Article
Neurosciences
Jin Fang, Kelei Hua, Feng Chen, Zhifang Wan, Yi Yin, Ping Liu, Tianyue Wang, Guihua Jiang
Summary: Patients with ankylosing spondylitis (AS) showed changes in cerebral blood flow (CBF), with increased CBF values in certain brain regions and decreased CBF values in others compared with healthy controls. However, there were no significant correlations between CBF values and specific clinical characteristics of AS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Eleonora Piccirilli, Antonio M. Chiarelli, Carlo Sestieri, Daniele Mascali, Darien Calvo Garcia, Adele Primavera, Rita Salomone, Richard G. Wise, Antonio Ferretti, Massimo Caulo
Summary: In preterm infants, disturbances in regional cerebral blood flow (CBF) can affect brain maturation and may not be associated with brain injury. This study aimed to investigate the spatial distribution of grey matter CBF in preterm and full-term newborns, as well as the relationship between CBF patterns, prematurity, and prematurity-related brain lesions. Using pCASL MRI, CBF measurements were obtained in 66 preterm and 38 full-term newborns. The findings showed that GM perfusion was associated with gestational age at birth and the presence of brain injury. The study also identified specific clusters of brain regions based on CBF patterns. These findings suggest that ASL MRI can be a valuable tool in assessing individuals at risk of domain-specific impairment.
HUMAN BRAIN MAPPING
(2023)
Article
Neuroimaging
Soudabeh Fazeli, Abraham Noorbakhsh, Steven G. Imbesi, Divya S. Bolar
Summary: This study evaluated cerebral perfusion changes in PRES patients using ASL technique, showing that the majority of patients had hyperperfusion in brain regions, supporting the hypothesis of autoregulatory failure.
NEUROIMAGE-CLINICAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shota Ishida, Makoto Isozaki, Yasuhiro Fujiwara, Naoyuki Takei, Masayuki Kanamoto, Hirohiko Kimura, Tetsuya Tsujikawa
Summary: Using simulation-based supervised DNNs can reduce the effects of Rician noise on ASL parameter estimation and compute unbiased CBF and ATT values. The study found that DNN outperforms conventional methods in terms of accuracy, precision, and noise immunity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Anne-Marthe Sanders, Genevieve Richard, Knut Kolskar, Kristine M. M. Ulrichsen, Dag Alnaes, Dani Beck, Erlend S. S. Dorum, Andreas Engvig, Martina Jonette Lund, Wibeke Nordhoy, Mads L. L. Pedersen, Jaroslav Rokicki, Jan Egil Nordvik, Lars T. T. Westlye
Summary: Cerebral blood flow is crucial for brain function, and age-related changes in CBF can lead to neurocognitive disorders and vascular events. This study examines the associations between physical and social activities and CBF in older adults. The findings show that low intensity physical activity, moderate to vigorous physical activity, participation in social activities, and reading are positively associated with CBF in different brain regions. The results also suggest that baseline levels of gardening and reading can affect changes in CBF over time. These findings highlight the importance of modifiable lifestyle factors in maintaining healthy brain aging.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Martin Kojan, Martin Gajdos, Pavel Riha, Irena Dolezalova, Zdenek Rehak, Ivan Rektor
Summary: ASL is a useful technique for presurgical evaluation in non-lesional epilepsy, showing better positive predictive value and sensitivity compared to PET in this study. Statistical analysis indicates that these methods have similar predictive power.
Article
Neuroimaging
Tracy Ssali, Udunna C. Anazodo, Lucas Narciso, Linshan Liu, Sarah Jesso, Lauryn Richardson, Matthias Guenther, Simon Konstandin, Klaus Eickel, Frank Prato, Elizabeth Finger, Keith St. Lawrence
Summary: The study aimed to evaluate the feasibility of ASL for longitudinal monitoring of FTD patients by quantifying voxel-by-voxel perfusion variability between sessions. The results showed good consistency and reliability of grey-matter perfusion between sessions in both patients and controls. Intensity normalization could reduce the impact of daily perfusion fluctuations.
NEUROIMAGE-CLINICAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph G. Woods, Eric C. Wong, Emma C. Boyd, Divya S. Bolar
Summary: In this study, a novel pulse sequence called VESPA ASL is introduced that combines velocity-selective and pseudo-continuous ASL to simultaneously label different pools of arterial blood for robust cerebral blood flow (CBF) and arterial transit time (ATT) measurement. The results show that VESPA ASL accurately measures CBF in the presence of long ATTs, and ATTs < TI can also be measured. VESPA ASL offers important advantages over existing methods for noninvasive perfusion and transit time imaging in vascular diseases with delayed arterial transit.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne L. Franklin, Nora Voormolen, Isabell K. Bones, Tijmen Korteweg, Martin N. J. M. Wasser, Henrike G. Dankers, Daniele Cohen, Marijn van Stralen, Clemens Bos, Matthias J. P. van Osch
Summary: The study investigates the technical feasibility of using VS-ASL for perfusion imaging in breast cancer patients and demonstrates its effectiveness in distinguishing mass lesions from nonmass lesions. The assessment results show that VS-ASL performs consistently well in terms of lesion visibility and artifact scores.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Manuel Taso, Veronica Aramendia-Vidaurreta, Erin K. K. Englund, Susan Francis, Suzanne Franklin, Ananth J. J. Madhuranthakam, Petros Martirosian, Krishna S. S. Nayak, Qin Qin, Xingfeng Shao, David L. L. Thomas, Zungho Zun, Maria A. A. Fernandez-Seara
Summary: This review article provides an overview of the developments and challenges in arterial spin labeling (ASL) perfusion imaging in the body outside of the brain. Specific challenges and developments in various body locations, including kidneys, lungs, heart, placenta, eye, liver, pancreas, and muscle, are discussed. The article also explores the possibilities of wider adoption of body ASL in clinical practice based on standardization efforts and recent advances in high/low-field systems and machine-learning.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sven Bambach, Mark Smith, P. Pearse Morris, Norbert G. Campeau, Mai-Lan Ho
Summary: Arterial spin labeling (ASL) is a noncontrast MRI technique used for quantitative evaluation of brain perfusion. This article discusses advanced applications of ASL across the lifespan, presenting case examples from children and adults with various pathologies. The article highlights the subtleties and pitfalls of ASL interpretation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Medicine, General & Internal
Kenji Takata, Hirohiko Kimura, Shota Ishida, Makoto Isozaki, Yoshifumi Higashino, Ken-Ichiro Kikuta, Hidehiko Okazawa, Tetsuya Tsujikawa
Summary: The relationship between MRI-arterial spin labeling (ASL) parameters and PET-cerebral blood flow (CBF)/cerebrovascular reactivity (CVR) was investigated in Moyamoya disease. The results showed significant correlations between ASL parameters and PET-CBF/PET-CVR. Furthermore, ASL-ATT in the MCA territories was found to be related to CVR.
Article
Neurosciences
Meher R. Juttukonda, Binyin Li, Randa Almaktoum, Kimberly A. Stephens, Kathryn M. Yochim, Essa Yacoub, Randy L. Buckner, David H. Salat
Summary: ASL MRI data from HCP-A was used to study cerebral hemodynamics in typically aging adults, revealing that white matter CBF decreases and white matter ATT lengthens with age. Additionally, CBF is lower and ATTs are longer in white matter compared to gray matter across the adult lifespan. Furthermore, sex differences were observed with females showing shorter white matter ATTs than males.
Review
Medicine, General & Internal
Efthymia Maria Kapasouri, Diomidis C. C. Ioannidis, Donnie Cameron, Vassilios S. S. Vassiliou, Michael Hornberger
Summary: This study aimed to systematically review and analyze the role of cerebral blood flow (CBF) in the medial temporal lobe (MTL) using arterial spin labeling magnetic resonance imaging (ASL-MRI) in patients with Alzheimer's disease (AD), individuals with mild cognitive impairment (MCI), and cognitively normal adults (CN). The results showed that CBF measured via ASL-MRI was impaired in AD compared to the CN group in subregions of the MTL, while there was no significant difference between MCI and CN participants in the MTL.
Article
Veterinary Sciences
Anne-Cecile Hoffmann, Yannick Ruel, Kirsten Gnirs, Stella Papageorgiou, Luca Zilberstein, Sarah Nahmani, Nathalie Boddaert, Hugues Gaillot
Summary: The study tested the feasibility of ASL using a 1.5 Tesla scanner in dogs and cats, providing recommendations for optimal quantification of cerebral blood flow. By implementing ASL sequences and optimizing CBF, valuable values for the characterization of various brain diseases in dogs and cats were obtained.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreea Hertanu, Lucas Soustelle, Arnaud Le Troter, Julie Buron, Julie Le Priellec, Victor N. D. Carvalho, Myriam Cayre, Pascale Durbec, Gopal Varma, David C. Alsop, Olivier M. Girard, Guillaume Duhamel
Summary: This study investigated T-1D-filtering methods for isolating different ranges of T-1D components based on their microstructural properties. The results showed that high RF power and low duty-cycle ihMT filters could successfully isolate long-T-1D and short-T-1D components in the brain.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neurosciences
An Vo, Katharina A. Schindlbeck, Nha Nguyen, Andrea Rommal, Phoebe G. Spetsieris, Chris C. Tang, Yoon Young Choi, Martin Niethammer, Vijay Dhawan, David Eidelberg
Summary: Functional imaging is widely used to identify disease-specific networks in neurodegenerative disorders. In Parkinson's disease, network assortativity increases over time, with high assortativity associated with clinically aggressive genetic variants and low assortativity associated with genes related to slow progression.
Meeting Abstract
Endocrinology & Metabolism
Donald C. Simonson, Manuel Taso, Colleen Mcgrath, Stephanie A. Waldman, Fotini Papadopoulou, David C. Alsop
Review
Radiology, Nuclear Medicine & Medical Imaging
Qin Qin, David C. Alsop, Divya S. Bolar, Luis Hernandez-Garcia, James Meakin, Dapeng Liu, Krishna S. Nayak, Sophie Schmid, Matthias J. P. van Osch, Eric C. Wong, Joseph G. Woods, Greg Zaharchuk, Moss Y. Zhao, Zungho Zun, Jia Guo
Summary: This review article provides an overview of the current status of velocity-selective arterial spin labeling (VSASL) perfusion MRI and discusses its concepts, implementation, clinical applications, and technical challenges.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Review
Biophysics
David C. Alsop, Ece Ercan, Olivier M. Girard, Alex L. Mackay, Carl A. Michal, Gopal Varma, Elena Vinogradov, Guillaume Duhamel
Summary: Off-resonance radio frequency irradiation can induce the ordering of proton spins in the dipolar fields of their neighbors, in molecules with restricted mobility. This dipolar order decays with a characteristic relaxation time, T-1D, that is very different from the T-1 and T-2 relaxation of the nuclear alignment with the main magnetic field. Inhomogeneous magnetization transfer (ihMT) imaging is a refinement of magnetization transfer (MT) imaging that isolates the MT signal dependence on dipolar order relaxation times within motion-constrained molecules.
NMR IN BIOMEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Manuel Taso, Fanny Munsch, Olivier M. Girard, Guillaume Duhamel, David C. Alsop, Gopal Varma
Summary: This study compared the benefits of fast spin echo (FSE) imaging with rapid gradient-echo (RAGE) in magnetization-prepared inhomogeneous magnetization transfer (ihMT) imaging. The results showed that FSE imaging generally has higher signal-to-noise ratio (SNR) compared to gradient-echo imaging, but it also has higher physiological noise. However, an inversion-recovery-based cerebrospinal fluid (CSF) suppression was shown to be efficient in mitigating the effects of CSF motion.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Tomaz Rus, Katharina A. Schindlbeck, Chris C. Tang, An Vo, Vijay Dhawan, Maja Trost, David Eidelberg
Summary: The study aimed to explore the relationship between the two brain networks, PDRP and PDCP, in patients with Parkinson's disease, finding a predominance of PDRP over PDCP which can aid in differential diagnosis and tracking disease progression in different types of Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Matej Perovnik, Tomaz Rus, Katharina A. Schindlbeck, David Eidelberg
Summary: Network analytical tools are used to study brain diseases by analyzing imaging maps. Specific networks can be identified and validated, allowing for quantitative assessment of pathway changes over time and during treatment. Network abnormalities can be identified before symptoms and used to track disease progression and treatment efficacy. The development of analogous methods for functional MRI has expanded the application of network tools to diverse patient populations.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Neurosciences
Andreea Hertanu, Lucas Soustelle, Julie Buron, Julie Le Priellec, Myriam Cayre, Arnaud Le Troter, Valentin H. Prevost, Jean-Philippe Ranjeva, Gopal Varma, David C. Alsop, Pascale Durbec, Olivier M. Girard, Guillaume Duhamel
Summary: This study investigated the association of ihMT signals with demyelination and remyelination in the acute cuprizone mouse model using multimodal MRI. The results showed that the ihMT high-pass T1D-filters were sensitive markers of demyelination and remyelination, and correlated well with histology. The ihMT band-pass T1D-filter was less sensitive to myelin changes and may be influenced by other pathological processes.
Article
Neurosciences
An Vo, Nha Nguyen, Koji Fujita, Katharina A. Schindlbeck, Andrea Rommal, Susan B. Bressman, Martin Niethammer, David Eidelberg
Summary: Primary dystonia is caused by abnormal functional relationships between basal ganglia and cerebellar motor circuits. Resting-state functional MRI (rs-fMRI) can provide unique information on the anatomy of abnormal brain circuits, and it is found that networks involving basal ganglia, cerebellum, thalamus, sensorimotor areas, and cortical association regions are elevated in hereditary and sporadic dystonia. The expression of these networks is correlated with dystonia motor ratings and can improve the accuracy of predictions for new treatments.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Soustelle, Thomas Troalen, Andreea Hertanu, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, Olivier M. Girard
Summary: The purpose of this study is to demonstrate the bias in quantitative MT (qMT) measures caused by dipolar order and on-resonance saturation (ONRS) effects in MT spoiled gradient-recalled (SPGR) acquisitions. The researchers propose changes to the acquisition and analysis strategies to remove these biases and improve the accuracy and reproducibility of qMT-SPGR studies.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Correction
Clinical Neurology
Matej Perovnik, Tomaz Rus, Katharina A. A. Schindlbeck, David Eidelberg
NATURE REVIEWS NEUROLOGY
(2023)
Article
Clinical Neurology
Martin Niethammer, Chris C. C. Tang, Roland Dominic G. Jamora, An Vo, Nha Nguyen, Yilong Ma, Shichun Peng, Jeff L. Waugh, Ana Westenberger, David Eidelberg
Summary: The objective of this study was to characterize a metabolic brain network associated with X-linked dystonia-parkinsonism (XDP). PET scans were conducted on Filipino men with XDP and healthy men without the condition. The results showed that XDP is associated with abnormal functional connectivity in the brain.
ANNALS OF NEUROLOGY
(2023)
Article
Pediatrics
J. P. Dyke, A. Voskrebenzev, L. K. Blatt, J. Vogel-Claussen, R. Grimm, S. Worgall, J. M. Perlman, A. Kovanlikaya
Summary: This study evaluated the use of functional lung MRI in premature infants to assess pulmonary ventilation. The results showed that preterm infants with bronchopulmonary dysplasia had significantly higher ventilation defect percentages compared to those without the disease. The study demonstrates that phase-resolved functional lung MRI is a feasible method to assess lung function in preterm infants.
PEDIATRIC RADIOLOGY
(2023)
Article
Neuroimaging
Phoebe G. Spetsieris, David Eidelberg
Summary: Notable progress has been made in the study of neurodegenerative diseases using reduction techniques such as principal component analysis (PCA) and sparse inverse covariance estimation (SICE) in positron emission tomography (PET) data. In a recent study on Parkinson's disease (PD) patients, SICE combined with PCA was used to optimize maps of functional metabolic connectivity and identify key regional hubs and their connections in the brain. This approach revealed a core subnetwork that remained consistent across PD patients and could serve as a target for disease modification.
NEUROIMAGE-CLINICAL
(2023)
