Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 33, Issue 11, Pages 1707-1710Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2013.158
Keywords
capillaries; cerebral blood flow measurement; cranial windows; microscopy; optical imaging
Categories
Funding
- NIH [R01-NS057476, R01-EB000790, P01NS055104]
- AFOSR [MFEL FA9550-07-1-0101]
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As capillaries exhibit heterogeneous and fluctuating dynamics even during baseline, a technique measuring red blood cell (RBC) speed and flux over many capillaries at the same time is needed. Here, we report that optical coherence tomography can capture individual RBC passage simultaneously over many capillaries located at different depths. Further, we demonstrate the ability to quantify RBC speed, flux, and linear density. This technique will provide a means to monitor microvascular flow dynamics over many capillaries at different depths at the same time.
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