Review
Biotechnology & Applied Microbiology
Jiayan Wang, Tianyou Wang, Mei Fang, Zexu Wang, Wei Xu, Bang Teng, Qijuan Yuan, Xin Hu
Summary: This review comprehensively discusses the pathology, available therapeutic drugs, and nanotechnology applied in treating intracerebral hemorrhage (ICH), aiming to provide novel and efficient strategies for ICH therapy in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Immunology
Siqi Xia, Yonghe Zheng, Feng Yan, Gao Chen
Summary: Intracerebral hemorrhage is the most common subtype of hemorrhagic stroke, with neuroinflammation being closely related to secondary brain injury and functional recovery. MicroRNAs have been found to play crucial roles in regulating the pathophysiological process of ICH, offering potential new directions for therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eva Giralt-Steinhauer, Joan Jimenez-Balado, Isabel Fernandez-Perez, Lucia Rey Alvarez, Ana Rodriguez-Campello, Angel Ois, Elisa Cuadrado-Godia, Jordi Jimenez-Conde, Jaume Roquer
Summary: This review summarizes the advances in genetics and epigenetics of intracerebral hemorrhage (ICH), shedding light on the understanding of ICH pathophysiology and the potential for developing therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Zelong Zheng, Qi Wang, Shujie Sun, Jinbiao Luo
Summary: Spontaneous intracerebral hemorrhage is one of the most devastating types of stroke, with high mortality and morbidity. The optimal management of this condition remains controversial, and conventional surgical interventions and medical management have shown limited benefit. However, minimally invasive surgery for intracerebral hemorrhage has shown promising results in early phase clinical trials.
FRONTIERS IN NEUROLOGY
(2022)
Article
Optics
Pengfei Liu, Hongyu Chen, Meijun Pang, Xiuyun Liu, Jiwei Wang, Xiao-Dong Zhang, Dong Ming
Summary: Airy light-sheet microscopy is gaining importance for imaging intact biological specimens due to its rapid speed, high resolution, and wide field nature. However, the depth of field of the detection objective imposes limitations on the modulation transfer function of the light sheet, affecting the size of the field of view. An optimized phase modulation model based on 'Airy-like' beam family and a planar 'Airy-like' light-sheet by two-photon excitation have been developed to improve resolution and widen the field of view, with potential applications in precise screening of drugs related to cerebral hemorrhage.
Review
Clinical Neurology
Zhe Li, Suliman Khan, Yang Liu, Ruixue Wei, V. Wee Yong, Mengzhou Xue
Summary: Stroke is the second leading cause of death worldwide, and intracerebral hemorrhage (ICH) is a type of stroke associated with poor neurological outcomes and high mortality. Experimental therapies have shown potential in improving functional outcomes for ICH patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Andreas Charidimou, Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
Summary: The study found that hematoma expansion is common in patients with unclear symptom onset of intracerebral hemorrhage and independently associated with worse outcome. These findings suggest that patients with unclear symptom onset may benefit from clinical trials of medical treatments targeting hematoma expansion.
Article
Biochemistry & Molecular Biology
Ekaterina Vasilevskaya, Aleksandr Makarenko, Galina Tolmacheva, Irina Chernukha, Anastasiya Kibitkina, Liliya Fedulova
Summary: The study conducted a comprehensive short-term study on the development of cerebrovascular disorders in rats with an intracerebral hematoma model. The overall lethality of the model was 43.7% and it reflects the main diagnostic criteria for acute disorders of cerebral circulation.
Article
Neurosciences
Jiawen Li, Dong Luo, Feifei Peng, Qi Kong, Huawei Liu, Meiyuan Chen, Lusha Tong, Feng Gao
Summary: The novel ANAID-ICH nomogram, incorporating age, NIHSS score, anemia, infratentorial location, presence of DWILs, and prior ICH, may facilitate the identification of patients at higher risk for an unfavorable outcome.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Medicine, General & Internal
Luca Marino, Rafael Badenes, Federico Bilotta
Summary: This systematic review presents clinical evidence on the association of heart rate variability with outcome prediction in intracerebral and subarachnoid hemorrhages. The literature search led to the retrieval of 19 significant studies. Heart rate variability was consistently associated with poor functional outcome and mortality, while controversial results were found regarding the association between heart rate variability and secondary brain injury and cardiovascular complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Junjie Zhang, Xianwei Su, Ao Qi, Lulu Liu, Lijian Zhang, Yu Zhong, Simin Xu, Ximei Liu, Juan Hu, Yusen Chen, Chun-yang Zhang, Chun Cai
Summary: The study developed a targeted metabolomic method to identify potential biomarkers for differentiating healthy individuals, AIS patients, and ICH patients, with 20-OH-LTB4 and CYP4F2 identified as potential biomarkers for ICH diagnosis and risk assessment. The method may provide a powerful platform for ICH diagnosis, prevention, and treatment assessment.
Article
Nanoscience & Nanotechnology
Fang Zhu, Liu Zi, Peng Yang, Yang Wei, Rui Zhong, Yan Wang, Chao You, Yiwen Li, Meng Tian, Zhipeng Gu
Summary: Novel dual-functional macromolecular nanoscavengers designed in this study can efficiently remove iron and ROS, reducing cell death caused by iron overload. This provides a new direction for improving therapeutic strategies for ICH.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Clinical Neurology
Yasser B. Abulhasan, Jeanne Teitelbaum, Khalsa Al-Ramadhani, Kathryn T. Morrison, Mark R. Angle
Summary: Despite aggressive treatment, patient outcomes after spontaneous intracerebral hemorrhage (ICH) remain poor. Unfavorable outcomes appear to be related to the direct effects of the primary injury rather than therapeutic nihilism. Lifesaving surgery for supratentorial lesions delayed mortality but did not alter functional outcomes.
Article
Clinical Neurology
Ronda Lun, Vignan Yogendrakumar, Greg Walker, Michel Shamy, Robert Fahed, Adnan Qureshi, Dar Dowlatshahi
Summary: The study validates revised definitions of hematoma expansion incorporating intraventricular hemorrhage expansion for predicting poor outcome, outperforming conventional definitions even after accounting for care limitations.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Ellis S. van Etten, Kanishk Kaushik, Wilmar M. T. Jolink, Emma A. Koemans, Merel S. Ekker, Ingeborg Rasing, Sabine Voigt, Floris H. B. M. Schreuder, Suzanne C. Cannegieter, Gabriel J. E. Rinkel, Willem M. Lijfering, Catharina J. M. Klijn, Marieke J. H. Wermer
Summary: This study identifies several trigger factors, such as caffeine consumption, lifting weights, sexual activity, and Valsalva maneuvers, that increase the risk of spontaneous intracerebral hemorrhage (ICH). These findings provide new insights into the pathophysiology of vessel rupture resulting in ICH.
Article
Emergency Medicine
Debbie Y. Madhok, Paul H. Mangasarian, Kevin J. Keenan, J. Claude Hemphill, John F. Brown, Anthony S. Kim
Summary: This study evaluated EMS activation to computed tomography and EMS activation to thrombolysis times for acute stroke in San Francisco, with findings showing that the Mission Protocol achieved treatment times approximately 15 minutes slower than Mobile Stroke Units.
PREHOSPITAL AND DISASTER MEDICINE
(2021)
Article
Medicine, General & Internal
Benjamin L. Brett, Mark D. Kramer, John Whyte, Michael A. McCrea, Murray B. Stein, Joseph T. Giacino, Mark Sherer, Amy J. Markowitz, Geoffrey T. Manley, Lindsay D. Nelson
Summary: This study identified four distinct neurobehavioral phenotypes in patients with TBI two weeks after injury, which significantly improved estimation of association with 6-month outcomes when added to demographic characteristics and other injury characteristics in models. These distinct phenotypes may assist in clinical decision-making and patient selection for clinical trials.
Article
Critical Care Medicine
Omer Doron, J. Claude Hemphill, Geoffrey Manley, Guy Rosenthal
Summary: The study found that treatment with mannitol significantly improved the PE ratio and led to a more effective reduction in ICP compared to before mannitol treatment. The combination of mannitol and CSF drainage resulted in a substantial decrease in ICP, with 77% of cases achieving an ICP below 20 mm Hg.
NEUROCRITICAL CARE
(2022)
Editorial Material
Critical Care Medicine
J. Claude Hemphill
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Kevin N. Sheth, Christopher D. Anderson, Alessandro Biffi, Nomazulu Dlamini, Guido J. Falcone, Christine K. Fox, Heather J. Fullerton, Steven M. Greenberg, J. Claude Hemphill, Anthony Kim, Helen Kim, Nerissa U. Ko, Jarod L. Roland, Lauren H. Sansing, Susanne J. van Veluw, Jonathan Rosand
Editorial Material
Clinical Neurology
Adeline L. Goss, J. Claude Hemphill, Romergryko G. Geocadin
ANNALS OF NEUROLOGY
(2022)
Review
Clinical Neurology
Christopher R. Green, J. Claude Hemphill
Summary: This article reviews the association between hypertension and stroke, discusses current guidelines for early blood pressure management, and highlights the need for further trials to determine the effects of blood pressure control in specific patient populations.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Clinical Neurology
Stefania Dallagiacoma, Chiara Robba, Francesca Graziano, Paola Rebora, J. Claude Hemphill, Stefania Galimberti, Giuseppe Citerio
Summary: This study analyzed the practice of ICP monitoring in patients with spontaneous ICH and found that ICP monitoring was associated with in-hospital and 6-month mortality reduction, but did not improve 6-month functional outcomes. Further research and randomized controlled trials are needed to provide higher-level medical evidence for guidelines on ICP use and treatment in patients with ICH.
Article
Clinical Neurology
Steven M. Greenberg, Wendy C. Ziai, Charlotte Cordonnier, Dar Dowlatshahi, Brandon Francis, Joshua N. Goldstein, J. Claude Hemphill, Ronda Johnson, Kiffon M. Keigher, William J. Mack, J. Mocco, Eileena J. Newton, Ilana M. Ruff, Lauren H. Sansing, Sam Schulman, Magdy H. Selim, Kevin N. Sheth, Nikola Sprigg, Katharina S. Sunnerhagen
Editorial Material
Medicine, General & Internal
J. Claude Hemphill, Wendy Ziai
Article
Anesthesiology
Sajeev A. Mahendran, Oliver Flower, J. Claude Hemphill
Summary: Head imaging is crucial for managing acute neurological emergencies involving the brain. Among various modalities, CT is the most widely used technique due to its availability and ease of implementation in critically ill patients. CT is particularly useful in identifying acute intracranial hemorrhage, while newer CT sequences can help in identifying early ischemia. Intensivists should be familiar with the advantages and limitations of head CT imaging and consider other modalities as needed.
MINERVA ANESTESIOLOGICA
(2022)
Article
Clinical Neurology
DaiWai M. Olson, J. Claude Hemphill, J. Javier Provencio, Paul Vespa, Shraddha Mainali, Len Polizzotto, Keri S. Kim, Molly McNett, Wendy Ziai, Jose Suarez
Summary: The recovery from coma is a crucial issue in patients with acute brain injuries, but there are still gaps in the scientific understanding of coma, resulting in inaccurate prognosis and limited interventions. However, recent studies have begun to uncover the mechanisms of consciousness after acute brain injuries and some pilot interventions have been tested. To promote scientific collaboration and advance research, education, and advocacy, the Neurocritical Care Society launched the Curing Coma Campaign in 2019.
SEMINARS IN NEUROLOGY
(2022)
Article
Clinical Neurology
E. Calabrese, S. Gandhi, J. Shih, M. Otero, D. Randazzo, C. Hemphill, R. Huie, J. F. Talbott, E. Amorim
Summary: This study retrospectively analyzed diffusion-weighted MR imaging data from 81 comatose patients following cardiac arrest, and found that those with poor outcome exhibited more severe brain injury, lower average whole-brain apparent diffusion coefficient (ADC), and larger volumes of tissue with ADC below a certain threshold. Voxelwise analysis revealed lower ADC in specific brain regions, while ROI-based principal component analysis showed an association between lower ADC in parieto-occipital regions and poor outcome.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Critical Care Medicine
Sung-Min Cho, Chiara Robba, Michael N. Diringer, Daniel F. Hanley, J. Claude Hemphill, Janneke Horn, Ariane Lewis, Sarah L. Livesay, David Menon, Tarek Sharshar, Robert D. Stevens, James Torner, Paul M. Vespa, Wendy C. Ziai, Marcus Spann, Raimund Helbok, Jose Suarez
Summary: To address the lack of knowledge regarding clinical trial design for patients with disorders of consciousness (DoC), a research group conducted a gap analysis and proposed optimal clinical trial designs for DoC studies.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Kevin J. Keenan, Wade S. Smith, Sara B. Cole, Christine Martin, J. Claude Hemphill, Debbie Y. Madhok
Summary: This study evaluates the prevalence of stroke and validates the predictive values of large vessel occlusion (LVO) stroke prediction scales. The findings demonstrate that multiple scales provide high negative predictive values, but are associated with a high rate of false positives.
BMJ NEUROLOGY OPEN
(2022)