Novel Mitochondrial Targets for Neuroprotection

Neuroprotection through Stimulation of Mitochondrial Antioxidant Protein Expression

(2017) Tiffany Greco et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Iron Metabolism and Its Role in Neurodegeneration

(2017) Maxx P. Horowitz et al.   JOURNAL OF ALZHEIMERS DISEASE

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation

(2011) L Cabon et al.   CELL DEATH AND DIFFERENTIATION

The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery

(2011) Catherine S. Palmer et al.   CELLULAR SIGNALLING

Sulforaphane inhibits mitochondrial permeability transition and oxidative stress

(2011) Tiffany Greco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

(2011) Kahlilia C Morris et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production

(2011) Alessandra Valerio et al.   JOURNAL OF NEUROCHEMISTRY

Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity

(2011) Rosemary A. Schuh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Autophagy in health and disease. 5. Mitophagy as a way of life

(2010) Roberta A. Gottlieb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial Approaches for Neuroprotection

(2010) Rajnish K. Chaturvedi et al.   Annals of the New York Academy of Sciences

Postischemic Oxidative Stress Promotes Mitochondrial Metabolic Failure in Neurons and Astrocytes

(2010) Gary Fiskum et al.   Annals of the New York Academy of Sciences

Signal Transducers and Activators of Transcription: STATs-Mediated Mitochondrial Neuroprotection

(2010) Hung Wen Lin et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes

(2010) Agnieszka Biala et al.   BLOOD PRESSURE

Calcium-dependent mitochondrial function and dysfunction in neurons

(2010) Natalia B. Pivovarova et al.   FEBS Journal

Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition

(2010) Tiffany Greco et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival following Excitotoxicity

(2010) Arezu Jahani-Asl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

(2010) Katia Aquilano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progesterone Increases Manganese Superoxide Dismutase Expression via a cAMP-Dependent Signaling Mediated by Noncanonical Wnt5a Pathway in Human Endometrial Stromal Cells

(2010) Aki Matsuoka et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mass-spectrometry based oxidative lipidomics and lipid imaging: applications in traumatic brain injury

(2010) Louis J. Sparvero et al.   JOURNAL OF NEUROCHEMISTRY

Metabolism of acetyl-l-carnitine for energy and neurotransmitter synthesis in the immature rat brain

(2010) Susanna Scafidi et al.   JOURNAL OF NEUROCHEMISTRY

Group IIA secretory phospholipase A2(GIIA) mediates apoptotic death during NMDA receptor activation in rat primary cortical neurons

(2010) Elena Chiricozzi et al.   JOURNAL OF NEUROCHEMISTRY

Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection

(2010) Joo Eun Jung et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrating multiple aspects of mitochondrial dynamics in neurons: Age-related differences and dynamic changes in a chronic rotenone model

(2010) Beth Arnold et al.   NEUROBIOLOGY OF DISEASE

Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?☆

(2009) Mariana G. Rosca et al.   ADVANCED DRUG DELIVERY REVIEWS

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial calcium function and dysfunction in the central nervous system

(2009) David G. Nicholls   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Multifaceted deaths orchestrated by mitochondria in neurones

(2009) Phillip Nagley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases

(2009) Vittorio Calabrese   Frontiers in Bioscience-Landmark

Oxygen Sensitivity of Mitochondrial Reactive Oxygen Species Generation Depends on Metabolic Conditions

(2009) David L. Hoffman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Combination therapy with Coenzyme Q10and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s Diseases

(2009) Lichuan Yang et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of Mn-Superoxide Dismutase Activity and Neuroprotection by STAT3 in Mice after Cerebral Ischemia

(2009) J. E. Jung et al.   JOURNAL OF NEUROSCIENCE

KATP channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production

(2009) Juan Xie et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Acylcarnitines: Role in brain

(2009) Lauren L. Jones et al.   PROGRESS IN LIPID RESEARCH

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Mitochondrial Targets for Stroke

(2009) Peter S. Vosler et al.   STROKE

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions

(2008) María L. Haces et al.   EXPERIMENTAL NEUROLOGY

Effects of overexpression of Huntingtin proteins on mitochondrial integrity

(2008) Hongmin Wang et al.   HUMAN MOLECULAR GENETICS

Combined R-α-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson’s disease

(2008) Hongyu Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Preconditioning Mediated by Sublethal Oxygen—Glucose Deprivation-Induced Cyclooxygenase-2 Expression via the Signal Transducers and Activators of Transcription 3 Phosphorylation

(2008) Eun J Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The ketogenic diet increases mitochondrial glutathione levels

(2008) Stuart G. Jarrett et al.   JOURNAL OF NEUROCHEMISTRY

Ischemic Preconditioning Targets the Respiration of Synaptic Mitochondria via Protein Kinase C 

(2008) K. R. Dave et al.   JOURNAL OF NEUROSCIENCE

Transient Hypoxia Stimulates Mitochondrial Biogenesis in Brain Subcortex by a Neuronal Nitric Oxide Synthase-Dependent Mechanism

(2008) D. R. Gutsaeva et al.   JOURNAL OF NEUROSCIENCE

Acetyl-l-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain

(2008) E. Alves et al.   NEUROSCIENCE

Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN

(2008) Catherine E. Hobbs et al.   PEDIATRICS INTERNATIONAL

Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

(2008) Wei Yin et al.   STROKE

Broccoli: A Unique Vegetable That Protects Mammalian Hearts through the Redox Cycling of the Thioredoxin Superfamily

(2007) Subhendu Mukherjee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY