Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Clinical Neurology
Mouhammad A. Jumaa, Alicia C. Castonguay, Hisham Salahuddin, Ashutosh P. Jadhav, Kaustubh Limaye, Mudassir Farooqui, Syed F. Zaidi, Nils Mueller-Kronast, David S. Liebeskind, Osama O. Zaidat, Santiago Ortega-Gutierrez
Summary: In the STRATIS Registry, patients with M2 occlusions achieved similar rates of successful reperfusion, good functional outcome, and mortality compared to M1 occlusions, although there were increased rates of symptomatic intracranial hemorrhage in the M2 group. Further studies are needed to understand the benefits of mechanical thrombectomy for M2 occlusions.
Article
Cardiac & Cardiovascular Systems
Ibolya Rutkai, Ivan Merdzo, Sanjay Wunnava, Catherine McNulty, Partha K. Chandra, Prasad Katakam, David W. Busija
Summary: Differences in mitochondrial characteristics, including morphology, respiration, and calcium sparks activity, between male and female rats may contribute to sex differences in protective and repair mechanisms in response to transient ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yen-Heng Lin, Sung-Chun Tang, Chih-Hao Chen, Chung-Wei Lee, Chi-Ju Lu, Li-Kai Tsai, Jiann-Shing Jeng
Summary: The presence of early hyperemia in cortical regions following endovascular thrombectomy for large vessel occlusion stroke is associated with better clinical outcomes at 90 days post-treatment, without an increased risk of hemorrhagic complications.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Wenbin Zhu, Catherine M. M. Davis, Elyse M. M. Allen, Sarah L. L. Feller, Thierno M. M. Bah, Robert E. E. Shangraw, Ruikang K. K. Wang, Nabil J. J. Alkayed
Summary: In this study, the researchers found that poor outcome after stroke in patients with type 2 diabetes (DM2) is linked to impaired microvascular tissue reperfusion. Furthermore, they discovered differences in microvascular reperfusion response between male and female DM2 mice after transient middle cerebral artery occlusion (MCAO). These findings suggest that DM2 impairs capillary perfusion and exacerbates ischemic brain injury in male but not female mice with DM2.
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
Jingxue Yuan, Ziniu Zhang, Jinxia Ni, Xiaona Wu, Haoyue Yan, Jingni Xu, Qi Zhao, Hongwei Yuan, Lei Yang
Summary: This systematic review aims to evaluate the evidence of autophagy in acupuncture therapy for animal models of middle cerebral artery occlusion (MCAO). The study will include publications from various databases and use risk of bias assessment tools and the GRADE system to evaluate the quality of evidence. The results may provide insights into the mechanism of acupuncture therapy for ischemic stroke.
Article
Clinical Neurology
Konstantinos M. Themistoklis, Themistoklis I. Papasilekas, Konstantinos S. Melanis, Konstantinos A. Boviatsis, Stefanos I. Korfias, Konstaninos Vekrellis, Damianos E. Sakas
Summary: The tifMCAO stroke model in rats is widely used and has been proven to reliably mimic human stroke. The surgical technique has been detailed with stepwise instructions and visual aids provided.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Li-Qin Zhao, Ankit Parikh, Yun-Xia Xiong, Qing-Yan Ye, Ying-Guo, Xin-Fu Zhou, Hai-Yun Luo
Summary: This study assessed the effect and mechanisms of oral edaravone on a rat model of middle cerebral artery occlusion. The results showed that oral edaravone improved sensorimotor functions, reduced cerebral infarction area, and provided neuroprotection by minimizing oxidative stress and alleviating synaptic damage.
NEUROTOXICITY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maozhu Liu, Mengyuan Chen, Ying Luo, Hong Wang, Haifeng Huang, Zhe Peng, Miaomiao Li, Huizhi Fei, Wen Luo, Junqing Yang
Summary: Celastrol, a compound isolated from traditional Chinese medicine, demonstrates effectiveness in protecting against cerebral ischemia/reperfusion injury. Through lipidomics analysis, it was found that celastrol can reduce cerebral infarct volume and apoptosis, and regulate lipid metabolism to exert its neuroprotective effects.
Review
Clinical Neurology
Fana Alemseged, Thanh N. Nguyen, Francisco Mont' Alverne, Xinfeng Liu, Wouter J. Schonewille, Raul G. Nogueira
Summary: Basilar artery occlusion is a devastating neurological condition with high risks of disability and death. Despite the lack of randomized controlled trials, recent studies have shown that endovascular therapy (EVT) is beneficial for basilar artery occlusion within 24 hours of onset. These studies emphasized the importance of consecutive recruitment, fast enrollment, and minimizing cross-over to demonstrate the efficacy of EVT. This topical review examines and contextualizes the current evidence on EVT for basilar artery occlusion.
Article
Clinical Neurology
Jingsi Xu, Zheyu Zhang, Bo Jin, Yu Geng, Longting Lin, Sheng Zhang
Summary: This study aimed to determine whether baseline delayed filling of the superficial middle cerebral vein (SMCV) was an independent cause of stroke prognosis in patients with acute anterior large vessel occlusion (LVO). The results showed a significant association between baseline delayed SMCV and a 3-month poor outcome, while SMCV reversal did not significantly change the stroke prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Johannes Goldberg, Peter Vajkoczy, Nils Hecht
Summary: Using indocyanine green videoangiography (ICG-VA) can facilitate identification of potential recipient vessels and detection of pathological flow patterns. Recipients with initially low flow, late appearance, and retrograde flow direction appear to have the highest potential for flow increase.
JOURNAL OF NEUROSURGERY
(2021)
Article
Pharmacology & Pharmacy
Fang Yang, Ze-Ran Chen, Xu-Hong Yang, Yue Xu, Ning-Jing Ran, Mei-Jun Liu, Shuo-Guo Jin, Hua-Nan Jia, Yang Zhang
Summary: This study found that Monomethyl lithospermate (MOL) has a protective effect against neural damage caused by ischemic stroke by activating the PI3K/AKT pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chiara Di Santo, Daniele La Russa, Rosaria Greco, Alessandra Persico, Anna Maria Zanaboni, Giacinto Bagetta, Diana Amantea
Summary: The identification of novel targets to modulate the immune response triggered by cerebral ischemia is crucial for stroke therapeutics. This study revealed the involvement of tumour necrosis factor (TNF)-alpha-stimulated gene 6 (TSG-6) in regulating immune and stromal cell functions in acute neurodegeneration caused by ischemic stroke. The elevated levels of TSG-6 in the brain and peripheral blood indicate its potential detrimental role in the early reperfusion stage, while providing protection against brain infarct volume and neurological deficits when administered acutely. These findings highlight the important role of TSG-6 in ischemic stroke pathobiology and warrant further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Isabel Wilches, Priscila Jimenez-Castillo, Nancy Cuzco, M. Victoria Clos, Francesc Jimenez-Altayo, Eugenia Penaherrera, Lourdes Jerves-Andrade, Vladimiro Tobar, Yvan Vander Heyden, Fabian Leon-Tamariz, Elisabet Vila
Summary: Peperomia galioides extract exhibited anti-inflammatory and sedative activities in mice, confirming its traditional uses.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Aida Muntsant, Francesc Jimenez-Altayo, Lidia Puertas-Umbert, Elena Jimenez-Xarrie, Elisabet Vila, Lydia Gimenez-Llort
Summary: The study reveals that life expectancy decreases with aging, with females having a worse healthy life expectancy. The bidirectional interactions between cardiovascular diseases and Alzheimer's disease are promising areas for further research.
Article
Geriatrics & Gerontology
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Haertig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Summary: The past decade has witnessed significant advancements in both diagnosis and treatment of cerebrovascular diseases, with the introduction of thrombectomy in ischemic stroke and the identification of new therapeutic targets based on deeper understanding of pathomechanisms. Additionally, translational aspects are increasingly recognized in basic science studies, enhancing their predictive value for clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Manuel Castro de Moura, Veronica Davalos, Laura Planas-Serra, Damiana Alvarez-Errico, Carles Arribas, Montserrat Ruiz, Sergio Aguilera-Albesa, Jesus Troya, Juan Valencia-Ramos, Valentina Velez-Santamaria, Agusti Rodriguez-Palmero, Judit Villar-Garcia, Juan P. Horcajada, Sergiu Albu, Carlos Casasnovas, Anna Rull, Laia Reverte, Beatriz Dietl, David Dalmau, Maria J. Arranz, Laia Llucia-Carol, Anna M. Planas, Jordi Perez-Tur, Israel Fernandez-Cadenas, Paula Villares, Jair Tenorio, Roger Colobran, Andrea Martin-Nalda, Pere Soler-Palacin, Francesc Vidal, Aurora Pujol, Manel Esteller
Summary: An epigenome-wide association study identified 44 CpG sites associated with the clinical severity of COVID-19, with some located in genes involved in interferon response to viral infection. A DNA methylation signature (EPICOVID) was established and could be useful in the clinical management of SARS-CoV-2 infected patients when combined with other factors.
Article
Endocrinology & Metabolism
Francesc Jimenez-Altayo, Julia Marzi, Maria Galan, Ana Paula Dantas, Marisa Ortega, Santiago Rojas, Gustavo Egea, Katja Schenke-Layland, Elena Jimenez-Xarrie, Anna M. Planas
Summary: The perivascular tissue surrounding the middle cerebral artery plays a critical role in regulating vessel function through sphingosine-1-phosphate (S1P)-induced vasoconstriction. The presence of the arachnoid membrane is associated with reduced MCA diameters and increased basal tone, with strong S1P signals detected in the arachnoid. Additionally, genetic deletion of SphK2 reduces arachnoid S1P content and vasoconstriction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Editorial Material
Immunology
Donald C. Vinh, Laurent Abel, Paul Bastard, Matthew P. Cheng, Antonio Condino-Neto, Peter K. Gregersen, Filomeen Haerynck, Maria-Pia Cicalese, David Hagin, Pere Soler-Palacin, Anna M. Planas, Aurora Pujol, Luigi D. Notarangelo, Qian Zhang, Helen C. Su, Jean-Laurent Casanova, Isabelle Meyts
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Emma B. Hodcroft, Moira Zuber, Sarah Nadeau, Timothy G. Vaughan, Katharine H. D. Crawford, Christian L. Althaus, Martina L. Reichmuth, John E. Bowen, Alexandra C. Walls, Davide Corti, Jesse D. Bloom, David Veesler, David Mateo, Alberto Hernando, Inaki Comas, Fernando Gonzalez Candelas, Tanja Stadler, Richard A. Neher
Summary: A variant of SARS-CoV-2, 20E (EU1), was identified in Spain in early summer 2020 and later spread across Europe. Despite not showing increased transmissibility, the variant's success can be attributed to rising incidence in Spain, resumption of travel, and lack of effective screening and containment measures. Travel played a significant role in introducing the variant multiple times to European countries during the summer, undermining local efforts to prevent SARS-CoV-2 infection.
Review
Nutrition & Dietetics
Carmen M. Claro-Cala, Francesc Jimenez-Altayo, Sebastian Zagmutt, Rosalia Rodriguez-Rodriguez
Summary: Dietary components, specifically olive oil triterpenes, have potential protective effects against obesity and related metabolic and cardiovascular disorders. This review focuses on understanding the molecular mechanisms and targets of these triterpenic compounds in improving glucose and insulin homeostasis, lipid metabolism, adiposity, and cardiovascular dysfunction in obesity. The study highlights the potential of olive oil as a dietary component for long-term management of obesity and metabolic syndrome in humans.
Article
Clinical Neurology
Nuria Puig, Pol Camps-Renom, Mercedes Camacho, Ana Aguilera-Simon, Francesc Jimenez-Altayo, Alejandro Fernandez-Leon, Rebeca Marin, Joan Marti-Fabregas, Jose Luis Sanchez-Quesada, Elena Jimenez-Xarrie, Sonia Benitez
Summary: In patients with atherothrombotic stroke and carotid plaque inflammation, elevated levels of soluble intercellular adhesion molecule-1 (sICAM-1) are associated with an increased risk of stroke recurrence.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Francesc Jimenez-Altayo, Anna Cabrera, Andrea Bagan, Lydia Gimenez-Llort, Pilar D'Ocon, Belen Perez, Merce Pallas, Carmen Escolano
Summary: This study provides evidence that I2R does not play a functional role in modulating vascular tone in mouse aorta. MCR5, an I2R ligand, acts as an endothelium-independent vasodilator and is resistant to aging.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Isaac Rodriguez-Rovira, Cristina Arce, Karo De Rycke, Belen Perez, Aitor Carretero, Marc Arbones, Gisela Teixido-Tura, Mari Carmen Gomez-Cabrera, Victoria Campuzano, Francesc Jimenez-Altayo, Gustavo Egea
Summary: This study reveals that XOR plays a role in the progression of MFS aortopathy, and inhibiting XOR can halt the development of aortic root aneurysm in MFS mice. The study also suggests that redox stress is an important determinant of aortic aneurysm formation and progression in MFS, and further evaluation of XOR inhibitors in MFS patients is warranted.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Clinical Neurology
Lidia Puertas-Umbert, Nuria Puig, Mercedes Camacho, Ana Paula Dantas, Rebeca Marin, Joan Marti-Fabregas, Elena Jimenez-Xarrie, Sonia Benitez, Pol Camps-Renom, Francesc Jimenez-Altayo
Summary: Severe carotid atherosclerosis may worsen endothelial dysfunction in stroke, increasing the risk of further cerebrovascular events. Serum from stroke patients induces endothelium dysfunction in mice carotid arteries, especially in patients with recurrent strokes or vascular death within 1 year. Serum from patients with high-grade stenosis induces more severe carotid artery endothelial dysfunction, associated with elevated levels of circulating IL-1 beta. The study suggests that targeting COX in the carotid artery wall may be a potential therapeutic strategy for secondary stroke prevention.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Nuria Puig, Pol Camps-Renom, Arnau Sole, Ana Aguilera-Simon, Elena Jimenez-Xarrie, Alejandro Fernandez-Leon, Mercedes Camacho, Marina Guasch-Jimenez, Rebeca Marin, Joan Marti-Fabregas, Alejandro Martinez-Domeno, Luis Prats-Sanchez, Francesca Casoni, Belen Perez, Francesc Jimenez-Altayo, Jose Luis Sanchez-Quesada, Sonia Benitez
Summary: This study aimed to identify modified LDLs and antioxidant enzymes associated with plaque vulnerability in patients with ischemic stroke and carotid atherosclerosis. Patients showed lower levels of cholesterol and apolipoproteins, as well as lower enzymatic activities of PAF-AH and PON-1 in HDL and higher levels of oxidized LDL and electronegative LDL. The proportion of LDL(-) was independently associated with carotid stenosis, hypoechoic plaque presence, and diffuse neovessels.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
