Article
Biochemistry & Molecular Biology
Yingying Liang, Sevin Turcan
Summary: Epigenetic drugs have been used in the treatment of hematologic malignancies, and their potential in solid tumors is still being investigated. Current evidence suggests that these drugs may enhance antitumor immunity by increasing antigen presentation and improving the therapeutic effect of immune checkpoint inhibitors.
Review
Biochemistry & Molecular Biology
Sarah S. Wang, Jihao Xu, Keely Y. Ji, Chang-Il Hwang
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a significant cause of cancer-related deaths in the United States. While genetic mutations driving PDA initiation and progression have been identified, the mechanisms underlying PDA metastasis remain elusive. It is suggested that epigenetic fluctuations may play a critical role in driving PDA metastasis.
Article
Chemistry, Medicinal
Gianluca Tedaldi, Chiara Molinari, Celina Sao Jose, Rita Barbosa-Matos, Ana Andre, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Luca Saragoni, Paolo Morgagni, Francesca Rebuzzi, Matteo Canale, Sara Pignatta, Elisa Ferracci, Giovanni Martinelli, Guglielmina Nadia Ranzani, Carla Oliveira, Daniele Calistri, Paola Ulivi
Summary: This study aimed to elucidate the role of genetic variants and DNA methylation of CDH1 promoter and enhancers in the regulation of gene expression in gastric cancer. The results showed that alterations in terms of genetic variants and DNA methylation patterns of both promoter and enhancers are associated with CDH1 expression levels and have a role in its regulation. The study revealed different methylation patterns in patients and controls, GC cell lines and GC tissues, expressing different E-cadherin levels.
Review
Hematology
Shuhui Zhuang, Zhaobo Yang, Zhuangzhuang Cui, Yuanyuan Zhang, Fengyuan Che
Summary: Lymphomas are complex and heterogeneous malignant tumors originating from the lymphopoietic system. Epigenetic modifications, such as DNA methylation, histone modifications, non-coding RNA regulation, and RNA modifications, have been found to play crucial roles in lymphoma pathogenesis. Drugs targeting epigenetic modifications have shown therapeutic efficacy and tolerability in both monotherapy and combination lymphoma therapy. This review discusses the pathogenic mechanisms and potential epigenetic therapeutic targets in common lymphomas, providing new avenues for lymphoma diagnosis and treatment. It also highlights the shortcomings of current lymphoma treatments and suggests potential areas for future research to improve lymphoma prediction and prognosis.
ANNALS OF HEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Diana Araujo, Eduarda Ribeiro, Irina Amorim, Nuno Vale
Summary: Gastric cancer is a leading cause of death worldwide, and most patients are diagnosed at an advanced stage with poor prognosis. Current treatment options include endoscopic detection, surgery, and chemotherapy or chemoradiotherapy. Drug repurposing, exploring new therapeutic indications for approved drugs, is an important approach to drug development.
Article
Chemistry, Medicinal
Desaboini Nageswara Rao, Jacqueto Zephyr, Mina Henes, Elise T. Chan, Ashley N. Matthew, Adam K. Hedger, Hasahn L. Conway, Mohsan Saeed, Alicia Newton, Christos J. Petropoulos, Wei Huang, Nese Kurt Yilmaz, Celia A. Schiffer, Akbar Ali
Summary: By designing and synthesizing compounds with different chemical scaffolds at the P2 and P4 positions, researchers developed pan-genotypic HCV NS3/4A protease inhibitors with excellent antiviral activity and improved drug resistance profiles.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Lirui Wang, Chunlei Zhang, Yuping Hong, Xinhong Li, Tangan Li, Ang Gao, Shaojun Pan, Bin Liu, Han Jin, Daxiang Cui
Summary: The study developed a method of combinatorial delivery of epigenetic modulatory drugs through self-assembly, effectively regulating DNA methylation and histone deacetylation, ultimately inhibiting tumor cell proliferation and promoting cell apoptosis.
Review
Biochemistry & Molecular Biology
Serena Battista, Maria Raffaella Ambrosio, Francesco Limarzi, Graziana Gallo, Luca Saragoni
Summary: The article reviews the diagnostic and prognostic values of molecular markers in gastric cancer, focusing on the correlation between molecular alterations and prognosis in preinvasive neoplasia and early gastric cancer, as well as the (immuno)histochemical characterization of diffuse-type gastric cancer. The aim is to evaluate suitable biomarkers used in the pre-surgical phase for distinguishing patients with different prognoses and determining the best therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xinmei Zhang, Chao Li, Weijun Cao, Zhenyu Zhang
Summary: Microbial infections are known to contribute to gastric carcinogenesis, and changes in gastric microbiota may aid in early diagnosis of gastric cancer. This study aimed to characterize microbial changes and identify taxonomic biomarkers across stages of gastric carcinogenesis. The results showed that the richness and diversity of gastric microbiota did not show a gradual changing trend, with certain oral bacteria continuously enriching from superficial gastritis to gastric cancer. Patients with gastric cancer had enrichments of both oral and environmental bacteria, while those with gastric intraepithelial neoplasia had an enrichment of intestinal commensals. Gastric cardia cancer and non-cardia cancer patients had significantly different microbiota profiles, with a higher abundance of Helicobacter in the cardia cancer patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Eduardo E. E. Montalvo-Jave, Natalia Nuno-Lambarri, Guillermo Nahum Lopez-Sanchez, Edwin A. A. Ayala-Moreno, Gabriela Gutierrez-Reyes, Joal Beane, Timothy M. M. Pawlik
Summary: Pancreatic cancer is a lethal disease driven by multiple genetic and epigenetic alterations. Advances in microarray and omics-based sequencing techniques have led to the discovery of novel disease markers, prognostic factors, and therapeutic targets for pancreatic ductal adenocarcinoma (PDAC).
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Narendra Wajapeyee, Romi Gupta
Summary: Cancer cells harbor multiple genetic and epigenetic alterations, but targeted therapy can still effectively treat various types of cancer. Resistance often emerges, posing a major clinical hurdle. Mechanisms for resistance to targeted therapy have been identified through alterations to the transcriptome and chromatin regulatory proteins.
Review
Oncology
Aisling Y. Coughlan, Giuseppe Testa
Summary: Ovarian cancer therapy has not seen significant advancements in the past 50 years, with surgery and chemotherapy remaining the main treatments. Alterations in epigenetic regulators are closely associated with ovarian cancer and may serve as therapeutic targets. New models and technologies allow for a better understanding of the epigenetic pathways in ovarian cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, Research & Experimental
Wei Zeng, Jinfeng Zhu, Dongqiang Zeng, Jian Guo, Genjie Huang, Yu Zeng, Ling Wang, Jianping Bin, Yulin Liao, Min Shi, Wangjun Liao
Summary: We developed an epigenetic modification-associated molecular classification for gastric cancer (GC) and identified signature genes. The classification system was highly associated with clinicopathological characteristics and existing classifications of GC. PIP4P2, an independent prognostic factor of the classification system, played a crucial role in predicting prognosis and immunotherapy efficacy.
LABORATORY INVESTIGATION
(2023)
Article
Oncology
Rui Peng, Shuai Liu, Wenhua You, Yedi Huang, Chupeng Hu, Ye Gao, Xuemei Jia, Gang Li, Zekuan Xu, Yun Chen
Summary: The study investigates the alterations in gastric microbiota in patients with gastric cancer and explores the potential association between these alterations and immune dysregulation. The results reveal that the gastric cancer microbiota is characterized by reduced diversity and enrichment of specific genera such as Oceanobacter, Methylobacterium and Syntrophomonas. Methylobacterium is significantly associated with poor prognoses in patients with gastric cancer and inversely correlated with the frequency of CD8+ tissue-resident memory T cells. It suggests that the tumor microbiota and exhausted CD8+ TRM cells in the tumor microenvironment are significantly correlated, and Methylobacterium may play a role in gastric carcinogenesis.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Marina V. Nemtsova, Alexey I. Kalinkin, Ekaterina B. Kuznetsova, Irina V. Bure, Ekaterina A. Alekseeva, Igor I. Bykov, Tatiana V. Khorobrykh, Dmitry S. Mikhaylenko, Alexander S. Tanas, Vladimir V. Strelnikov
Summary: Epigenetic mechanisms play a crucial role in gene expression patterns, and their deregulations can affect oncogenesis and metastasis in gastric cancer. Mutations in epigenetic regulation genes, particularly in KMT2D, KMT2C, ARID1A, and CHD7, were found to be associated with reduced overall survival of patients, especially in those with metastases and signet ring cell tumors. This suggests that mutations in epigenetic regulation genes may serve as valuable clinical markers for prognosis in gastric cancer patients.
Review
Cell Biology
Sadegh Fattahi, Mohadeseh Kosari-Monfared, Monireh Golpour, Zakieh Emami, Mohammad Ghasemiyan, Maryam Nour, Haleh Akhavan-Niaki
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Hamed Tashakkorian, Vahid Hasantabar, Amrollah Mostafazadeh, Monire Golpour
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Oncology
Mostafa Kardan, Alireza Rafiei, Monireh Golpour, Mohammad Ali Ebrahimzadeh, Haleh Akhavan-Niaki, Sadegh Fattahi
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2020)
Article
Neurosciences
Mohammad Saied Salehi, Sareh Pandamooz, Anahid Safari, Benjamin Jurek, Amin Tamadon, Mohammad Reza Namavar, Mehdi Dianatpour, Leila Dargahi, Negar Azarpira, Sadegh Fattahi, Seyed Mostafa Shid Moosavi, Somaye Keshavarz, Zahra Khodabandeh, Shahrokh Zare, Somayeh Nazari, Mojdeh Heidari, Sadegh Izadi, Maryam Poursadeghfard, Afshin Borhani-Haghighi
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Article
Genetics & Heredity
Roghayeh Pourbagher, Haleh Akhavan-Niaki, Seyed Gholam Ali Jorsaraei, Sadegh Fattahi, Davood Sabour, Ebrahim Zabihi, Zeinab Abedian, Masoumeh Ghasemi, Monireh Golpour, Amrollah Mostafazadeh
Article
Environmental Sciences
Hoda Talebian, Ali Shabestani Monfared, Haleh Akhavan Niaki, Sadegh Fattahi, Elaheh Bakhtiari, Vahid Changizi
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2020)
Article
Cardiac & Cardiovascular Systems
Azin Aghamajidi, Hesam Babaei Khameneh, Narges Amirjamshidi, Seyed Farzad Jalali, Haleh Akhavan-Niaki, Soraya Khafri, Seyedeh Narges Mousavi, Monireh Golpour, Maryam Mehri, Amrollah Mostafazadeh
Summary: Cellular stress response is crucial in the pathophysiology of CAD, and proteins derived from heat-stressed fibroblasts show potential therapeutic application for the diagnosis and management of CAD. The study found that fibroblast-derived heat shock proteins can be used as a diagnostic tool for CAD through antibody production.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Dermatology
Monireh Golpour, Mina Alimohammadi, Farshad Sohbatzadeh, Sadegh Fattahi, Sander Bekeschus, Alireza Rafiei
Summary: Despite advances in therapy, malignant melanoma remains a fatal disease. Cold atmospheric pressure plasma (CAP), which releases reactive oxygen and nitrogen species (ROS/RNS), has shown promising results as a novel antitumor agent in preclinical models. In addition, malignant melanoma can be targeted by mild starvation. This study investigated the combined effect of starvation and CAP treatment on melanoma in vitro and in vivo, finding that the combination exhibited enhanced antitumor effects.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Monireh Golpour, Mina Alimohammadi, Alireza Mohseni, Ehsan Zaboli, Farshad Sohbatzadeh, Sander Bekeschus, Alireza Rafiei
Summary: This study evaluated the effects of cold plasma or plasma-treated solutions on the hematologic parameters of CLL patients. The results showed that these treatments did not significantly affect the blood parameters of the patients but increased lipid peroxidation and RNS deposition, while decreasing the metabolic activity of white blood cells.
APPLIED SCIENCES-BASEL
(2022)
Article
Immunology
Monireh Golpour, Tahoora Mousavi, Mina Alimohammadi, Ali Mosayebian, Mohammadreza Shiran, Reza Alizadeh Navaei, Alireza Rafiei
Summary: The study evaluated the efficacy of Colchicine in the treatment of COVID-19, with results showing that Colchicine therapy is associated with decreased mortality rate and hospitalization time in COVID-19 patients.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Monireh Golpour, Pouya Vatanpour, Mina Amini, Majid Saeedi, Nasim Hafezi, Alireza Rafiei
Summary: The study examined the market of monoclonal therapeutic antibodies in Iran and found that the majority were humanized antibodies used for cancer treatment. By 2025, sales of MTA-based medications are projected to grow significantly.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2021)
Article
Genetics & Heredity
Alireza Paniri, Mohammad Mahdi Hosseini, Mojtaba Moballegh-Eslam, Haleh Akhavan-Niaki
Summary: This study revealed that certain SNPs within the ACE2 gene may affect its function and stability, consequently influencing susceptibility to and response to COVID-19 infection. This sheds light on the potential factors contributing to individual variability in drug response among patients.
