Article
Orthopedics
Alejandro Estepa-Gallego, Alfonso Javier Ibanez-Vera, Maria Dolores Estudillo-Martinez, Yolanda Castellote-Caballero, Marco Bergamin, Stefano Gobbo, Miguel Angel Lerida-Ortega, David Cruz-Diaz
Summary: This study showed that global postural reeducation (GPR) may be effective in enhancing ankle function, including improvements in static postural control, dynamic balance, and ankle dorsiflexion range of motion (DFROM) in patients with symptomatic mild to moderate hallux abducto valgus (HAV).
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Rehabilitation
Paula T. Bezerra, Lorenna M. Santiago, Isaira A. Silva, Aline A. Souza, Camila L. Pegado, Clecia M. Damascena, Tatiana S. Ribeiro, Ana R. Lindquist
Summary: Combining action observation, motor imagery, and gait training did not show greater effectiveness than isolated gait training for balance and freezing of gait in individuals with Parkinson's disease. However, motor imagery training can moderate the effects of action observation and enhance motor learning when used together.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Review
Rehabilitation
Silvia Marazzi, Pawel Kiper, Katie Palmer, Michela Agostini, Andrea Turolla
Summary: This review suggests that whole body vibration treatment can significantly improve gait performance in patients with Parkinson's disease compared to standard treatment, but not significantly better for other outcomes. Studies on localized vibration were not suitable for quantitative meta-analysis due to high heterogeneity.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Clinical Neurology
Chatkaew Pongmala, Margherita Fabbri, Maurizio Zibetti, Yuvadee Pitakpatapee, Takarn Wangthumrong, Tanita Sangpeamsook, Jindapa Srikajon, Prachaya Srivanitchapoom, Jinyoung Youn, Jin Whan Cho, Minkyeong Kim, Heba M. Zamil Shinawi, Mona Talib Obaid, Alexander Baumanni, Nils G. Margraf, Filipa Pona-Ferreiraj, Mariana Leitaoj, Teresa Loboj, Joaquim J. Ferreiraj, Leonardo Lopiano, Carlo Alberto Artusi
Summary: The study indicates that axial postural abnormalities, particularly severe anterior trunk flexion, have a detrimental impact on gait in Parkinson's disease patients, resulting in decreased gait velocity and step length. Personalized rehabilitation strategies should be developed based on the different features of postural abnormalities to target a combined treatment approach.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Rehabilitation
Patricia Lorenzo-Garcia, Ivan Cavero-Redondo, Ana Isabel Torres-Costoso, Maria Jose Guzman-Pavon, Sergio Nunez de Arenas-Arroyo, Celia Alvarez-Bueno
Summary: The systematic review included 12 randomized controlled trials, indicating that body weight support gait training has a positive effect on improving the clinical severity and balance of patients with Parkinson's disease, but the impact on gait parameters is not statistically significant.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Neurosciences
Bauke W. Dijkstra, Moran Gilat, L. Eduardo Cofre Lizama, Martina Mancini, Bruno Bergmans, Sabine M. P. Verschueren, Alice Nieuwboer
Summary: Patients with Parkinson's disease and freezing of gait have significant deficits in dynamic balance control, characterized by hypokinetic weight-shift amplitudes. Medication, particularly levodopa, can improve mediolateral weight-shifting in patients with freezing of gait, along with decreasing the freezing ratio. Further research is needed to investigate whether training can further ameliorate weight-shifting and freezing severity in these patients.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Physiology
Yunzhi Wu, Yuqi Dong, Yunqi Tang, Weiran Wang, Yulong Bo, Cui Zhang
Summary: This study aims to review the relationship between motor performance and cortical activity of older patients with neurological disorders during walking and balance tasks. The results showed that motor performance and cortical activation were affected under difficult task conditions, with poor performance and increased activation observed in Parkinson's disease, stroke, and multiple sclerosis patients. More comprehensive and profound analysis is needed to further understand the relationship between motor performance and activation of the motor-related cortex.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Rehabilitation
Ryo ONUMA, Tadashi MASUDA, Fumihiko HOSHI, Tadamitsu MATSUDA, Tomoko SAKAI, Atsushi OKAWA, Tetsuya JINNO
Summary: This study aimed to investigate reduced anticipatory postural adjustments during gait initiation in post-stroke hemiplegic patients through measuring the center of pressure. The results showed that the latency and magnitude of center of pressure displacement peak for the paretic leg were significantly different compared to controls, and correlated with clinical measures of motor dysfunction and postural balance.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Clinical Neurology
Madli Bayot, Arnaud Delval, Caroline Moreau, Luc Defebvre, Clint Hansen, Walter Maetzler, Christian Schlenstedt
Summary: This study investigated the impact of FOG on gait initiation in PD patients. The results showed that PD+FOG patients had slower and shorter steps during gait initiation, indicating a significant influence of initial posture on gait initiation.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Jesco Streumer, Ashok K. Selvaraj, Erkan Kurt, Bastiaan R. Bloem, Rianne A. J. Esselink, Ronald H. M. A. Bartels, Dejan Georgiev, R. Saman Vinke
Summary: Axial disability, including gait disturbances, is common in Parkinson's disease (PD), especially in advanced stages. Epidural spinal cord stimulation (SCS) has been investigated as a treatment option for gait disorders in PD. This review examines the literature on SCS in PD and evaluates its efficacy, optimal stimulation parameters, optimal electrode locations, possible effects of concurrent deep brain stimulation, and possible working mechanisms on gait.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Computer Science, Artificial Intelligence
Ju Dai, Hao Li, Rui Zeng, Junxuan Bai, Feng Zhou, Junjun Pan
Summary: Recent studies have made significant progress in 3D human motion prediction, but they mainly describe motion using kinematic knowledge, failing to reveal the physical characteristics of human motion. In this paper, we propose a Kinematic and Dynamic coupled transFormer (KD-Former) that combines dynamics with kinematics to learn powerful features for high-fidelity motion prediction. We formulate a reduced-order dynamic model of the human body to calculate joint forces and construct a non-autoregressive encoder-decoder framework based on the transformer structure. Experimental results on Hu-man3.6M and CMU MoCap benchmarks demonstrate the effectiveness and superiority of our method.
PATTERN RECOGNITION
(2023)
Article
Clinical Neurology
Anouk Tosserams, Lisanne Wit, Ingrid H. W. M. Sturkenboom, Maarten J. Nijkrake, Bastiaan R. Bloem, Jorik Nonnekes
Summary: This study investigates the use and efficacy of compensation strategies for gait impairments in Parkinson's disease patients. The findings suggest that the effectiveness of different strategies varies depending on the context, highlighting the importance of personalized approaches for individuals.
Article
Neurosciences
Annagh Macie, Taylor Matson, Alison Schinkel-Ivy
Summary: This study compared the relationships between postural stability and joint kinematics during gait in younger and older adults, and found differences in these relationships related to age. Older adults exhibited stronger and more tightly clustered relationships at the ankle, while younger adults exhibited stronger and more tightly clustered relationships at the hip. By studying these relationships, early predictors of gait impairments can be identified and targeted interventions can be implemented to prevent functional decline in older adulthood.
Article
Clinical Neurology
Arnaldo Fim Neto, Julia Baldi de Luccas, Bruno Leonardo Bianqueti, Luiz Ricardo da Silva, Tiago Paggi Almeida, Andre Kazuo Takahata, Manoel Jacobsen Teixeira, Eberval Gadelha Figueiredo, Slawomir J. Nasuto, Maria Sheila Guimaraes Rocha, Diogo Coutinho Soriano, Fabio Godinho
Summary: This study investigated the dynamics of subthalamic nucleus local field potentials (STN-LFP) in Parkinson's disease patients and found differences in low-frequency beta bursts between tremor-dominant and postural instability and gait disorder phenotypes. These differences were correlated with motor symptoms.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yi Hu, Diyang Zou, Qi Sun, Mengda Jiang, Huiwu Li, Tsung-Yuan Tsai, Jingwei Zhang
Summary: This study found strong correlations between postoperative structures, especially hip center positions, and gait range of motion in unilateral hip dysplasia patients after total hip arthroplasty. It suggests that particular caution should be taken in surgical treatment of postoperative prosthesis structures, especially hip center positions, as they have a significant impact on hip gait motion range.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Gianpaolo Maggi, Alfonsina D'Iorio, Edoardo Nicolo Aiello, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani, Marianna Amboni, Carmine Vitale, Gabriella Santangelo
Summary: This study assessed the psychometric and diagnostic properties of the Beck Depression Inventory-II (BDI-II) in an Italian Parkinson's disease (PD) cohort. The results showed that the BDI-II performed well in terms of internal consistency and construct validity, making it a reliable tool for screening depression in PD patients.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Simona Raimo, Roberto Giorgini, Mariachiara Gaita, Antonio Costanzo, Daniele Spitaleri, Liana Palermo, Marco Tullio Liuzza, Gabriella Santangelo
Summary: Cognitive impairment is common in Multiple Sclerosis (MS) and greatly impacts patients' quality of life. This study aims to assess the sensitivity of cognitive tests included in three widely used batteries for MS-associated CI. The results show that executive functioning tests are the most sensitive in differentiating cognitive functioning between MS patients and healthy controls.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Psychology, Clinical
Manuela Altieri, Francesco Cerciello, Antonio Gallo, Gabriella Santangelo
Summary: This meta-analytic study aimed to assess the relationship between depressive symptomatology and cognitive abilities in patients with multiple sclerosis (MS). The results showed a small effect size for the association between depression and verbal memory, spatial memory, verbal fluency, and inhibitory control, and a medium effect size for the association between depression and global cognition, attention, processing speed, and working memory. The relationship between depression and set-shifting abilities was not significant. These findings suggest that MS patients with higher levels of depressive symptomatology may experience difficulties in various cognitive domains.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Alfonsina D'Iorio, Federica Solca, Silvia Torre, Ruggero Bonetti, Francesco Scheveger, Eleonora Colombo, Alessio Maranzano, Luca Maderna, Claudia Morelli, Alberto Doretti, Marianna Amboni, Carmine Vitale, Federico Verde, Roberta Ferrucci, Sergio Barbieri, Eleonora Zirone, Alberto Priori, Gabriella Pravettoni, Gabriella Santangelo, Vincenzo Silani, Nicola Ticozzi, Andrea Ciammola, Barbara Poletti
Summary: This study assessed the clinimetrics and feasibility of the FAB in non-demented PD patients, revealing that the FAB is a reliable and feasible screener for detecting cognitive impairment in these patients.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Alfonsina D'Iorio, Edoardo Nicolo Aiello, Assunta Trinchillo, Vincenzo Silani, Nicola Ticozzi, Andrea Ciammola, Barbara Poletti, Marcello Esposito, Gabriella Santangelo
Summary: This study aimed to evaluate the clinimetrics of the Montreal Cognitive Assessment (MoCA) in Italian patients with adult-onset idiopathic focal dystonia (AOIFD). The MoCA was administered to 86 AOIFD patients and 92 healthy controls (HCs). The results showed that the MoCA had a reliable structure and was correlated with TMT, BMT, and DAS scores, but not with BDI-II scores. The adjusted MoCA scores accurately detected cognitive impairment and discriminated between patients and HCs. It was also unrelated to disease duration, severity, and motor phenotypes.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Manuela Altieri, Gianpaolo Maggi, Valentina Rippa, Gabriella Santangelo
Summary: This study validated the reliability and validity of the AMI in a healthy Italian population and provided normative data for the scale. The results showed that the AMI had good psychometric properties and a three-factor structure. The study also found that the variation in AMI scores was not related to sociodemographic variables and identified three cut-offs for mild, moderate, and severe apathy using the Youden's J statistic.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Gianpaolo Maggi, Carmine Vitale, Francesco Cerciello, Gabriella Santangelo
Summary: Sleep disorders are common in Parkinson's disease and have variable prevalence rates. They are multifactorial in etiology, resulting from degenerative processes, drug interactions, and clinical features. A meta-analytic study found that RBD had a prevalence of 46% and was associated with older age, lower education, longer disease duration, higher medication doses, and more severe symptoms. EDS had a prevalence of 35% and was associated with older age, longer disease duration, more severe symptoms, higher medication doses, and reduced autonomy. Insomnia was reported in 44% of patients and was related to longer disease duration, higher medication doses, and more severe depression. Sleep disorders are associated with a more severe clinical phenotype of Parkinson's disease, and further research is needed to understand their underlying mechanisms and develop targeted therapies.
SLEEP MEDICINE REVIEWS
(2023)
Article
Neurosciences
Gianpaolo Maggi, Carmine Vitale, Alessia Delle Curti, Marianna Amboni, Gabriella Santangelo
Summary: Altered self-awareness or anosognosia may affect everyday life and independent functioning of PD patients. The present study aimed to explore the awareness of apathy in PD patients through comparing self-reported evaluations with caregivers' ratings. The study found that there was fair agreement between patients' self-reports and caregivers' ratings on apathy scores. Patients reported less severe apathetic symptoms compared to their caregivers' reports, especially those related to executive and auto-activation processing. Executive functioning mediated the relationship between disease stage and awareness of apathy. Awareness of executive apathy impacted patients' self-reported quality of life. Anosognosia for apathy in PD patients may affect their quality of life perception and delays diagnosis and treatment.
Article
Pediatrics
Nicola Davide Cavallo, Gianpaolo Maggi, Francesco Ferraiuolo, Anna Sorrentino, Silverio Perrotta, Marco Carotenuto, Gabriella Santangelo, Claudia Santoro
Summary: This study examined the prevalence of bullying/cyberbullying behaviors and victimization behaviors in children and adolescents with NF1. The findings show that victimization behaviors were more common than bullying/cyberbullying ones. Participants also reported depressive and anxiety symptoms, reduced self-esteem, and low psychosocial quality of life, with females experiencing more severe effects. Reduced self-esteem was associated with more visible NF1 symptoms, and victimization behaviors mediated the relationship between anxiety and psychosocial quality of life. These results highlight the importance of a multidisciplinary approach in the diagnosis and treatment of NF1.
Review
Clinical Neurology
Gianpaolo Maggi, Chiara Giacobbe, Federica Iannotta, Gabriella Santangelo, Carmine Vitale
Summary: OSA affects nearly half of PD patients and is associated with older age, male sex, higher BMI, more severe motor disturbances, and periodic limb movements. However, it has no relationship with cognitive functioning and neuropsychiatric manifestations. Future studies should focus on determining the impact of clinical features and dopaminergic medication on the development of PD-OSA.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Simona Raimo, Gabriella Santangelo, Maria Cropano, Mariachiara Gaita, Lidia Ammendola, Daniela Malangone, Giacomo Lus, Elisabetta Signoriello
Summary: This study evaluated the feasibility and reliability of teleneuropsychology (TeleNP) in assessing the cognitive profile of people with multiple sclerosis (PwMS) compared to face-to-face assessment (F-F). The results showed similar cognitive test performance regardless of the administration type, but better visuospatial test performance in the F-F condition. Therefore, TeleNP is a feasible and highly reliable approach in MS clinical practice.
MULTIPLE SCLEROSIS JOURNAL
(2023)
