Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Gastroenterology & Hepatology
Gangarao Davuluri, Nicole Welch, Jinendiran Sekar, Mahesha Gangadhariah, Khaled Alsabbagh Alchirazi, Maradumane L. Mohan, Avinash Kumar, Sashi Kant, Samjhana Thapaliya, McKenzie Stine, Megan R. McMullen, Rebecca L. McCullough, George R. Stark, Laura E. Nagy, Sathyamangla V. Naga Prasad, Srinivasan Dasarathy
Summary: Despite the high clinical significance of sarcopenia in alcohol-associated cirrhosis, the mechanisms of ethanol-induced impaired protein homeostasis are poorly understood. This study identified PP2A as a key mediator in ethanol-induced dysregulation of protein balance, suggesting potential therapeutic approaches targeting the PI3K gamma-PP2A axis.
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Chemistry, Medicinal
Ziwei Yao, Jiayuan Li, Lihua Bian, Qiuyu Li, Xiaomei Wang, Xue Yang, Xiaojia Wei, Guohui Wan, Yuqing Wang, Jinli Shi, Jianyou Guo
Summary: This study systematically investigated the efficacy and mechanism of action of Nootkatone (NKT) in a rotenone-induced Parkinson's disease model. The results demonstrated that NKT alleviated behavioral dysfunction, protected dopaminergic neurons, and reduced neuroinflammation through activation of the PI3K/Akt signaling pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rachel Aruldas, Laura Buczek Orenstein, Sade Spencer
Summary: Repeated cocaine exposure induces changes in AMPK and pAMPK in different brain regions and cellular compartments, with some differences between acute withdrawal and ongoing cocaine treatment. Pretreatment with metformin, an indirect AMPK activator, enhances acute cocaine-induced locomotor activity but blocks the development of sensitization. These findings provide insights into the dynamics of AMPK activation in subcellular compartments and support the potential use of metformin for the treatment of cocaine use disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vikram Jeet Singh, Bharti Sharma, Pooja A. Chawla
Summary: The article focuses on the MAPK signaling pathway and the role of different heterocyclic compounds with nitrogen, sulfur, and oxygen in blocking the MAPK signaling pathway. Heterocyclic compounds are important due to their high potency and selectivity against various targets involved in the MAPK signaling pathway for cancer management. The potential of these compounds in inhibiting MAPK cascade and recent advancements in developing MAPK signaling pathway inhibitors are discussed in detail.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
T. G. Sahana, Ke Zhang
Summary: Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease with multiple genetic and non-genetic risk factors. Cellular stress plays a significant role in ALS conditions, with the MAPK pathway being implicated in the disease pathogenesis and potential drug targeting.
Article
Agriculture, Multidisciplinary
Kai-yuan Ji, Ru-jun Wen, Zheng-zhou Wang, Qian-qian Tian, Wei Zhang, Yun-hai Zhang
Summary: In mammals, miRNAs regulate the expression of target genes and play crucial roles in various biological processes. The expression levels of miR-370-5p differ significantly in sheep with different hair colors, but its function is not clear. This study investigated the roles of miR-370-5p in sheep melanocytes and found that its overexpression significantly inhibited cell proliferation (P<0.01), tyrosinase activity (P=0.001), and melanin production (P<0.001).
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Cardiac & Cardiovascular Systems
Yun Liu, Jing Hu, Weiwei Wang, Qian Wang
Summary: This study explored the effect of miR-145 on cardiac fibrosis in heart failure mice and its target gene MAP3K3. The levels of miR-145 were decreased in heart failure mice and Ang II-treated cardiac fibroblasts. Upregulation of miR-145 improved cardiac dysfunction and inhibited fibrosis by suppressing MAP3K3 expression. Blocking MAP3K3 or upregulating miR-145 can be potential treatments for heart failure and cardiac fibrosis.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Hsin-Yu Ho, Ping-Ju Chen, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Picrasidine I exerts anticancer effects in nasopharyngeal carcinoma by modulating HO-1 via the ERK and Akt signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Tae-Won Jang, Jae-Ho Park
Summary: The research demonstrated that the callus of Abeliophyllum distichum has anti-inflammatory effects by inhibiting the MAPK, PI3K/Akt, and NF-kappa B signaling pathways. The presence of acteoside and isoacteoside in CAO contributes to its potential as an anti-inflammatory agent by suppressing the release of inflammation factors in RAW 264.7 cells.
Article
Cell Biology
Yuanxi Yang, Xin Ran, Hefei Wang, Yingsheng Chen, Shuang Hou, Zhanqing Yang, Shoupeng Fu, Juxiong Liu, Guiqiu Hu, Wenjin Guo
Summary: Evodiamine was found to significantly alleviate pathological injury and pro-inflammatory cytokine production in breast tissue, as well as inhibit the activation of inflammation-related pathways.