Article
Biochemistry & Molecular Biology
Zhengzheng Ruan, Dongdong Zhang, Ruixue Huang, Wei Sun, Liyan Hou, Jie Zhao, Qingshan Wang
Summary: Chronic neuroinflammation damages dopaminergic neurons in a rotenone-induced mouse PD model through blood-brain barrier dysfunction mediated by microglial MMP-2/-9 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Chunfu Li, Yongzhi Wang, Huiting Liu, Xinghua Zhang, Dalai Baolige, Shihua Zhao, Wei Hu, Yang Yang
Summary: Lab-attenuated rabies virus (RABV) is a less pathogenic variant compared to wild-type RABV, and through serial passage in mice brains, a safe and well-replicating strain was developed with specific amino acid substitutions on the G protein. This decreased pathogenicity was linked to increased RABV-G expression, higher apoptosis levels in infected cells, and effects on DCs and blood-brain barrier permeability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Ruchi Shukla, Jayantee Kalita, Rudrashish Haldar, Usha K. Misra
Summary: BCB permeability in TBM is associated with inflammatory cytokines, CSF pleocytosis, and presence of exudates on MRI, but not with severity of meningitis and outcome.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carla Rodriguez-Mogeda, Sabela Rodriguez-Lorenzo, Jiji Attia, Jack van Horssen, Maarten E. Witte, Helga E. de Vries
Summary: Multiple sclerosis is an inflammatory disease where B cells play a crucial role in the pathogenesis, migrating into the central nervous system through various routes. Understanding the routes of B cell entry into the inflamed CNS is essential for comprehending the disease.
Review
Engineering, Biomedical
Xing Tian, Taojian Fan, Wentian Zhao, Ghulam Abbas, Bo Han, Ke Zhang, Nan Li, Ning Liu, Weiyuan Liang, Hao Huang, Wen Chen, Bing Wang, Zhongjian Xie
Summary: This review focuses on the potential applications of nanotechnology in stroke treatment. It discusses the main molecular pathological mechanisms of ischemic stroke, the role of the blood-brain barrier, and summarizes the challenges and future prospects of nanomedicine-based stroke treatments.
BIOACTIVE MATERIALS
(2021)
Review
Immunology
Marija Djukic, Peter Lange, Frank Erbguth, Roland Nau
Summary: The cerebrospinal fluid (CSF) space is complex and influenced by various factors. The equilibrium of CSF components depends on the size of molecules or particles, and the typical features of CSF analysis vary between different parts. Identification of pathogens is crucial in the diagnosis of central nervous system infections.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neuroimaging
Michael S. Stringer, Anna K. Heye, Paul A. Armitage, Francesca Chappell, Maria del C. Valdes Hernandez, Stephen D. J. Makin, Eleni Sakka, Michael J. Thrippleton, Joanna M. Wardlaw
Summary: The study showed that there is an increase in subtle blood-brain barrier permeability in small vessel disease. With the severity of white matter hyperintensity increasing, the permeability-surface area product increased in grey and normal-appearing white matter. Additionally, patients with more severe white matter hyperintensity had lower blood plasma volume in affected white matter, but higher in normal-appearing white matter.
NEUROIMAGE-CLINICAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stig P. Cramer, Henrik B. W. Larsson, Maria H. Knudsen, Helle J. Simonsen, Mark B. Vestergaard, Ulrich Lindberg
Summary: This study investigates the reproducibility of DCE-MRI in healthy controls and evaluates the impact of arterial input function selection and manual region of interests delineation versus automated global segmentation. The results show excellent reproducibility of pharmacokinetic variables derived from DCE-MRI in healthy controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Hui-min Gao, Hao Chen, Gui-Yun Cui, Jin-Xia Hu
Summary: This article briefly describes the role and mechanism of action of the blood-brain barrier (BBB), as well as the functional proteins involved. Additionally, it discusses the mechanisms of BBB damage following an ischemic stroke and presents several therapeutic strategies addressing these impairments. The article aims to provide innovative ideas for drug delivery research via the BBB.
CELL AND BIOSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Jianglong Kong, Runxuan Chu, Yi Wang
Summary: Stroke is a major cause of death and disability worldwide. Neuroprotective therapy, combined with thrombolytic therapy, is an important treatment for stroke.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Immunology
Katrien Skorobogatov, Livia De Picker, Robert Verkerk, Violette Coppens, Marion Leboyer, Norbert Mueller, Manuel Morrens
Summary: This study found moderate to strong concordance between peripheral and central concentrations of kynurenine and 3-hydroxykynurenine, not only in psychiatric disorders, but in other physiological conditions. Despite discordant findings for other metabolites, blood metabolite levels were associated with clinical symptoms and treatment response in psychiatric patients, as well as with observed neuroanatomical abnormalities and glial activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Madeeha H. Sheikh, Mariella Errede, Antonio D'Amati, Noorafza Q. Khan, Silvia Fanti, Rodrigo A. Loiola, Simon McArthur, Gareth S. D. Purvis, Caroline E. O'Riordan, Davide Ferorelli, Alessandro Dell'Erba, Julius Kieswich, Chis Reutelingsperger, Eugenio Maiorano, Magdi Yaqoob, Christoph Thiemermann, Andrea Baragetti, Alberico Luigi Catapano, Giuseppe Danilo Norata, Federica Marelli-Berg, Daniela Virgintino, Egle Solito
Summary: Mounting evidence suggests a link between metabolic disease and neurovascular disorders and cognitive decline. This study used mouse models and post-mortem brains of T2DM patients to show that metabolic disease damages the blood-brain barrier (BBB), leading to increased leukocyte extravasation and neuroinflammation. Therapeutic interventions such as pharmacological treatment and dietary changes were found to reduce BBB damage.
Review
Biotechnology & Applied Microbiology
Danping Zhuang, Huifen Zhang, Genwen Hu, Bing Guo
Summary: This review summarizes the recent advances in MRI contrast agents and dual-modal or triple-modal nanoprobes for glioblastoma (GBM) imaging, and discusses potential obstacles and prospects for future research and clinical translation of these contrast agents.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Patrick Lyden, Alastair Buchan, Johannes Boltze, Marc Fisher
Summary: Despite years of research, ischemic stroke remains a major public health concern, and STAIR XI workshop addressed challenges such as redefining neuroprotection paradigm, using tissue window for patient selection, and proposing target window for therapies targeting elements of the neurovascular unit at different times.
Article
Plant Sciences
Hairong Zhao, Mei Wang, Xi Huang, Xiumei Wu, Huai Xiao, Fanmao Jin, Jiaming Lv, Jidong Cheng, Yu Zhao, Chenggui Zhang
Summary: Wasp venom exhibits potential neuroprotective effects on acute ischaemic stroke (AIS) in rats, improving neurological impairment, promoting blood flow recovery, reducing infarct volume, and regulating blood-brain barrier permeability. The venom also inhibits inflammation and apoptosis, and modulates angiogenesis factors in the brain.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Neurosciences
Theresa Rizk, L. Christine Turtzo, Martin Cota, Andre J. Van Der Merwe, Lawrence Latour, Mark D. Whiting, Leighton Chan
Article
Clinical Neurology
Katie A. Edwards, Cassandra L. Pattinson, Vivian A. Guedes, Jordan Peyer, Candace Moore, Tara Davis, Christina Devoto, L. Christine Turtzo, Lawrence Latour, Jessica M. Gill
FRONTIERS IN NEUROLOGY
(2020)
Article
Neurosciences
Panagiotis Mastorakos, Nicole Mihelson, Marie Luby, Scott R. Burks, Kory Johnson, Amie W. Hsia, Jaclyn Witko, Joseph A. Frank, Lawrence Latour, Dorian B. McGavern
Summary: Positive vascular recanalization after endovascular thrombectomy may lead to cerebral edema and worsened clinical outcomes, especially in patients with hemorrhagic transformation. Resident microglia initially stabilize damaged vessels, followed by an influx of myelomonocytic cells causing severe edema. Prolonged blockade of myeloid cell recruitment can prevent severe edema but also interfere with vascular repair.
NATURE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Amie W. Hsia, Marie L. Luby, Richard Leigh, John K. Lynch, Zurab Nadareishvili, Richard T. Benson, Chandni Kalaria, Shannon P. Burton, Larry Latour
Summary: Patients with minor acute ischemic stroke (mAIS) who received IV tPA treatment showed more frequent MRI targets compared to untreated patients, even in those without clearly disabling deficits.
Article
Clinical Neurology
Andrea L. C. Schneider, Elizabeth Selvin, Lawrence Latour, L. Christine Turtzo, Josef Coresh, Thomas Mosley, Geoffrey Ling, Rebecca F. Gottesman
Summary: The study showed a dose-dependent relationship between head injury and dementia risk, with stronger associations among female and White participants.
ALZHEIMERS & DEMENTIA
(2021)
Meeting Abstract
Clinical Neurology
Yongwoo Kim, Marie Luby, Nina-Serena F. Burkett, Gina Norato, Richard Leigh, Clinton B. Wright, Kyle C. Kern, Amie W. Hsia, John K. Lynch, Malik M. Adil, Lawrence Latour
Meeting Abstract
Clinical Neurology
Marie Luby, Saeed Ansari, Rachel Davis, Marc Fisher, Lawrence Latour, Rena Sukhdeo Singh, Clinton B. Wright, John K. Lynch
Article
Clinical Neurology
Yongwoo Kim, Marie Luby, Nina-Serena Burkett, Gina Norato, Richard Leigh, Clinton B. Wright, Kyle C. Kern, Amie W. Hsia, John K. Lynch, Malik M. Adil, Lawrence L. Latour
Summary: The presence of an ischemic lesion on FLAIR within 4.5 hours of stroke onset is associated with a reduced likelihood of favorable outcomes 90 days after IV thrombolysis.
CEREBROVASCULAR DISEASES
(2021)
Article
Critical Care Medicine
L. Christine Turtzo, Marie Luby, Neekita Jikaria, Allison Diane Griffin, Danielle Greenman, Reinoud P. H. Bokkers, Gunjan Parikh, Nicole Peterkin, Mark Whiting, Lawrence L. Latour
Summary: MRI may identify TBI-related lesions not detected by CT, predicting clinical outcomes and aiding in predicting patient recovery processes.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Marie Luby, Jose G. Merino, Rachel Davis, Saeed Ansari, Marc Fisher, Amie W. Hsia, Yongwoo Kim, Lawrence L. Latour, Evan S. McCreedy, Rena Sukhdeo Singh, Clinton B. Wright, John K. Lynch
Summary: Despite complete recanalization after mechanical thrombectomy, residual hypoperfusion and lesion growth at 24 hours post-EVT are associated with multiple-pass thrombectomy. Patients with residual hypoperfusion have a lower rate of early neurological improvement and worse long-term outcomes. Immediate adjunctive therapy may benefit patients with residual hypoperfusion to limit lesion growth and improve clinical outcomes.
CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Young-Eun Cho, Hyangkyu Lee, Heekyong R. Bae, Hyungsuk Kim, Sijung Yun, Rany Vorn, Ann Cashion, Mary Jo Rucker, Mariam Afzal, Lawrence Latour, Jessica Gill
Summary: In this study, the transcriptomics of peripheral blood mononuclear cells (PBMCs) in patients with mild ischemic stroke were analyzed using single-cell RNA sequencing. The results showed an increased number of NK cells and the presence of new monocyte subclusters in patients. These findings contribute to the understanding of immune response and potential therapeutic development in mild ischemic stroke.
STROKE AND VASCULAR NEUROLOGY
(2022)
Article
Clinical Neurology
Dennys Reyes, Alexis N. Simpkins, Emi Hitomi, John K. Lynch, Amie W. Hsia, Zurab Nadareishvili, Marie Luby, Lawrence L. Latour, Richard Leigh
Summary: In this study, the National Institutes of Health (NIH) FHV score was developed to quantify the burden of fluid-attenuated inversion recovery hyperintense vessels (FHVs) and investigate its potential as a surrogate for perfusion weighted imaging (PWI). The study found a strong association between the NIH-FHV score and PWI lesion volume, and when combined with diffusion weighted imaging, it may be helpful in determining the presence of a clinically relevant diffusion-perfusion mismatch in situations where perfusion imaging is not available.
Letter
Clinical Neurology
Amie W. Hsia, Marie Luby, Lawrence L. Latour
ANNALS OF NEUROLOGY
(2022)
Meeting Abstract
Critical Care Medicine
Danielle Greenman, Yi-Yu Chou, Elizabeth Magrath Ucci, Lawrence Latour, Dzung Pham, John Butman
JOURNAL OF NEUROTRAUMA
(2021)
Meeting Abstract
Critical Care Medicine
L. Christine Turtzo, Nicole Peterkin, Nikita Chapagain, Lawrence Latour
JOURNAL OF NEUROTRAUMA
(2021)