Article
Clinical Neurology
Ana Marques, Daniel Roquet, Elie Matar, Natasha Louise Taylor, Bruno Pereira, Claire O'Callaghan, Simon J. G. Lewis
Summary: Research compared brain alterations in the reward system between idiopathic REM sleep behavior disorder (iRBD) patients, healthy controls, and PD patients, finding differences in volumetric and functional connectivity characteristics, particularly in relation to hypersexuality. The presence of impulse control disorders (ICDs) correlated with altered functional connectivity within the reward system.
JOURNAL OF NEUROLOGY
(2021)
Review
Neurosciences
Andrea Augustine, Catharine A. Winstanley, Vaishnav Krishnan
Summary: Parkinson's disease patients are not only affected by motor impairments, but also at risk for impulse control disorders. There is currently a lack of consensus on the best approach to addressing these symptoms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
S. Jesus, M. T. Perinan, C. Cortes, D. Buiza-Rueda, D. Macias-Garcia, A. Adarmes, L. Munoz-Delgado, M. a. Labrador-Espinosa, C. Tejera-Parrado, M. P. Gomez-Garre, P. Mir
Summary: Impulse control disorders are common in patients with Parkinson's disease, with 25.1% of cases experiencing them. Younger patients with higher rates of anxiety are more likely to have ICDs. Genetic studies suggest that polymorphisms in the DDC gene may modulate the risk of ICDs in PD, with genotype data increasing predictability by 11%.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Psychiatry
Jun-Fang Zhang, Xi-Xi Wang, Ya Feng, Robert Fekete, Joseph Jankovic, Yun-Cheng Wu
Summary: ICDs in PD refer to aberrant behaviors such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically result from dopaminergic therapy. Research has focused on the broad spectrum of ICDs-related behaviors and their significant impact on patients and their families, with recent advances improving our understanding of this issue.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Dongling Zhang, Junye Yao, Jinghong Ma, Linlin Gao, Junyan Sun, Jiliang Fang, Hongjian He, Tao Wu
Summary: This study investigated the functional connectivity of corticostriatal circuits in nonmanifesting LRRK2 G2385R and R1628P mutation carriers. Compared to noncarriers, mutation carriers showed reduced connectivity in certain regions and increased connectivity in others. The study found that mutation carriers have a lower likelihood of developing parkinsonian motor symptoms.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Ana Marques, Michela Figorilli, Celine Lambert, Bruno Pereira, Tiphaine Vidal, Jacques Montplaisir, Franck Durif, Maria Livia Fantini
Summary: The study identified a clinical association between impulse control disorders (ICDs) and restless legs syndrome (RLS) in Parkinson's disease patients, with ICDs leading to increased subjective discomfort during the SIT test.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Sara C. Staubo, Ole Martin Fuskevag, Mathias Toft, Ingeborg H. Lie, Kirsti M. J. Alvik, Pal Jostad, Stein H. Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Storset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
Summary: The study suggests that the occurrence of impulse control disorders (ICDs) among patients using ropinirole is dependent on serum concentration and drug exposure, while the use of pramipexole may inherently increase ICD risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Mauricio Ivan Garcia-Rubio, Maria Elisa Otero-Cerdeira, Christian Gabriel Toledo-Lozano, Sofia Lizeth Alcaraz-Estrada, Juan Antonio Suarez-Cuenca, Ramon Mauricio Coral-Vazquez, Paul Mondragon-Teran, Juan Antonio Pineda-Juarez, Luis Fernando Diaz-Lopez, Silvia Garcia
Summary: This study identified dopamine agonists as being associated with the development of ICDs in PD patients, while the tremorgenic form may have a protective effect. Positive associations were found between the rigid-akinetic form and compulsive shopping, and between males and hypersexuality. Binge eating, compulsive shopping, and hypersexuality were the most common ICDs observed.
Article
Neuroimaging
Teresa Esteban-Penalba, Pedro M. Paz-Alonso, Irene Navalpotro-Gomez, Maria C. Rodriguez-Oroz
Summary: Our findings indicate that PD patients with ICD completed the inhibition task correctly, showing altered engagement of inhibitory and attentional areas. During proactive inhibition they showed bilateral hyperactivation of two inhibitory regions, while during restrained inhibition they showed additional involvement of attentional areas responsible for alerting and orienting.
NEUROIMAGE-CLINICAL
(2021)
Review
Rehabilitation
Irene Battel, Irene Calvo, Margaret Walshe
Summary: The use of biofeedback in the treatment of dysphagia in patients with PD shows potential positive effects on swallowing-related quality of life. However, existing studies have low methodological quality and high risk of bias, future research should be rigorously designed to determine the optimal types, schedules, and timing of biofeedback treatment.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Medicine, General & Internal
Li-Shu Wang, Teng-Fei Yu, Bin Chai, Wen He
Summary: This study evaluated the application of transcranial sonography (TCS) for the differential diagnosis of Parkinson disease (PD) and other movement disorders in Chinese individuals. The results showed that SN positivity effectively differentiated PD from ET, PSP, and MSA, while the incidence of lenticular hyperechoic area also played a role in distinguishing between these diseases.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
John R. Younce, Meghan C. Campbell, Tamara Hershey, Aaron B. Tanenbaum, Mikhail Milchenko, Mwiza Ushe, Morvarid Karimi, Samer D. Tabbal, Albert E. Kim, Abraham Z. Snyder, Joel S. Perlmutter, Scott A. Norris
Summary: Resting-state functional connectivity MRI may predict motor response to subthalamic nucleus deep brain stimulation, with stronger connectivity between the left subthalamic nucleus and ipsilateral internal globus pallidus correlating with greater improvement in postsurgical motor outcomes. The integrity of pallidal-subthalamic nucleus circuits may be critical to motor benefits from deep brain stimulation.
MOVEMENT DISORDERS
(2021)
Article
Cell Biology
Haydar M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Ali K. Albuhadily
Summary: Prolactin appears to have a neuroprotective effect against Parkinson's disease neuropathology by inhibiting inflammation and protecting against neuroinflammation. Further research is needed to fully understand the potential role and mechanisms.
AGEING RESEARCH REVIEWS
(2023)
Review
Clinical Neurology
Lenise G. Soileau, Norris C. Talbot, Nicholas R. Storey, Noah J. Spillers, James V. D'antoni, Peter C. Carr, Connor M. Galardo, Patil Shilpadevi, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye
Summary: This study is the first systematic review and meta-analysis to assess the occurrence of impulse control disorders (ICDs) in Parkinson's disease (PD) patients treated with oral dopamine agonists (DAs): ropinirole (ROP) and pramipexole (PRX). The results show that the usage of PRX or ROP significantly increases the risk of developing ICDs in PD patients. Compared to the transdermal patch rotigotine (RTG), PRX has a significantly higher relative risk (P < 0.0001) of 3.46 (95% CI 2.07-5.76), and ROP has a significantly higher relative risk (P < 0.0001) of 2.98 (95% CI 1.77-5.02). The data collected indicates that RTG is approximately three times less likely to cause ICDs than oral PRX and ROP.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Mateusz Tos, Anna Grazynska, Sofija Antoniuk, Joanna Siuda
Summary: Parkinson's disease (PD) is a common neurodegenerative disease characterized by motor and non-motor symptoms. Impulse Control Disorders (ICDs) are a group of disorders in which patients have a strong desire for specific activities. This study aimed to develop a profile of Polish PD patients with ICDs and assess the frequency and risk factors associated with these disorders.
MEDICINA-LITHUANIA
(2023)
Article
Clinical Neurology
Christopher Leroy, Jean-Louis Bourriez, Kathy Dujardin, Behnam Molaee-Ardekani, Claudio Babiloni, Dominique Deplanque, Amelie Ponchel, Sophie Hennion, Lucie Plomhause, Herve Devanne, Julie Deguil, Pierre Payoux, Olivier Blin, Deborah Meligne, Joelle Micallef, Nicolas Chauveau, Laura Lanteaume, Celine Vervueren, Francois Guimont, Claire Thalamas, Catherine Casse-Perrot, Franck Rouby, Regis Bordet, Philippe Derambure
CLINICAL NEUROPHYSIOLOGY
(2019)
Article
Neuroimaging
Kathy Dujardin, David Roman, Guillaume Baille, Delphine Pins, Stephanie Lefebvre, Christine Delmaire, Luc Defebvre, Renaud Jardri
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Clinical Neurology
Nacim Betrouni, Renaud Lopes, Luc Defebvre, Albert F. G. Leentjens, Kathy Dujardin
MOVEMENT DISORDERS
(2020)
Review
Neurosciences
Arnaud Delval, Madli Bayot, Luc Defebvre, Kathy Dujardin
Correction
Neurosciences
Gregory M. Pontone, Nadeeka Dissanayaka, Liana Apostolova, Richard G. Brown, Roseanne Dobkin, Kathy Dujardin, Joseph H. Friedman, Albert F. G. Leentjens, Eric J. Lenze, Laura Marsh, Lynda Mari, Oury Monchi, Irene H. Richard, Anette Schrag, Antonio P. Strafella, Beth Vernaleo, Daniel Weintraub, Zoltan Mari
NPJ PARKINSONS DISEASE
(2020)
Review
Clinical Neurology
Guillaume Carey, Meltem Gormezoglu, Joost J. A. de Jong, Paul A. M. Hofman, Walter H. Backes, Kathy Dujardin, AlbertF G. Leentjens
Summary: Anxiety symptoms in Parkinson's disease are associated with structural and functional changes in the fear and limbic cortico-striato-thalamocortical circuits. The neuropathology of PD may affect these circuits in different ways, which explains the high prevalence of anxiety and associated symptoms in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
David Maltete, David Wallon, Julie Bourilhon, Romain Lefaucheur, Teodor Danaila, Stephane Thobois, Luc Defebvre, Kathy Dujardin, Jean-Luc Houeto, Olivier Godefroy, Pierre Krystkowiak, Olivier Martinaud, Andre Gillibert, Mathieu Chastan, Pierre Vera, Didier Hannequin, Marie-Laure Welter, Stephane Derrey
Summary: The study found that for patients with LBD who underwent bilateral NBM-DBS surgery, active NBM-DBS stimulation did not significantly alter selective recall scores compared to sham stimulation.
Article
Geriatrics & Gerontology
Quentin Devignes, Romain Viard, Nacim Betrouni, Guillaume Carey, Gregory Kuchcinski, Luc Defebvre, Albert F. G. Leentjens, Renaud Lopes, Kathy Dujardin
Summary: PD-MCI patients with posterior cortical deficits show more abundant and extensive structural alterations, independently of age, disease duration, and severity, which may explain their increased risk of dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Quentin Devignes, Cecile Bordier, Romain Viard, Luc Defebvre, Gregory Kuchcinski, Albert F. G. Leentjens, Renaud Lopes, Kathy Dujardin
Summary: The dual syndrome hypothesis in mild cognitive impairment (MCI) in Parkinson's disease distinguishes between frontostriatal and posterior cortical subtypes, and this study found specific changes in resting-state functional connectivity associated with these subtypes. Patients with posterior cortical deficits showed increased functional connectivity within the basal ganglia network, while patients with frontostriatal deficits showed reduced inter-network connectivity compared to healthy controls and patients with normal cognition or a posterior cortical subtype.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Nacim Betrouni, Edouard Alazard, Madli Bayot, Guillaume Carey, Philippe Derambure, Luc Defebvre, Albert Fg Leentjens, Arnaud Delval, Kathy Dujardin
Summary: Through high density electroencephalography (hd-EEG) recordings and comparisons in 108 Parkinson's disease patients, it was found that patients with anxiety symptoms had lower relative power in the alpha1 frequency band in the right prefrontal cortex, and showed different characteristics in functional connectivity compared to those without anxiety.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Behavioral Sciences
Nacim Betrouni, Quentin Devignes, Madli Bayot, Philippe Derambure, Luc Defebvre, Albert FG. Leentjens, Arnaud Delval, Kathy Dujardin
Summary: This study investigates EEG modifications associated with mild cognitive impairment in Parkinson's disease (PD-MCI) subtypes. The results show that patients with a frontostriatal subtype exhibit spectral and functional EEG alterations, while the posterior cortical subtype does not differ significantly from the normal cognition group. This study provides evidence for the dual syndrome hypothesis and highlights the importance of identifying PD-MCI subtypes.
Article
Neurosciences
Quentin Devignes, Sami Daoudi, Romain Viard, Renaud Lopes, Nacim Betrouni, Gregory Kuchcinski, Anne-Sophie Rolland, Caroline Moreau, Luc Defebvre, Eric Bardinet, Marie Bonnet, Christine Brefel-Courbon, Christine Delmaire, Fouzia El Mountassir, Frederique Fluchere, Anne Fradet, Caroline Giordana, Elodie Hainque, Jean-Francois Houvenaghel, Bechir Jarraya, Helene Klinger, David Maltete, Ana Marques, Mylene Meyer, Olivier Rascol, Tiphaine Rouaud, Melissa Tir, Thomas Wirth, Jean-Christophe Corvol, David Devos, Kathy Dujardin
Summary: The study found that a significant proportion of candidates for subthalamic deep brain stimulation (STN-DBS) have Parkinson's disease mild cognitive impairment (PD-MCI), which is associated with cortical and subcortical alterations. Among the PD-MCI subtypes, patients with posterior cortical deficits (PD-PC) had lower global efficiency and worse performance on visuospatial functions, episodic memory, and language, suggesting a higher risk of dementia. There were no significant differences between the PD-MCI subtypes.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Psychology, Clinical
Charlotte Manceau, Emilie Constant, Elodie Brugalle, Emilie Wawrziczny, Celine Sokolowski, Berengere Flinois, Guillaume Baille, Luc Defebvre, Kathy Dujardin, Pascal Antoine
Summary: This qualitative study aims to understand the experience and functioning of couples during the honeymoon period of Parkinson's disease. The results highlight different dynamics between couples, with some adjusting flexibly and positively while others oscillate between rigid hyperprotection and control/avoidance.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Clinical Neurology
Amee F. Wolters, Stijn Michielse, Mark L. Kuijf, Luc Defebvre, Renaud Lopes, Kathy Dujardin, Albert F. G. Leentjens
Summary: This study compared cognitive and brain network connectivity differences between different subtypes of Parkinson's disease. While the PIGD subtype performed worse in cognitive domains compared to the TD subtype, there were no significant differences in brain network connectivity between the two subtypes.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Neurosciences
Gregory M. Pontone, Nadeeka Dissanayka, Liana Apostolova, Richard G. Brown, Roseanne Dobkin, Kathy Dujardin, Joseph H. Friedman, Albert F. G. Leentjens, Eric J. Lenze, Laura Marsh, Lynda Mari, Oury Monchi, Irene H. Richard, Anette Schrag, Antonio P. Strafella, Beth Vernaleo, Daniel Weintraub, Zoltan Mari
NPJ PARKINSONS DISEASE
(2019)