Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 33, Issue 8, Pages 1148-1152Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2013.89
Keywords
brain recovery; cortical mapping; electrophysiology; global ischemia; reperfusion
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Funding
- Heart and Stroke Foundation of BC
- Yukon
- Canadian Institutes of Health Research (CIHR) [MOP-111009]
- Human Frontier Science Program grant
- Canadian Stroke Network
- CIHR Vanier scholarship
- Four Year Fellowship from the University of British Columbia
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Recently we have shown that despite reperfusion, sensory processing exhibits persistent deficits after global ischemia in a mouse in vivo model. We now address how motor output, specifically cortically evoked muscle activity, stimulated by channelrhodopsin-2 is affected by global ischemia and reperfusion. We find that the light-based optogenetic motor map recovers to 80% within an hour. Moreover, motor output recovers relatively faster and more completely than the sensory processing after 5-minute period of global ischemia. Our results suggest a differential sensitivity of sensory and motor systems to the effects of global ischemia and reperfusion that may have implications for rehabilitation.
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