MEK1/2 Inhibitor U0126 but Not Endothelin Receptor Antagonist Clazosentan Reduces Upregulation of Cerebrovascular Contractile Receptors and Delayed Cerebral Ischemia, and Improves Outcome after Subarachnoid Hemorrhage in Rats

Early events triggering delayed vasoconstrictor receptor upregulation and cerebral ischemia after subarachnoid hemorrhage

(2013) Gro Klitgaard Povlsen et al.   BMC NEUROSCIENCE

Signal Transduction in Cerebral Arteries after Subarachnoid Hemorrhage—A Phosphoproteomic Approach

(2013) Benjamin L Parker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

(2012) Tommaso Zoerle et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway

(2012) Aida Maddahi et al.   Journal of Neuroinflammation

Randomized Trial of Clazosentan in Patients With Aneurysmal Subarachnoid Hemorrhage Undergoing Endovascular Coiling

(2012) R. Loch Macdonald et al.   STROKE

In vivo experimental stroke and in vitro organ culture induce similar changes in vasoconstrictor receptors and intracellular calcium handling in rat cerebral arteries

(2012) Gro Klitgaard Povlsen et al.   EXPERIMENTAL BRAIN RESEARCH

Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage

(2011) Saema Ansar et al.   BMC NEUROSCIENCE

Vascular plasticity in cerebrovascular disorders

(2011) Lars IH Edvinsson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blockade of the MEK/ERK Pathway with a Raf Inhibitor Prevents Activation of Pro-Inflammatory Mediators in Cerebral Arteries and Reduction in Cerebral Blood Flow after Subarachnoid Hemorrhage in a Rat Model

(2010) Aida Maddahi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Improvement in neurological outcome and abolition of cerebrovascular endothelin B and 5-hydroxytryptamine 1B receptor upregulation through mitogen-activated protein kinase kinase 1/2 inhibition after subarachnoid hemorrhage in rats

(2010) Carl Christian Larsen et al.   JOURNAL OF NEUROSURGERY

Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage

(2009) Saema Ansar et al.   JOURNAL OF NEUROSURGERY

Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser Doppler flowmetry study in rats

(2008) Gerrit A. Schubert et al.   JOURNAL OF NEUROSURGERY