Article
Immunology
Aaron M. Gusdon, Carol B. Thompson, Kendel Quirk, Yunis M. Mayasi, Radhika Avadhani, Issam A. Awad, Daniel F. Hanley, Wendy C. Ziai
Summary: The study found that in patients with ICH and IVH, treatment with alteplase compared to saline resulted in significantly enhanced inflammatory response in CSF leukocyte subtypes. Increased serum lymphocytes may be associated with better outcomes, while increased neutrophil-to-lymphocyte ratio (NLR) may be associated with worse outcomes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, General & Internal
Te-Chang Wu, Yan-Lin Liu, Jeon-Hor Chen, Yang Zhang, Tai-Yuan Chen, Ching-Chung Ko, Min-Ying Su
Summary: In this study, radiomics analysis was used to predict hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (sICH) and investigate the impact of intraventricular hemorrhage (IVH). The results showed that the radiomics model improved the accuracy of HE prediction and was associated with poor clinical outcomes.
Article
Biochemistry & Molecular Biology
Wendy C. Ziai, Adrian R. Parry-Jones, Carol B. Thompson, Lauren H. Sansing, Michael T. Mullen, Santosh B. Murthy, Andrew Mould, Saman Nekoovaght-Tak, Daniel F. Hanley
Summary: The study investigated the expression of inflammatory cytokines in cerebrospinal fluid and their relationship with disease severity in patients with acute IVH. Results showed that some inflammatory cytokine levels peaked earlier in IVH patients, with positive correlations with IVH and ICH volumes. Time trends of cytokines support the association of cerebral inflammatory responses with the severity of ICH/IVH.
Article
Cardiac & Cardiovascular Systems
Wen-Song Yang, Shu-Qiang Zhang, Yi-Qing Shen, Xiao Wei, Li-Bo Zhao, Xiong-Fei Xie, Lan Deng, Xin-Hui Li, Xin-Ni Lv, Fa-Jin Lv, Dar Dowlatshahi, Qi Li, Peng Xie
Summary: The study revealed that NCCT markers are independently associated with IVH growth and RHE, with the expansion-prone hematoma showing higher predictive accuracy. These findings can aid in risk stratification based on NCCT markers for predicting active bleeding.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Yue Gong, Yifei Wang, Du Chen, Feng Xu, Peng Yang
Summary: This study found that hyperglycemia is associated with increased mortality and hematoma expansion in patients with intracerebral hemorrhage. The hyperglycemic group had higher rates of hematoma expansion and larger hematoma volumes compared to the normoglycemic group. Multivariate logistic analysis showed that blood glucose is an independent predictor of hematoma expansion.
Article
Medicine, General & Internal
Jens Witsch, David J. Roh, Radhika Avadhani, Alexander E. Merkler, Hooman Kamel, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study found that intraventricular alteplase use in patients with a large IVH was associated with a small reduction in parenchymal ICH volume, but this association did not translate into improved functional outcomes or mortality. Therefore, intraventricular thrombolysis should be examined in patients with moderate to large ICH with IVH, especially in a thalamic location.
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Andreas Charidimou, Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
Summary: The study found that hematoma expansion is common in patients with unclear symptom onset of intracerebral hemorrhage and independently associated with worse outcome. These findings suggest that patients with unclear symptom onset may benefit from clinical trials of medical treatments targeting hematoma expansion.
Article
Clinical Neurology
Chuanying Wang, Wenjuan Wang, Guangshuo Li, Anxin Wang, Xiaoli Zhang, Yunyun Xiong, Xingquan Zhao
Summary: The study found that glycemic gap is associated with poor outcomes in patients with spontaneous intracerebral hemorrhage. Patients with higher glycemic gap are more likely to have poor clinical outcomes and higher 1-year mortality rate. Adding glycemic gap to intracerebral hemorrhage score improves the accuracy of predicting poor clinical outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biology
Jin Pyeong Jeon, Sung Woo Han, Tae Yeon Kim, Seung Hyuk Lim, Dong Hyuk Youn, Jong Kook Rhim, Jeong Jin Park, Jun Hyong Ahn, Heung Cheol Kim, Jinseo Yang
Summary: The study found that patients with Hp2-2 phenotype had a higher likelihood of developing perihematomal edema compared to those with Hp1-1. Additionally, higher relative alpha 1 intensities were closely associated with perihematomal edema in patients with Hp2-1.
Article
Hematology
Hau C. Kwaan
Summary: Spontaneous intracerebral hemorrhage is a nontraumatic bleeding into the brain, with risk factors including age, gender, ethnicity, and hypertension. Factors like hematoma location, volume, and extension impact the prognosis. Better understanding of risk factors and prevention measures can improve outcomes.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Medicine, General & Internal
Chao-Chun Yang, Ming-Hsue Lee, Kuo-Tai Chen, Martin Hsiu-Chu Lin, Ping-Jui Tsai, Jen-Tsung Yang
Summary: This study investigated the predicting factors for in-hospital outcomes of patients with spontaneous supratentorial intracerebral hemorrhage (ICH) and found that larger initial hematoma and concurrent in-hospital infection were statistically related to higher mortality, while in-hospital infection and surgery were correlated with a longer length of stay. Additionally, poor change in activity of daily living (ADL) was associated with larger initial ICH, in-hospital concurrent infection, and lack of rehabilitation training program.
Article
Clinical Neurology
Yujian Li, Huiqing Zhou, Xiang Yang, Jun Zheng, Fan Zhang, Mangmang Xu, Hao Li
Summary: This study found that neck circumference is an independent predictor of 180-day functional outcome in ICH patients, and can predict poor functional outcome at 6 months.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Zelong Zheng, Qi Wang, Shujie Sun, Jinbiao Luo
Summary: Spontaneous intracerebral hemorrhage is one of the most devastating types of stroke, with high mortality and morbidity. The optimal management of this condition remains controversial, and conventional surgical interventions and medical management have shown limited benefit. However, minimally invasive surgery for intracerebral hemorrhage has shown promising results in early phase clinical trials.
FRONTIERS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Sung-Ho Ahn, Jeong-Ho Hong, Glenda L. Torres, Jude P. Savarraj, Chang Hyeun Kim, Young Ha Kim, Arthur L. Day, H. Alex Choi, James C. Grotta, Kiwon Lee, Tiffany R. Chang
Summary: In this study, the relationship between the spot sign, intraventricular hemorrhage (IVH), and hematoma characteristics in patients with spontaneous intracerebral hemorrhage (ICH) was examined. The spot sign was associated with greater hematoma volume, decreased white blood cell count, and prolonged activated partial thromboplastin time. IVH was associated with greater hematoma volume and nonlobar location of hematoma. Furthermore, the spot sign was found to be a greater risk factor for adverse outcomes compared to IVH.
NEUROCRITICAL CARE
(2022)
Article
Medicine, General & Internal
Taek Min Nam, Ji Hwan Jang, Seung Hwan Kim, Kyu Hong Kim, Young Zoon Kim
Summary: This study found that spontaneous thalamic hemorrhage patients with intraventricular hemorrhage have higher mortality rates and lower rates of good functional recovery. Additionally, treatment involving external ventricular drainage may lead to a higher incidence of delayed normal pressure hydrocephalus in these patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Letter
Cardiac & Cardiovascular Systems
Jens Witsch, Saad A. Mir, Neal S. Parikh, Santosh B. Murthy, Hooman Kamel, Babak B. Navi, Alan Z. Segal, Matthew E. Fink, Stephanie B. Rutrick, Monika M. Safford, Nupoor Narula, Parag Goyal, Mario Gaudino, Leonard N. Girardi, Richard B. Devereux, Mary J. Roman, Cenai Zhang, Alexander E. Merkler
Article
Multidisciplinary Sciences
Mercy H. Mazurek, Bradley A. Cahn, Matthew M. Yuen, Anjali M. Prabhat, Isha R. Chavva, Jill T. Shah, Anna L. Crawford, E. Brian Welch, Jonathan Rothberg, Laura Sacolick, Michael Poole, Charles Wira, Charles C. Matouk, Adrienne Ward, Nona Timario, Audrey Leasure, Rachel Beekman, Teng J. Peng, Jens Witsch, Joseph P. Antonios, Guido J. Falcone, Kevin T. Gobeske, Nils Petersen, Joseph Schindler, Lauren Sansing, Emily J. Gilmore, David Y. Hwang, Jennifer A. Kim, Ajay Malhotra, Gordon Sze, Matthew S. Rosen, W. Taylor Kimberly, Kevin N. Sheth
Summary: The authors presented a portable low-field MRI device for accurate detection of intracerebral hemorrhage, which provides a new approach for intracerebral hemorrhage detection. The results showed that low-field pMRI can match conventional imaging and is correlated with quantified outcomes and clinical prognosis.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Jens Witsch, David J. Roh, Radhika Avadhani, Alexander E. Merkler, Hooman Kamel, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study found that intraventricular alteplase use in patients with a large IVH was associated with a small reduction in parenchymal ICH volume, but this association did not translate into improved functional outcomes or mortality. Therefore, intraventricular thrombolysis should be examined in patients with moderate to large ICH with IVH, especially in a thalamic location.
Article
Clinical Neurology
Lindsey R. Kuohn, Jens Witsch, Thorsten Steiner, Kevin N. Sheth, Hooman Kamel, Babak B. Navi, Alexander E. Merkler, Santosh B. Murthy, Stephan A. Mayer
Summary: This study examined the relationship between different locations (deep versus lobar) of intracerebral hemorrhage (ICH) and early neurological deterioration, hematoma expansion (HE), and outcome. The results showed that lobar ICH location was associated with more common HE and early neurological deterioration, while deep ICH location was associated with smaller hematoma size. However, after adjusting for prognostic variables, deep ICH was associated with worse outcome.
Meeting Abstract
Clinical Neurology
Jens Witsch, David J. Roh, Stephanie E. Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E. Kasner, Stephan A. Mayer, Santosh B. Murthy
Meeting Abstract
Clinical Neurology
Jens Witsch, Yunshi Luo, Kelly L. Sloane, Aaron Rothstein, Jae W. Song, Christopher G. Favilla, Brett L. Cucchiara, Scott E. Kasner, Steven R. Messe, Huimahn A. Choi, Stephan A. Mayer, Quy Cao, Aaron M. Gusdon
Meeting Abstract
Clinical Neurology
Yu Sakai, Quy Cao, Pouyan Pasyar, Peter B. Noel, Jens Witsch, Scott E. Kasner, Brett L. Cucchiara, Jae W. Song
Article
Geriatrics & Gerontology
Aaron Rothstein, Yian Zhang, Anthony Q. Briggs, Mark A. Bernard, Yongzhao Shao, Christopher Favilla, Kelly Sloane, Jens Witsch, Arjun V. Masurkar
Summary: In this study, the impact of white matter hyperintensities (WMH) on subjective cognitive decline (SCD) was investigated. The results showed that moderate-to-severe WMH was associated with worse cognitive performance and higher SCD burden in executive and memory domains.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Jens Witsch, David Roh, Stephanie Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E. Kasner, Stephan A. Mayer, Santosh B. Murthy
Summary: Neutrophil-mediated inflammation exacerbates intracerebral hemorrhage (ICH) outcomes. This study aimed to investigate the association between serum levels of sICAM-1 and poor outcomes after ICH. After adjustment, sICAM-1 was found to be associated with mortality, poor outcome, and hematoma expansion.
Letter
Clinical Neurology
Jens Witsch, Stephanie B. Rutrick, Kelsey N. Lansdale, Alison Seitz, Hooman Kamel, Neal S. Parikh, Alan Z. Segal, Saad A. Mir, Santosh B. Murthy, Sumit N. Niogi, Mario Gaudino, Leonard N. Girardi, Jiwon Kim, Richard B. Devereux, Mary J. Roman, Costantino Iadecola, Scott E. Kasner, Cenai Zhang, Alexander E. Merkler
Article
Cardiac & Cardiovascular Systems
Kelly L. Sloane, Scott E. Kasner, Christopher G. Favilla, Aaron Rothstein, Jens Witsch, Roy H. Hamilton, Andrea L. C. Schneider
Summary: This study investigates the roles of optimism and depression in stroke recovery and finds that patients who are optimistic and without depression have the best recovery, while patients who lack optimism and have depression have the slowest recovery.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jens Witsch, Scott E. Kasner
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Sahily Reyes-Esteves, Monisha Kumar, Scott E. Kasner, Jens Witsch
Summary: Prognostication of neurological clinical outcomes after acute brain injury is crucial for discussions with patients and families, treatment planning, and resource allocation. However, the lack of standardized approaches in the development and validation of clinical grading scales makes it challenging for clinicians to rely on and integrate them into clinical practice.
SEMINARS IN NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
Jens Witsch, Valerie Spalart, Kimberly Martinod, Hauke Schneider, Joachim Oertel, Juergen Geisel, Sina Hemmer, Philipp Hendrix
ANNALS OF NEUROLOGY
(2022)
Review
Clinical Neurology
Jens Witsch, Bob Siegerink, Christian H. Nolte, Maximilian Spruegel, Thorsten Steiner, Matthias Endres, Hagen B. Huttner
Summary: Currently available prognostic scores for ICH lack essential quality standards, necessitating the development of novel prognostic scores to inform research study design and enhance clinical care.
NEUROLOGICAL RESEARCH AND PRACTICE
(2021)