Article
Chemistry, Multidisciplinary
Jiawei Zhao, Yugang Wang, Wenjing Wang, Ying Tian, Zhongdong Gan, Yanlei Wang, Hongyan He, Wei Chen, Xiao Zhang, Yuanbin Wu, Rongrong Jia, Min Shi, Wei Wei, Guanghui Ma
Summary: This study demonstrates the successful enhancement of therapeutic performance of antioxidants by growing cerium oxide nanocrystals onto red blood cell vesicles, leading to strong ROS scavenging activity in inflammatory disease models. Moreover, the hybridization of vesicles with exosomes shows additional repair function for damaged tissues.
Article
Materials Science, Multidisciplinary
Qingling Yang, Xiaoyan Luo, Yujiao Wang, Hui Li, Luping Cong, Yingpu Sun
Summary: Cerium oxide nanoparticles (CeO2 NPs) can protect against high fat diet-induced oocyte dysfunction in mice, improving mitochondrial functions, reducing ER stress, and enhancing oocyte quality.
APPLIED MATERIALS TODAY
(2021)
Article
Cell Biology
Nikita N. Chukavin, Vladimir K. Ivanov, Anton L. Popov
Summary: This study investigated a new type of cerium oxide nanoparticles that can monitor intracellular reactive oxygen species (ROS) activity by releasing fluorescent dye calcein. The results show that these nanoparticles have selective cytotoxicity against cancer cells and can modulate the expression of key genes related to cell redox status and proliferation/migration activity.
Article
Biology
Emory Bibb, Noura Alajlan, Saad Alsuwailem, Benjamin Mitchell, Amy Brady, Muhammad Maqbool, Remo George
Summary: Research shows that internalized nanoceria can reduce reactive oxygen species levels at different radiation doses, improving the health of breast cancer cells and providing radiation protection.
Article
Biotechnology & Applied Microbiology
Jiwang Deng, Bangxian Yu, Zhenglin Chang, Sicheng Wu, Guanlin Li, Wenzhe Chen, Shujue Li, Xiaolu Duan, Wenqi Wu, Xinyuan Sun, Guohua Zeng, Hongxing Liu
Summary: Oxidative stress damage to renal epithelial cells plays a significant role in the formation of calcium oxalate calculi. In this study, porous nanorods CeO2 nanoparticles (CNPs) were used as an antioxidant reagent to suppress kidney calcium oxalate crystal depositions. The results showed that CNPs could effectively reduce oxidative damage, inhibit calcium oxalate crystallization, and protect renal epithelial cells from stress damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Mohd Aslam Saifi, Sudipta Seal, Chandraiah Godugu
Summary: Cerium oxide nanoparticles possess outstanding ROS scavenging activities, protecting from oxidative stress and having environment-dependent ROS modulating properties. They have advantages over other NPs, but their potential still needs critical evaluation.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Iason Chatzimentor, Ioannis Tsamesidis, Maria-Eleni Ioannou, Georgia K. Pouroutzidou, Anastasia Beketova, Veronica Giourieva, Rigini Papi, Eleana Kontonasaki
Summary: This study investigated the biological properties and antimicrobial behavior of cerium oxide nanoparticles (CeO2 NPs). The results showed that CeO2 NPs have the potential to promote proliferation and osteogenic differentiation of human periodontal ligament cells, inhibit bacterial proliferation, and control inflammatory conditions.
Article
Biochemistry & Molecular Biology
Mohd Jahir Khan, Abrar Ahmad, Mahmood Ahmad Khan, Sahabjada Siddiqui
Summary: This study investigated the anticancer properties of zinc oxide nanoparticles (ZnO-NPs) on human epidermoid carcinoma cells and found that ZnO-NPs induce apoptosis in A431 cells through DNA degradation and generation of reactive oxygen species via p53, bax/bcl-2, and caspase pathways.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Ying-juan Hao, Xiao Zhang, Hang Zhang, Yue-guang Ma, Ying Liu, Yi-lei Li, Jun Zhao, Fa-tang Li
Summary: Understanding the activity enhancement mechanism of VOC oxidation reaction is crucial for the development of efficient and cost-effective photothermocatalytic materials. In this study, porous and low-cost CeO2-MgO composite oxides were synthesized and applied for toluene photothermocatalytic oxidation. The optimized sample achieved a conversion rate of 90% for 1500 ppm toluene under the conditions of 330 degrees C and a gas hourly space velocity of 60,000 mL center dot g(-1)center dot h(-1). Gas phase oxygen and reactive oxygen species (ROS) were found to play a dominant role in the photothermocatalytic activity, while the contribution of photoinduced holes and surface lattice oxygen was 25%. In situ Fourier transform infrared and electron paramagnetic resonance results indicated that the synergistic photothermo activation of molecular oxygen accelerated the formation of low-temperature ROS.
ACS APPLIED NANO MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Balaashwin Babu, Samantha Archer Stoltz, Agastya Mittal, Shreya Pawar, Elayaraja Kolanthai, Melanie Coathup, Sudipta Seal
Summary: Nanotechnology has revolutionized cancer treatment by developing functional nanoparticle formulations that can increase tumor cell radiolysis and achieve localized therapeutic effects. These radiosensitive nanomaterials can selectively target tumor cells under specific physiological conditions, while minimizing damage to healthy cells.
Article
Dentistry, Oral Surgery & Medicine
Wenjia Hu, Kendrick Hii Ru Yie, Chongxing Liu, Jinlei Zhu, Zhuo Huang, Bingbing Zhu, Dongyang Zheng, Bingqian Yang, Benheng Huang, Lili Yao, Jinsong Liu, Xinkun Shen, Zhennan Deng
Summary: This study investigates the anti-oxidative stress potential of titanium surface cerium oxide nanoparticles (CNPs) coatings doped with different concentrations of lanthanum ions (La3+). The results show that the La-CNPs group with a doping concentration of 30% exhibits the best cell proliferation and osteogenic differentiation, as well as activation of the FoxO1 pathway and inhibition of ROS production. These findings suggest that the 30% La-CNPs coating holds promising potential for implant applications in patients with oxidative stress-related diseases.
Article
Biotechnology & Applied Microbiology
Xunshan Ren, Huangming Zhuang, Yuelong Zhang, Panghu Zhou
Summary: The study utilized antioxidant PEG-CeONPs to enhance the function of hUCMSCs in the tendon injury area, reduce oxidative stress, and facilitate tendon healing.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ali Ghorbani Ranjbary, Golnaz Karbalaei Saleh, Mohammadreza Azimi, Fatemeh Karimian, Jalil Mehrzad, Javad Zohdi
Summary: This study investigated the induction of apoptosis in colon cancer cells by Fe3O4 MNPs and its mechanism. The results showed that Fe3O4 MNPs successfully induced apoptosis in HT-29 cells by increasing the production of ROS and Ca2+, causing DNA damage, and regulating the expression of apoptotic proteins.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Renkai Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Wen Wang, Yiu-Wa Kwan, Emily Sze-Wan Wong, Yanbo Zhang, Jingjing Li, George Pak-Heng Leung
Summary: Despite various therapeutic approaches, developing novel and more effective methods for colorectal cancer treatment is crucial due to its high fatality rate. The recent study explored the anticancer effects of GAR E, a bioactive xanthone found in mangosteen, and identified the involvement of the ROS/JNK signaling pathway in its mechanism of action. The experiments demonstrated that GAR E inhibited colony formation and wound healing in cancer cells, triggered ROS production, induced mitochondrial dysfunction and apoptosis, and caused cell cycle arrest. In vivo experiments also confirmed the antitumor effect of GAR E in a xenograft mouse model. These findings suggest that GAR E could be a potential chemotherapeutic agent for colorectal cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Akhil Patel, Jessica Kosanovich, Sameera Sansare, Sricharani Balmuri, Vinayak Sant, Kerry M. Empey, Shilpa Sant
Summary: This study investigates the potential of cube and sphere-shaped cerium oxide nanoparticles (CNP) to modulate reactive oxygen (ROS) and nitrogen (RNS) species and immune cell phenotypes in the presence of RSV infection. The results show that cube CNP significantly reduces RSV-induced ROS levels and drives an M1 phenotype in RSV-infected macrophages. Sphere CNP increases RSV-induced RNS levels with minimal effect on ROS levels and decreases M2 marker CD206 expression. Cube CNP preferentially accumulates in murine alveolar macrophages and induces their activation, avoiding enhanced uptake and activation of other inflammatory cells.
BIOACTIVE MATERIALS
(2023)
Article
Neurosciences
Mohaddeseh Sadat Alavi, Sahar Fanoudi, Azar Hosseini, Mohammad Jalili-Nik, Amirbehzad Bagheri, Hamid R. Sadeghnia
Summary: This study aimed to investigate the neuroprotective potential of everolimus (EVR), a selective and potent mTOR inhibitor, against glutamate-induced toxicity in PC12 cells. The results demonstrated that EVR significantly increased cell viability, inhibited glutamate-induced apoptosis, and regulated the expression of apoptosis-related proteins. This is the first study to discover the protective effect of EVR against glutamate-mediated PC12 cell death through the inhibition of apoptosis.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Inorganic & Nuclear
Morvarid Najjar, Mohammad Ali Nasseri, Ali Allahresani, Majid Darroudi
Summary: The application of Ocimum basilicum L. seed was investigated in this study for the synthesis of photoluminescence carbon quantum dots (CQDs) using a simple one-step hydrothermal method. The structural and optical properties of the synthesized CQDs were characterized, and their photocatalytic activity for dye degradation and ion adsorption in water was evaluated. The results showed that the synthesized CQDs exhibited high water solubility, satisfactory optical properties, and a small average size. This study provides valuable insights into the use of CQDs for various applications.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Negin Alizadehmohajer, Shahrzad Zahedifar, Ehsan Sohrabi, Sedighe Shaddel Basir, Shima Nourigheimasi, Reza Falak, Reza Nedaeinia, Gordon A. Ferns, Asieh Emami Nejad, Mostafa Manian
Summary: This study investigated seventeen mutations in the spike protein of SARS-CoV-2 and identified two mutations, H146Y and S221W, as the most pathogenic. Mutations at positions D614G, A829T, and P1263L may also have deleterious effects. The study also found that interactions between the spike protein and ACE2 receptor may limit the infection or have detrimental effects. These findings have important implications for understanding the transmission and pathogenesis of SARS-CoV-2, as well as potential drug repurposing and immune therapies.
BIOCHEMICAL GENETICS
(2023)
Article
Environmental Sciences
Mahmood Kermani, Asma Mostafapour, Zahra Sabouri, Seyed Mohammad Gheibihayat, Majid Darroudi
Summary: This study achieved the manufacturing of zinc oxide nanoparticles using Trigonella foenum-graecum L extract as a stabilizing and reducing agent through the sol-gel method. The effects of calcination temperature on the size of the nanoparticles were observed. The photocatalytic performance of the nanoparticles showed efficient degradation of dyes, and the nanoparticles also exhibited antibacterial and anticancer properties.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Azar Hosseini, Elham Pourheidar, Arezoo Rajabian, Elham Asadpour, Hossein Hosseinzadeh, Hamid Reza Sadeghnia
Summary: This study explored the neuroprotective mechanisms of linalool and its enantiomer against oxygen and glucose deprivation/reoxygenation (OGD/R) in PC12 cells, and found that they alleviated oxidative stress and apoptosis.
FOOD SCIENCE & NUTRITION
(2023)
Article
Engineering, Environmental
Zahra Sabouri, Mohammad Sabouri, Samaneh Sadat Tabrizi Hafez Moghaddas, Majid Darroudi
Summary: The goal of this study was to synthesize amino-functionalized Fe3O4@SiO2 core-shell magnetic nanoparticles as an efficient photocatalyst for removing organic dyes from water. The core-shell structure of magnetic Fe3O4@SiO2 was obtained through the co-precipitation method using a silica source. The nanoparticles were then functionalized with 3-Aminopropyltriethoxysilane (APTES) via a post-synthesis link. XRD, VSM, FT-IR, FESEM, EDAX, and DLS/Zeta potential analyses were used to characterize the chemical structure, magnetic properties, and shape of the manufactured photocatalyst (Fe3O4@SiO2-NH2). The nanoparticles showed high photocatalytic activity for MB degradation, with a degradation performance of approximately 90% under optimum conditions. Furthermore, the cytotoxicity of the nanoparticles was evaluated on CT-26 cells, and they exhibited potential for inhibiting cancer cell growth.
JOURNAL OF ENVIRONMENTAL HEALTH SCIENCE AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Seyedeh Mozhdeh Mirzaei, Reza Kazemi Oskuee, Kayvan Sadri, Zahra Sabouri, Bahareh Farasati Far, Hadi Sajid Abdulabbas, Majid Darroudi
Summary: In this study, sulfur quantum dots (SQDs) were synthesized from cheap sublimated sulfur powder and stabilized with sucrose for enhanced stability and biocompatibility. The SQDs exhibited good water dispersity, high quantum yield, and uniformly spherical shape. Cell uptake experiments showed that cancer cells had higher uptake of SQDs compared to normal cells. In vivo biodistribution results demonstrated that SQDs mainly accumulated in the kidneys and had rapid renal clearance. These findings suggest the potential of SQDs for diagnosis and therapy.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Pegah Mahmoodi, Alireza Motavalizadehkakhky, Majid Darroudi, Jamshid Mehrzad, Rahele Zhiani
Summary: Cerium oxide nanoparticles (CeO2-NPs) and Zn-Ni dual-doped CeO2-NPs were synthesized using a green approach with zucchini peel extract. The dual-doped CeO2-NPs had a spherical morphology and increased in size at higher temperatures. MTT assay on Huh-7 cells showed 50% cell death with undoped CeO2-NPs and Zn-Ni dual-doped CeO2-NPs at inhibitory concentrations (IC50) of 700 and 185.4 µg/mL, respectively. Enzymatic functionality of SOD and CAT was dose-dependent for undoped and dual-doped CeO2-NPs, with Zn-Ni dual-doped CeO2-NPs increasing CAT activity without affecting SOD activity at similar concentrations.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Materials Science, Ceramics
Zohreh Efati, S. Shirin Shahangian, Majid Darroudi, Hamed Amiri, Seyed Isaac Hashemy, Mahmoud Reza Aghamaali
Summary: This study describes a green synthesis method for zinc oxide nanoparticles (ZnO-NPs) using Lepidium sativum L. seed extract as a capping agent, and evaluates their anticancer activities against human colorectal cancer cells. The results demonstrate the significant cytotoxic effect of ZnO-NPs on cancer cells and their potential as a novel therapeutic agent for colorectal cancer treatment.
CERAMICS INTERNATIONAL
(2023)
Article
Physics, Multidisciplinary
Mahin Velayati, Hassan Hassani, Hasan Ali Hosseini, Zahra Sabouri, Asma Mostafapour, Majid Darroudi
Summary: In this paper, Selenium nanoparticles (Se-NPs) were synthesized using a green approach and their morphology, structure, and properties were characterized. The results showed that the Se-NPs had excellent photocatalytic performance for dye degradation and exhibited certain toxicity against the cell line.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Biotechnology & Applied Microbiology
Mohammad Javad Javid-Naderi, Zahra Sabouri, Amin Jalili, Hossein Zarrinfar, Saeed Samarghandian, Majid Darroudi
Summary: Copper oxide nanoparticles (CuO-NPs) were synthesized using okra fruit extract as a stabilizer and reducing agent. The resulting CuO-NPs exhibited a monoclinic structure with a size of about 25 nm. The CuO-NPs showed effective photocatalytic and anticancer properties.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Review
Multidisciplinary Sciences
Zohreh Abdi-Moghadam, Yeganeh Mazaheri, Alieh Rezagholizade-shirvan, Maryam Mahmoudzadeh, Mansour Sarafraz, Mahnaz Mohtashami, Samira Shokri, Ahmad Ghasemi, Farshid Nickfar, Majid Darroudi, Hedayat Hossieni, Zahra Hadian, Ehsan Shamloo, Zeinab Rezaei
Summary: Essential oils derived from plants possess antioxidant and antimicrobial properties, and have been extensively studied for their potential applications in the food industry, agriculture, and skin health. In particular, essential oils have demonstrated antifungal activity against various species of Aspergillus and other fungal pathogens. These findings suggest the potential of essential oils as alternative preservatives to enhance the shelf life of food products.
Review
Nutrition & Dietetics
Zohreh Abdi-Moghadam, Majid Darroudi, Maryam Mahmoudzadeh, Mahnaz Mohtashami, Amir Mohammad Jamal, Ehsan Shamloo, Zeinab Rezaei
Summary: The food industry has focused on producing enriched products to improve physiological function and enhance nutritional value. Yogurt, as a functional food, has gained popularity due to its high nutritional value and low price, making it a good candidate for enrichment with micronutrients and probiotics.
CLINICAL NUTRITION ESPEN
(2023)
Article
Engineering, Biomedical
Samaneh Hashemi Ghoochani, Hasan Ali Hosseini, Zahra Sabouri, Mohammad Hasan Soheilifar, Hoda Keshmiri Neghab, Alireza Hashemzadeh, Mahin Velayati, Majid Darroudi
Summary: The study involves the use of photodynamic treatment to remove specific cancer cells by activating a photosensitizer with specific light. Zinc porphyrin (Zn[TPP]) was prepared and encapsulated into MIL-101 (Zn[TPP]@MIL-101) for use in photodynamic therapy against MCF-7 breast cancer cells under red light-emitting diode. Various characterization methods were used to investigate the changes in structure, morphology, surface area, and composition. The MTT assay demonstrated an IC50 of 14.3 and 81.6 mg/mL for light and dark groups respectively, indicating the efficient eradication of cancer cells using Zn[TPP]@MIL-101 in photodynamic therapy.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Chemistry, Physical
Samaneh Ghazal, Mahdi Mirzaee, Majid Darroudi, Zahra Sabouri, Sara Khadempir
Summary: In this study, pure tungsten oxide nanoparticles and silver-doped tungsten oxide nanoparticles were synthesized using chitosan as the reducing and stabilizing agent. The nanoparticles were characterized using various techniques and their cytotoxicity and photocatalytic properties were evaluated. The results showed that the silver-doped tungsten oxide nanoparticles exhibited inhibitory effects on cancer cells and had a higher photocatalytic degradation efficiency compared to the pure tungsten oxide nanoparticles.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2024)
