignancies or post-HSE NMDARE tend to have poorer outcomes. Maintenance therapy did not reduce the relapse rate in NMDARE patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Environmental Sciences
Kelig Mahe, Claire Gentil, Blandine Brisset, Hugues Evano, Camille Lepetit, Romane Boymond-Morales, Solene Telliez, Antoine Dussuel, Tevamie Rungassamy, Romain Elleboode, Kirsteen MacKenzie, David Roos
Summary: The study highlights the vulnerability of groupers in Reunion Island due to increasing fishing pressure. By examining five main exploited grouper species, valuable data on reproduction, growth, and species management has been provided.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Infectious Diseases
Mathys Carras, Olivier Maillard, Julien Cousty, Patrick Gerardin, Malik Boukerrou, Loic Raffray, Patrick Mavingui, Patrice Poubeau, Andre Cabie, Antoine Bertolotti
Summary: This study aimed to identify the factors associated with severe dengue during the 2019 epidemic. The results showed that delayed time to hospital consultation, history of cardiovascular disease, and Western European origin were risk factors associated with severe dengue fever.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Multidisciplinary Sciences
Chunyan Su, Kaiyun Ding, Jingwen Xu, Jianchao Wu, Jiansheng Liu, Jiayuan Shen, Hongning Zhou, Hongqi Liu
Summary: This study established a convenient and sensitive double-reporter CHIKV pseudovirus system for screening anti-CHIKV drugs and evaluating vaccines against CHIKV, providing a new tool for research on CHIKV virus.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Laura Krogh Herlin, Kristoffer Skaalum Hansen, Jacob Bodilsen, Lykke Larsen, Christian Brandt, Christian Ostergaard Andersen, Birgitte Ronde Hansen, Hans Rudolf Luttichau, Jannik Helweg-Larsen, Lothar Wiese, Merete Storgaard, Henrik Nielsen, Trine H. Mogensen
Summary: Varicella zoster virus (VZV) encephalitis primarily affects elderly or immunocompromised patients, with a higher incidence than previously estimated. Delayed diagnosis and treatment are common. Risk factors for unfavorable outcomes include age, cerebral vasculitis, and GCS <15.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Ameya Patwardhan, Atchayaram Nalini, Priyanka Priyadarshini Baishya, Karthik Kulanthaivelu, Haripriya Krishnareddy, Debayan Dutta, Tanushree Chawla, Ravindranadh Mundlamuri Chowdary, Ravi Yadav, Seena Vengalil
Summary: This case report describes a 45-year-old male patient with a rare neurological complication following Chikungunya virus infection, showing unusual MRI findings. The patient showed improvement after treatment with plasmapheresis and steroids, but some symptoms persisted. Early recognition and prompt immunomodulatory treatment may be beneficial in such cases.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Public, Environmental & Occupational Health
Khin S. A. Myint, Arthur H. P. Mawuntu, Sotianingsih Haryanto, Darma Imran, Sofiati Dian, Yora P. Dewi, Ahmad R. Ganiem, Riane Anggreani, Mirna M. Iskandar, Janno B. B. Bernadus, Kartika Maharani, David Susanto, Riwanti Estiasari, Hasna Dewi, Amanda Kristiani, Lidia Gaghiwu, Edison Johar, Frilasita A. Yudhaputri, Ungke Antonjaya, Jeremy P. Ledermann, Reinout van Crevel, Raph L. Hamers, Ann M. Powers
Summary: Chikungunya virus (CHIKV), although rarely considered, can cause neurological manifestations in endemic areas. This study identified four cases of CHIKV-associated neurological disease in Indonesia, highlighting the need to consider CHIKV as a cause of neurologic disease in these regions, especially during outbreaks.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Angelique E. Boutzoukas, Daniel A. Freedman, Christine Koterba, Garrett W. Hunt, Kathy Mack, Jennifer Cass, Vedat O. Yildiz, Emily de los Reyes, Jaime Twanow, Melissa G. Chung, Christopher P. Ouellette
Summary: La Crosse virus (LACV) is the most common neuroinvasive arboviral infection in children in the United States, but there is limited data on predictors of disease severity and neurologic outcomes. This study found that altered mental status and seizures at presentation were independent predictors of severe disease, and epileptiform discharges on electroencephalogram were associated with long-term epilepsy diagnosis. Long-term neurobehavioral issues were also found to be frequent among children with LACV-ND.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Umberto Palatini, Niccolo Alfano, Rebeca Lejarazu Carballar, Xiao-Guang Chen, Helene Delatte, Mariangela Bonizzoni
Summary: Mosquitoes' nonretroviral endogenous viral elements (nrEVEs) have recently been described as a new form of heritable, sequence-specific mechanism of antiviral immunity. In this study, we used bioinformatics and molecular approaches to identify and characterize viral integrations in wild collected Aedes albopictus mosquitoes. We found that the landscape of viral integrations is dynamic and not correlated with the virome. However, our results confirmed an interaction between nrEVEs and the piRNA and siRNA pathways in mosquitoes.
Article
Multidisciplinary Sciences
Satoshi Ikegame, Takao Hashiguchi, Chuan-Tien Hung, Kristina Dobrindt, Kristen J. Brennand, Makoto Takeda, Benhur Lee
Summary: Measles virus (MeV) is resurgent and can establish chronic latent infections in the brain, leading to fatal conditions like SSPE or MIBE. Mutations in the F gene may result in hyperfusogenic phenotypes, allowing for efficient spread in neurons, but how these mutants are selected and their advantage in neuronal spread remains unclear. Screening of MeV-F mutants has identified hyperfusogenic mutations, providing a valuable resource for future studies on MeV neuropathogenesis and paramyxovirus F regulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
K. Lamy, A. Tran, T. Portafaix, M. D. Leroux, T. Baldet
Summary: This study investigates the impact of climate change on Ae. albopictus abundance and finds that temperature and precipitation significantly influence its abundance. Decreasing precipitation in low-elevation areas leads to a reduction in Ae. albopictus abundance, while in mid and high-elevation areas, the decrease in precipitation is counterbalanced by significant warming, resulting in increased abundance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Norah Anthony, Lea Bruneau, Sebastien Leruste, Jean-Marc Franco, Alain Domercq, Christine Kowalczyk, Estelle Nobecourt, C. Marimoutou
Summary: This study aims to identify factors associated with incident type 2 diabetes mellitus in subjects with pre-diabetes diagnosed in primary care. The study is based on an observational, non-randomised prospective cohort design, with follow-up by general practitioners and collection of data. The results will be disseminated through various channels.
Article
Geosciences, Multidisciplinary
Zacharie Duputel, Valerie Ferrazzini, Olivier Lengline, Laurent Michon, Fabrice R. Fontaine, Frederick Massin
Summary: The island of La Reunion is comprised of two main shield volcanoes, with a wide variety of seismic events observed including tectonic events and volcano-tectonic earthquakes. The seismicity on the island illuminates different levels of its volcanic plumbing system, with earthquakes clustered at different depths beneath the volcanoes. Major events such as the collapse of the summit caldera of Piton de la Fournaise in 2007 have been observed, along with ongoing seismic activity under the oceanic crust.
COMPTES RENDUS GEOSCIENCE
(2021)
Article
Environmental Sciences
Emanuela Valerio, Claudio De Luca, Riccardo Lanari, Mariarosaria Manzo, Maurizio Battaglia
Summary: This study uses DInSAR measurements to investigate the ground displacements during the eruption of Piton de la Fournaise volcano in 2019. The results reveal the presence of five volcanic sources that correlate well with the location of the fissures, seismic activity, and known geophysical evidence.
Article
Virology
Sakshi Chaudhary, Jaspreet Jain, Ramesh Kumar, Jatin Shrinet, Scott C. Weaver, Albert J. Auguste, Sujatha Sunil
Summary: This study utilized genome sequencing and phylogenetic analysis to investigate the evolutionary dynamics of the Chikungunya virus (CHIKV) since its reintroduction into India in 2005. Results showed evidence of frequent reintroduction of the virus into India and that the most recent CHIKV outbreak shares a common ancestor as recently as 2006.
Article
Immunology
Caroline Charlier, Elsa Kermorvant-Duchemin, Elodie Perrodeau, Alexandra Moura, Mylene M. Maury, Helene Bracq-Dieye, Pierre Thouvenot, Guillaume Vales, Alexandre Leclercq, Philippe Ravaud, Marc Lecuit
Summary: This study investigated the characteristics of neonatal listeriosis and found that maternal antimicrobial treatment before delivery is associated with a decrease in the severity of neonatal presentation.
CLINICAL INFECTIOUS DISEASES
(2022)
Letter
Infectious Diseases
Baptiste Hoellinger, Celestine Simand, Katy Jeannot, Carlos Garijo, Mircea Cristinar, Fanny Reisz, Francois Danion, Axel Ursenbach, Nicolas Lefebvre, Pierre Boyer, Yves Hansmann, Antoine Studer, Frederic Schramm, Yvon Ruch
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Obstetrics & Gynecology
Bertrand Gachon, Oceane Clergue, Xavier Fritel, Fabrice Pierre, Antoine Nordez
Summary: This study aimed to assess the reliability of shear wave elastography in evaluating the elastic properties of the external anal sphincter in term pregnant women. The results showed that shear wave elastography is a reliable tool for this assessment.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Immunology
Carla Palacios-Gorba, Alexandra Moura, Yuval Markovich, Nathalie Tessaud-Rita, Angel Gomez-Martin, Helene Bracq-Dieye, Jesus Gomis, Guillaume Vales, Maria Pastor-Martin, Pierre Thouvenot, Carles Escrig, Alexandre Leclercq, Marc Lecuit, Juan J. Quereda
Summary: Two species of pathogenic Listeria, L. monocytogenes and L. ivanovii, can asymptomatically colonize udders and tonsils of ruminants without fecal shedding. Their whole-genome sequences contain known core virulence and antibiotic resistance genes. This study highlights the importance of udders and tonsils as intra-host sites of Listeria colonization.
MICROBES AND INFECTION
(2023)
Article
Multidisciplinary Sciences
Richard Wheeler, Paulo Andre Dias Bastos, Olivier Disson, Aline Rifflet, Ilana Gabanyi, Julia Spielbauer, Marion Berard, Marc Lecuit, Ivo Gomperts Boneca
Summary: Peptidoglycan, the major component of bacterial cell walls, plays a crucial role in affecting physiological and behavioral changes in mammalian hosts. However, the mechanism and regulation of its translocation from the gut to host tissues have not been fully understood. This study investigated the absorption and dissemination of peptidoglycan across the intestine. The results showed that peptidoglycan has a preference for certain host organs, particularly the brain, when absorbed through the gut. The translocation of peptidoglycan is an active process regulated by the microbiota-induced parasympathetic pathway through muscarinic acetylcholine receptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, General & Internal
Susie De Gracia, Brigitte Fatton, Michel Cosson, Sandrine Campagne-Loiseau, Philippe Ferry, Jean-Philippe Lucot, Philippe Debodinance, Laure Panel, Xavier Deffieux, Olivier Garbin, Gery Lamblin, Caroline Carlier-Guerin, Rajeev Ramanah, Arnaud Fauconnier, Chris Serrand, Xavier Fritel, Renaud de Tayrac
Summary: This study evaluated the rates of serious complications and reoperation for recurrence following sacrospinous ligament fixation (SSLF) for apical pelvic organ prolapse. The results showed that SSLF is an effective and safe surgical treatment, with comparable safety profiles for different surgical approaches and materials. However, the anterior approach and the use of mesh were associated with a lower risk of reoperation for recurrence compared with the posterior approach and the use of native tissue.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Infectious Diseases
Baptiste Hoellinger, Francois Danion, Yves Hansmann, Frederic Schramm, Yvon Ruch
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Cyrille Huchon, Hocine Drioueche, Martin Koskas, Aubert Agostini, Estelle Bauville, Nicolas Bourdel, Herve Fernandez, Xavier Fritel, Olivier Graesslin, Guillaume Legendre, Jean-Philippe Lucot, Pierre Panel, Cyril Raiffort, Geraldine Giraudet, Laurence Bussieres, Arnaud Fauconnier
Summary: A randomized controlled trial of 574 patients with incomplete spontaneous abortion compared surgical management by hysteroscopy and vacuum aspiration in patients intending to conceive again. The results showed no difference in subsequent births or safety profile between the two methods. However, hysteroscopy had longer surgery duration and hospitalization time.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Xavier Fritel, Marion Ravit, Anne-Cecile Pizzoferrato, Sandrine Campagne-Loiseau, Georges Bader, Perrine Capmas, Michel Cosson, Philippe Debodinance, Xavier Deffieux, Herve Fernandez, Philippe Ferry, Olivier Garbin, Bernard Jacquetin, Guillaume Legendre, Christian Saussine, Renaud de Tayrac, Laurent Wagner, Jean-Philippe Lucot, Arnaud Fauconnier, PROSPERE Team
Summary: Women's preoperative hopes and fears before cystocele repair were examined and compared to those anticipated by surgeons. Data from the PROSPERE trial were analyzed, and it was found that women's expectations were reasonable and consistent with the scientific literature. Surgeons' expectations were found to be similar to those of the majority of women. This analysis highlights the importance of considering individual women's expectations before pelvic-floor repair.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Anne-Cecile Pizzoferrato, Caroline Thuillier, Aurelien Venara, Nicole Bornsztein, Sylvain Bouquet, Martine Cornillet-Bernard, Odile Cotelle, Florence Cour, Sophie Cretinon, Pia De Reilhac, Jerome Loriau, Francoise Pellet, Melanie Cayrac, Marie-Aimee Perrouin-Verben, Anne-Gaeurolle Pourcelot, Christine Revel-Delhom, Benoit Steenstrup, Thomas Vogel, Loic Le Normand, Xavier Fritel
Summary: When evaluating a patient with symptoms of pelvic organ prolapse (POP), it is important to assess the symptoms, their impact on daily life, and rule out other pelvic pathologies. The diagnosis of POP is clinical, but additional exams may be requested to explore symptoms associated with the observed prolapse. Non-surgical treatment options such as pelvic floor muscle training and pessaries are recommended as first-line therapy. Surgery should be considered if conservative options do not meet the patient's expectations and the symptoms are significant. The choice of surgical approach depends on the type and extent of prolapse as well as the patient's individual characteristics.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
A. C. Pizzoferrato, A. R. Briant, C. Le Grand, L. Gaichies, R. Fauvet, A. Fauconnier, X. Fritel
Summary: This systematic review found that primiparous women who have urinary incontinence (UI) before delivery have a higher risk of postpartum UI after vaginal delivery compared to cesarean section. The effect of cesarean section in preventing postpartum UI appears to be controversial, especially in women with prenatal UI.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2023)
Article
Microbiology
Peiqi Yin, Bennett J. Davenport, Judy J. Wan, Arthur S. Kim, Michael S. Diamond, Brian C. Ware, Karen Tong, Therese Couderc, Marc Lecuit, Jonathan R. Lai, Thomas E. Morrison, Margaret Kielian
Summary: The Chikungunya virus (CHIKV) forms long intercellular extensions that connect infected and neighboring cells, facilitating efficient transmission of the virus. These extensions are critical for CHIKV transmission, which occurs through endocytosis and endosomal acidification, rather than the CHIKV receptor MXRA8. In vivo experiments demonstrate that neutralizing antibodies are unable to block infection when the virus is transferred through infected cells. This study suggests that the contact sites of the intercellular extensions shield CHIKV from neutralizing antibodies, promoting efficient virus transmission both in vitro and in vivo.
NATURE MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Miguel Garcia-de la Virgen, Inmaculada Lopez-Almela, Alexandra Moura, Sergio Vazquez, Sara Perez-Montagud, Alexandre Leclercq, Marc Lecuit, Juan J. Quereda
Summary: This report describes a case of Listeria monocytogenes-associated mesenteric lymphadenitis in a cat, highlighting the importance of this syndrome for veterinary clinicians and microbiologists in terms of health and food safety for animals and humans.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Frouin Arthur, Fabien Laporte, Hafner Lukas, Maury Mylene, Marc Lecuit, Chikhi Rayan, Hugues Aschard
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Obstetrics & Gynecology
C. Mathelin, E. Barranger, M. Boisserie-Lacroix, G. Boutet, S. Brousse, N. Chabbert-Buffet, C. Coutant, E. Darai, Y. Delpech, M. Duraes, M. Espie, F. Golfier, A. S. Hamy, E. Kermarrec, V Lavoue, M. Lodi, E. Luporsi, C. Maugard, S. Moliere, J-Y Seror, N. Taris, C. Uzan, C. Vaysse, X. Fritel
Summary: The Commission of Senology of the College National des Gynecologues Obstetriciens Francais conducted an updated review of the international literature on risk reducing mastectomies in non-genetic context and developed recommendations on the techniques to be chosen and their implementation.
GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE
(2022)