Article
Biochemistry & Molecular Biology
Stanislav Rodkin, Valentina Dzreyan, Mikhail Bibov, Alexey Ermakov, Tatyana Derezina, Evgeniya Kirichenko
Summary: Peripheral-nerve injury can cause disability, and there is currently a lack of clinically effective neuroprotectors. This study investigated the role of NO-dependent expression of p53 in the death of neurons and glial cells following axotomy. The results showed that axotomy led to redistribution of p53 in neurons, and the application of a NO donor increased p53 levels in nuclei and cytoplasm of neurons, as well as karyoplasm of glial cells. In contrast, inhibition of iNOS had a neuroprotective effect. These findings suggest that the NO-dependent expression of p53 may play a signaling mechanism in neural and glial cell death after axotomy.
Review
Biochemistry & Molecular Biology
Wenshuo Xie, Nianhong Xing, Jicheng Qu, Dongwu Liu, Qiuxiang Pang
Summary: This review summarizes the structure, isoforms, and physiological role of CAPON, as well as its relationship with heart diseases, diabetes, psychiatric disorders, and tumors. The C-terminal PDZ-binding motif of CAPON plays a regulatory role in nitric oxide production and neuronal development. Clarifying the future research directions on the signal pathways related to CAPON will facilitate the study of its regulatory mechanism and provide new ideas for treating human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jeeyoung Lee, Soumyadeep Dey, Praveen K. Rajvanshi, Randall K. Merling, Ruifeng Teng, Heather M. Rogers, Constance T. Noguchi
Summary: Erythropoietin (EPO) is produced in the kidney in response to hypoxia and is essential for red blood cell production. In addition to its role in erythropoiesis, EPO also increases the production of nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) in non-erythroid tissue, which improves oxygen delivery. This study found that during erythroid differentiation, EPO induces neuronal nitric oxide synthase (nNOS) and that nNOS is required for a normal erythropoietic response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kundan Solanki, Sajjan Rajpoot, Evgeny E. Bezsonov, Alexander N. Orekhov, Rohit Saluja, Anita Wary, Cassondra Axen, Kishore Wary, Mirza S. Baig
Summary: This article discusses the importance of nitric oxide synthases 1 (NOS1) and its byproduct nitric oxide (NO) in different tissues and diseases, highlighting the significance of understanding NOS1-derived NO signaling and identification of NO-metabolites for disease diagnosis and prognosis.
Article
Biochemistry & Molecular Biology
Ming-Jie Hou, Pan Wang, Bao Ting Zhu
Summary: In this study, it was found that protein disulfide isomerase (PDI)-mediated neuronal nitric oxide synthase (nNOS) activation plays a critical role in chemically-induced ferroptosis, which is characterized by the accumulation of nitric oxide (NO), reactive oxygen species (ROS), and lipid-ROS. Inhibition or knockdown of PDI can effectively prevent ferroptotic cell death.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Peripheral Vascular Disease
Jie Zhang, Ximing Wang, Yu Cui, Shan Jiang, Jin Wei, Jenna Chan, Anish Thalakola, Thanh Le, Lan Xu, Liang Zhao, Lei Wang, Kun Jiang, Feng Cheng, Trushar Patel, Jacentha Buggs, Volker Vallon, Ruisheng Liu
Summary: This study investigates the mechanism of hypertension in patients with diabetes and suggests that in early diabetes, upregulation of NOS1 in the macula densa plays a role in inhibiting TGF and increasing glomerular filtration rate, which helps in maintaining normal blood pressure.
Article
Biochemistry & Molecular Biology
Huayu Zheng, John M. Weaver, Changjian Feng
Summary: The study found that Hsp90 alpha can significantly increase superoxide generation from nNOS mu and nNOS alpha proteins under L-Arg-depleted conditions, and has varying effects on superoxide production by these two nNOS splice variants.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Kevin O'Gallagher, Francesca Puledda, Owen O'Daly, Matthew Ryan, Luke Dancy, Philip J. Chowienczyk, Fernando Zelaya, Peter J. Goadsby, Ajay M. Shah
Summary: This study reveals the fundamental physiological role of nNOS in regulating cerebral blood flow and functional connectivity in the human hippocampus.
CARDIOVASCULAR RESEARCH
(2022)
Article
Clinical Neurology
Keiichiro Matsuda, Mika Sasaki, Hiroshi Baba, Yoshinori Kamiya
Summary: Dexamethasone supplementation to local anesthetics prolongs the analgesic effect by inhibiting the activity of neuronal NOS, and p-p38 MAPK may not be involved.
Article
Nutrition & Dietetics
Ping Wang, Fan-Zhi Kong, Xiao-Hong Hong, Li Zhang, Wan-Hong Zhao, Jin-Cui Yang, Heng Zhang
Summary: A high shortening diet may contribute to obesity and depressive behaviors, which are regulated by neuronal nitric oxide synthase (nNOS).
Article
Cardiac & Cardiovascular Systems
Somy Yoon, Mira Kim, Hangyeol Lee, Gaeun Kang, Kenneth Bedi, Kenneth B. Margulies, Rajan Jain, Kwang-Il Nam, Hyun Kook, Gwang Hyeon Eom
Summary: The study reveals that neuronal nitric oxide synthase induces diastolic dysfunction by S-nitrosylation of HDAC2, suggesting a new therapeutic platform for refractory heart failure with preserved ejection fraction.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Arjun Pendharkar, Daniel Smerin, Lorenzo Gonzalez, Eric H. Wang, Sabrina Levy, Stephanie Wang, Shunsuke Ishizaka, Masaki Ito, Haruto Uchino, Terrance Chiang, Michelle Y. Cheng, Gary K. Steinberg
Summary: Post-stroke optogenetic stimulation and systemic nNOS inhibition both lead to functional improvements after stroke, suggesting a potentially maladaptive role of nNOS in post-stroke recovery.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Anatomy & Morphology
Li Chen, Jing Qin, Chun Cheng, Shuqiong Niu, Yonghua Liu, Shuxian Shi, Hai'Ou Liu, Aiguo Shen
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2008)
Article
Engineering, Biomedical
Kang Zhou, Shuqiong Niu, Giacomo Bianchi, Xufeng Wei, Narayana Garimella, Bartley P. Griffith, Zhongjun J. Wu
Article
Biochemistry & Molecular Biology
Datong Zheng, Shuqiong Niu, Dan Yu, Xiaoguo H. Zhan, Xianchun Zeng, Bota Cui, Yanping Chen, Jennifer Yoon, Stuart S. Martin, Xiang Lu, Xi Zhan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2010)
Article
Biochemistry & Molecular Biology
Shuqiong Niu, Min Fei, Chun Cheng, Meijuan Yan, Shangfeng Gao, Mengling Chen, Haibo Wang, Xin Li, Xiaowei Yu, Ji Qian, Jing Qin, Jian Zhao, Jianxin Gu, Aiguo Shen
JOURNAL OF CHEMICAL NEUROANATOMY
(2008)
Article
Cardiac & Cardiovascular Systems
Xufeng Wei, Tieluo Li, Shuying Li, Ho Sung Son, Pablo Sanchez, Shuqiong Niu, A. Claire Watkins, Christopher DeFilippi, Robert Jarvik, Zhongjun J. Wu, Bartley P. Griffith
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2013)
Article
Biochemistry & Molecular Biology
Shangfeng Gao, Chun Cheng, Han Zhao, Mengling Chen, Xin Li, Shuxian Shi, Shuqlong Niu, Jing Qin, Mudan Lu, Aiguo Shen
NEUROCHEMISTRY INTERNATIONAL
(2008)
Article
Clinical Neurology
Aiguo Shen, Shangfeng Gao, Zhiyun Ben, Haibo Wang, Junxia Jia, Tao Tao, Shugiong Niu, Xin Li, Chun Cheng
NEUROLOGICAL SCIENCES
(2008)
Article
Multidisciplinary Sciences
Dan Yu, Xiaoguo H. Zhan, Shuqiong Niu, Irina Mikhailenko, Dudley K. Strickland, Jianwei Zhu, Meng Cao, Xi Zhan
Article
Cell Biology
Meng-Ling Chen, Chun Cheng, Qing-Shan Lv, Zhi-Qin Guo, Ying Gao, Shang-Feng Gao, Xin Li, Shu-Qiong Niu, Shu-Xian Shi, Ai-Guo Shen
JOURNAL OF MOLECULAR HISTOLOGY
(2008)
Article
Cell Biology
Ji Qian, Chun Cheng, Haiou Liu, Jianping Chen, Meijuan Yan, Shuqiong Niu, Jing Qin, Linlin Sun, Lei Liu, Jianxin Gu, Aiguo Shen
Article
Biochemistry & Molecular Biology
Chun Cheng, Mengling Chen, Shuxian Shi, Shangfeng Gao, Shuqiong Niu, Xin Li, Haiou Liu, Yongwei Qin, Aiguo Shen
JOURNAL OF MOLECULAR NEUROSCIENCE
(2007)
Article
Biochemistry & Molecular Biology
Mengling Chen, Chun Cheng, Meijuan Yan, Shuqiong Niu, Shangfeng Gao, Shuxian Shi, Haiou Liu, Yongwei Qin, Aiguo Shen
JOURNAL OF MOLECULAR NEUROSCIENCE
(2008)