Article
Critical Care Medicine
Juan Piantino, Daniel L. Schwartz, Madison Luther, Craig Newgard, Lisa Silbert, Murray Raskind, Kathleen Pagulayan, Natalia Kleinhans, Jeffrey Iliff, Elaine Peskind
Summary: The study found that mild traumatic brain injury (mTBI) may increase the burden of perivascular spaces (PVS) in Iraq/Afghanistan veterans, and poor sleep quality may exacerbate this effect. Additionally, there is a correlation between PVS burden and the severity of persistent post-concussive symptoms.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bio Joo, So Yeon Won, Ralph Sinkus, Seung-Koo Lee
Summary: This study investigated the feasibility of using magnetic resonance elastography (MRE) to assess the viscoelastic properties of the brain and its relationship with glymphatic function in neurologically normal individuals. The results showed a significant correlation between the viscoelastic properties of the brain and glymphatic function.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Zhuozhi Dai, Zhiqi Yang, Zhaolin Li, Mu Li, Hongfu Sun, Zerui Zhuang, Weichao Yang, Zehuan Hu, Xiaofeng Chen, Daiying Lin, Xianheng Wu
Summary: The aim of this study was to investigate the changes in glymphatic system activity in patients with mild traumatic brain injury (mTBI), particularly in those with negative MRI scans, using analysis along the perivascular space (ALPS) technology. The results suggest that the activity level of the glymphatic system was enhanced in mTBI patients, including those with negative MRI scans, based on ALPS index analysis. These findings provide important insights for understanding the pathophysiology of mild TBI.
FRONTIERS IN NEUROLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Xianjun Li, Zixuan Lin, Congcong Liu, Ruiliang Bai, Dan Wu, Jian Yang
Summary: This review discusses the development of the glymphatic system, advances in imaging techniques, and their applications in pediatric disorders. The development of the glymphatic system is a long-lasting process that continues into adulthood. There is a need for improved glymphatic imaging techniques that are non-invasive and fast for pediatric applications. The glymphatic dysfunction is associated with a large number of pediatric disorders, but only a few have been investigated.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Kevin A. Gonzalez, Wassim Tarraf, Ariana M. Stickel, Sonya Kaur, Christian Agudelo, Susan Redline, Linda C. Gallo, Carmen R. Isasi, Jianwen Cai, Martha L. Daviglus, Fernando D. Testai, Charles Decarli, Hector M. Gonzalez, Alberto R. Ramos
Summary: This study examined the association between sleep pattern and brain disease outcomes in diverse Hispanics/Latinos. The results showed that longer sleep duration was associated with smaller total brain and gray matter volume, highlighting the importance of sleep on brain aging in this population.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Xin Li, Cailian Ruan, Abdoulaye Issotina Zibrila, Mazen Musa, Yifan Wu, Zhengxiang Zhang, Heng Liu, Mustafa Salimeen
Summary: This study used DTI-ALPS to assess glymphatic system function in autism spectrum disorder (ASD) and found dysfunction in ASD patients, which is associated with age.
Review
Biochemistry & Molecular Biology
Andie Scott-Massey, Matthew K. Boag, Annie Magnier, Dharah P. C. F. Bispo, Tien K. Khoo, Dean L. Pountney
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein aggregations and dopaminergic neuron degeneration. Sleep disturbance, as a risk factor, may be closely linked to PD pathogenesis. Research suggests that optimizing glymphatic clearance through improving sleep quality could potentially reduce disease progression and symptom severity in PD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Filipp Maximilian Filippopulos, Thomas D. Fischer, Klaus Seelos, Konstanze Dunker, Bozidar Belanovic, Alexander Crispin, Robert Stahl, Thomas Liebig, Andreas Straube, Robert Forbrig
Summary: The study aimed to establish a clinical MRI study protocol for visualizing lymphatic vessels as part of the glymphatic system (GLS) in humans and to describe the dynamic changes of a contrast agent in these lymphatic vessels over time. This study may provide a basis for evaluating the GLS function in various neurological pathologies in the future.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Clinical Neurology
Jiuqi Wang, Yiming Tian, Chi Qin, Lin Meng, Renyi Feng, Shuqin Xu, Yanping Zhai, Dongxiao Liang, Rui Zhang, Haiyan Tian, Han Liu, Yongkang Chen, Yu Fu, Pei Chen, Qingyong Zhu, Junfang Teng, Xuejing Wang
Summary: Obstructive sleep apnea (OSA) is a prevalent and potentially undiagnosed condition that increases the risk of cognitive impairment. The study found a correlation between morphological changes in perivascular spaces (PVSs) and cognitive impairment in OSA patients. Additionally, novel magnetic resonance imaging methods were developed to assess the fluid dynamics of the glymphatic drainage system, which showed significant changes in inflow and outflow parameters in OSA patients. These changes were associated with cognitive impairment and hypoxia levels. Treatment with continuous positive airway pressure (CPAP) improved the functionality of the glymphatic drainage system in OSA patients.
JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kamila Kopec, Stanislaw Szleszkowski, Dariusz Koziorowski, Stanislaw Szlufik
Summary: Neurodegenerative diseases are complex and not fully understood. Insufficiency of the glymphatic system and mitochondrial disorders play roles in the development of pathology. These factors interact and drive each other, potentially leading to protein accumulation, impaired glymphatic clearance, and sleep disorders. Clarifying the connection between the glymphatic system and mitochondria in relation to neurodegeneration could lead to new multidirectional therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiani Hu, Yimin Shen, Lara M. Fahmy, Satish Krishnamurthy, Jie Li, Li Zhang, Yongsheng Chen, E. Mark Haacke, Quan Jiang
Summary: Using MRI imaging techniques, this study investigated the role of the parenchymal vascular system in the clearance of cerebrospinal fluid tracers. The results showed that the tracers mainly accumulated in the cerebral venous vessels, suggesting the direct participation of the parenchymal vascular system in waste clearance.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin-Xin Wang, Qin-Chen Cao, Jun-Fang Teng, Rui-Fang Wang, Zi-Tao Yang, Meng-Ge Wang, Zheng-Hao Cao
Summary: This study found that enlarged perivascular spaces (EPVS) visible on MRI in certain brain regions were significantly increased in chronic insomnia patients with impaired cognition. These increased EPVS were also associated with higher levels of CSF beta-amyloid 42, total tau, and phosphorylated tau in patients with impaired cognition. MRI-visible EPVS in the basal ganglia and centrum semiovale showed high sensitivity and specificity in distinguishing chronic insomnia patients with impaired cognition from those with normal cognition.
EUROPEAN RADIOLOGY
(2022)
Article
Neurosciences
Sutton B. Richmond, Swati Rane, Moriah R. Hanson, Mehmet Albayram, Jeffrey J. Iliff, Dawn Kernagis, Jens T. Rosenberg, Rachael D. Seidler
Summary: We visualized and quantified delayed tissue enhancement following intravenous administration of gadolinium-based contrast agent in healthy human participants using magnetic resonance imaging. Our findings showed that peripheral tissues and blood vessels exhibited high enhancement at 30 minutes, while gray matter and white matter enhancement peaked at 90 minutes and declined thereafter. We also identified distinct distribution volumes reflecting different regions of the brain that exhibit a sequential enhancement pattern.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Koji Kamagata, Yuya Saito, Christina Andica, Wataru Uchida, Kaito Takabayashi, Seina Yoshida, Akifumi Hagiwara, Shohei Fujita, Moto Nakaya, Toshiaki Akashi, Akihiko Wada, Kouhei Kamiya, Masaaki Hori, Shigeki Aoki
Summary: This review focuses on the application of noninvasive magnetic resonance imaging (MRI) techniques for studying the glymphatic system, a mechanism responsible for the removal of interstitial solutes within the central nervous system. It introduces several noninvasive MRI techniques and discusses their strengths and limitations in studying interstitial fluid dynamics, blood-brain barrier permeability, and cerebrospinal fluid flow. The review also addresses the correlation between glymphatic system activity and pathological alterations, as well as the challenges of conducting multisite studies.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul D. Griffiths, Mariasavina Severino, Deborah Jarvis, Laura Mandefield, Cecilia Parazzini, Lorenzo Pinelli, Marco Di Maurizio, Fabio Triulzi, Elisa Scola, Giorgio Conte, Giovanni Palumbo, Maurilio Genovese, Andrea Rossi, Renzo Guerrini, Andrea Righini
Summary: The study included 64 foetuses with cortical formation abnormalities (CFA) who underwent two in utero magnetic resonance (iuMR) exams, with 62% showing consistent CFA description between the two studies. In 38% of cases, there was a category change, including cases without CFA initially detected, changes in laterality/symmetry, and re-classification within the same group. Brain abnormalities other than CFA were present in around half of the cases on both first and second studies. Prognosis was predicted to have changed in 8% of cases based on the second study, with all indicating a worse prognosis.
EUROPEAN RADIOLOGY
(2021)
