Epigenetic Mechanisms in Cerebral Ischemia

Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells

(2013) Zhixin Qiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toxicological and metabolic considerations for histone deacetylase inhibitors

(2013) Joanna Fraczek et al.   Expert Opinion on Drug Metabolism & Toxicology

Sirt1 Mediates Hyperbaric Oxygen Preconditioning-Induced Ischemic Tolerance in Rat Brain

(2013) Wenjun Yan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Epigenetic Reprogramming in Cancer

(2013) M. L. Suva et al.   SCIENCE

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Development and therapeutic impact of HDAC6-selective inhibitors

(2012) Sabrina Dallavalle et al.   BIOCHEMICAL PHARMACOLOGY

Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke

(2012) Werner Hacke et al.   BMC Medicine

Comparative Epigenomic Annotation of Regulatory DNA

(2012) Shu Xiao et al.   CELL

Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection

(2012) Yan-Ting Chen et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Do stroke models model stroke?

(2012) P. Mergenthaler et al.   Disease Models & Mechanisms

Role of CpG context and content in evolutionary signatures of brain DNA methylation

(2012) Yurong Xin et al.   Epigenetics

HDAC modulation and cell death in the clinic

(2012) Carmela Dell'Aversana et al.   EXPERIMENTAL CELL RESEARCH

HDAC inhibitors for the treatment of cutaneous T-cell lymphomas

(2012) Sophia Rangwala et al.   Future Medicinal Chemistry

Phase II Activity of Belinostat (PXD-101), Carboplatin, and Paclitaxel in Women With Previously Treated Ovarian Cancer

(2012) Don S. Dizon et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Phase I/II Intra-patient Dose Escalation Study of Vorinostat in Children with Relapsed Solid Tumor, Lymphoma or Leukemia

(2012) O. Witt et al.   KLINISCHE PADIATRIE

Neuroprotective effects of valproic acid following transient global ischemia in rats

(2012) Aiguo Xuan et al.   LIFE SCIENCES

Evolutionary Conservation of Histone Modifications in Mammals

(2012) Y. H. Woo et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

(2012) Céline Bellenguez et al.   NATURE GENETICS

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

(2012) Annamaria Lanzillotta et al.   NEUROBIOLOGY OF DISEASE

Neural Mechanisms of Stress Resilience and Vulnerability

(2012) Tamara B. Franklin et al.   NEURON

Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death

(2012) K.-M. Noh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke

(2012) M. Mengozzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Valproate Treatment Enhances Postischemic Angiogenesis and Promotes Functional Recovery in a Rat Model of Ischemic Stroke

(2012) Zhifei Wang et al.   STROKE

Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours

(2011) R Pili et al.   BRITISH JOURNAL OF CANCER

A randomized phase II study of two doses of vorinostat in combination with 5-FU/LV in patients with refractory colorectal cancer

(2011) M. G. Fakih et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Chromatin as an oxygen sensor and active player in the hypoxia response

(2011) Andrew Melvin et al.   CELLULAR SIGNALLING

Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke

(2011) Colin A. Graham et al.   CLINICAL BIOCHEMISTRY

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone Deacetylase Inhibitors Preserve White Matter Structure and Function during Ischemia by Conserving ATP and Reducing Excitotoxicity

(2011) S. Baltan et al.   JOURNAL OF NEUROSCIENCE

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(2011) Na'ama Shein et al.   MOLECULAR MEDICINE

Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes

(2011) Johannes Gräff et al.   PHYSIOLOGICAL REVIEWS

Acetylation of the Pro-Apoptotic Factor, p53 in the Hippocampus following Cerebral Ischemia and Modulation by Estrogen

(2011) Limor Raz et al.   PLoS One

Expression of Histone Deacetylases in Cellular Compartments of the Mouse Brain and the Effects of Ischemia

(2011) Selva Baltan et al.   Translational Stroke Research

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pharmacokinetic and pharmacodynamic properties of an oral formulation of the histone deacetylase inhibitor Belinostat (PXD101)

(2010) N. L. Steele et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

In pursuit of the first recognized epigenetic signal––DNA methylation: A 1976 to 2008 synopsis

(2010) Walter Doerfler   Epigenetics

MicroRNAs as Effectors of Brain Function with Roles in Ischemia and Injury, Neuroprotection, and Neurodegeneration

(2010) Julie A Saugstad   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of Salt-Induced Kinase 1 in Androgen Neuroprotection against Cerebral Ischemia

(2010) Jian Cheng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Valproic Acid Attenuates Blood–Brain Barrier Disruption in a Rat Model of Transient Focal Cerebral Ischemia: The Roles of HDAC and MMP-9 Inhibition

(2010) Zhifei Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Final Results From a Multicenter, International, Pivotal Study of Romidepsin in Refractory Cutaneous T-Cell Lymphoma

(2010) Sean J. Whittaker et al.   JOURNAL OF CLINICAL ONCOLOGY

Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies

(2010) Claire L. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons

(2010) Zoya Marinova et al.   NEUROPHARMACOLOGY

MicroRNA in ischemic stroke etiology and pathology

(2010) Cameron Rink et al.   PHYSIOLOGICAL GENOMICS

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE

Regulation of Apoptotic and Inflammatory Cell Signaling in Cerebral Ischemia

(2009) Rona G. Giffard et al.   ANESTHESIOLOGY

A Phase I Dose-Finding Study of 5-Azacytidine in Combination with Sodium Phenylbutyrate in Patients with Refractory Solid Tumors

(2009) J. Lin et al.   CLINICAL CANCER RESEARCH

Dose-Dependent Effects of Androgens on Outcome after Focal Cerebral Ischemia in Adult Male Mice

(2009) Masayoshi Uchida et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

(2009) Zoya Marinova et al.   JOURNAL OF NEUROCHEMISTRY

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

(2009) Hyeon Ju Kim et al.   JOURNAL OF NEUROCHEMISTRY

Histone Deacetylase Inhibitors Prevent p53-Dependent and p53-Independent Bax-Mediated Neuronal Apoptosis through Two Distinct Mechanisms

(2009) T. Uo et al.   JOURNAL OF NEUROSCIENCE

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

(2009) Ulrich Dirnagl et al.   LANCET NEUROLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

HDAC6 is a target for protection and regeneration following injury in the nervous system

(2009) M. A. Rivieccio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Histone Deacetylases as a Multifaceted Approach to Treat the Diverse Outcomes of Stroke

(2009) Brett Langley et al.   STROKE

Phase 2 study of sodium phenylbutyrate in ALS

(2008) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

Improving Outcome after Stroke: Overcoming the Translational Roadblock

(2008) Matthias Endres et al.   CEREBROVASCULAR DISEASES

A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas

(2008) L. Gore et al.   CLINICAL CANCER RESEARCH

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

(2008) T ABEL et al.   CURRENT OPINION IN PHARMACOLOGY

Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1 in Cell Cycle-Independent Neuroprotection

(2008) B. Langley et al.   JOURNAL OF NEUROSCIENCE

Brain Chromatin Remodeling: A Novel Mechanism of Alcoholism

(2008) S. C. Pandey et al.   JOURNAL OF NEUROSCIENCE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

Genome-wide approaches to studying chromatin modifications

(2008) Dustin E. Schones et al.   NATURE REVIEWS GENETICS

Epigenetic regulation of the estrogen receptor alpha promoter in the cerebral cortex following ischemia in male and female rats

(2008) J.M. Westberry et al.   NEUROSCIENCE

Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury

(2007) Ferah Yildirim et al.   EXPERIMENTAL NEUROLOGY